A prospective cohort study on Allium vegetable consumption, garlic supplement use, and the risk of lung carcinoma in The Netherlands.

abstract：:Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors and cyclooxygenase-1 (COX-1) is now being reconsidered as a target for chemoprevention. Our aims were to determine whether selective COX-1 inhibition could delay or prevent cancer development a...

journal_title：Cancer research

authors： Li H,Zhu F,Chen H,Cheng KW,Zykova T,Oi N,Lubet RA,Bode AM,Wang M,Dong Z

更新日期：2014-01-01 00:00:00

abstract：:Metastasis requires cytoskeletal remodeling for migration, adhesion, and extravasation of metastatic cells. Although protein kinase C (PKC) is involved in tumor promotion/progression and cytoskeletal remodeling, its role in metastasis has not been defined. PKCdelta levels are increased in highly metastatic 13762NF mam...

journal_title：Cancer research

authors： Kiley SC,Clark KJ,Goodnough M,Welch DR,Jaken S

更新日期：1999-07-01 00:00:00

abstract：:Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a dual-function phosphatase with tumor suppressor function compromised in a wide spectrum of cancers. Because tissue polarity and architecture are crucial modulators of normal and malignant behavior, we postulated that PTEN may play a role in maintena...

journal_title：Cancer research

authors： Fournier MV,Fata JE,Martin KJ,Yaswen P,Bissell MJ

更新日期：2009-05-15 00:00:00

abstract：:We and others have reported previously that adults with glioma are 1.5- to 4-fold less likely than controls to report a variety of allergic conditions. The consistent nature of this relationship calls for a biological explanation so that preventative or therapeutic modalities can be explored. We enrolled 403 newly dia...

journal_title：Cancer research

authors： Wiemels JL,Wiencke JK,Patoka J,Moghadassi M,Chew T,McMillan A,Miike R,Barger G,Wrensch M

更新日期：2004-11-15 00:00:00

abstract：:The receptor tyrosine kinase ErbB-2 plays an important role in the regulation of growth factor-induced signal transduction cascades in the epithelium, and ErbB-2 is frequently overexpressed in epithelial tumors. Our previous studies on clinical prostate cancer specimens indicated that ErbB-2 expression was increased i...

journal_title：Cancer research

authors： Casimiro M,Rodriguez O,Pootrakul L,Aventian M,Lushina N,Cromelin C,Ferzli G,Johnson K,Fricke S,Diba F,Kallakury B,Ohanyerenwa C,Chen M,Ostrowski M,Hung MC,Rabbani SA,Datar R,Cote R,Pestell R,Albanese C

更新日期：2007-05-01 00:00:00

abstract：:In vivo 31P nuclear magnetic resonance spectroscopy was used to examine the bioenergetics of the rat 9L gliosarcoma during untreated growth and in response to chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Tumor growth was associated with a decline in the phosphocreatine and nucleoside triphosphate resonances...

journal_title：Cancer research

authors： Steen RG,Tamargo RJ,McGovern KA,Rajan SS,Brem H,Wehrle JP,Glickson JD

更新日期：1988-02-01 00:00:00

abstract：:Multiple cytokines stimulate hepatic lipogenesis in rodents. We have previously shown that lipogenic cytokines can be divided into 2 classes by their mechanism of action and their synergistic interactions. We now report the effects of interleukin 4, a cytokine known to inhibit the synthesis and action of other cytokin...

journal_title：Cancer research

authors： Grunfeld C,Soued M,Adi S,Moser AH,Fiers W,Dinarello CA,Feingold KR

更新日期：1991-06-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:Several metabolic processes, such as DNA organization and replication, transcription, and RNA processing are closely associated with the nuclear matrix. Nuclear matrix attachment regions are nucleotide sequences holding DNA tightly complexed with the nuclear scaffold and are resistant to extractions with detergents an...

journal_title：Cancer research

authors： Brylawski BP,Tsongalis GJ,Cordeiro-Stone M,May WT,Comeau LD,Kaufman DG

更新日期：1993-09-01 00:00:00

abstract：:Prostate cancer stem-like cells (PCSLC) are believed to be responsible for prostate cancer onset and metastasis. Autocrine and microenvironmental signals dictate PCSLC behavior and patient outcome. In prostate cancer patients, IL30/IL27p28 has been linked with tumor progression, but the mechanisms underlying this link...

journal_title：Cancer research

authors： Sorrentino C,Ciummo SL,Cipollone G,Caputo S,Bellone M,Di Carlo E

更新日期：2018-05-15 00:00:00

abstract：:To better understand the events occurring during immunotherapy of liver metastases with effector cells, we have developed a clinically relevant animal model in which both effector-tumor cell interactions and survival can be evaluated. A cell line of human gastric carcinoma (HR) metastatic to the liver has been establi...

journal_title：Cancer research

authors： Yasumura S,Lin WC,Hirabayashi H,Vujanovic NL,Herberman RB,Whiteside TL

更新日期：1994-07-15 00:00:00

abstract：:Complementary DNA (cDNA)-oligodeoxythmidylate-celluloses were prepared from cDNA copies of polysomal messenger RNA (mRNA) of Novikoff hepatoma, normal rat liver, and regenerating rat liver. cDNA synthesis with reverse transcriptase was approximately 46% with respect to input mRNA with oligodeoxythymidylate-cellulose p...

journal_title：Cancer research

authors： Hirsch FW,Nall KN,Hayes LC,Raju KS,Spohn WH,Busch H

更新日期：1977-10-01 00:00:00

abstract：:Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells. In t...

journal_title：Cancer research

authors： Kalashnikova EV,Revenko AS,Gemo AT,Andrews NP,Tepper CG,Zou JX,Cardiff RD,Borowsky AD,Chen HW

更新日期：2010-11-15 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00

abstract：:Using in vitro double labeling with two different doses of [3H]thymidine, we measured the S-phase duration and the labeling index in biopsy samples taken from human rectal and colonic adenocarcinomas. Samples from the adjacent healthy mucosa, taken at the same time as the tumor samples, were simultaneously subjected t...

journal_title：Cancer research

authors： Bleiberg H,Galand P

更新日期：1976-02-01 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:The presence of metastases in the regional lymph nodes is the major prognostic factor in breast cancer in the absence of overt distant metastases and is also an important indicator of the need for adjuvant therapy in "early" breast cancer. Currently, the accurate assessment of axillary lymph node status requires axill...

journal_title：Cancer research

authors： Tjandra JJ,Russell IS,Collins JP,Andrews JT,Lichtenstein M,Binns D,McKenzie IF

更新日期：1989-03-15 00:00:00

abstract：:Latent prostate tumors are commonly found with similar frequency in many countries and ethnic groups. In contrast, aggressive prostate cancer (PC) is significantly less prevalent among Asian men, where the intake of soy products is very high. High consumption of foods containing soy results in high plasma, urine, and ...

journal_title：Cancer research

authors： Mentor-Marcel R,Lamartiniere CA,Eltoum IE,Greenberg NM,Elgavish A

更新日期：2001-09-15 00:00:00

abstract：:Hemodynamic (blood flow rate, hematocrit, hemoglobin concentration, and blood viscosity) and pH responses to glucose (6 g/kg, i.p.) injections were studied in ten Walker 256 carcinoma tumors (0.5-1.8 g) grown in the "tissue-isolated" tumor preparation. A maximum blood flow reduction of 57 +/- 19% (SD) occurred concurr...

journal_title：Cancer research

authors： Sevick EM,Jain RK

更新日期：1988-03-01 00:00:00

abstract：:The plasma of dogs afflicted with mammary carcinoma was perfused through chambers bearing Staphylococcus aureus Cowan strain I in an attempt to remove tumor-promoting, immunosuppressive immune complexes from the peripheral blood of these animals. In this canine model of spontaneous mammary carcinoma, reduction of brea...

journal_title：Cancer research

authors： Holohan TV,Phillips TM,Bowles C,Deisseroth A

更新日期：1982-09-01 00:00:00

abstract：:Hypoxia inducible factors (HIF) are critical mediators of the cellular response to decreased oxygen tension and are overexpressed in a number of tumors. Although HIF1alpha and HIF2alpha share a high degree of sequence homology, recent work has shown that the two alpha subunits can have contrasting and tissue-specific ...

journal_title：Cancer research

authors： Bertout JA,Patel SA,Fryer BH,Durham AC,Covello KL,Olive KP,Goldschmidt MH,Simon MC

更新日期：2009-04-01 00:00:00

abstract：:Previous experiments have suggested that some mutant forms of p53 are able to inactivate the endogenous wild-type p53 protein in a dominant-negative fashion. However, it remains unknown whether tumors with such dominant-negative (transdominant) p53 mutants have a biological significance that is different from that of ...

journal_title：Cancer research

authors： Marutani M,Tonoki H,Tada M,Takahashi M,Kashiwazaki H,Hida Y,Hamada J,Asaka M,Moriuchi T

更新日期：1999-10-01 00:00:00

abstract：:Disulfiram (DSF) and its metabolites, diethyldithiocarbamic acid (DDC) and diethylamine (DEA), were studied as pretreatments in combination with the alkylating agent nitrogen mustard (HN2) on the cytotoxicity of HN2 against both leukemia cells and normal hematopoietic stem cells. Both time intervals and dose relations...

journal_title：Cancer research

authors： Valeriote F,Grates HE

更新日期：1989-12-01 00:00:00

abstract：:After 5 or 20 mg cyclophosphamide per kg body weight, given once i.v., the output in thoracic duct lymph of small and large lymphoid cells, cells incorporating [3H]lymidine in vitro, mitotic cells, pyknotic cells, and/or the number of lymphocytes and neutrophils in peripheral blood were measured in six calves. The med...

journal_title：Cancer research

authors： Wagner JP,Chanana AD,Cottier H,Cronkite EP,Gassmann A,Joel DD,Laissue JA

更新日期：1976-09-01 00:00:00

abstract：:The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to as...

journal_title：Cancer research

authors： Leng S,Stidley CA,Liu Y,Edlund CK,Willink RP,Han Y,Landi MT,Thun M,Picchi MA,Bruse SE,Crowell RE,Van Den Berg D,Caporaso NE,Amos CI,Siegfried JM,Tesfaigzi Y,Gilliland FD,Belinsky SA

更新日期：2012-02-01 00:00:00

abstract：:Muscle-invasive bladder cancer (MIBC) generally responds poorly to treatment and tends to exhibit significant mortality. Here we show that expression of the tumor suppressor p14ARF (ARF) is upregulated in aggressive subtypes of MIBC. Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated r...

journal_title：Cancer research

authors： Owczarek TB,Kobayashi T,Ramirez R,Rong L,Puzio-Kuter AM,Iyer G,Teo MY,Sánchez-Vega F,Wang J,Schultz N,Zheng T,Solit DB,Al-Ahmadie HA,Abate-Shen C

更新日期：2017-02-15 00:00:00

abstract：:The kinetic properties of a soluble, magnesium-dependent 5'-nucleotidase from human malignant lymphocytes have been determined. The partially purified enzyme is distinct from plasma membrane-associated 5'-nucleotidase and is free of nonspecific phosphatase activity. Among purine ribonucleotides, it reacted efficiently...

journal_title：Cancer research

authors： Carson DA,Wasson DB

更新日期：1982-11-01 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates angiogenesis by enhancing endothelial cell survival and migration. It is also known that Ang1 activates Tie2, an endothelial-specific tyrosine kinase receptor, but the molecular mechanism of this process is not clear. In this study, we investigated whether reactive oxygen species (ROS) p...

journal_title：Cancer research

authors： Kim YM,Kim KE,Koh GY,Ho YS,Lee KJ

更新日期：2006-06-15 00:00:00

abstract：:The inhibitor of caspase-3-activated DNase (ICAD) is a caspase-3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of M(r) 45,000, ICAD-L/DNA fragmentation factor (DFF) 45; and a M(r) 35,000 isoform, ICAD-S/DFF35. ICAD-deficient murine cells display resistance to apoptotic stimuli ...

journal_title：Cancer research

authors： Charrier L,Jarry A,Toquet C,Bou-Hanna C,Chedorge M,Denis M,Vallette G,Laboisse CL

更新日期：2002-04-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome characterized by early age of onset colorectal cancer (mean 45 years) as well as endometrial, urinary tract, and upper gastrointestinal adenocarcinomas. The HNPCC phenotype has been shown to segregate with germline mutations in ...

journal_title：Cancer research

authors： Weber TK,Conlon W,Petrelli NJ,Rodriguez-Bigas M,Keitz B,Pazik J,Farrell C,O'Malley L,Oshalim M,Abdo M,Anderson G,Stoler D,Yandell D

更新日期：1997-09-01 00:00:00