Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

abstract：:The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (CCR6) by multiple myeloma (MM) and microenvironment cells and their potential relationship with osteoclast (OC) formation and osteolytic bone lesions in MM patients was ...

journal_title：Cancer research

authors： Giuliani N,Lisignoli G,Colla S,Lazzaretti M,Storti P,Mancini C,Bonomini S,Manferdini C,Codeluppi K,Facchini A,Rizzoli V

更新日期：2008-08-15 00:00:00

abstract：:After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified ad...

journal_title：Cancer research

authors： Amundson SA,Grace MB,McLeland CB,Epperly MW,Yeager A,Zhan Q,Greenberger JS,Fornace AJ Jr

更新日期：2004-09-15 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:The effect of retinoic acid (RA) on N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation of primary cultures of rat tracheal epithelial cells was investigated. RA inhibited transformation of rat tracheal epithelial cells by up to 95% at concentrations of 3.3 to 33 nM which did not substantially affect cell surv...

journal_title：Cancer research

authors： Mass MJ,Nettesheim P,Beeman DK,Barrett JC

更新日期：1984-12-01 00:00:00

abstract：:The lack of markers to predict chemotherapy responses in patients poses a major handicap in cancer treatment. We searched for gene expression patterns that correlate with docetaxel or cisplatin response in a mouse model for breast cancer associated with BRCA1 deficiency. Array-based expression profiling did not identi...

journal_title：Cancer research

authors： Rottenberg S,Vollebergh MA,de Hoon B,de Ronde J,Schouten PC,Kersbergen A,Zander SA,Pajic M,Jaspers JE,Jonkers M,Lodén M,Sol W,van der Burg E,Wesseling J,Gillet JP,Gottesman MM,Gribnau J,Wessels L,Linn SC,Jonkers J,

更新日期：2012-05-01 00:00:00

abstract：:Metastatic prostate cancer continues to pose a difficult therapeutic challenge. Prostate cancer progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events is uncertain. Here we report spontaneous metastasis of human prostate cancer xenografts that...

journal_title：Cancer research

authors： Tsai CH,Tzeng SF,Chao TK,Tsai CY,Yang YC,Lee MT,Hwang JJ,Chou YC,Tsai MH,Cha TL,Hsiao PW

更新日期：2016-10-01 00:00:00

abstract：:HsRec2/Rad51B is a 350-amino acid protein with a molecular mass of 38,300 Da that appears to be involved in cell cycle regulation and UV-induced apoptosis. The mouse and human genes were isolated based on their homology to a recombinational repair gene from Ustilago maydis and contain functional domains to hRAD51 and ...

journal_title：Cancer research

authors： Havre PA,Rice MC,Noe M,Kmiec EB

更新日期：1998-10-15 00:00:00

abstract：:Molecular docking is a standard computational approach to predict binding modes of protein-ligand complexes by exploring alternative orientations and conformations of the ligand (i.e., by exploring ligand flexibility). Docking tools are largely used for virtual screening of small drug-like molecules, but their accurac...

journal_title：Cancer research

authors： Antunes DA,Moll M,Devaurs D,Jackson KR,Lizée G,Kavraki LE

更新日期：2017-11-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:The association between the consumption of onions and leeks (vegetables belonging to the Allium genus), garlic supplements, and the risk of lung carcinoma was investigated in a large-scale prospective cohort study on diet and cancer in the Netherlands. The Netherlands Cohort Study was started in 1986 among 120,852 men...

journal_title：Cancer research

authors： Dorant E,van den Brandt PA,Goldbohm RA

更新日期：1994-12-01 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00

abstract：:Administration of nerve growth factor (NGF) to the offspring of Sprague-Dawley rats transplacentally exposed to 50 mg/kg ethylnitrosourea on the 20th day of gestation resulted in a significant reduction of trigeminal and peripheral nerve neurinomas. Forty, 60, and 80 micrograms of NGF was administered in five s.c. dos...

journal_title：Cancer research

authors： Raju NR,Koestner A,Marushige K,Lovell KL,Okazaki D

更新日期：1989-12-15 00:00:00

abstract：:Malignant changes are often accompanied by alterations in activity and composition of the plasminogen activators (PA). To study the relationship between PA expression and the development of colorectal cancer, we determined urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) activit...

journal_title：Cancer research

authors： de Bruin PA,Griffioen G,Verspaget HW,Verheijen JH,Lamers CB

更新日期：1987-09-01 00:00:00

abstract：:The aldehyde reagent methoxyamine is able to interact with apurinic/apyrimidinic sites formed in vivo within cells and displays both an anti-cytotoxic and an antimutagenic activity on N-ethyl-N'-nitro-N-nitrosoguanidine-induced DNA damage in Chinese hamster ovary cells. To clarify the underlying mechanism we have exam...

journal_title：Cancer research

authors： Fortini P,Calcagnile A,Vrieling H,van Zeeland AA,Bignami M,Dogliotti E

更新日期：1993-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and biological significance in GBM remain elusive. Here, we show that multiple GBM cell subpopulations could be purified from the specimens o...

journal_title：Cancer research

authors： Mazzoleni S,Politi LS,Pala M,Cominelli M,Franzin A,Sergi Sergi L,Falini A,De Palma M,Bulfone A,Poliani PL,Galli R

更新日期：2010-10-01 00:00:00

abstract：:Monoclonal antibodies (Mabs) against human ovarian mucinous and serous carcinoma were obtained by the Mab technique. Their reactivities against human tumors were tested by indirect immunofluorescence. One of the Mabs, named 4C7, derived from the spleen cells of mice immunized with mucinous carcinoma line OVA-1, reacte...

journal_title：Cancer research

authors： Tsuji Y,Suzuki T,Nishiura H,Takemura T,Isojima S

更新日期：1985-05-01 00:00:00

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:Cancer procoagulant (CP) is a Mr 68,000 cysteine proteinase that initiates blood coagulation and is expressed by a variety of malignant cells but not by normally differentiated cells. Polyclonal immunoglobulin G and monoclonal immunoglobulin M antibodies were developed to purified CP and used to develop an enzyme-link...

journal_title：Cancer research

authors： Gordon SG,Cross BA

更新日期：1990-10-01 00:00:00

abstract：:One-week-old male and female mice of the A, BALB/c (C), and C3H/He (C3) strains and of the AC3 and CC3 F1 hybrids were treated with a single dose (300 mg/kg s.c.) of urethan and then kept without further treatment until 30 and 40 weeks (males) or 30 and 65 weeks (females). The degree of difference in susceptibility to...

journal_title：Cancer research

authors： Dragani TA,Manenti G,Della Porta G

更新日期：1991-12-01 00:00:00

abstract：:We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human cancer cells and tumors. Survivin inhibits caspase-9, blocks apoptosis, and is associated with resistance to chemotherapy and radiation. Survivin is a client p...

journal_title：Cancer research

authors： Ferrario A,Rucker N,Wong S,Luna M,Gomer CJ

更新日期：2007-05-15 00:00:00

abstract：:Pleural fluid from a child previously treated for rhabdomyosarcoma produced colonies in vitro. Cells from these colonies appeared to have the light and electron microscopic appearance of rhabdomyosarcoma cells. In this case, the malignant nature of the effusion had been suspected because of the patient's previous hist...

journal_title：Cancer research

authors： Altman AJ,Crussi FG,Rierden WJ,Baehner RL

更新日期：1975-07-01 00:00:00

abstract：:Rats were fed sodium saccharin as 5 or 7.5% of the diet by weight, and proliferation of the bladder epithelium was assessed by autoradiography, histology, and scanning electron microscopy. In Experiment 1, male F344 rats, 5 weeks old, were placed on a diet of 0, 5, or 7.5% NaS mixed in Prolab 3200, NIH-07, or AIN-76A ...

journal_title：Cancer research

authors： Garland EM,Sakata T,Fisher MJ,Masui T,Cohen SM

更新日期：1989-07-15 00:00:00

abstract：:Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 ot...

journal_title：Cancer research

authors： Luistro L,He W,Smith M,Packman K,Vilenchik M,Carvajal D,Roberts J,Cai J,Berkofsky-Fessler W,Hilton H,Linn M,Flohr A,Jakob-Røtne R,Jacobsen H,Glenn K,Heimbrook D,Boylan JF

更新日期：2009-10-01 00:00:00

abstract：:The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously reported that ROCK kinase expression increases with human and mouse pancrea...

journal_title：Cancer research

authors： Rath N,Munro J,Cutiongco MF,Jagiełło A,Gadegaard N,McGarry L,Unbekandt M,Michalopoulou E,Kamphorst JJ,Sumpton D,Mackay G,Vennin C,Pajic M,Timpson P,Olson MF

更新日期：2018-06-15 00:00:00

abstract：:Five different lipid conjugates of 1-beta-D-arabinofuranosylcytosine (ara-C) were tested for their therapeutic activity on the growth and metastasis of Lewis lung carcinoma (3-LL). Among 1 ester-linked lipid conjugate (Ara-CDP-L-dipalmitin), 3 1-O-alkyl-lipid conjugates (ara-CDP-D,L-PBA, ara-CDP-D,L-PCA, ara-CDP-D,L-M...

journal_title：Cancer research

authors： Berdel WE,Danhauser S,Hong CI,Schick HD,Reichert A,Busch R,Rastetter J,Vogler WR

更新日期：1988-02-15 00:00:00

abstract：:Overexpression of the adverse prognostic marker ERBB2 occurs in 30% of breast cancers; however, therapies targeting this gene have not proved to be as effective as was initially hoped. Transcriptional profiling meta-analyses have shown that there are approximately 150 genes co-overexpressed with ERBB2, suggesting that...

journal_title：Cancer research

authors： Kourtidis A,Jain R,Carkner RD,Eifert C,Brosnan MJ,Conklin DS

更新日期：2010-03-01 00:00:00

abstract：:Tumors must manipulate the host vasculature to provide a blood supply adequate for their proliferation. Although tumors may arise as avascular masses, there is increasing evidence that some tumors begin to proliferate by first co-opting preexisting host blood vessels. By fluorescent vascular imaging, we provide eviden...

journal_title：Cancer research

authors： Lu W,Schroit AJ

更新日期：2005-02-01 00:00:00

abstract：:We have produced a panel of monoclonal antibodies directed against a dimethylbenzanthracene-induced murine mammary tumor. Five rat-mouse hybridomas produced antibodies that bound to some murine mammary tumors, but not to normal renal adherent cells, lymphocytes, 3T3 fibroblasts, red blood cells, or mammary gland. One ...

journal_title：Cancer research

authors： Johnson CW,Wei WZ,Barth RF,Tuttle SE,Andrews CA

更新日期：1985-08-01 00:00:00

abstract：:The introduction of MAPK pathway inhibitors paved the road for significant advancements in the treatment of BRAF-mutant (BRAF(MUT)) melanoma. However, even BRAF/MEK inhibitor combination therapy has failed to offer a curative treatment option, most likely because these pathways constitute a codependent signaling netwo...

journal_title：Cancer research

authors： Herkert B,Kauffmann A,Mollé S,Schnell C,Ferrat T,Voshol H,Juengert J,Erasimus H,Marszalek G,Kazic-Legueux M,Billy E,Ruddy D,Stump M,Guthy D,Ristov M,Calkins K,Maira SM,Sellers WR,Hofmann F,Hall MN,Brachmann SM

更新日期：2016-01-15 00:00:00

abstract：:Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 we...

journal_title：Cancer research

authors： Li CI,Nishi N,McDougall JA,Semmens EO,Sugiyama H,Soda M,Sakata R,Hayashi M,Kasagi F,Suyama A,Mabuchi K,Davis S,Kodama K,Kopecky KJ

更新日期：2010-09-15 00:00:00