Modulation of p53 expression by human recombinant interferon-alpha2a correlates with abrogation of cisplatin resistance in a human melanoma cell line.

abstract：:The binding of labeled insulin to dissociated R3230AC mammary adenocarcinoma cells from diabetic and intact rats was investigated in vitro. At 20 degrees, specific binding (total binding minus binding in the presence of 1000-fold excess or 10(-6) M unlabeled insulin) reached a plateau at 45 to 60 min and was directly ...

journal_title：Cancer research

authors： Harmon JT,Hilf R

更新日期：1976-11-01 00:00:00

abstract：:Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted systemic therapy for hepatocellular carcinoma. The gene for a foreign enzyme is selectively expressed in the tumor cells and a nontoxic prodrug is then given, whi...

journal_title：Cancer research

authors： Schepelmann S,Hallenbeck P,Ogilvie LM,Hedley D,Friedlos F,Martin J,Scanlon I,Hay C,Hawkins LK,Marais R,Springer CJ

更新日期：2005-06-15 00:00:00

abstract：:Endogenous retroviruses and retroviral elements represent a substantial component of vertebrate genomes. They are inherited as stable Mendelian genes and may be activated spontaneously or by physical or chemical agents. In the human genome various retroviral elements have been detected by their relationship with mamma...

journal_title：Cancer research

authors： Leib-Mösch C,Brack-Werner R,Werner T,Bachmann M,Faff O,Erfle V,Hehlmann R

更新日期：1990-09-01 00:00:00

abstract：:Our understanding of noncoding mutations in cancer genomes has been derived primarily from mutational recurrence analysis by aggregating clinical samples on a large scale. These cohort-based approaches cannot directly identify individual pathogenic noncoding mutations from personal cancer genomes. Therefore, although ...

journal_title：Cancer research

authors： Wang C,Li J

更新日期：2020-11-01 00:00:00

abstract：:The promotion of crude shark cartilage extracts as a cure for cancer has contributed to at least two significant negative outcomes: a dramatic decline in shark populations and a diversion of patients from effective cancer treatments. An alleged lack of cancer in sharks constitutes a key justification for its use. Here...

journal_title：Cancer research

authors： Ostrander GK,Cheng KC,Wolf JC,Wolfe MJ

更新日期：2004-12-01 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00

abstract：:These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]-thymidine is characterized by a rapid initial velocity that approximates membrane transport followed by a slower rate of uptake t...

journal_title：Cancer research

authors： Yalowich JC,Goldman ID

更新日期：1984-03-01 00:00:00

abstract：:We have studied the sensitivities of four hematopoietic stem cell types to heat stress as well as their abilities to develop thermotolerance. Granulocyte-macrophage colony forming units were the most heat resistant bone marrow progenitors tested. Of the erythroid progenitors tested, erythrocyte colony forming units we...

journal_title：Cancer research

authors： Mivechi NF,Li GC

更新日期：1986-01-01 00:00:00

abstract：:The introduction of normal chromosomes into tumor cells by microcell fusion-mediated transfer is a powerful technique to identify putative tumor suppressor genes. We have used this approach to independently transfer human chromosomes 3 and 12 into a human prostate cancer cell line, DU 145. We showed that while the ext...

journal_title：Cancer research

authors： Bérubé NG,Speevak MD,Chevrette M

更新日期：1994-06-15 00:00:00

abstract：:We have developed a new strain of rats (resistant rat) which exhibit resistance against the carcinogenic action of several carcinogenic compounds. In the present study, we compared the ability of resistant rat liver to activate 3'-methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene to highly reactive metabolite...

journal_title：Cancer research

authors： Yano M,Higashi T,Kano S,Tateishi N,Kido Y,Mori T,Higashi K,Sakamoto Y

更新日期：1989-10-01 00:00:00

abstract：:Previously, we showed that prostate and prostate cancer cells express a truncated T-cell receptor gamma chain mRNA that uses an alternative reading frame to produce a novel nuclear T-cell receptor gamma chain alternate reading frame protein (TARP). TARP is expressed in the androgen-sensitive LNCaP prostate cancer cell...

journal_title：Cancer research

authors： Wolfgang CD,Essand M,Lee B,Pastan I

更新日期：2001-11-15 00:00:00

abstract：:Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage-activated signaling pathway, which regulates cellular resistance to DNA cross-linking agen...

journal_title：Cancer research

authors： Jacquemont C,Taniguchi T

更新日期：2007-08-01 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:Collagenase-3 (matrix metalloproteinase 13; MMP-13), a protease originally identified in breast carcinoma, is characterized by a potent degrading activity against a wide spectrum of extracellular matrix proteins. The aims of this study were to localize and identify the MMP-13-expressing cells in invasive human breast ...

journal_title：Cancer research

authors： Nielsen BS,Rank F,López JM,Balbin M,Vizoso F,Lund LR,Danø K,López-Otín C

更新日期：2001-10-01 00:00:00

abstract：:Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative E...

journal_title：Cancer research

authors： Iljin K,Wolf M,Edgren H,Gupta S,Kilpinen S,Skotheim RI,Peltola M,Smit F,Verhaegh G,Schalken J,Nees M,Kallioniemi O

更新日期：2006-11-01 00:00:00

abstract：:S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was shown to provide marked protection against development of radiation-induced leg contractures in C3Hf/Kam mice whose legs were exposed to single doses of gamma-radiation. The radiation doses ranged from 3300 to 6200 rads delivered to the right hind thighs ...

journal_title：Cancer research

authors： Hunter N,Milas L

更新日期：1983-04-01 00:00:00

abstract：:Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients previously treated with alkylating agents, but not with cisplatin, expressed greater than 23-fold differences in cisplatin sensitivities in vitro. Cisplatin resistance in SK-OV-3 cells appeared to be associated with increased levels of g...

journal_title：Cancer research

authors： Shellard SA,Hosking LK,Hill BT

更新日期：1991-09-01 00:00:00

abstract：:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, an...

journal_title：Cancer research

authors： Long CW,Bruszewski JA,Christensen WL,Suk WA

更新日期：1979-08-01 00:00:00

abstract：:The ability of the bovine C-type leukemia virus to induce syncytia formation in monolayer cell cultures has been used to develop a specific and simple infectivity assay for the virus. Using bovine embryonic spleen cells or human diploid embryonic lung cells as indicator cells, the results of the assay can be evaluated...

journal_title：Cancer research

authors： Ferrer JF,Diglio CA

更新日期：1976-03-01 00:00:00

abstract：:Chicken chondrocytes isolated from 11-day-old chicken vertebrate cartilage were transformed by Rous sarcoma virus ts LA24 of the Prague strain as well as by the wild-type Prague strain of Rous sarcoma virus. The morphology of chondrocytes transformed by Rous sarcoma virus ts LA 24 was dependent on the temperature, and...

journal_title：Cancer research

authors： Okayama M,Yoshimura M,Muto M,Chi J,Roth S,Kaji A

更新日期：1977-03-01 00:00:00

abstract：:Inherited mutations of the human BRCA2 gene confer increased risks for developing breast, ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a homozygous germ-line deletion of Brca2 exon 27 that exhibit a mo...

journal_title：Cancer research

authors： McAllister KA,Bennett LM,Houle CD,Ward T,Malphurs J,Collins NK,Cachafeiro C,Haseman J,Goulding EH,Bunch D,Eddy EM,Davis BJ,Wiseman RW

更新日期：2002-02-15 00:00:00

abstract：:Aberrant crypt foci (ACF) are distinct microscopic lesions of the colon thought to be the earliest identifiable precursors of colon cancer. As precursors of colon cancer, ACF may contain mutations in genes that are altered early in colorectal tumorigenesis. Candidates for these genes include APC, K-Ras, and those of t...

journal_title：Cancer research

authors： Heinen CD,Shivapurkar N,Tang Z,Groden J,Alabaster O

更新日期：1996-12-01 00:00:00

abstract：:Regulation of tyrosine aminotransferase gene expression was studied in an adult rat hepatocyte line (RALA255-10G) which is temperature sensitive for the maintenance of the differentiated liver phenotype. Glucocorticoid hormones such as cortisol were necessary for expression of the aminotransferase gene. In the absence...

journal_title：Cancer research

authors： Chou JY,Yeoh GC

更新日期：1987-10-15 00:00:00

abstract：:A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where t...

journal_title：Cancer research

authors： Hsu FC,Sun J,Wiklund F,Isaacs SD,Wiley KE,Purcell LD,Gao Z,Stattin P,Zhu Y,Kim ST,Zhang Z,Liu W,Chang BL,Walsh PC,Duggan D,Carpten JD,Isaacs WB,Grönberg H,Xu J,Zheng SL

更新日期：2009-04-01 00:00:00

abstract：:Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote anisotropic fiber orientation, tw...

journal_title：Cancer research

authors： Stanisavljevic J,Loubat-Casanovas J,Herrera M,Luque T,Peña R,Lluch A,Albanell J,Bonilla F,Rovira A,Peña C,Navajas D,Rojo F,García de Herreros A,Baulida J

更新日期：2015-01-15 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. On the basis of its histopathology and molecular-genomic changes, ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC xenografts that recapit...

journal_title：Cancer research

authors： Ricci F,Bizzaro F,Cesca M,Guffanti F,Ganzinelli M,Decio A,Ghilardi C,Perego P,Fruscio R,Buda A,Milani R,Ostano P,Chiorino G,Bani MR,Damia G,Giavazzi R

更新日期：2014-12-01 00:00:00

abstract：:In this study, we performed high-resolution array comparative genomic hybridization with an array of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted to exclude non-tumor DNA and increase our ability to detect gene copy number changes....

journal_title：Cancer research

authors： Loo LW,Grove DI,Williams EM,Neal CL,Cousens LA,Schubert EL,Holcomb IN,Massa HF,Glogovac J,Li CI,Malone KE,Daling JR,Delrow JJ,Trask BJ,Hsu L,Porter PL

更新日期：2004-12-01 00:00:00

abstract：:Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect of perineural invasion on the microenvironment and how this affects PDAC progression. Transcriptome expression profiles of PDAC tissues with different perineural invasion status were compared, and the i...

journal_title：Cancer research

authors： Yang MW,Tao LY,Jiang YS,Yang JY,Huo YM,Liu DJ,Li J,Fu XL,He R,Lin C,Liu W,Zhang JF,Hua R,Li Q,Jiang SH,Hu LP,Tian GA,Zhang XX,Niu N,Lu P,Shi J,Xiao GG,Wang LW,Xue J,Zhang ZG,Sun YW

更新日期：2020-05-15 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell survival and function during oxidative stress. The role of the PI3k/Akt signaling pathway in promoting cell viability was studied in vascular endothelial cells treated wi...

journal_title：Cancer research

authors： Geng L,Tan J,Himmelfarb E,Schueneman A,Niermann K,Brousal J,Fu A,Cuneo K,Kesicki EA,Treiberg J,Hayflick JS,Hallahan DE

更新日期：2004-07-15 00:00:00

abstract：:We have examined three methods that may be useful for improving the therapeutic efficacy of antibody-targeted radionuclides. The principal limitation of radioimmunotherapy is myelotoxicity and thrombocytopenia. These are due mainly to the length of time the radioantibody remains in the blood. The clearance time of a r...

journal_title：Cancer research

authors： Sharkey RM,Blumenthal RD,Hansen HJ,Goldenberg DM

更新日期：1990-02-01 00:00:00