Abstract：
:To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), in 22 inflammation-related genes, in a population-based case-control study conducted in Shanghai, China, where the incidence of biliary tract cancer has been increasing in recent decades. The study included 411 cases with biliary tract cancer (237 gallbladder, 127 extrahepatic bile duct, and 47 ampulla of Vater), 895 with biliary stones, and 786 controls randomly selected from the population. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association of individual SNPs and haplotypes with biliary stones and biliary tract cancer. Of the 62 SNPs examined, 14 were related to the risk of biliary cancer and stones. Specifically, variants in the IL8, IL8RB, RNASEL, and NOS2 genes were associated with biliary stones, whereas VEGF variants were associated with gallbladder cancer. Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype. In summary, common variants in genes that influence inflammatory responses may predispose to gallstones and biliary tract cancer, suggesting the need for future studies into the immunologic and inflammatory pathways that contribute to biliary diseases, including cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Hsing AW,Sakoda LC,Rashid A,Andreotti G,Chen J,Wang BS,Shen MC,Chen BE,Rosenberg PS,Zhang M,Niwa S,Chu L,Welch R,Yeager M,Fraumeni JF Jr,Gao YT,Chanock SJdoi
10.1158/0008-5472.CAN-08-0444subject
Has Abstractpub_date
2008-08-01 00:00:00pages
6442-52issue
15eissn
0008-5472issn
1538-7445pii
68/15/6442journal_volume
68pub_type
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