Abstract：
:In a preceding paper for brain tumors, we demonstrate a tight association between regional hypermethylation at locus D17S5 of chromosome 17p and allelic loss of this chromosome. Because 17p allelic losses occur at the earliest stages of brain tumors, the exact temporal relationship between this event and the hypermethylation could not be elucidated. In renal cancers, two linked structural changes on chromosome 17p, allelic loss and p53 gene mutations, generally occur late in progression. We now show that D17S5 hypermethylation is tightly coupled to both of these genetic changes in late stage renal tumors. However, the methylation change is the only one of the 17p abnormalities which occurs at a high incidence in early-stage renal cancers (hypermethylation, 50%; 17p allelic loss, 13%; p53 mutations, 0%). Our results firmly suggest that D17S5 regional hypermethylation precedes the appearance of the consistent 17p genetic changes in renal cancers, suggesting that this event either marks, or may even cause, chromatin changes which predispose to genetic instability.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Makos M,Nelkin BD,Reiter RE,Gnarra JR,Brooks J,Isaacs W,Linehan M,Baylin SBsubject
Has Abstractpub_date
1993-06-15 00:00:00pages
2719-22issue
12eissn
0008-5472issn
1538-7445journal_volume
53pub_type
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