Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture.

abstract：:We have recently identified human epidermal growth factor-like immunoreactive factor synthesized and secreted by human breast cancer cells (MCF-7) as a secretory protein encoded by the pS2 gene, the transcription of which is directly induced by estrogen. We demonstrated in this paper that synthesis and secretion of pS...

journal_title：Cancer research

authors： Kida N,Yoshimura T,Mori K,Hayashi K

更新日期：1989-07-01 00:00:00

abstract：:Effective autologous bone marrow transplantation for leukemia and lymphoma is likely to depend upon the selective removal in vitro of malignant cells from normal human bone marrow precursors. Highly specific cytotoxic conjugates formed by coupling ricin A chain to monoclonal antibodies might prove useful for the selec...

journal_title：Cancer research

authors： Bregni M,De Fabritiis P,Raso V,Greenberger J,Lipton J,Nadler L,Rothstein L,Ritz J,Bast RC Jr

更新日期：1986-03-01 00:00:00

abstract：:Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

journal_title：Cancer research

authors： Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

更新日期：2006-05-15 00:00:00

abstract：:Development of novel approaches for quantitative analysis of gene expression in intact tumor cells should provide new means for cancer detection and for studying the response of cancer cells to biological and therapeutic reagents. We developed procedures for detecting the levels of expression of multiple genes in fixe...

journal_title：Cancer research

authors： Peng XH,Cao ZH,Xia JT,Carlson GW,Lewis MM,Wood WC,Yang L

更新日期：2005-03-01 00:00:00

abstract：:The rate of tumor growth in vivo in adult rats (250- to 350-g total body weight) is stimulated during an acute fast. No tumor growth stimulation is observed in fasted immature rats (less than about 200-g total body weight). The different tumor growth responses in rats of these two age groups appear to depend on the in...

journal_title：Cancer research

authors： Sauer LA,Dauchy RT

更新日期：1987-02-15 00:00:00

abstract：:Little is known about the genetic changes underlying invasive tumor growth in bladder cancer. Because alterations that are linked to invasive tumor growth may be detectable in minimally invasive (stage pT1) but not in noninvasive (stage pTa) tumors, we searched for genetic differences between 28 pTa and 28 papillary p...

journal_title：Cancer research

authors： Richter J,Jiang F,Görög JP,Sartorius G,Egenter C,Gasser TC,Moch H,Mihatsch MJ,Sauter G

更新日期：1997-07-15 00:00:00

abstract：:In an attempt to develop better combination therapies for use with local radiation, the interaction between bleomycin and hyperthermia +/- radiation was studied in the FSaIIC tumor system. In cells exposed in vitro to bleomycin at 37 degrees C and at pH 7.40, the drug was substantially more toxic toward normally oxyge...

journal_title：Cancer research

authors： Teicher BA,Herman TS,Holden SA

更新日期：1988-11-15 00:00:00

abstract：:Oncogenic transformation of mouse 10T 1/2 fibroblasts induced upon exposure to X-ray or N-methyl-N'-nitro-N-nitrosoguanidine was suppressed if lipopolysaccharide (LPS) was present in the culture medium. The suppressive effect of LPS was exerted within 24 h after irradiation. Suppression was dependent on the concentrat...

journal_title：Cancer research

authors： Sakiyama H,Yasukawa M,Terasima T,Kanegasaki S

更新日期：1986-08-01 00:00:00

abstract：:A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but did not potentiate drug toxicity in drug-sensitiv...

journal_title：Cancer research

authors： Coon JS,Knudson W,Clodfelter K,Lu B,Weinstein RS

更新日期：1991-02-01 00:00:00

abstract：:Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and protein expression patterns in tumors collected from current, past, and never sm...

journal_title：Cancer research

authors： Prueitt RL,Wallace TA,Glynn SA,Yi M,Tang W,Luo J,Dorsey TH,Stagliano KE,Gillespie JW,Hudson RS,Terunuma A,Shoe JL,Haines DC,Yfantis HG,Han M,Martin DN,Jordan SV,Borin JF,Naslund MJ,Alexander RB,Stephens RM,Loffr

更新日期：2016-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

journal_title：Cancer research

authors： Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

更新日期：2014-07-15 00:00:00

abstract：:The interaction of the activating receptor NKG2D with its ligands plays an important role in immunosurveillance of tumors and infectious pathogens, but dysregulation of this system may lead to autoimmunity. The expression of NKG2D ligands is induced by cellular "stress." However, the regulation of expression of these ...

journal_title：Cancer research

authors： Valés-Gómez M,Chisholm SE,Cassady-Cain RL,Roda-Navarro P,Reyburn HT

更新日期：2008-03-01 00:00:00

abstract：:Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate that DNA methylation contributes to down-regulation of miRNAs during tumorigenesis. To explore the epigenetic alterations of miRNAs in ALL...

journal_title：Cancer research

authors： Agirre X,Vilas-Zornoza A,Jiménez-Velasco A,Martin-Subero JI,Cordeu L,Gárate L,San José-Eneriz E,Abizanda G,Rodríguez-Otero P,Fortes P,Rifón J,Bandrés E,Calasanz MJ,Martín V,Heiniger A,Torres A,Siebert R,Román-Gomez J,

更新日期：2009-05-15 00:00:00

abstract：:We generated DNA expression vectors encoding the full-length neu cDNA (designated pNeuN), the neu extracellular domain (pNeuE), or the neu extracellular and transmembrane domains (pNeuTM). The 293 cells transfected with pNeuN or pNeuTM expressed the neu extracellular domain on the surface membrane, whereas 293 cells t...

journal_title：Cancer research

authors： Chen Y,Hu D,Eling DJ,Robbins J,Kipps TJ

更新日期：1998-05-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) is an evolutionally conserved nuclear protein present in most eukaryotic species and catalyzes the formation of ADP-ribose polymers covalently attached to proteins. PARP is strongly activated by DNA single- or double-strand breaks and is thought to be involved in cellular responses t...

journal_title：Cancer research

authors： Kupper JH,Müller M,Bürkle A

更新日期：1996-06-15 00:00:00

abstract：:Combination treatment of SKCO1 human colon carcinoma cells with beta ser-interferon (IFN-beta ser) and gamma-interferon (IFN-gamma) results in a synergistic antiproliferative effect. The role of IFN-beta ser and IFN-gamma receptor modulation was investigated as a possible mechanism for this response. IFN-gamma (0.05-5...

journal_title：Cancer research

authors： Schiller JH,Bushmeyer SM,Ruzicka FJ,Princler GL,Faltynek CR,Borden EC

更新日期：1990-01-01 00:00:00

abstract：:To assess the in vivo behavior of cytotoxic agents linked to antibodies, deferoxamine, known to form stable chelates with 67Ga, was conjugated with monoclonal antibodies using three different methods. One method used a homocoupling reagent, glutaraldehyde, whereas two other methods used heterocoupling reagents, N-succ...

journal_title：Cancer research

authors： Koizumi M,Endo K,Kunimatsu M,Sakahara H,Nakashima T,Kawamura Y,Watanabe Y,Saga T,Konishi J,Yamamuro T

更新日期：1988-03-01 00:00:00

abstract：:The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitr...

journal_title：Cancer research

authors： Andrejauskas-Buchdunger E,Regenass U

更新日期：1992-10-01 00:00:00

abstract：:Glioblastoma multiforme lacks effective therapy options. Although deregulated kinase pathways are drivers of malignant progression in glioblastoma multiforme, glioma cells exhibit intrinsic resistance toward many kinase inhibitors, and the molecular basis of this resistance remains poorly understood. Here, we show tha...

journal_title：Cancer research

authors： Kaur A,Denisova OV,Qiao X,Jumppanen M,Peuhu E,Ahmed SU,Raheem O,Haapasalo H,Eriksson J,Chalmers AJ,Laakkonen P,Westermarck J

更新日期：2016-12-01 00:00:00

abstract：:The rapidly expanding understanding of the progressive processes of carcinogenesis provides opportunities for the identification of molecular biological markers reflecting events from exposure through clinical disease. These molecular biological markers can be classified into categories of markers of exposure reflecti...

journal_title：Cancer research

authors： Groopman JD,Wogan GN,Roebuck BD,Kensler TW

更新日期：1994-04-01 00:00:00

abstract：:Cyclin A is an S- and G2-M-phase regulatory protein, and its abnormal expression has been implicated in cellular transformation. This work was undertaken to investigate the frequency of cyclin A overexpression and the correlated clinical outcome in human hepatocellular carcinoma (HCC). Herein, 12 of 31 (39%) patients ...

journal_title：Cancer research

authors： Chao Y,Shih YL,Chiu JH,Chau GY,Lui WY,Yang WK,Lee SD,Huang TS

更新日期：1998-03-01 00:00:00

abstract：:The correlation between telomerase activity, telomere lengths, and cellular replicative capacity has led to the theory that maintenance of telomere lengths by telomerase acts as a molecular clock to control replicative capacity and senescence. Regulation of this molecular clock may have applications in the treatment o...

journal_title：Cancer research

authors： Ulaner GA,Hu JF,Vu TH,Giudice LC,Hoffman AR

更新日期：1998-09-15 00:00:00

abstract：:MCF-7 cells have been shown to contain estrogen receptor in several cell fractions following homogenization: nuclei, microsomes, and cytosol. The amount of 17 beta-estradiol-binding capacity found in each cellular compartment depended on the inclusion of detergent in homogenization buffers and on the use of 0.25 M suc...

journal_title：Cancer research

authors： Brooks SC,Hansen ER,Saunders DE,Battelli MG,Shafie SM

更新日期：1984-09-01 00:00:00

abstract：:Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein (FRAP) occurs via autocrine stimulation or inactivation of the tumor suppressor PTEN in many cancers. Here we demonstrate that in human pro...

journal_title：Cancer research

authors： Zhong H,Chiles K,Feldser D,Laughner E,Hanrahan C,Georgescu MM,Simons JW,Semenza GL

更新日期：2000-03-15 00:00:00

abstract：:We have investigated the ability of tamoxifen to regulate members of the transforming growth factor beta (TGF-beta) family in human breast cancers in vivo. Using immunohistochemical techniques, we find that 3 months of tamoxifen treatment causes a consistent induction of extracellular TGF-beta 1 in breast cancer biops...

journal_title：Cancer research

authors： Butta A,MacLennan K,Flanders KC,Sacks NP,Smith I,McKinna A,Dowsett M,Wakefield LM,Sporn MB,Baum M

更新日期：1992-08-01 00:00:00

abstract：:Smoking prevention will decrease lung cancer incidence in time. However, early detection would improve lung cancer prognosis in subjects at risk provided that specific markers could be identified. We previously reported that retinoic acid receptor (RAR) and retinoid X receptor (RXR) expression was altered in lung tumo...

journal_title：Cancer research

authors： Martinet N,Alla F,Farré G,Labib T,Drouot H,Vidili R,Picard E,Gaube MP,Le Faou D,Siat J,Borelly J,Vermylen P,Bazarbachi T,Vignaud JM,Martinet Y

更新日期：2000-06-01 00:00:00

abstract：:Cell systems as different as normal human blood lymphocytes and frog auricles release spontaneously a nucleoprotein complex in their culture medium. This release seems to be an active mechanism that is unrelated to cell death. The presence of RNA in this complex is demonstrated. The amount of extracellular RNA is regu...

journal_title：Cancer research

authors： Stroun M,Anker P,Beljanski M,Henri J,Lederrey C,Ojha M,Maurice PA

更新日期：1978-10-01 00:00:00

abstract：:It has been suggested that oxygen-carrying blood substitutes, perfluorochemical (PFC) emulsions, can increase blood flow and oxygen delivery to poorly perfused tumor regions. Local cerebral blood flow was measured in male Wistar rats bearing intracranial Walker 256 tumor with and without blood-PFC exchange using [14C]...

journal_title：Cancer research

authors： Hiraga S,Klubes P,Owens ES,Cysyk RL,Blasberg RG

更新日期：1987-06-15 00:00:00

abstract：:The long-term effects on mammary glands of 5beta-dihydrotestosterone, considered to be biologically inactive, were studied in female SHN mice with mammary tumor, virus. 5beta-Dihydrotestosterone was adminstered to mothers for 4 days from Day 12 to Day 15 of pregnancy (prenatal treatment) and to pups for 5 days of post...

journal_title：Cancer research

authors： Yanai R,Mori T,Nagasawa H

更新日期：1977-12-01 00:00:00

abstract：:In order to explore whether immune complex (IC) formation and immunoglobulin M-class rheumatoid factor (RF) synthesis are related to tumor progression, solid-phase enzyme immunoassays were used to test for ICs and RF in rats bearing three different syngeneic mammary adenocarcinomas. The mammary adenocarcinoma cell lin...

journal_title：Cancer research

authors： Hoon DB,Ziola B,Carlsen S,Warrington R,Ramshaw I

更新日期：1983-01-01 00:00:00