Tumor cell kinetics following antineoplastic ether phospholipid treatment.

abstract：:Vascular endothelial growth factor (VEGF) has been investigated as a potent mediator of brain tumor angiogenesis, vascular permeability, and glioma growth. Using a VEGF ELISA, we determined the concentration of VEGF in the sera and tumor extracts of 19 brain tumor patients including glioblastoma, anaplastic astrocytom...

journal_title：Cancer research

authors： Takano S,Yoshii Y,Kondo S,Suzuki H,Maruno T,Shirai S,Nose T

更新日期：1996-05-01 00:00:00

abstract：:Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-agent preclinical activity in cancers with high levels of replication st...

journal_title：Cancer research

authors： Rogers RF,Walton MI,Cherry DL,Collins I,Clarke PA,Garrett MD,Workman P

更新日期：2020-04-15 00:00:00

abstract：:Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with germline BRCA gene mutations. In hypothesizing that ad...

journal_title：Cancer research

authors： Bajrami I,Frankum JR,Konde A,Miller RE,Rehman FL,Brough R,Campbell J,Sims D,Rafiq R,Hooper S,Chen L,Kozarewa I,Assiotis I,Fenwick K,Natrajan R,Lord CJ,Ashworth A

更新日期：2014-01-01 00:00:00

abstract：:Certain ductal carcinoma in situ (DCIS) lesions overexpress the HER-2/neu receptor at this early stage of breast cancer development. Recently, we showed that a HER-2-targeted dendritic cell vaccine could be used to eliminate HER-2-overexpressing cells in patients that harbor these high-risk DCIS lesions. Our findings ...

journal_title：Cancer research

authors： Czerniecki BJ,Roses RE,Koski GK

更新日期：2007-07-15 00:00:00

abstract：:The local growth rate of Morris Hepatoma 44 (generation time, 6 months) was inhibited by 66 to 87%, and host survival was prolonged by 36 to 78% after the induction of hypothyroidism within 2 weeks of tumor implantation by propylthiouracil (0.1% in Purina chow), 131I(1 mCi/100 g body weight i.p.), or surgical thyroide...

journal_title：Cancer research

authors： Mishkin SY,Pollack R,Yalovsky MA,Morris HP,Mishkin S

更新日期：1981-08-01 00:00:00

abstract：:Specific binding sites for prolactin (PRL) were present in membrane preparations from 7,12-dimethylbenz(a)-anthracene-induced rat mammary tumors. The specific binding of PRL was time and temperature dependent. A significant negative correlation was noted between administered doses of estrogen and the subsequent bindin...

journal_title：Cancer research

authors： Kledzik GS,Bradley CJ,Marshall S,Campbell GA,Meites J

更新日期：1976-09-01 00:00:00

abstract：:Monoclonal antibody HT462 recognizes a human T-cell leukemia virus type I (HTLV-I)-associated Mr 52,000 glycoprotein (HA-gp52), which is found on the surface of HTLV-infected cells. Whether HA-gp52 is encoded by the virus or by the infected cells has not yet been established. Using monoclonal HT462 in a competitive bi...

journal_title：Cancer research

authors： Robert-Guroff M,Clark JW

更新日期：1985-07-01 00:00:00

abstract：:Previous studies have shown that enforced expression of IFN-beta suppressed tumor growth and metastasis. In this report, we determined whether the induction of nitric oxide synthase II (NOS II) gene is required for IFN-beta-mediated antitumor activity using syngeneic mice with intact (NOS II+/+) or genetically disrupt...

journal_title：Cancer research

authors： Wang B,Xiong Q,Shi Q,Le X,Abbruzzese JL,Xie K

更新日期：2001-01-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignan...

journal_title：Cancer research

authors： Fava G,Alpini G,Rychlicki C,Saccomanno S,DeMorrow S,Trozzi L,Candelaresi C,Venter J,Di Sario A,Marzioni M,Bearzi I,Glaser S,Alvaro D,Marucci L,Francis H,Svegliati-Baroni G,Benedetti A

更新日期：2008-08-15 00:00:00

abstract：:Epidemiological and animal studies suggest a role for calcium in the chemoprevention of colorectal neoplasia. This study was designed to investigate whether supplemental oral calcium has a suppressant effect on colonic mucosal ornithine decarboxylase (ODC) and tyrosine kinase activities in patients with adenomatous po...

journal_title：Cancer research

authors： Lans JI,Jaszewski R,Arlow FL,Tureaud J,Luk GD,Majumdar AP

更新日期：1991-07-01 00:00:00

abstract：:p53 is regulated at multiple levels. We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. These drugs reduced the basal levels of p53 protein at nanomolar concentrations in a dose-, time-, and cancer ...

journal_title：Cancer research

authors： Wang Z,Zheng M,Li Z,Li R,Jia L,Xiong X,Southall N,Wang S,Xia M,Austin CP,Zheng W,Xie Z,Sun Y

更新日期：2009-08-15 00:00:00

abstract：:L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decreas...

journal_title：Cancer research

authors： Wang Q,Bailey CG,Ng C,Tiffen J,Thoeng A,Minhas V,Lehman ML,Hendy SC,Buchanan G,Nelson CC,Rasko JE,Holst J

更新日期：2011-12-15 00:00:00

abstract：:MicroRNAs (miRNA) are a recently discovered class of noncoding RNAs that negatively regulate gene expression. Recent evidence indicates that miRNAs may play an important role in cancer. However, the mechanism of their deregulation in neoplastic transformation has only begun to be understood. To elucidate the role of t...

journal_title：Cancer research

authors： Corney DC,Flesken-Nikitin A,Godwin AK,Wang W,Nikitin AY

更新日期：2007-09-15 00:00:00

abstract：:The ability of tumor cells to express elevated levels of proteinases capable of degrading tissue matrix and basement membrane components in vitro has been correlated to their invasive and metastatic potential. Many in vitro invasion assays have been performed either in the presence of serum or with tumor cells that ha...

journal_title：Cancer research

authors： Neri A,Bohoslawec O,Anderson TD,Tokes ZA

更新日期：1991-02-15 00:00:00

abstract：:The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158 liters/kg) and the systemic clearance (0.0407-0.252 ml/h/kg) were ext...

journal_title：Cancer research

authors： Fuse E,Tanii H,Kurata N,Kobayashi H,Shimada Y,Tamura T,Sasaki Y,Tanigawara Y,Lush RD,Headlee D,Figg WD,Arbuck SG,Senderowicz AM,Sausville EA,Akinaga S,Kuwabara T,Kobayashi S

更新日期：1998-08-01 00:00:00

abstract：:Diethyldithiocarbamate (DDTC) has been shown to protect against the toxicity of cis-diamminedichloroplatinum(II) (DDP) without inhibition of antitumor effect. We report here that DDTC is unreactive toward DDP complexes in which both chlorides have been replaced by guanine residues but removes platinum from a variety o...

journal_title：Cancer research

authors： Bodenner DL,Dedon PC,Keng PC,Borch RF

更新日期：1986-06-01 00:00:00

abstract：:Brain tumors such as medulloblastoma (MB) and glioblastoma multiforme (GBM) can derive from neural precursors. For instance, many MBs are thought to arise from the uncontrolled proliferation of cerebellar granule neuron precursors (GNP). GNPs normally proliferate in early postnatal stages in mice but then they become ...

journal_title：Cancer research

authors： Tatard VM,Xiang C,Biegel JA,Dahmane N

更新日期：2010-02-01 00:00:00

abstract：:Our previous studies have defined reactive stroma in human prostate cancer and have developed the differential reactive stroma (DRS) xenograft model to evaluate mechanisms of how reactive stroma promotes carcinoma tumorigenesis. Analysis of several normal human prostate stromal cell lines in the DRS model showed that ...

journal_title：Cancer research

authors： Yang F,Tuxhorn JA,Ressler SJ,McAlhany SJ,Dang TD,Rowley DR

更新日期：2005-10-01 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:The Rb/E2F pathway is deregulated in most human brain tumors, and the finding that loss of E2F1 reduced pituitary tumorigenesis in Rb(+/-) mice suggests that loss of pRb induces brain tumors by activating E2F1. We therefore investigated the role of E2F1 in the development and maintenance of brain cancer using a transg...

journal_title：Cancer research

authors： Olson MV,Johnson DG,Jiang H,Xu J,Alonso MM,Aldape KD,Fuller GN,Bekele BN,Yung WK,Gomez-Manzano C,Fueyo J

更新日期：2007-05-01 00:00:00

abstract：:The growth of human melanoma cells FO-1 in nude mice is strongly inhibited or even abrogated when the cells are stably transfected with a plasmid expressing an antisense RNA to the insulin-like growth factor 1 receptor (IGF-1R) RNA, which causes a marked reduction in the number of IGF-1 receptors. When a tumor arises ...

journal_title：Cancer research

authors： Resnicoff M,Coppola D,Sell C,Rubin R,Ferrone S,Baserga R

更新日期：1994-09-15 00:00:00

abstract：:The DNA of L1210 cells exposed to low concentrations of 1-(2-chloroethyl)=3-cyclohexyl-1-nitrosourea has been analyzed for the presence of single-strand breaks. DNA from 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea-treated cells both sediments more slowly than control DNA on alkaline sucrose gradients andshows a great...

journal_title：Cancer research

authors： Hilton J,Bowie DL,Gutin PH,Zito DM,Walker MD

更新日期：1977-07-01 00:00:00

abstract：:In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic stimulation and tumor development. Characteristic features of tumor ischemia include hypoxia and glucose deprivation, leading to the activation of hypoxia-inducible factor-1-dependent signaling...

journal_title：Cancer research

authors： Drogat B,Auguste P,Nguyen DT,Bouchecareilh M,Pineau R,Nalbantoglu J,Kaufman RJ,Chevet E,Bikfalvi A,Moenner M

更新日期：2007-07-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:We have assessed the role of the p53 tumor suppressor gene in cell cycle arrest and cytotoxicity of ionizing radiation in 17 Burkitt's lymphoma and lymphoblastoid cell lines. Cell cycle arrest was assessed by flow cytometry of cells 16 h following irradiation. In addition to the usual G2 arrest, the cell lines exhibit...

journal_title：Cancer research

authors： O'Connor PM,Jackman J,Jondle D,Bhatia K,Magrath I,Kohn KW

更新日期：1993-10-15 00:00:00

abstract：:In 2002, the National Cancer Institute created the Initiative for Chemical Genetics (ICG), to enable public research using small molecules to accelerate the discovery of cancer-relevant small-molecule probes. The ICG is a public-access research facility consisting of a tightly integrated team of synthetic and analytic...

journal_title：Cancer research

authors： Tolliday N,Clemons PA,Ferraiolo P,Koehler AN,Lewis TA,Li X,Schreiber SL,Gerhard DS,Eliasof S

更新日期：2006-09-15 00:00:00

abstract：:Members of the phosphatidylinositol 3-kinase-related kinase family, in particular the ataxia-telangiectasia mutated (ATM) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), regulate cellular responses to DNA double-strand breaks. Increased sensitivity to ionizing radiation (IR) in DNA-PKc...

journal_title：Cancer research

authors： Arlander SJ,Greene BT,Innes CL,Paules RS

更新日期：2008-01-01 00:00:00

abstract：:Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single constitutively expressed control gene. However, in recent years, it has become...

journal_title：Cancer research

authors： Andersen CL,Jensen JL,Ørntoft TF

更新日期：2004-08-01 00:00:00

abstract：:Successful chemotherapy accounts for both tumor-related factors and host immune response. Compelling evidence suggests that some chemotherapeutic agents can induce an immunogenic type of cell death stimulating tumor-specific immunity. Here, we show that cyclophosphamide (CTX) exerts two types of actions relevant for t...

journal_title：Cancer research

authors： Schiavoni G,Sistigu A,Valentini M,Mattei F,Sestili P,Spadaro F,Sanchez M,Lorenzi S,D'Urso MT,Belardelli F,Gabriele L,Proietti E,Bracci L

更新日期：2011-02-01 00:00:00