Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.

abstract：:Several reports have suggested that a decrease or absence of adenosine deaminase complexing protein (ADCP) is consistently associated with cancer. However, in other studies, decreased as well as increased ADCP levels were found. In the present study, we investigated ADCP levels in 37 colorectal adenocarcinomas and cor...

journal_title：Cancer research

authors： ten Kate J,Wijnen JT,van der Goes RG,Quadt R,Griffioen G,Bosman FT,Khan PM

更新日期：1984-10-01 00:00:00

abstract：:Adult female rat urinary bladders were exposed to N-methyl-N-nitrosourea in vivo. After 12 weeks, urothelial hyperplasia was established. Ultrastructural changes of the luminal plasma membrane were studied with thin sectioning and freeze-fracturing techniques. The mosaic pattern which is a characteristic specializatio...

journal_title：Cancer research

authors： Hainau B

更新日期：1979-09-01 00:00:00

abstract：:Tumor-suppressors have commanded attention due to the selection for their inactivating mutations in human tumors. However, relatively little is understood about the inverse, namely, that tumors do not select for a large proportion of seemingly favorable mutations in tumor-suppressor genes. This could be explained by a...

journal_title：Cancer research

authors： Cunningham SC,Gallmeier E,Hucl T,Dezentje DA,Calhoun ES,Falco G,Abdelmohsen K,Gorospe M,Kern SE

更新日期：2006-06-01 00:00:00

abstract：:This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed by activated macrophages, the presence of tumor-associated macropha...

journal_title：Cancer research

authors： Klimp AH,Hollema H,Kempinga C,van der Zee AG,de Vries EG,Daemen T

更新日期：2001-10-01 00:00:00

abstract：:Interleukin 2 (IL2) was injected peritumorally and intranodally in 36 patients with unresectable squamous cell carcinoma of the head and neck enrolled in an Eastern Cooperative Oncology Group-sponsored phase Ib trial (EST P-Z388). Groups of 6 patients received escalating doses(200, 2 x 10(3), 2 x 10(4), 2 x 10(5), 2 x...

journal_title：Cancer research

authors： Whiteside TL,Letessier E,Hirabayashi H,Vitolo D,Bryant J,Barnes L,Snyderman C,Johnson JT,Myers E,Herberman RB

更新日期：1993-12-01 00:00:00

abstract：:Both nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX) 2-selective inhibitors such as celecoxib are being reported as having potent anticancer activity in laboratory models. Several reports have suggested that the mechanism of action of these agents in reducing tumor volume/burden is unrelated to ...

journal_title：Cancer research

authors： Zweifel BS,Davis TW,Ornberg RL,Masferrer JL

更新日期：2002-11-15 00:00:00

abstract：:beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K+ assays. We show that beta-lapachone can induce apoptosis in certain cells, such as in human promyelocytic leukemia (HL-60) and human ...

journal_title：Cancer research

authors： Planchon SM,Wuerzberger S,Frydman B,Witiak DT,Hutson P,Church DR,Wilding G,Boothman DA

更新日期：1995-09-01 00:00:00

abstract：:DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer. In this study, we elucidated an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase in...

journal_title：Cancer research

authors： Fang F,Cardenas H,Huang H,Jiang G,Perkins SM,Zhang C,Keer HN,Liu Y,Nephew KP,Matei D

更新日期：2018-02-01 00:00:00

abstract：:Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1+ T cells present before therapy. Thus, analyzing early-stage primary tumors may reveal the presence of T cells that are not yet functionally impaired. In this study, we report that activated (HLA-DR+...

journal_title：Cancer research

authors： Tassi E,Grazia G,Vegetti C,Bersani I,Bertolini G,Molla A,Baldassari P,Andriani F,Roz L,Sozzi G,Pastorino U,Mortarini R,Anichini A

更新日期：2017-02-15 00:00:00

abstract：:EphB4 receptor and its ligand ephrinB2 play an important role in vascular development during embryogenesis. In blood vessels, ephrinB2 is expressed in arterial endothelial cells (EC) and mesenchymal supporting cells, whereas EphB4 is only expressed in venous ECs. Previously, we reported that OP9 stromal cells, which s...

journal_title：Cancer research

authors： Huang X,Yamada Y,Kidoya H,Naito H,Nagahama Y,Kong L,Katoh SY,Li WL,Ueno M,Takakura N

更新日期：2007-10-15 00:00:00

abstract：:Inherent and acquired therapeutic resistance in breast cancer remains a major clinical challenge. In human breast cancer samples, overexpression of the oncogenic transcription factor FoxM1 has been suggested to be a marker of poor prognosis. In this study, we report that FoxM1 overexpression confers resistance to the ...

journal_title：Cancer research

authors： Carr JR,Park HJ,Wang Z,Kiefer MM,Raychaudhuri P

更新日期：2010-06-15 00:00:00

abstract：:A high-affinity localization of [2H]methylcholanthrene and/or its metabolites to a specific nuclear fraction (Fraction l) between 4 and 72 hr of exposure is described. Other carcinogenic hydrocarbons, such as benzo(a)pyrene and dibenz(a,h)anthracene, demonstrate a similar markded localization in Fraction l after 24 hr...

journal_title：Cancer research

authors： Spelsberg TC,Zytkovicz TH,Moses HL

更新日期：1977-05-01 00:00:00

abstract：:We examined the therapeutic effect of lipopolysaccharide (LPS), a differentiation inducer, in combination with daunomycin, an antileukemia drug possessing differentiation-inducing potential, on a rat myelomonocytic leukemia (c-WRT-7). c-WRT-7 cells were found to differentiate into macrophage-like cells and to lose the...

journal_title：Cancer research

authors： Fujii Y,Yuki N,Takeichi N,Kobayashi H,Miyazaki T

更新日期：1987-03-15 00:00:00

abstract：:RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic and antitumorigenic properties. Decreased expression of RKIP has been described in several human malignancies, including acute myelogenous leukemia (AML). As the mechanisms leading to RKIP loss in AML...

journal_title：Cancer research

authors： Hatzl S,Geiger O,Kuepper MK,Caraffini V,Seime T,Furlan T,Nussbaumer E,Wieser R,Pichler M,Scheideler M,Nowek K,Jongen-Lavrencic M,Quehenberger F,Wölfler A,Troppmair J,Sill H,Zebisch A

更新日期：2016-06-15 00:00:00

abstract：:Mitochondrial dysfunctions are frequently reported in cancer cells, but their direct involvement in tumorigenesis remains unclear. To understand this relation, we stimulated mitochondrial activity by overexpression of the mitochondrial triiodothyronine receptor (p43) in human dermal fibroblasts. In all clones, this st...

journal_title：Cancer research

authors： Grandemange S,Seyer P,Carazo A,Bécuwe P,Pessemesse L,Busson M,Marsac C,Roger P,Casas F,Cabello G,Wrutniak-Cabello C

更新日期：2005-05-15 00:00:00

abstract：:The renal handling of cis-diamminedichloroplatinum (CP) was investigated by measuring the renal clearance of creatinine, inulin, and free platinum in ten cancer patients. Free platinum clearances exceeded the glomerular filtration rate in all time periods. For example, at 1 to 2 hr, the mean clearance of free platinum...

journal_title：Cancer research

authors： Jacobs C,Coleman CN,Rich L,Hirst K,Weiner MW

更新日期：1984-08-01 00:00:00

abstract：:Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which is critical for the functionality of dimeric inhibin A/B, correlates w...

journal_title：Cancer research

authors： Singh P,Jenkins LM,Horst B,Alers V,Pradhan S,Kaur P,Srivastava T,Hempel N,Győrffy B,Broude EV,Lee NY,Mythreye K

更新日期：2018-06-01 00:00:00

abstract：:To investigate the relationship between serum micronutrients and the subsequent risk of oral and pharyngeal cancer, a nested case-control study was conducted within a cohort of 25,802 adults in Washington County, MD, whose blood samples were collected in 1974 and stored at -70 degrees C for subsequent assays. The seru...

journal_title：Cancer research

authors： Zheng W,Blot WJ,Diamond EL,Norkus EP,Spate V,Morris JS,Comstock GW

更新日期：1993-02-15 00:00:00

abstract：:Fresh surgical explants of human carcinomas were implanted as first transplant generation xenografts under the kidney capsule of mice. Immunocompetent and immune-deficient mice were compared for their ability to support the persistence and growth of these xenografts. Consistent growth of tumor xenografts could not be ...

journal_title：Cancer research

authors： Bennett JA,Pilon VA,MacDowell RT

更新日期：1985-10-01 00:00:00

abstract：:Recently, there has been increased interest in the use of hyperthermia (temperatures, 42 to 45 degrees) as an adjuvant modality to radiation therapy or chemotherapy for the treatment of cancer. This paper discusses the use of the finite element method as a technique for calculating the power deposited per unit volume ...

journal_title：Cancer research

authors： Strohbehn JW

更新日期：1984-10-01 00:00:00

abstract：:The linear chromosomes of vertebrates terminate in telomeres that consist of a tandemly repeated hexameric sequence, 5'TTAGGG3'. Telomeres form a protective loop structure (t-loop), which is thought to prevent them from being recognized as a double-strand break. Approximately 10% of human tumors prevent shortening of ...

journal_title：Cancer research

authors： Fasching CL,Neumann AA,Muntoni A,Yeager TR,Reddel RR

更新日期：2007-08-01 00:00:00

abstract：:Cockayne syndrome (CS) patients are deficient in the transcription coupled repair (TCR) subpathway of nucleotide excision repair (NER) but in contrast to xeroderma pigmentosum patients, who have a defect in the global genome repair subpathway of NER, CS patients do not have an elevated cancer incidence. To determine t...

journal_title：Cancer research

authors： Wijnhoven SW,Kool HJ,van Oostrom CT,Beems RB,Mullenders LH,van Zeeland AA,van der Horst GT,Vrieling H,van Steeg H

更新日期：2000-10-15 00:00:00

abstract：:The occurrence of spontaneous skin papillomas in Japanese newts (Cynops pyrrhogaster) from Niigata prefecture in Northern Japan was monitored over four seasons covering a period of 2 years. Of 13,613 newts, 249 were found to possess papillomas. The percentage of newts with papillomas was highest in autumn, ranging fro...

journal_title：Cancer research

authors： Asashima M,Komazaki S,Satou C,Oinuma T

更新日期：1982-09-01 00:00:00

abstract：:The pathogenetic relationship between high-grade prostatic intraepithelial neoplasia (PIN), prostatic carcinoma, and metastases is poorly understood. We used fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, 10, 12, and Y to evaluate numeric chromosomal anomalies in PIN (6...

journal_title：Cancer research

authors： Qian J,Bostwick DG,Takahashi S,Borell TJ,Herath JF,Lieber MM,Jenkins RB

更新日期：1995-11-15 00:00:00

abstract：:Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout...

journal_title：Cancer research

authors： van der Horst A,Khanna KK

更新日期：2009-08-15 00:00:00

abstract：:The chemokine receptor, CXCR4, is expressed by human melanomas, and its ligand, CXCL12, is frequently produced at sites of melanoma metastasis. Herein, we examine CXCR4-enhanced binding of B16 murine melanoma cells to endothelial cells (ECs) and recombinant adhesion molecules in vitro to determine the role of tumor- a...

journal_title：Cancer research

authors： Cardones AR,Murakami T,Hwang ST

更新日期：2003-10-15 00:00:00

abstract：:The vast majority of patients with plasma cell neoplasms die of progressive disease despite high response rates to novel agents. Malignant plasma cells are very radiosensitive, but the potential role of radioimmunotherapy (RIT) in the management of plasmacytomas and multiple myeloma has undergone only limited evaluati...

journal_title：Cancer research

authors： Green DJ,Orgun NN,Jones JC,Hylarides MD,Pagel JM,Hamlin DK,Wilbur DS,Lin Y,Fisher DR,Kenoyer AL,Frayo SL,Gopal AK,Orozco JJ,Gooley TA,Wood BL,Bensinger WI,Press OW

更新日期：2014-02-15 00:00:00

abstract：:Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult. Eighteen HLA A*0201(+) patients with metastatic melanoma received injections s.c. of CD34(+)progenitor-derived autologous dendritic cells (DCs), which included Langerhans cells. DCs were pulsed wi...

journal_title：Cancer research

authors： Banchereau J,Palucka AK,Dhodapkar M,Burkeholder S,Taquet N,Rolland A,Taquet S,Coquery S,Wittkowski KM,Bhardwaj N,Pineiro L,Steinman R,Fay J

更新日期：2001-09-01 00:00:00

abstract：:The possible influence of phenobarbital and phenytoin treatment on cancer risk was investigated in a case-control study nested in a cohort of 8004 epileptic patients in Denmark. Information on anticonvulsive treatments was abstracted for 95% of 60 patients with cancers of the liver and biliary tract or malignant lymph...

journal_title：Cancer research

authors： Olsen JH,Schulgen G,Boice JD Jr,Whysner J,Travis LB,Williams GM,Johnson FB,McGee JO

更新日期：1995-01-15 00:00:00

abstract：:Cyclooxygenase-2 is a valid target for cancer prevention and treatment. This has been shown in preclinical and clinical cancer prevention studies by using a cyclooxygenase-2 inhibitor, celecoxib. When used in a randomized cancer prevention clinical trial on patients with the inherited autosomal dominant condition, fam...

journal_title：Cancer research

authors： Xiao Z,Luke BT,Izmirlian G,Umar A,Lynch PM,Phillips RK,Patterson S,Conrads TP,Veenstra TD,Greenwald P,Hawk ET,Ali IU

更新日期：2004-04-15 00:00:00