Abstract:
:Fusions of the ETV6/TEL gene to receptor or protein tyrosine kinases (TKs), such as PDGFRbeta, JAK2, ABL, ABL2, TRKC, and Syk, have been reported in various hematological malignancies. Expression of the resultant chimeric proteins is believed to lead to constitutive TK activity through activation by the helix-loop-helix (HLH) domain of ETV6. We identified a novel ETV6 partner gene, fibroblast growth factor receptor 3 (FGFR3), in a patient with peripheral T-cell lymphoma (PTCL) with a t(4;12)(p16;p13) translocation. The ETV6-FGFR3 transcript showed a fusion of exon 5 of ETV6 to exon 10 of FGFR3, resulting in an open reading frame for a chimeric protein consisting of the HLH domain of ETV6 and the TK domains of FGFR3. This is the first report of ETV6 and FGFR3 involvement in PTCL.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Yagasaki F,Wakao D,Yokoyama Y,Uchida Y,Murohashi I,Kayano H,Taniwaki M,Matsuda A,Bessho Msubject
Has Abstractpub_date
2001-12-01 00:00:00pages
8371-4issue
23eissn
0008-5472issn
1538-7445journal_volume
61pub_type
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