Species differences in the formation of benzo(a)pyrene-DNA adducts in rodent and human endometrium.

abstract：:Specific immunity to Rous virus-induced sarcoma (RSL) was investigated by the tube leukocyte adherence inhibition (LAI) assay in rats immunized with Bacillus Calmette-Guérin (BCG). Peritoneal cells from Lewis rats immunized s.c. with BCG gave positive reactions in the tube LAI assay with the antigen prepared from RSL ...

journal_title：Cancer research

authors： Holán V,Chutná J,Hasek M

更新日期：1979-02-01 00:00:00

abstract：:The specific activity (dpm/mg protein) of the acid-soluble nuclear material extracted from spleens or lymph nodes (but not other tissues) of tumor-bearing BALB/c mice was approximately twice that of the corresponding tissues from tumor-free mice of the same age and sex following i.p. injection of L-[U-14C]lysine. Auto...

journal_title：Cancer research

authors： Mashburn LT

更新日期：1985-05-01 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00

abstract：:The pathogenesis of choroid plexus papillomas, intraventricular papillary neoplasms most often occurring sporadically in children and young adults, remains poorly understood. To identify pathways operative in the development of choroid plexus papillomas, gene expression profiles obtained from laser-microdissected huma...

journal_title：Cancer research

authors： Hasselblatt M,Mertsch S,Koos B,Riesmeier B,Stegemann H,Jeibmann A,Tomm M,Schmitz N,Wrede B,Wolff JE,Zheng W,Paulus W

更新日期：2009-03-15 00:00:00

abstract：:Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ve...

journal_title：Cancer research

authors： Groothuis DR,Pasternak JF,Fischer JM,Blasberg RG,Bigner DD,Vick NA

更新日期：1983-07-01 00:00:00

abstract：:Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients previously treated with alkylating agents, but not with cisplatin, expressed greater than 23-fold differences in cisplatin sensitivities in vitro. Cisplatin resistance in SK-OV-3 cells appeared to be associated with increased levels of g...

journal_title：Cancer research

authors： Shellard SA,Hosking LK,Hill BT

更新日期：1991-09-01 00:00:00

abstract：:Promoter methylation of the mismatch repair gene plays a key role in sporadic microsatellite instability (MSI) colorectal cancers. However, promoter methylation often occurs in proximal colon cancers, and molecular phenotypes underlying MSI cancers in distal colon have not been fully clarified. Our goal was to clarify...

journal_title：Cancer research

authors： Watanabe T,Kobunai T,Toda E,Yamamoto Y,Kanazawa T,Kazama Y,Tanaka J,Tanaka T,Konishi T,Okayama Y,Sugimoto Y,Oka T,Sasaki S,Muto T,Nagawa H

更新日期：2006-10-15 00:00:00

abstract：:Strategies to address resistance to platin drugs are greatly needed in human epithelial cancers (e.g., ovarian, head/neck, and lung) where platins are used widely and resistance occurs commonly. We found that upon ΔNp63α overexpression, AKT1 and phospho-AKT1 levels are upregulated in cancer cells. Investigations using...

journal_title：Cancer research

authors： Sen T,Sen N,Brait M,Begum S,Chatterjee A,Hoque MO,Ratovitski E,Sidransky D

更新日期：2011-02-01 00:00:00

abstract：:Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains challenging because TGFβ has tumor suppressor functions in many epithel...

journal_title：Cancer research

authors： Ostapoff KT,Cenik BK,Wang M,Ye R,Xu X,Nugent D,Hagopian MM,Topalovski M,Rivera LB,Carroll KD,Brekken RA

更新日期：2014-09-15 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with immunoblastic B-cell lymphomas in immunosuppressed or human immunodeficiency virus-infected individuals and in SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors. The risk of tumors appearing in the hu-PBL-SCID...

journal_title：Cancer research

authors： Mosier DE,Picchio GR,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-10-01 00:00:00

abstract：:Bone marrow biopsy specimens from patients with myeloma were cultured in either 1 of 2 thin-film culture systems, a controlled environment steady state system or a rocker tube configuration of the system, for periods up to 42 days. Both functional and morphological characteristics of the myeloma cells were well-mainta...

journal_title：Cancer research

authors： Gailani S,McLimans WF,Mundy GR,Nussbaum A,Roholt O,Zeigel R

更新日期：1976-04-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:R115777 [(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] is a potent and selective inhibitor of farnesyl protein transferase with significant antitumor effects in vivo subsequent to oral administration in mice. In vitro, using isolated human farnesyl prote...

journal_title：Cancer research

authors： End DW,Smets G,Todd AV,Applegate TL,Fuery CJ,Angibaud P,Venet M,Sanz G,Poignet H,Skrzat S,Devine A,Wouters W,Bowden C

更新日期：2001-01-01 00:00:00

abstract：:We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10(-10) M or less were capable of producing 50% inhibition of g...

journal_title：Cancer research

authors： Corbeil J,Richman DD,Wrasidlo W,Nicolaou KC,Looney DJ

更新日期：1994-08-15 00:00:00

abstract：:Frequent loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) has been reported in many types of human malignancies, including gastric carcinoma. One of the targets of 5q-LOH in colorectal carcinoma is certainly the adenomatous polyposis coli (APC) gene on 5q21. However, other evidence has suggested the p...

journal_title：Cancer research

authors： Tamura G,Ogasawara S,Nishizuka S,Sakata K,Maesawa C,Suzuki Y,Terashima M,Saito K,Satodate R

更新日期：1996-02-01 00:00:00

abstract：:Chronic myelogenous leukemia is characterized by a specific chromosomal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chimeric BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, whi...

journal_title：Cancer research

authors： ten Hoeve J,Kaartinen V,Fioretos T,Haataja L,Voncken JW,Heisterkamp N,Groffen J

更新日期：1994-05-15 00:00:00

abstract：:The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions. Here, we describe for the first time the expression and function of Foxp3 in pancreatic ductal adenocarcinoma cells and tumors. Foxp3 e...

journal_title：Cancer research

authors： Hinz S,Pagerols-Raluy L,Oberg HH,Ammerpohl O,Grüssel S,Sipos B,Grützmann R,Pilarsky C,Ungefroren H,Saeger HD,Klöppel G,Kabelitz D,Kalthoff H

更新日期：2007-09-01 00:00:00

abstract：:The ability of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA) to lead to the activation of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase was investigated in three cell lines. In the Reuber H35 hepatoma cells, TPA (1.6 microM) led to an increase in the protein kinase...

journal_title：Cancer research

authors： Byus CV,Trevillyan JM,Cavit LJ,Fletcher WH

更新日期：1983-07-01 00:00:00

abstract：:We have defined the chromosomal location of the human MAGE (melanoma antigen) gene family by polymerase chain reaction amplification of several segments of the MAGE genes from somatic cell hybrids containing well-defined groups of human chromosomes and hybrids containing human derivative chromosomes. The data show tha...

journal_title：Cancer research

authors： Oaks MK,Hanson JP Jr,O'Malley DP

更新日期：1994-04-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) levels are dramatically increased in human keratinocytes (HKc) immortalized with full-length human papillomavirus type 16 (HPV16) DNA (HKc/HPV16), but increases in EGFR levels actually precede immortalization. In some normal HKc strains, acute expression of HPV16 E6 (but not HPV...

journal_title：Cancer research

authors： Akerman GS,Tolleson WH,Brown KL,Zyzak LL,Mourateva E,Engin TS,Basaraba A,Coker AL,Creek KE,Pirisi L

更新日期：2001-05-01 00:00:00

abstract：:Recent studies have indicated that angiogenesis may be regulated, in part, by p53 tumor suppressor gene function. We hypothesized that wild-type p53 replacement would down-regulate vascular endothelial growth factor (VEGF) expression and inhibit angiogenesis. KM12L4 and SW620, human colon cancer cell lines with p53 mu...

journal_title：Cancer research

authors： Bouvet M,Ellis LM,Nishizaki M,Fujiwara T,Liu W,Bucana CD,Fang B,Lee JJ,Roth JA

更新日期：1998-06-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:Previous data on the effects of a single dose of hydroxyurea on C3H mouse duodenum and mammary tumors from a fast growing line (S102F) were used to predict times that may be optimal (i.e., minimize killing of the duodenal S-phase cells while enhancing the killing of tumor S-phase cells) for the administration of subse...

journal_title：Cancer research

authors： Dethlefsen LA,Sorensen SP,Riley RM

更新日期：1975-03-01 00:00:00

abstract：:We have established and characterized a diploid cell strain of normal human endothelial cells, RuBa 7E. RuBa 7E cells have an average cloning efficiency of 20% during early passages and undergo approximately 50 doublings in vitro before senescing spontaneously. At confluence, RuBa 7E cells form a homogeneous monolayer...

journal_title：Cancer research

authors： Reznikoff CA,DeMars R

更新日期：1981-03-01 00:00:00

abstract：:Eleven patients with advanced breast cancer and four with astrocytoma were treated with plasma perfused over columns containing staphylococcal Protein A (SPA). Doses of 5 to 20 mg of SPA were bound to collodion charcoal particles, and this treatment resulted in partial remissions in one patient with astrocytoma and in...

journal_title：Cancer research

authors： Bertram JH,Grunberg SM,Shulman I,Apuzzo ML,Boquiren D,Kunkel L,Hengst JC,Nelson J,Waugh WJ,Plotkin D

更新日期：1985-09-01 00:00:00

abstract：:Salvage of preformed nucleosides requires transport across the plasma membrane by sodium-dependent (concentrative) and sodium-independent (equilibrative) mechanisms. These transport systems are also the route of cellular uptake for nucleoside analogues, including gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytid...

journal_title：Cancer research

authors： Rauchwerger DR,Firby PS,Hedley DW,Moore MJ

更新日期：2000-11-01 00:00:00

abstract：:Cigarette smoke contains low levels of agonists for the aryl hydrocarbon receptor (AhR; also called the dioxin receptor). However, little is understood about the whole potential of cigarette smoke for activating AhR. In this report, we evaluated the total "dioxin-like" activity of cigarette smoke using in vitro and in...

journal_title：Cancer research

authors： Kasai A,Hiramatsu N,Hayakawa K,Yao J,Maeda S,Kitamura M

更新日期：2006-07-15 00:00:00

abstract：:A complex of polyinosinic-polycytidylic acid [poly(I) x poly(C)] and cationic liposome (LIC) inhibited the growth of many tumor cell lines at low concentration in vitro, but poly(I) x poly(C) alone had no such antiproliferative effect. The IC50 values of LIC against the tumor cells ranged from 0.1 to 1000 ng/ml. LIC h...

journal_title：Cancer research

authors： Hirabayashi K,Yano J,Inoue T,Yamaguchi T,Tanigawara K,Smyth GE,Ishiyama K,Ohgi T,Kimura K,Irimura T

更新日期：1999-09-01 00:00:00

abstract：:Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and humans. However, low overall success rates and intense side effects prevent such approaches from being employed clinically. In this work, we titered bacteria and/or the proinflammatory cytokine TNFα in a set of establ...

journal_title：Cancer research

authors： Hatzikirou H,López Alfonso JC,Leschner S,Weiss S,Meyer-Hermann M

更新日期：2017-04-01 00:00:00

abstract：:Numerous studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in chemoprevention or treatment of cancer. Nevertheless, the mechanisms underlying these antineoplastic effects remain poorly understood. Here, we report that induction of the cancer-specific proapoptotic cytokine melanoma different...

journal_title：Cancer research

authors： Zerbini LF,Czibere A,Wang Y,Correa RG,Otu H,Joseph M,Takayasu Y,Silver M,Gu X,Ruchusatsawat K,Li L,Sarkar D,Zhou JR,Fisher PB,Libermann TA

更新日期：2006-12-15 00:00:00