Significance of bacterial flora in abdominal irradiation-induced inhibition of lung metastases.

Abstract:

:We have previously reported that abdominal irradiation prior to i.v. injection of syngeneic tumor cells reduced metastases in lung. Our report described an investigation of the significance of intestinal organisms in the radiation effect. We found that eliminating intestinal organisms with antibiotics totally abolished the radiation effect. Monoassociation of germ-free mice revealed that the radiation effect was observable only for Enterobacter cloacae, never for Streptococcus faecium, Bifidobacterium adlesentis, or Escherichia coli. After abdominal irradiation of regular mice, E. cloacae multiplied in cecal contents, adhered to mucous membranes, invaded the cecal wall, and translocated to mesenteric lymph nodes. Intravenous administration of E. cloacae in place of abdominal irradiation inhibited metastases. E. cloacae-monoassociated mice developed fewer metastases than germ-free mice, and the reduction was further enhanced by abdominal irradiation. We concluded that abdominal irradiation caused the invasion of E. cloacae from the mucous membrane of the intestine and inhibited formation of lung metastases.

journal_name

Cancer Res

journal_title

Cancer research

authors

Matsumoto T,Ando K,Koike S

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

3031-4

issue

11

eissn

0008-5472

issn

1538-7445

journal_volume

48

pub_type

杂志文章
  • Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction.

    abstract::Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days lat...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-0027

    authors: Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CL

    更新日期:2011-07-15 00:00:00

  • Abundance of the primary transcript and its processed product of growth-related genes in normal and leukemic cells during proliferation and differentiation.

    abstract::The relative abundance of primary transcript and mature mRNA of the c-myc, calcyclin, S14 ribosomal protein, and rRNA genes was determined densitometrically after reverse transcriptase-polymerase chain reaction and Northern blotting analysis in resting and mitogen-stimulated lymphocytes, proliferating and terminally d...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ferrari S,Tagliafico E,Manfredini R,Grande A,Rossi E,Zucchini P,Torelli G,Torelli U

    更新日期:1992-01-01 00:00:00

  • Effect of tamoxifen on the multidrug-resistant phenotype in human breast cancer cells: isobologram, drug accumulation, and M(r) 170,000 glycoprotein (gp170) binding studies.

    abstract::We have performed isobologram analyses of the ability of tamoxifen (TAM) to alter the response to Adriamycin (ADR) and vinblastine (VBL) in human breast cancer cells. MCF-7 cells express functional receptors for estrogen and progesterone but do not express detectable levels of M(r) 170,000 glycoprotein (gp170). CL 10....

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Leonessa F,Jacobson M,Boyle B,Lippman J,McGarvey M,Clarke R

    更新日期:1994-01-15 00:00:00

  • Positive correlation between calmodulin content and hepatoma growth rates.

    abstract::Calmodulin contents of normal rat liver, host liver [bearing hepatoma 5123t.c.(h)], regenerating liver, and Morris hepatomas 7800, 5123t.c.(h), and 7794A were determined by phosphodiesterase assay and by radioimmunoassay. The calmodulin levels determined by both assays were significantly increased in three hepatomas w...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Wei JW,Morris HP,Hickie RA

    更新日期:1982-07-01 00:00:00

  • Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.

    abstract::Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefined, limiting the ability to address resistant tumors or develop less toxic targ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-16-1303

    authors: Ding LW,Sun QY,Tan KT,Chien W,Mayakonda A,Yeoh AEJ,Kawamata N,Nagata Y,Xiao JF,Loh XY,Lin DC,Garg M,Jiang YY,Xu L,Lim SL,Liu LZ,Madan V,Sanada M,Fernández LT,Hema Preethi SS,Lill M,Kantarjian HM,Kornblau SM,

    更新日期:2017-01-15 00:00:00

  • ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.

    abstract::Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells. In t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-1199

    authors: Kalashnikova EV,Revenko AS,Gemo AT,Andrews NP,Tepper CG,Zou JX,Cardiff RD,Borowsky AD,Chen HW

    更新日期:2010-11-15 00:00:00

  • Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.

    abstract::Several lines of evidence suggest that apoptosis dysregulation plays an important role in cancer metastasis. In this study, to explore the possibility that the mutations of death receptors are involved in the metastasis mechanism, we analyzed the death domains of Fas and tumor necrosis factor-related apoptosis-inducin...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Shin MS,Kim HS,Lee SH,Park WS,Kim SY,Park JY,Lee JH,Lee SK,Lee SN,Jung SS,Han JY,Kim H,Lee JY,Yoo NJ

    更新日期:2001-07-01 00:00:00

  • Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study.

    abstract::In a European joint project carried out in 6 laboratories a disease-oriented program was set up consisting of a panel of 7 tumor types, each represented by 4 to 8 different human tumor lines, for secondary screening of promising anticancer drugs. Human tumor lines were selected on the basis of differences in histology...

    journal_title:Cancer research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Boven E,Winograd B,Berger DP,Dumont MP,Braakhuis BJ,Fodstad O,Langdon S,Fiebig HH

    更新日期:1992-11-01 00:00:00

  • Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.

    abstract::Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-3012

    authors: Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

    更新日期:2006-05-15 00:00:00

  • Growth of preneoplastic mammary epithelial cells in serum-free medium.

    abstract::The conditions for growing preneoplastic mammary epithelial cells in primary cell cultures with serum-free factor-defined medium were established in a series of experiments. The cells, grown in Dulbecco's modified Eagle's medium with 0.6 mM Ca2+, epidermal growth factor, transferrin, insulin, and Na2SeO3, were fibrobl...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Medina D,Oborn CJ

    更新日期:1980-11-01 00:00:00

  • DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.

    abstract::Bifunctional alkylating agents are known to produce cross-links between DNA and protein and between paired DNA strands. The possibility of discriminating these two classes of cross-links in L1210 cells treated with haloethylnitrosoureas or nitrogen mustard was explored with the alkaline elution technique. Two classes ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ewig RA,Kohn KW

    更新日期:1978-10-01 00:00:00

  • Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: a model for lung carcinogenesis.

    abstract::We have previously described the neoplastic transformation of immortalized human bronchial epithelial cells (BEAS-2B) by the combination of the c-raf-1 and c-myc protooncogenes and the concomitant induction of neuron-specific enolase mRNA expression (A. Pfeifer et al., Proc. Natl. Acad. Sci. USA, 86: 10075-10079, 1989...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Pfeifer AM,Jones RT,Bowden PE,Mann D,Spillare E,Klein-Szanto AJ,Trump BF,Harris CC

    更新日期:1991-07-15 00:00:00

  • Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.

    abstract::Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

    更新日期:2002-02-01 00:00:00

  • Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

    abstract::Approximately one third of breast cancers grow independently of estrogen, lack detectable estrogen receptor (ER) protein, and rarely respond to hormonal treatment. Previous studies correlated the lack of ER gene expression in ER-negative breast tumor cells with hypermethylation of a CpG island in the 5' region of the ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ferguson AT,Lapidus RG,Baylin SB,Davidson NE

    更新日期:1995-06-01 00:00:00

  • Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea.

    abstract::Male inbred F344 weanling rats were fed semipurified diets containing 20 or 5% beef fats. At 7 weeks of age, all animals except controls were given 1,2-dimethylhydrazine [DMH (150 mg/kg body weight s.c.; one dose)], methylazoxymethanol acetate [MAM acetate (35 mg/kg body weight i.p.; one dose)], or methylnitrosourea (...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Reddy BS,Watanabe K,Weisburger JH

    更新日期:1977-11-01 00:00:00

  • A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis.

    abstract::Aneuploidy is invariably associated with poor proliferation of primary cells, but the specific contributions of abnormal karyotypes to cancer, a disease characterized by aneuploidy and dysregulated proliferation, remain unclear. In this study, I demonstrate that the transcriptional alterations caused by aneuploidy in ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-0749

    authors: Sheltzer JM

    更新日期:2013-11-01 00:00:00

  • Polycyclic aromatic hydrocarbon toxicity and induction of metabolism in cultivated esophageal and epidermal keratinocytes.

    abstract::Serially cultivated keratinocytes of human and rat epidermis and esophagus were compared with respect to their sensitivity to toxic effects of 3-methylcholanthrene and ability to metabolize benzo(a)pyrene. 3-Methylcholanthrene was highly toxic to the human keratinocytes and to early-passage rat epidermal keratinocytes...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Heimann R,Rice RH

    更新日期:1983-10-01 00:00:00

  • Acid pH in tumors and its potential for therapeutic exploitation.

    abstract::Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major mechanisms which lead to tumor acidity probably include the production of lactic acid and hydrolysis of ATP in hypoxic regions of tumors. Further reduction in pH may be achieved in some tumo...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tannock IF,Rotin D

    更新日期:1989-08-15 00:00:00

  • Relationship between radiation exposure and risk of second primary cancers among atomic bomb survivors.

    abstract::Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 we...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-0276

    authors: Li CI,Nishi N,McDougall JA,Semmens EO,Sugiyama H,Soda M,Sakata R,Hayashi M,Kasagi F,Suyama A,Mabuchi K,Davis S,Kodama K,Kopecky KJ

    更新日期:2010-09-15 00:00:00

  • Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens.

    abstract::Technical modifications of the quantitative determination of unscheduled DNA synthesis in cultured hepatocytes are described which allow for the rapid identification of potentially carcinogenic chemicals on a large-scale screening basis. The test is based on the biochemical quantification of [methyl-3H]thymidine incor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Althaus FR,Lawrence SD,Sattler GL,Longfellow DG,Pitot HC

    更新日期:1982-08-01 00:00:00

  • Pentraxin 3: a novel biomarker for predicting progression from prostatic inflammation to prostate cancer.

    abstract::Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discrimi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-0369

    authors: Stallone G,Cormio L,Netti GS,Infante B,Selvaggio O,Fino GD,Ranieri E,Bruno F,Prattichizzo C,Sanguedolce F,Tortorella S,Bufo P,Grandaliano G,Carrieri G

    更新日期:2014-08-15 00:00:00

  • Enhancer-dependent splicing of FGFR1 alpha-exon is repressed by RNA interference-mediated down-regulation of SRp55.

    abstract::The FGFR1 gene transcript is alternatively processed to produce functionally different receptor forms. Previously, we identified a 69-nucleotide exonic splicing enhancer (ESE) required for alpha-exon inclusion in JEG3 cells. In the present study, we found that this sequence is composed of three independent elements, t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-0716

    authors: Jin W,Cote GJ

    更新日期:2004-12-15 00:00:00

  • Effects of tumor promoters on the expression of a tumor-related multigenic set in human cells.

    abstract::We previously found that a minor subfraction of the human genomic DNA, corresponding to 2500-3000 nonrepetitive sequences of 3 kilobases each and designated as tumor-activated DNA (TaDNA) was transcriptionally active in Burkitt's lymphoma cells and almost inactive in normal lymphocytes growing in vitro following integ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hanania N,Castagna M,Shaool D,Zeliszewski D,Harel J

    更新日期:1985-12-01 00:00:00

  • Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

    abstract::Angiogenesis, the sprouting of new blood vessels from existing vessels, occurs in many physiological and pathological processes, including embryonic development, wound healing, and tumor growth. It is required for tumor growth because new blood vessel formation is necessary for tumors to expand beyond a minimum volume...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Millauer B,Longhi MP,Plate KH,Shawver LK,Risau W,Ullrich A,Strawn LM

    更新日期:1996-04-01 00:00:00

  • Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer.

    abstract::TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-2637

    authors: Grawenda AM,Møller EK,Lam S,Repapi E,Teunisse AF,Alnæs GI,Børresen-Dale AL,Kristensen VN,Goding CR,Jochemsen AG,Edvardsen H,Bond GL

    更新日期:2015-02-15 00:00:00

  • Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.

    abstract::Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabilization, complete remissions are rare and a substantial proportion of...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-1449

    authors: Bauer S,Parry JA,Mühlenberg T,Brown MF,Seneviratne D,Chatterjee P,Chin A,Rubin BP,Kuan SF,Fletcher JA,Duensing S,Duensing A

    更新日期:2010-01-01 00:00:00

  • Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53.

    abstract::Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

    更新日期:1997-11-01 00:00:00

  • Interferon effect on collagen and fibronectin distribution in the extracellular matrix of murine sarcoma virus-transformed cells.

    abstract::The transformation of murine BALB/c embryonic fibroblasts by murine sarcoma virus, Moloney strain, followed by prolonged treatment with murine interferon, resulted in the appearance of a new cell population (MSV-IF+). These MSV-IF+ cells are characterized by the recovery of a normal phenotype, contact inhibition, and ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gerfaux J,Rousset S,Chany-Fournier F,Chany C

    更新日期:1981-09-01 00:00:00

  • A truncated human xeroderma pigmentosum complementation group A protein expressed from an adenovirus sensitizes human tumor cells to ultraviolet light and cisplatin.

    abstract::Individuals with the genetic disease xeroderma pigmentosum (XP) have impaired nucleotide excision repair (NER). Group A XP cells are defective in the XPA protein essential for NER and serve, together with other NER proteins, as a nucleation factor for the demarcation of bulky DNA damage. Because XPA cells are extremel...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rosenberg E,Taher MM,Kuemmerle NB,Farnsworth J,Valerie K

    更新日期:2001-01-15 00:00:00

  • Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.

    abstract::Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumo...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-3060

    authors: Yeo CW,Ng FS,Chai C,Tan JM,Koh GR,Chong YK,Koh LW,Foong CS,Sandanaraj E,Holbrook JD,Ang BT,Takahashi R,Tang C,Lim KL

    更新日期:2012-05-15 00:00:00