Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions.

abstract：:1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonally active form of vitamin D3, was shown previously to enhance chemically induced transformation of BALB 3T3 cells and Syrian hamster embryo cells. This report demonstrates that 1 alpha,25(OH)2D3, like phorbol ester tumor promoters, induces anchorage-indepen...

journal_title：Cancer research

authors： Hosoi J,Abe E,Suda T,Colburn NH,Kuroki T

更新日期：1986-11-01 00:00:00

abstract：:Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. Abrogation of HPV-E6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. Here, we show that a small-molecule reactivation of p53 and induc...

journal_title：Cancer research

authors： Zhao CY,Szekely L,Bao W,Selivanova G

更新日期：2010-04-15 00:00:00

abstract：:Retinoic acid (RA) is a master epigenetic regulator that plays a pivotal role in both breast morphogenesis and development. Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2...

journal_title：Cancer research

authors： Bistulfi G,Pozzi S,Ren M,Rossetti S,Sacchi N

更新日期：2006-11-01 00:00:00

abstract：:E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell matrix adhesion receptors. We show here that inhibition of E-cadheri...

journal_title：Cancer research

authors： Sawada K,Mitra AK,Radjabi AR,Bhaskar V,Kistner EO,Tretiakova M,Jagadeeswaran S,Montag A,Becker A,Kenny HA,Peter ME,Ramakrishnan V,Yamada SD,Lengyel E

更新日期：2008-04-01 00:00:00

abstract：:Paclitaxel has been shown to activate Raf-1 and cause phosphorylation of Bcl-2, which has been correlated with paclitaxel-induced apoptosis of cancer cells. In the present studies, we demonstrate that in human AML HL-60 cells that express Bcl-2 but little Bcl-xL (HL-60/neo cells), paclitaxel-induced phosphorylation of...

journal_title：Cancer research

authors： Ibrado AM,Liu L,Bhalla K

更新日期：1997-03-15 00:00:00

abstract：:R115777 [(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] is a potent and selective inhibitor of farnesyl protein transferase with significant antitumor effects in vivo subsequent to oral administration in mice. In vitro, using isolated human farnesyl prote...

journal_title：Cancer research

authors： End DW,Smets G,Todd AV,Applegate TL,Fuery CJ,Angibaud P,Venet M,Sanz G,Poignet H,Skrzat S,Devine A,Wouters W,Bowden C

更新日期：2001-01-01 00:00:00

abstract：:MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that BRAFV600E -mutated colorectal cancers acquire resistance to MEK1 inhibition by inducing expression of the scaffold protein CEMIP through a β-catenin- and FRA-1-dependent ...

journal_title：Cancer research

authors： Duong HQ,Nemazanyy I,Rambow F,Tang SC,Delaunay S,Tharun L,Florin A,Büttner R,Vandaele D,Close P,Marine JC,Shostak K,Chariot A

更新日期：2018-08-15 00:00:00

abstract：:Dendritic cells (DCs) are attractive candidates for innovative cancer immunotherapy by virtue of their potential to function as professional antigen-presenting cells for initiating cellular immune responses. In this study, we evaluated a possible synergy of conventional chemotherapy together with intratumoral injectio...

journal_title：Cancer research

authors： Tong Y,Song W,Crystal RG

更新日期：2001-10-15 00:00:00

abstract：:nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellu...

journal_title：Cancer research

authors： Iizuka N,Oka M,Noma T,Nakazawa A,Hirose K,Suzuki T

更新日期：1995-02-01 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homologue (PTEN) is involved in cell proliferation, adhesion, and apoptosis. PTEN overexpression in mammary epithelium leads to reduced cell number and impaired differentiation and secretion. In contrast, overexpression of the proto-oncogene Wnt-1 in mammary epithelium leads...

journal_title：Cancer research

authors： Zhao H,Cui Y,Dupont J,Sun H,Hennighausen L,Yakar S

更新日期：2005-08-01 00:00:00

abstract：:Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

journal_title：Cancer research

authors： White DL,Brown AL,D'Andrea RJ,Rice AM

更新日期：2012-09-01 00:00:00

abstract：:The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell- and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b(+)CD11c(+)Ly6C(high)Ly6G(-)MHCII(+) dendritic cell-like an...

journal_title：Cancer research

authors： Ma Y,Mattarollo SR,Adjemian S,Yang H,Aymeric L,Hannani D,Portela Catani JP,Duret H,Teng MW,Kepp O,Wang Y,Sistigu A,Schultze JL,Stoll G,Galluzzi L,Zitvogel L,Smyth MJ,Kroemer G

更新日期：2014-01-15 00:00:00

abstract：:The mechanism of albumin biosynthesis was studied in Morris hepatoma 5123tc in vivo and in hepatoma cell suspensions obtained by solubilizing the intercellular matrix with collagenase and hyaluronidase. In the in vivo experiments, L-[-14C]leucine was injected i.v. into rats bearing hepatomas in the muscles of both hin...

journal_title：Cancer research

authors： Edwards K,Schreiber G,Dryburgh H,Millership A,Urban J

更新日期：1976-09-01 00:00:00

abstract：:Growth factors play an important role in regulating neural stem cell proliferation and differentiation. This study shows that platelet-derived growth factor (PDGF) induces a partial differentiation of neural stem/progenitor cells (NSPCs) in the absence of other mitogens in vitro. NSPCs thus acquire an immature morphol...

journal_title：Cancer research

authors： Erlandsson A,Brännvall K,Gustafsdottir S,Westermark B,Forsberg-Nilsson K

更新日期：2006-08-15 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, inhibited B16 melanoma-induced angiogenesis in chick embryo chorioallantoic membrane and subsequently the growth of the tumor on the chorioallantoic membrane. These inhibitions were reversed by exogenous putrescine and spermidi...

journal_title：Cancer research

authors： Takigawa M,Enomoto M,Nishida Y,Pan HO,Kinoshita A,Suzuki F

更新日期：1990-07-01 00:00:00

abstract：:DDX3 is a DEAD box RNA helicase with diverse biological functions. Using colony formation assay, our results revealed that DDX3 inhibited the colony formation ability of various tumor cells, and this inhibition might be due to a reduced growth rate caused by DDX3. Additionally, we identified p21(waf1/cip1), a cyclin-d...

journal_title：Cancer research

authors： Chao CH,Chen CM,Cheng PL,Shih JW,Tsou AP,Lee YH

更新日期：2006-07-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:Inactivation of the p53 tumor suppressor gene is a common finding in human cancer. In most cases, inactivation is due to a point mutation in the gene, but rearrangement of the p53 gene is sometimes observed. We analyzed the inactivation of p53 in the human pancreas cancer cell line Hs766T, which harbors a structural a...

journal_title：Cancer research

authors： Slebos RJ,Resnick MA,Taylor JA

更新日期：1998-12-01 00:00:00

abstract：:We have previously shown that topotecan, a topoisomerase I poison, inhibits hypoxia-inducible factor (HIF)-1alpha protein accumulation by a DNA damage-independent mechanism. Here, we report that daily administration of topotecan inhibits HIF-1alpha protein expression in U251-HRE glioblastoma xenografts. Concomitant wi...

journal_title：Cancer research

authors： Rapisarda A,Zalek J,Hollingshead M,Braunschweig T,Uranchimeg B,Bonomi CA,Borgel SD,Carter JP,Hewitt SM,Shoemaker RH,Melillo G

更新日期：2004-10-01 00:00:00

abstract：:In the era of omics-driven research, it remains a common dilemma to stratify individual patients based on the molecular characteristics of their tumors. To improve molecular stratification of patients with breast cancer, we developed the Gaussian mixture model (GMM)-based classifier. This probabilistic classifier was ...

journal_title：Cancer research

authors： Prabakaran I,Wu Z,Lee C,Tong B,Steeman S,Koo G,Zhang PJ,Guvakova MA

更新日期：2019-07-01 00:00:00

abstract：:Multiple myeloma is a B-cell malignancy for which no curative therapies exist to date, despite enormous research efforts. The remarkable activity of the proteasome inhibitor bortezomib (PS-341, Velcade) observed in clinical trials of patients with relapsed refractory myeloma has led to investigations of the role of th...

journal_title：Cancer research

authors： Altun M,Galardy PJ,Shringarpure R,Hideshima T,LeBlanc R,Anderson KC,Ploegh HL,Kessler BM

更新日期：2005-09-01 00:00:00

abstract：:We have shown previously that hepatocyte growth factor (HGF), which is produced by lung fibroblasts, is a potent mitogen and motogen for both normal and neoplastic bronchial epithelium, and that expression of the HGF receptor, the c-met proto-oncogene protein, is uniformly found in the human bronchial epithelium and i...

journal_title：Cancer research

authors： Siegfried JM,Weissfeld LA,Singh-Kaw P,Weyant RJ,Testa JR,Landreneau RJ

更新日期：1997-02-01 00:00:00

abstract：:The human inducible nitric oxide synthase (hiNOS) gene is regulated by nuclear factor kappaB (NF-kappaB) and has recently been shown to be a target of the Wnt/beta-catenin pathway. In this study, we tested the hypothesis that Wnt/beta-catenin signaling might regulate cytokine- or tumor necrosis factor alpha (TNFalpha)...

journal_title：Cancer research

authors： Du Q,Zhang X,Cardinal J,Cao Z,Guo Z,Shao L,Geller DA

更新日期：2009-05-01 00:00:00

abstract：:DNA methylation patterns are established and maintained by three DNA methyltransferases (DNMT): DNMT1, DNMT3A, and DNMT3B. Although essential for development, methylation patterns are frequently disrupted in cancer and contribute directly to carcinogenesis. Recent studies linking polycomb group repression complexes (P...

journal_title：Cancer research

authors： Jin B,Yao B,Li JL,Fields CR,Delmas AL,Liu C,Robertson KD

更新日期：2009-09-15 00:00:00

abstract：:The radionuclide of choice for use in diagnosis in most nuclear medicine diagnostic procedures is 99mTc. It is important, therefore, to establish whether there is potential clinical efficacy of an antitumor antigen directed monoclonal antibody labeled with 99mTc. We have investigated the potential use of a 99mTc label...

journal_title：Cancer research

authors： Brown BA,Dearborn CB,Drozynski CA,Sands H

更新日期：1990-02-01 00:00:00

abstract：:The effect of basic fibroblast growth factor (b-FGF), one of the commonest angiogenic factors in various cancer types, on lymphocyte adhesion and transmigration across the endothelial cell monolayer was investigated using human umbilical vein-derived endothelial cells (HUVEC) and type I collagen gel. Forty-eight h exp...

journal_title：Cancer research

authors： Kitayama J,Nagawa H,Yasuhara H,Tsuno N,Kimura W,Shibata Y,Muto T

更新日期：1994-09-01 00:00:00

abstract：:Cancers are initiated as a result of changes that occur in the genome. Identification of gains and losses in the structure and expression of tumor-suppressor genes and oncogenes lies at the root of the understanding of cancer cell biology. Here, we show that the mitogen-activated protein kinase (MAPK) MKK3 suppresses ...

journal_title：Cancer research

authors： MacNeil AJ,Jiao SC,McEachern LA,Yang YJ,Dennis A,Yu H,Xu Z,Marshall JS,Lin TJ

更新日期：2014-01-01 00:00:00

abstract：:We demonstrate here that paclitaxel exposure to RPMI-1788 B lymphoblasts caused a dose- and time-dependent increase in nuclear factor activator protein 1 (AP-1) DNA binding activity. The basal DNA binding activities of nuclear factors NF-kappaB and Ets were not affected by paclitaxel. Consistent with these biochemical...

journal_title：Cancer research

authors： Amato SF,Swart JM,Berg M,Wanebo HJ,Mehta SR,Chiles TC

更新日期：1998-01-15 00:00:00

abstract：:Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing receptor (CaSR) in gastric cancer development. CaSR expression was enha...

journal_title：Cancer research

authors： Xie R,Xu J,Xiao Y,Wu J,Wan H,Tang B,Liu J,Fan Y,Wang S,Wu Y,Dong TX,Zhu MX,Carethers JM,Dong H,Yang S

更新日期：2017-12-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) that arises in immune-deficient patients is an aggressive B-cell neoplasm that is universally associated with the EBV. Patients with EBV(+) PCNSL face a particularly poor prognosis with median survival times of 2-12 months despite aggressive management with radiation the...

journal_title：Cancer research

authors： Roychowdhury S,Peng R,Baiocchi RA,Bhatt D,Vourganti S,Grecula J,Gupta N,Eisenbeis CF,Nuovo GJ,Yang W,Schmalbrock P,Ferketich A,Moeschberger M,Porcu P,Barth RF,Caligiuri MA

更新日期：2003-03-01 00:00:00