Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer.

abstract：:The correlation between the clinical outcome in patients with esophageal squamous cell carcinoma and coamplification of the proto-oncogenes int-2 and hst-1, which are partially homologous to angiogenesis-inducing fibroblast growth factor, was analyzed retrospectively. Coamplification of these genes was examined by slo...

journal_title：Cancer research

authors： Kitagawa Y,Ueda M,Ando N,Shinozawa Y,Shimizu N,Abe O

更新日期：1991-03-01 00:00:00

abstract：:PAX5 is a transcription factor essential for B-cell development. Recently, it has been found as a frequent target of aberrancies in childhood acute lymphoblastic leukemia (ALL; 30% of B cell ALL cases), showing monoallelic loss, point mutations, or chromosomal translocations. The role of these aberrancies is still poo...

journal_title：Cancer research

authors： Fazio G,Palmi C,Rolink A,Biondi A,Cazzaniga G

更新日期：2008-01-01 00:00:00

abstract：:Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endotheli...

journal_title：Cancer research

authors： Ngwa VM,Edwards DN,Philip M,Chen J

更新日期：2019-08-15 00:00:00

abstract：:To investigate the possible involvement of a tumor suppressor gene(s) on chromosome 8 in prostatic neoplasms, we performed a comprehensive loss of heterozygosity (LOH) study on 99 tumors from 97 prostate cancer patients. One of the carcinomas was a lymph node metastasis; the other 98 were primary carcinomas. Pure popu...

journal_title：Cancer research

authors： Vocke CD,Pozzatti RO,Bostwick DG,Florence CD,Jennings SB,Strup SE,Duray PH,Liotta LA,Emmert-Buck MR,Linehan WM

更新日期：1996-05-15 00:00:00

abstract：:Tumors routinely attract and co-opt macrophages to promote their growth, angiogenesis, and metastasis. Macrophages are also the key effector cell for mAb therapies. Here we report that the tumor microenvironment creates an immunosuppressive signature on tumor-associated macrophages (TAM), which favors expression of in...

journal_title：Cancer research

authors： Dahal LN,Dou L,Hussain K,Liu R,Earley A,Cox KL,Murinello S,Tracy I,Forconi F,Steele AJ,Duriez PJ,Gomez-Nicola D,Teeling JL,Glennie MJ,Cragg MS,Beers SA

更新日期：2017-07-01 00:00:00

abstract：:The activity of the serine protease plasminogen activator (PA), which correlates with tumorigenicity and metastatic capacity, was examined using the 125I-labeled fibrin plate assay in cell extracts from four human glioma lines as a function of growth in vitro. Cell-associated inhibitory activity to plasmin and urokina...

journal_title：Cancer research

authors： Gross JL,Behrens DL,Mullins DE,Kornblith PL,Dexter DL

更新日期：1988-01-15 00:00:00

abstract：:The role of the intestinal flora in the conversion of N-hydroxy-4-acetyl-aminobiphenyl (N-OH-AABP) to 4-acetylaminobiphenyl has been examined. This reaction, which reverses the metabolic activation of the parent carcinogen, can be demonstrated in cultures of some bacteria indigenous to the intestinal microflora. These...

journal_title：Cancer research

authors： Wheeler LA,Soderberg FB,Goldman P

更新日期：1975-11-01 00:00:00

abstract：:In principle, the inhibition of candidate gain-of-function genes defined through genomic analyses of large patient cohorts offers an attractive therapeutic strategy. In this study, we focused on changes in expression of CD24, a well-validated clinical biomarker of poor prognosis and a driver of tumor growth and metast...

journal_title：Cancer research

authors： Agarwal N,Dancik GM,Goodspeed A,Costello JC,Owens C,Duex JE,Theodorescu D

更新日期：2016-09-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic ina...

journal_title：Cancer research

authors： Ragazzon B,Libé R,Gaujoux S,Assié G,Fratticci A,Launay P,Clauser E,Bertagna X,Tissier F,de Reyniès A,Bertherat J

更新日期：2010-11-01 00:00:00

abstract：:Sera from 91 adult acute nonlymphocytic leukemia patients were tested for circulating immune complexes by the C1q binding test. In 42 patients tested prior to the initiation of therapy, C1q binding activity was inversely correlated with leukemic infiltrate of the bone marrow (rs = -0.34, p less than 0.02), but it was ...

journal_title：Cancer research

authors： Crane MM,Rossen RD,McCredie KB,Trujillo JM

更新日期：1984-07-01 00:00:00

abstract：:Cancer cells often fail to respond to stimuli that normally activate their intrinsic apoptotic machinery. Moreover, they are able to adapt to hypoxia by changing their glycolytic rate. Pyruvate kinase (PK) is a rate-limiting enzyme in glycolysis that is converted to a less active dimer form of PKM2 isoenzyme during on...

journal_title：Cancer research

authors： Steták A,Veress R,Ovádi J,Csermely P,Kéri G,Ullrich A

更新日期：2007-02-15 00:00:00

abstract：:Several in vitro cell systems were exposed to hematoporphyrin derivative (HPD): established lines of rat kangaroo epithelial kidney; normal mouse embryonic fibroblasts; and differentiated neonatal rat myocardial cells. The uptake of HPD (25 to 100 micrograms/ml) by individual cells occurred rapidly over a 2-hr period ...

journal_title：Cancer research

authors： Berns MW,Dahlman A,Johnson FM,Burns R,Sperling D,Guiltinan M,Siemens A,Walter R,Wright W,Hammer-Wilson M,Wile A

更新日期：1982-06-01 00:00:00

abstract：:The ability of the vitamin E (RRR-alpha-tocopherol) derivatives alpha-tocopheryl succinate (alpha-TOS) and alpha-tocopheryloxyacetic acid (alpha-TEA) to suppress tumor growth in preclinical animal models has recently led to increased interest in their potential use for treating human cancer. To make the use of these v...

journal_title：Cancer research

authors： Hahn T,Szabo L,Gold M,Ramanathapuram L,Hurley LH,Akporiaye ET

更新日期：2006-10-01 00:00:00

abstract：:The environmental contaminant 6-nitrochrysene (6-NC) has been shown to induce adenomas and adenocarcinomas in the colons of rats. The present study aimed at providing a better understanding of mechanisms that are responsible for this effect. Three female CD rats were injected i.p. with [3,4,9,10-3H]6-NC [9 mumol/rat (...

journal_title：Cancer research

authors： Chae YH,Delclos KB,Blaydes B,el-Bayoumy K

更新日期：1996-05-01 00:00:00

abstract：:The expression of genes which may be involved in the regulation of human mammary epithelial cell growth [transforming growth factors alpha and beta] and tumorigenesis [c-myc, erbB2, epidermal growth factor receptor (EGFR), Ha-ras, pS2] has been compared in similarly cultured normal cell strains and tumor cell lines. W...

journal_title：Cancer research

authors： Zajchowski D,Band V,Pauzie N,Tager A,Stampfer M,Sager R

更新日期：1988-12-15 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:B-cell precursor acute lymphoblastic leukemia (BCP-ALL/B-precursor ALL) is characterized by a high rate of tissue infiltration. The mechanism of BCP-ALL cell extravasation is not fully understood. In the present study, we have investigated the major carrier of carbohydrate selectin ligands in the BCP-ALL cell line NAL...

journal_title：Cancer research

authors： Nonomura C,Kikuchi J,Kiyokawa N,Ozaki H,Mitsunaga K,Ando H,Kanamori A,Kannagi R,Fujimoto J,Muroi K,Furukawa Y,Nakamura M

更新日期：2008-02-01 00:00:00

abstract：:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leverag...

journal_title：Cancer research

authors： Rao VA

更新日期：2019-12-15 00:00:00

abstract：:The present study was undertaken to investigate the role of plasminogen activator inhibitor type 1 (PAI-1) and activated protein C (APC) in the regulation of tumor cell invasion. PAI-1 was purified in active form from conditioned medium of human umbilical vein endothelial cells under denaturing conditions (4 M guanidi...

journal_title：Cancer research

authors： Kobayashi H,Moniwa N,Gotoh J,Sugimura M,Terao T

更新日期：1994-01-01 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:Dietary factors can modify metabolic events involved in the initiation, promotion, or progression of tumors. To determine whether a high-sucrose diet has any effect on the development of enzyme-altered foci during the promotion step of chemical hepatocarcinogenesis in rats, 1-day-old Sprague-Dawley rats were given a s...

journal_title：Cancer research

authors： Hei TK,Sudilovsky O

更新日期：1985-06-01 00:00:00

abstract：:Cytokine production and cytotoxicity for tumor cells are two important aspects of monocyte function and the inflammatory response against tumors and infectious agents. In the present studies we provide direct evidence at the mRNA and protein levels for the existence of autocrine tumor necrosis factor (TNF) and its imp...

journal_title：Cancer research

authors： Smith DM,Lackides GA,Epstein LB

更新日期：1990-06-01 00:00:00

abstract：:We have previously identified amplification at 4q12 in testicular germ cell tumors of adolescents and adults centered around the KIT gene encoding a tyrosine kinase transmembrane receptor. Analysis of primary testicular germ cell tumors totaling 190 cases revealed 21% of the seminoma subtype with an increased copy num...

journal_title：Cancer research

authors： McIntyre A,Summersgill B,Grygalewicz B,Gillis AJ,Stoop J,van Gurp RJ,Dennis N,Fisher C,Huddart R,Cooper C,Clark J,Oosterhuis JW,Looijenga LH,Shipley J

更新日期：2005-09-15 00:00:00

abstract：:Coded skin fibroblast cell strains from ataxia telangiectasia (AT) families and apparently normal individuals were obtained from two different sources. AT homozygous strains were clearly identified on the basis of marked hypersensitivity to cell killing by X-irradiation. AT heterozygotes were intermediate in their cyt...

journal_title：Cancer research

authors： Nagasawa H,Kraemer KH,Shiloh Y,Little JB

更新日期：1987-01-15 00:00:00

abstract：:The treatment of glioblastoma (GBM) remains challenging in part due to the presence of stem-like tumor-propagating cells that are resistant to standard therapies consisting of radiation and temozolomide. Among the novel and targeted agents under evaluation for the treatment of GBM are BRAF/MAPK inhibitors, but their e...

journal_title：Cancer research

authors： Lerner RG,Grossauer S,Kadkhodaei B,Meyers I,Sidorov M,Koeck K,Hashizume R,Ozawa T,Phillips JJ,Berger MS,Nicolaides T,James CD,Petritsch CK

更新日期：2015-12-15 00:00:00

abstract：:Although aberrant microRNA (miRNA) is expressed in different types of human cancer tissues, its pathophysiologic role and the relevance of tumorigenesis and metastasis are still largely unknown. Here, we defined miRNAs involved in cancer metastasis (metastamirs) using an established mouse model for peritoneal dissemin...

journal_title：Cancer research

authors： Takei Y,Takigahira M,Mihara K,Tarumi Y,Yanagihara K

更新日期：2011-02-15 00:00:00

abstract：:Specific progesterone binding by cultured human breast carcinoma T47D, MCF-7, and ZR75-1 cells was decreased 25-40% by epidermal growth factor (EGF), with a 50% effective dose of 0.1 nM EGF. Studies with the soluble and particulate fractions prepared after homogenization of T47D cells grown in glass roller bottles rev...

journal_title：Cancer research

authors： Sarup JC,Rao KV,Fox CF

更新日期：1988-09-15 00:00:00

abstract：:Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product/cytokine that catalyzes a step in glycolysis and gluconeogenesis, and acts as a multifunctional cytokine associated with aggressive tumors. PGI/AMF has been correlated significantly with breast cancer progression and poor progn...

journal_title：Cancer research

authors： Funasaka T,Hogan V,Raz A

更新日期：2009-07-01 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs also modulate cell division, cell cycle progression, and signal transduction pathways. As our basic understanding of IAPs has inc...

journal_title：Cancer research

authors： Schimmer AD

更新日期：2004-10-15 00:00:00

abstract：:Bladder cancer progression is thought to be associated with sequential genetic events. To search for the specific genetic changes associated with the metastatic process, comparative genomic hybridization was performed on 22 primary tumors and 24 metastases (10 distant and 14 nodal metastases) from 17 patients with sta...

journal_title：Cancer research

authors： Hovey RM,Chu L,Balazs M,DeVries S,Moore D,Sauter G,Carroll PR,Waldman FM

更新日期：1998-08-15 00:00:00