Abstract：
:Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. Here, we report that periostin, a highly expressed cell adhesion molecule, is a key component of a novel tumor-invasive signature obtained from an organotypic culture model of engineered ESCC. This tumor-invasive signature classifies with human ESCC microarrays, underscoring its utility in human cancer. Genetic modulation of periostin promotes tumor cell migration and invasion as revealed in gain-of-loss and loss-of-function experiments. Inhibition of epidermal growth factor receptor signaling and restoration of wild-type p53 function were each found to attenuate periostin, suggesting the interdependence of two common genetic alterations with periostin function. Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Michaylira CZ,Wong GS,Miller CG,Gutierrez CM,Nakagawa H,Hammond R,Klein-Szanto AJ,Lee JS,Kim SB,Herlyn M,Diehl JA,Gimotty P,Rustgi AKdoi
10.1158/0008-5472.CAN-10-0704subject
Has Abstractpub_date
2010-07-01 00:00:00pages
5281-92issue
13eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-10-0704journal_volume
70pub_type
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