Chemiluminescence and oxygen radical generation by Walker carcinosarcoma cells following chemotactic stimulation.

abstract：:Glycosylation, a posttranslational modification, has a major role in recombinant anticancer therapeutic proteins, as most of the approved recombinant therapeutics are glycoproteins. The constant amino acid sequence of therapeutics determines the enzymatic activity, while the presence of glycans influences their pharma...

journal_title：Cancer research

authors： Nadeem T,Khan MA,Ijaz B,Ahmed N,Rahman ZU,Latif MS,Ali Q,Rana MA

更新日期：2018-06-01 00:00:00

abstract：:Reduced expression of neural cell adhesion molecule (NCAM) has been implicated in the progression to tumor malignancy in cancer patients. Previously, we have shown that the loss of NCAM function causes the formation of lymph node metastasis in a transgenic mouse model of pancreatic beta cell carcinogenesis (Rip1Tag2)....

journal_title：Cancer research

authors： Crnic I,Strittmatter K,Cavallaro U,Kopfstein L,Jussila L,Alitalo K,Christofori G

更新日期：2004-12-01 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14. Recent studies have demonstrated that TWEAK can stimulate numerous cellular responses in...

journal_title：Cancer research

authors： Ho DH,Vu H,Brown SA,Donohue PJ,Hanscom HN,Winkles JA

更新日期：2004-12-15 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a master transcription factor that is critical for the regulation of a variety of cellular functions. HIF-1alpha is rapidly degraded under normoxic conditions by ubiquitin-mediated proteasome pathway controlled by the tumor suppressor von Hippel Lindau (VHL). Several rec...

journal_title：Cancer research

authors： Zhang D,Li J,Costa M,Gao J,Huang C

更新日期：2010-01-15 00:00:00

abstract：:Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-induced skin cancer. Consistent with the ability of Pol eta to efficiently bypass UV light-induced cyclobutane pyrimidine dimers, XPV...

journal_title：Cancer research

authors： Lin Q,Clark AB,McCulloch SD,Yuan T,Bronson RT,Kunkel TA,Kucherlapati R

更新日期：2006-01-01 00:00:00

abstract：:Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130(F/F) (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation...

journal_title：Cancer research

authors： Brooks GD,McLeod L,Alhayyani S,Miller A,Russell PA,Ferlin W,Rose-John S,Ruwanpura S,Jenkins BJ

更新日期：2016-02-15 00:00:00

abstract：:PTEN/MMAC1 is a major new tumor suppressor gene that encodes a dual-specificity phosphatase with sequence similarity to the cytoskeletal protein tensin. Recently, we reported that PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits cell migration, spreading, and focal adhesion formation. Here, the effects o...

journal_title：Cancer research

authors： Tamura M,Gu J,Takino T,Yamada KM

更新日期：1999-01-15 00:00:00

abstract：:High levels of anti-phosphatidylinositol (PtdIns) autoantibodies (autoAb) have been previously described in sera of cancer patients and in plasma of dimethylbenzanthracene-treated female Sprague-Dawley rats. The presence of anti-PtdIns autoAb was tested in a model of highly malignant sarcomas induced by a single dose ...

journal_title：Cancer research

authors： Faiderbe S,Chagnaud JL,Geffard M

更新日期：1992-05-15 00:00:00

abstract：:The interaction of dietary fat and the thymus in the induction of mammary tumors by dimethylbenz(a)anthracene has been examined in female Sprague-Dawley rats. In these experiments, rats fed diets of 0.5% (low fat), 5% (normal fat), or 20% (high fat) corn oil from weaning (21 days of age) were thymectomized or sham thy...

journal_title：Cancer research

authors： Wagner DA,Naylor PH,Kim U,Shea W,Ip C,Ip MM

更新日期：1982-04-01 00:00:00

abstract：:Complementary DNA (cDNA)-oligodeoxythmidylate-celluloses were prepared from cDNA copies of polysomal messenger RNA (mRNA) of Novikoff hepatoma, normal rat liver, and regenerating rat liver. cDNA synthesis with reverse transcriptase was approximately 46% with respect to input mRNA with oligodeoxythymidylate-cellulose p...

journal_title：Cancer research

authors： Hirsch FW,Nall KN,Hayes LC,Raju KS,Spohn WH,Busch H

更新日期：1977-10-01 00:00:00

abstract：:The DNA of L1210 cells exposed to low concentrations of 1-(2-chloroethyl)=3-cyclohexyl-1-nitrosourea has been analyzed for the presence of single-strand breaks. DNA from 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea-treated cells both sediments more slowly than control DNA on alkaline sucrose gradients andshows a great...

journal_title：Cancer research

authors： Hilton J,Bowie DL,Gutin PH,Zito DM,Walker MD

更新日期：1977-07-01 00:00:00

abstract：:The p21-activated Ser/Thr kinase 1 (PAK1) kinase has an essential role in tumorigenesis and cell survival in many cancers, but its regulation is not fully understood. In this study, we showed that in response to irradiation of lung cancer cells, PAK1 was upregulated, tyrosine phosphorylated, and translocated to the nu...

journal_title：Cancer research

authors： Kim E,Youn H,Kwon T,Son B,Kang J,Yang HJ,Seong KM,Kim W,Youn B

更新日期：2014-10-01 00:00:00

abstract：:Valinomycin (NSC 122023) is a cyclic depsipeptide antibiotic with potassium selective ionophoric activity. This drug has been reported to display antitumor effects but its utilization has been limited by its extreme toxicity. Here we report that the incorporation of valinomycin into multilamellar liposomes composed of...

journal_title：Cancer research

authors： Daoud SS,Juliano RL

更新日期：1986-11-01 00:00:00

abstract：:We evaluated the differences in prevalence and functional activity of human estrogen receptor alpha (hER) variant mRNA between 21 normal breast tissues and 41 primary breast carcinomas using a functional assay in yeast for the hER First, we found that the presence of wild-type hER, relative to the total amount of hER,...

journal_title：Cancer research

authors： van Dijk MA,Hart AA,van 't Veer LJ

更新日期：2000-02-01 00:00:00

abstract：:Five different lipid conjugates of 1-beta-D-arabinofuranosylcytosine (ara-C) were tested for their therapeutic activity on the growth and metastasis of Lewis lung carcinoma (3-LL). Among 1 ester-linked lipid conjugate (Ara-CDP-L-dipalmitin), 3 1-O-alkyl-lipid conjugates (ara-CDP-D,L-PBA, ara-CDP-D,L-PCA, ara-CDP-D,L-M...

journal_title：Cancer research

authors： Berdel WE,Danhauser S,Hong CI,Schick HD,Reichert A,Busch R,Rastetter J,Vogler WR

更新日期：1988-02-15 00:00:00

abstract：:The lysyl oxidase gene family members function as extracellular matrix modulating enzymes. We have found that another member of this family, lysyl oxidase related protein-1 (LOR-1), is highly expressed in metastatic breast cancer-derived cell lines but not in the nonmetastatic estrogen-dependent MCF-7 cells. Furthermo...

journal_title：Cancer research

authors： Akiri G,Sabo E,Dafni H,Vadasz Z,Kartvelishvily Y,Gan N,Kessler O,Cohen T,Resnick M,Neeman M,Neufeld G

更新日期：2003-04-01 00:00:00

abstract：:Cyclin A is an S- and G2-M-phase regulatory protein, and its abnormal expression has been implicated in cellular transformation. This work was undertaken to investigate the frequency of cyclin A overexpression and the correlated clinical outcome in human hepatocellular carcinoma (HCC). Herein, 12 of 31 (39%) patients ...

journal_title：Cancer research

authors： Chao Y,Shih YL,Chiu JH,Chau GY,Lui WY,Yang WK,Lee SD,Huang TS

更新日期：1998-03-01 00:00:00

abstract：:DNA methyltransferase 1 (DNMT1)-deficient mice are tumor-prone, and this has been proposed to result from the induction of genomic instability. To address whether loss of DNMT1, or the related protein DNMT3b, results in genomic instability in human cancer cells, we used a near-diploid human colorectal cancer cell line...

journal_title：Cancer research

authors： Karpf AR,Matsui S

更新日期：2005-10-01 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:Molecules that physiologically control cell proliferation are often produced locally in tissues and are rapidly destroyed when they enter circulation. This allows local effects while avoiding interference with other systems. Unfortunately, it also limits the therapeutic use of these molecules via systemic delivery. We...

journal_title：Cancer research

authors： Studeny M,Marini FC,Champlin RE,Zompetta C,Fidler IJ,Andreeff M

更新日期：2002-07-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabilization, complete remissions are rare and a substantial proportion of...

journal_title：Cancer research

authors： Bauer S,Parry JA,Mühlenberg T,Brown MF,Seneviratne D,Chatterjee P,Chin A,Rubin BP,Kuan SF,Fletcher JA,Duensing S,Duensing A

更新日期：2010-01-01 00:00:00

abstract：:Dissemination to draining lymph nodes is a frequent first step in prostate cancer metastasis. Although tumors metastasize to lymph nodes via the lymphatics, the importance of lymphangiogenesis in mediating the process remains controversial. Here, we inhibit intratumoral lymphangiogenesis in s.c. and surgical orthotopi...

journal_title：Cancer research

authors： Wong SY,Haack H,Crowley D,Barry M,Bronson RT,Hynes RO

更新日期：2005-11-01 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:Altered DNA methylation is a key feature of cancer, and aberrant methylation is important in nasopharyngeal carcinoma (NPC) development. However, the methylation mechanisms underlying metastasis of NPC remain unclear. Analyzing data from public databases and conducting our own experiments, we report here that promoter...

journal_title：Cancer research

authors： Zhang J,Li YQ,Guo R,Wang YQ,Zhang PP,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

更新日期：2019-02-15 00:00:00

abstract：:That ferritin, an iron storage protein, can be produced by neuroblastoma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neurobl...

journal_title：Cancer research

authors： Blatt J,Stitely S

更新日期：1987-04-01 00:00:00

abstract：:Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. Here, we report that periostin, a highly expressed cell adhesion molec...

journal_title：Cancer research

authors： Michaylira CZ,Wong GS,Miller CG,Gutierrez CM,Nakagawa H,Hammond R,Klein-Szanto AJ,Lee JS,Kim SB,Herlyn M,Diehl JA,Gimotty P,Rustgi AK

更新日期：2010-07-01 00:00:00

abstract：:We have examined the distribution of radiolabeled liposomes in tumor-bearing mice after i.v. injection. Two mouse tumors (B16 melanoma, J6456 lymphoma) and a human tumor (LS174T colon carcinoma) inoculated i.m., s.c., or in the hind footpad were used in these studies. When various liposome compositions with a mean ves...

journal_title：Cancer research

authors： Gabizon A,Price DC,Huberty J,Bresalier RS,Papahadjopoulos D

更新日期：1990-10-01 00:00:00

abstract：:We analyzed the gene expression profiles of clinical lung carcinomas using a cDNA microarray containing 27,648 genes or expressed sequence tags, and identified CDCA5 (cell division cycle associated 5) to be upregulated in the majority of lung cancers. Tumor tissue microarray analysis of 262 non-small cell lung cancer ...

journal_title：Cancer research

authors： Nguyen MH,Koinuma J,Ueda K,Ito T,Tsuchiya E,Nakamura Y,Daigo Y

更新日期：2010-07-01 00:00:00