Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro.

abstract：:Carcinoembryonic antigen (CEA) is currently being used as a target antigen in the radioimmunodetection of cancer. Circulating CEA may adversely affect the outcome of such studies by formation of intravascular immune complexes. The following studies were undertaken to expand our knowledge of the production, secretion, ...

journal_title：Cancer research

authors： Martin KW,Halpern SE

更新日期：1984-12-01 00:00:00

abstract：:Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocytoma formation and progression. In an effort to identify novel gene expression changes associated with astrocytoma formation, which might reveal new potential targets for glioma therapeutic drug design, we use...

journal_title：Cancer research

authors： Huang ZY,Wu Y,Burke SP,Gutmann DH

更新日期：2003-06-01 00:00:00

abstract：:Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma. Recently, suramin has been shown to inhibit bone resorption in organ cultures of mouse calvarial bones. In the present study, we exam...

journal_title：Cancer research

authors： Yoneda T,Williams P,Rhine C,Boyce BF,Dunstan C,Mundy GR

更新日期：1995-05-01 00:00:00

abstract：:Alkaline phosphatase was monitored in 17 mice with s.c.-implanted tumors to relate the total circulating alkaline phosphatase to the total number of tumor cells in each mouse. There was a semilogarithmic relationship between the alkaline phosphatase units and the number of tumor cells. A time-independent standard plot...

journal_title：Cancer research

authors： Hiramoto RN,Ghanta VK,Soong SJ,Hurst DC

更新日期：1977-02-01 00:00:00

abstract：:Multiple copies of N-myc proto-oncogene are only rarely detected in localized neuroblastomas (NBs), and the prognostic relevance of amplification in this subset of patients is not clear. We analyzed a series of 850 children with NB admitted to a Pediatric Oncology Group NB Biology Study and identified six patients wit...

journal_title：Cancer research

authors： Cohn SL,Look AT,Joshi VV,Holbrook T,Salwen H,Chagnovich D,Chesler L,Rowe ST,Valentine MB,Komuro H

更新日期：1995-02-15 00:00:00

abstract：:Untargeted effects of ionizing radiation (de novo effects in the unirradiated descendants or neighbors of irradiated cells) challenge widely held views about the mechanisms of radiation-induced DNA damage with implications for the health consequences of radiation exposures particularly in the context of the induction ...

journal_title：Cancer research

authors： Lorimore SA,McIlrath JM,Coates PJ,Wright EG

更新日期：2005-07-01 00:00:00

abstract：:Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the past three decades. HNSCCs often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important progno...

journal_title：Cancer research

authors： Patel V,Marsh CA,Dorsam RT,Mikelis CM,Masedunskas A,Amornphimoltham P,Nathan CA,Singh B,Weigert R,Molinolo AA,Gutkind JS

更新日期：2011-11-15 00:00:00

abstract：:Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreadin...

journal_title：Cancer research

authors： Hartung N,Mollard S,Barbolosi D,Benabdallah A,Chapuisat G,Henry G,Giacometti S,Iliadis A,Ciccolini J,Faivre C,Hubert F

更新日期：2014-11-15 00:00:00

abstract：:The thymidylate synthase inhibitor 5-fluorouracil (5-FU) continues to play a pivotal role in the treatment of cancer. A downstream event of thymidylate synthase inhibition involves the induction of a self-defeating base excision repair process. With the depletion of TTP pools, there is also an increase in dUMP. Metabo...

journal_title：Cancer research

authors： Fischer JA,Muller-Weeks S,Caradonna SJ

更新日期：2006-09-01 00:00:00

abstract：:To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer cells with those of vinblastine. At their respective concentrations that result in 50% inhibition of clonogenic growth, both drugs caused an accumulation of cells blocked at mitosis and simi...

journal_title：Cancer research

authors： Dahllöf B,Billström A,Cabral F,Hartley-Asp B

更新日期：1993-10-01 00:00:00

abstract：:MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed MRI image features of regional lymph nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained a faster re...

journal_title：Cancer research

authors： Lu Y,Yu Q,Gao Y,Zhou Y,Liu G,Dong Q,Ma J,Ding L,Yao H,Zhang Z,Xiao G,An Q,Wang G,Xi J,Yuan W,Lian Y,Zhang D,Zhao C,Yao Q,Liu W,Zhou X,Liu S,Wu Q,Xu W,Zhang J,Wang D,Sun Z,Gao Y,Zhang X,Hu J,Zha

更新日期：2018-09-01 00:00:00

abstract：:The gastrin gene is expressed widely in pancreatic adenocarcinomas and the study aimed to assess its role in both the resistance of cancer cells to apoptosis and the sensitivity of cells to chemotherapeutic agents. Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels an...

journal_title：Cancer research

authors： Harris JC,Gilliam AD,McKenzie AJ,Evans SA,Grabowska AM,Clarke PA,McWilliams DF,Watson SA

更新日期：2004-08-15 00:00:00

abstract：:Estramustine is an estradiol-based antimicrotubule agent that accumulates in malignant glioma cells, resulting in a concentration-dependent inhibition of proliferation. This agent has been shown to synchronize human glioma cells at G2-M consistent with its known effects on the mitotic spindle and potentially could be ...

journal_title：Cancer research

authors： Yoshida D,Piepmeier J,Weinstein M

更新日期：1994-03-15 00:00:00

abstract：:Evaluation of a large panel of radiation-induced rat skin tumors of diverse size and histological type revealed a correlation between c-myc copy number and tumor size. Both the frequency and degree of c-myc gene amplification were increased in large compared to small carcinomas, but none of the sarcomas examined showe...

journal_title：Cancer research

authors： Garte SJ,Burns FJ,Ashkenazi-Kimmel T,Felber M,Sawey MJ

更新日期：1990-05-15 00:00:00

abstract：:Four murine monoclonal antibodies against human lung carcinoma were generated using a novel immunization procedure. BALB/c mice were rendered neonatally tolerant to normal human lung tissues and subsequently immunized with human lung tumor tissues. The lower level of antibody-reactivity to the tolerogen was seen in th...

journal_title：Cancer research

authors： Hanai N,Shitara K,Yoshida H

更新日期：1986-09-01 00:00:00

abstract：:The nonhistone chromosomal protein, high mobility group 1 (HMG1), which is ubiquitously expressed in higher eukaryotic cells, preferentially binds to cisplatin-modified DNA. The observation that HMG1 is overexpressed in cisplatin-resistant human cancer cells suggests that cisplatin resistance may be closely associated...

journal_title：Cancer research

authors： Nagatani G,Nomoto M,Takano H,Ise T,Kato K,Imamura T,Izumi H,Makishima K,Kohno K

更新日期：2001-02-15 00:00:00

abstract：:Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various v...

journal_title：Cancer research

authors： Pendurthi UR,Tran TT,Post M,Rao LV

更新日期：2005-11-01 00:00:00

abstract：:We and others have reported previously that adults with glioma are 1.5- to 4-fold less likely than controls to report a variety of allergic conditions. The consistent nature of this relationship calls for a biological explanation so that preventative or therapeutic modalities can be explored. We enrolled 403 newly dia...

journal_title：Cancer research

authors： Wiemels JL,Wiencke JK,Patoka J,Moghadassi M,Chew T,McMillan A,Miike R,Barger G,Wrensch M

更新日期：2004-11-15 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14. Recent studies have demonstrated that TWEAK can stimulate numerous cellular responses in...

journal_title：Cancer research

authors： Ho DH,Vu H,Brown SA,Donohue PJ,Hanscom HN,Winkles JA

更新日期：2004-12-15 00:00:00

abstract：:Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In...

journal_title：Cancer research

authors： Hakim F,Wang Y,Zhang SX,Zheng J,Yolcu ES,Carreras A,Khalyfa A,Shirwan H,Almendros I,Gozal D

更新日期：2014-03-01 00:00:00

abstract：:The majority of colorectal cancers have lost/inactivated the p53 tumor suppressor gene. Using isogenic human colon cancer cells that differ only in their p53 status, we demonstrate that loss of p53 renders tumor cells relatively resistant to the topoisomerase I inhibitor, irinotecan. Whereas irinotecan-induced up-regu...

journal_title：Cancer research

authors： Ravi R,Jain AJ,Schulick RD,Pham V,Prouser TS,Allen H,Mayer EG,Yu H,Pardoll DM,Ashkenazi A,Bedi A

更新日期：2004-12-15 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

journal_title：Cancer research

authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

更新日期：2012-03-15 00:00:00

abstract：:Mechanism, in addition to protein kinase C activation may mediate 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated differentiation of leukemic cells. We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the pro...

journal_title：Cancer research

authors： Ways DK,Dodd RC,Earp HS

更新日期：1987-07-01 00:00:00

abstract：:Patients with longstanding extensive ulcerative colitis have an increased risk of developing colorectal cancer (CRC). There are significant differences in the early pathogenesis of colitis-associated tumors compared with common CRC, whereas the frequency, degree, and significance of microsatellite instability (MSI) as...

journal_title：Cancer research

authors： Kohonen-Corish MR,Daniel JJ,te Riele H,Buffinton GD,Dahlstrom JE

更新日期：2002-04-01 00:00:00

abstract：:Tumor development is angiogenesis dependent, and vascular endothelial growth factor (VEGF) is a key growth factor in this process. We demonstrate that high expression of VEGF mRNA in 55 superficial bladder cancers was associated with earlier recurrence (P = 0.001; hazard ratio, 3.09) and progression to a more invasive...

journal_title：Cancer research

authors： Crew JP,O'Brien T,Bradburn M,Fuggle S,Bicknell R,Cranston D,Harris AL

更新日期：1997-12-01 00:00:00

abstract：:Cloning efficiencies of 67 fresh human tumor specimens, consisting of 29 ovarian, 10 lung, and 7 each of colon, breast, mesenchymal, and miscellaneous tumors, from 58 patients were studied using the technique of Hamburger and Salmon to evaluate the effect of incubation in a 5% rather than 20% oxygen environment. Under...

journal_title：Cancer research

authors： Sridhar KS,Plasse TF,Holland JF,Shapiro M,Ohnuma T

更新日期：1983-10-01 00:00:00

abstract：:MSN-1 is a monoclonal antibody, which was raised by immunizing mice with a human endometrial cancer cell line, SNG-II. The MSN-1 specifically recognizes a blood group carbohydrate antigen, Leb. We investigated the subcellular and suborganellar localization of the MSN-1-reactive carbohydrate antigens in the endometrial...

journal_title：Cancer research

authors： Susumu N,Kawakami H,Aoki D,Hirano H,Nozawa S

更新日期：1993-08-01 00:00:00

abstract：:In this study, the mitochondrial phototoxicity of the cationic rhodacyanine MKT-077 was investigated by comparing its effects on the inhibition of mitochondrial respiration and the structural integrity of mitochondrial DNA (mtDNA) in the presence and absence of added high-intensity visible light (7.5 J/cm2). Results i...

journal_title：Cancer research

authors： Modica-Napolitano JS,Brunelli BT,Koya K,Chen LB

更新日期：1998-01-01 00:00:00

abstract：:Macrophage migration inhibition responses of mice immunized with mutant polyoma viruses or with cells transformed and/or infected by them have been studied. The macrophage migration inhibition reaction revealed individual differences. In several cases, mice immunized with a mutant virus responded preferentially or exc...

journal_title：Cancer research

authors： Szigeti R,Dalianis T,Ramqvist T,Ito Y,Klein G

更新日期：1984-03-01 00:00:00