Inhibition of X-ray or chemical carcinogen-induced neoplastic transformation of C3H10T1/2 fibroblasts by lipopolysaccharides.

abstract：:Previous studies have shown dose-dependent growth inhibition of the human mammary carcinoma cell line MDA-MB-231 xenotransplanted in athymic mice using retinol. In this study, the growth inhibitory effect of retinoic acid (RA) and 13-cis-retinoic acid (13-cis-RA) was examined in vitro and in vivo. With both agents the...

journal_title：Cancer research

authors： Halter SA,Fraker LD,Adcock D,Vick S

更新日期：1988-07-01 00:00:00

abstract：:The semisynthetic anthracycline, 5-iminodaunorubicin (IM), was investigated to see whether modification of the benzoquinone moiety to produce a drug with low free radical potential would alter the cytotoxic and biochemical characteristics of this drug in comparison to Adriamycin (ADR), an agent with high free radical ...

journal_title：Cancer research

authors： Glazer RI,Hartman KD,Richardson CL

更新日期：1982-01-01 00:00:00

abstract：:The potentiation of monoclonal antibody/ligand toxin (immunotoxin) cytotoxicity by the ionophore monensin (Mo) or by human serum albumin-monensin (HSA-Mo) conjugates was investigated. Since disulfide cross-linked HSA-Mo (HSA-SPDP-Mo) is rapidly inactivated by human serum (M. Colombatti et al., Cancer Res., 50: 1385-13...

journal_title：Cancer research

authors： Candiani C,Franceschi A,Chignola R,Pasti M,Anselmi C,Benoni G,Tridente G,Colombatti M

更新日期：1992-02-01 00:00:00

abstract：:The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, bu...

journal_title：Cancer research

authors： Katagiri YU,Sleeman J,Fujii H,Herrlich P,Hotta H,Tanaka K,Chikuma S,Yagita H,Okumura K,Murakami M,Saiki I,Chambers AF,Uede T

更新日期：1999-01-01 00:00:00

abstract：:The development of toxicity to 4'-demethylepipodophyllotoxin-9-(4,6,-O-thenylidene-beta-glucopyranoside) an epipodophyllotoxin with oncolytic activity, was characterized in mice treated three times at 3-day intervals with 10 mg of drug i.p. per kg of body weight. Changes in organ function and general metabolism were d...

journal_title：Cancer research

authors： Hacker M,Roberts DW

更新日期：1975-07-01 00:00:00

abstract：:Thyroid-stimulating hormone (TSH) has long been recognized as the major proliferative and functional stimulus for thyroid follicular cells. TSH receptor (TSHR) engagement stimulates the production of cyclic AMP and the subsequent activation of downstream effector molecules, including protein kinase A, S6K1, and Rap1, ...

journal_title：Cancer research

authors： Brewer C,Yeager N,Di Cristofano A

更新日期：2007-09-01 00:00:00

abstract：:p21 (WAF1/CIP1; CDKN1a) is a universal cell-cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led to novel therapeutic strategies. The discovery in 1993 and subsequent ...

journal_title：Cancer research

authors： El-Deiry WS

更新日期：2016-09-15 00:00:00

abstract：:Alternative splicing is an important mechanism for the generation of protein diversity at a post-transcriptional level. Modifications in the splicing patterns of several genes have been shown to contribute to the malignant transformation of different tissue types. In this study, we used the Affymetrix Exon arrays to i...

journal_title：Cancer research

authors： Menghi F,Jacques TS,Barenco M,Schwalbe EC,Clifford SC,Hubank M,Ham J

更新日期：2011-03-15 00:00:00

abstract：:We developed a novel orthotopic mouse tumor model of renal cell carcinoma to collect and characterize cells spontaneously shed from SN12C (renal cell carcinoma) and SN12L1 (high metastatic variant of SN12C) tumors grown in kidneys of severe combined immunodeficient mice. Viability of the shed cell population was great...

journal_title：Cancer research

authors： Bockhorn M,Roberge S,Sousa C,Jain RK,Munn LL

更新日期：2004-04-01 00:00:00

abstract：:Lymphocytes isolated from the peripheral blood of patients with nonmalignant and malignant disorders were studied for fluidity of membrane lipids and lateral mobility of concanavalin A (Con A) receptors. The degree of fluidity of the surface membrane lipid core was monitored quantitatively by fluorescence polarization...

journal_title：Cancer research

authors： Ben-Bassat H,Polliak A,Rosenbaum SM,Naparstek E,Shouval D,Inbar M

更新日期：1977-05-01 00:00:00

abstract：:Although monoallelic expression (MAE) is a frequent genomic event in normal tissues, its role in tumorigenesis remains unclear. Here we carried out single-nucleotide polymorphism arrays on DNA and RNA from a large cohort of pediatric and adult brain tumor tissues to determine the genome-wide rate of MAE, its role in s...

journal_title：Cancer research

authors： Walker EJ,Zhang C,Castelo-Branco P,Hawkins C,Wilson W,Zhukova N,Alon N,Novokmet A,Baskin B,Ray P,Knobbe C,Dirks P,Taylor MD,Croul S,Malkin D,Tabori U

更新日期：2012-02-01 00:00:00

abstract：:Suramin, a polysulfonated naphthylurea widely used in the treatment of trypanosomiasis and onchocerciasis, is currently being investigated as an antitumor agent for the treatment of advanced cancer. Suramin exerts a wide variety of biological effects. We have shown that suramin inhibits cell proliferation and DNA synt...

journal_title：Cancer research

authors： Jindal HK,Anderson CW,Davis RG,Vishwanatha JK

更新日期：1990-12-15 00:00:00

abstract：:The influences of pure human pluripotent colony-stimulating factor, highly purified pluripoietin alpha, pure recombinant human tumor necrosis factor alpha, pure recombinant human gamma-interferon, and natural prostaglandin E1 (PGE1) were evaluated on colony formation of multipotential and erythroid progenitor cells in...

journal_title：Cancer research

authors： Lu L,Welte K,Gabrilove JL,Hangoc G,Bruno E,Hoffman R,Broxmeyer HE

更新日期：1986-09-01 00:00:00

abstract：:To directly examine a multistage carcinogenesis model and the role of UV light in human tissues, we grafted human skin onto mice with severe combined immunodeficiency disease. We found that the maximum dose of UV radiation in the B range (UVB; 280-320 nm) tolerated by these grafts was 500 J/m2 three times weekly. One ...

journal_title：Cancer research

authors： Soballe PW,Montone KT,Satyamoorthy K,Nesbit M,Herlyn M

更新日期：1996-02-15 00:00:00

abstract：:Single-chain antigen-binding proteins, or sFvs, represent potentially unique molecules for targeted delivery of drugs, toxins, or radionuclides to a tumor site. In previous studies (Cancer Res., 51:6363-6371, 1991) using a human colon carcinoma xenograft model, it was demonstrated that the sFv has an extremely rapid p...

journal_title：Cancer research

authors： Yokota T,Milenic DE,Whitlow M,Schlom J

更新日期：1992-06-15 00:00:00

abstract：:Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of pharmacologic agents to target RAF proteins or their effector kinases is an area of intense investigation. Here we report the biological properties of GDC-0879, a hig...

journal_title：Cancer research

authors： Hoeflich KP,Herter S,Tien J,Wong L,Berry L,Chan J,O'Brien C,Modrusan Z,Seshagiri S,Lackner M,Stern H,Choo E,Murray L,Friedman LS,Belvin M

更新日期：2009-04-01 00:00:00

abstract：:Bifunctional alkylating agents are known to produce cross-links between DNA and protein and between paired DNA strands. The possibility of discriminating these two classes of cross-links in L1210 cells treated with haloethylnitrosoureas or nitrogen mustard was explored with the alkaline elution technique. Two classes ...

journal_title：Cancer research

authors： Ewig RA,Kohn KW

更新日期：1978-10-01 00:00:00

abstract：:Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse the tumor phenotype. Here, we report the characterization of SB-590885, a novel triarylimidazole that selectively inhibits Raf kinases with more p...

journal_title：Cancer research

authors： King AJ,Patrick DR,Batorsky RS,Ho ML,Do HT,Zhang SY,Kumar R,Rusnak DW,Takle AK,Wilson DM,Hugger E,Wang L,Karreth F,Lougheed JC,Lee J,Chau D,Stout TJ,May EW,Rominger CM,Schaber MD,Luo L,Lakdawala AS,Adams JL,

更新日期：2006-12-01 00:00:00

abstract：:1-Nitropyrene (1-NP) originating from such sources as diesel exhaust emissions and coal combustion fly ash has been detected in the environment. 1-NP, in addition to being both a bacterial and mammalian mutagen, is carcinogenic in rats. The purpose of this study was to quantitate 1-NP metabolism and macromolecular cov...

journal_title：Cancer research

authors： Bond JA,Mauderly JL

更新日期：1984-09-01 00:00:00

abstract：:One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling, such that tamoxifen nonresponsiveness or resi...

journal_title：Cancer research

authors： Busch S,Sims AH,Stål O,Fernö M,Landberg G

更新日期：2015-04-01 00:00:00

abstract：:A quantitative assessment of rate-limiting steps in metastasis has always been challenging because of the difficulty of detecting small tumor cell populations. We have developed a highly sensitive assay for monitoring the metastatic dissemination of human tumor cells in the chick embryo and used this assay to investig...

journal_title：Cancer research

authors： Zijlstra A,Mellor R,Panzarella G,Aimes RT,Hooper JD,Marchenko ND,Quigley JP

更新日期：2002-12-01 00:00:00

abstract：:Disease recurrence and metastasis are frequently observed in many successfullytreated localized cancers, including hepatocellular carcinoma in which intrahepatic and extrahepatic recurrence (metastasis) are frequently observed after curative resection. The present study aimed at identifying metastasis-associated genes...

journal_title：Cancer research

authors： Cheung ST,Chen X,Guan XY,Wong SY,Tai LS,Ng IO,So S,Fan ST

更新日期：2002-08-15 00:00:00

abstract：:Smoking prevention will decrease lung cancer incidence in time. However, early detection would improve lung cancer prognosis in subjects at risk provided that specific markers could be identified. We previously reported that retinoic acid receptor (RAR) and retinoid X receptor (RXR) expression was altered in lung tumo...

journal_title：Cancer research

authors： Martinet N,Alla F,Farré G,Labib T,Drouot H,Vidili R,Picard E,Gaube MP,Le Faou D,Siat J,Borelly J,Vermylen P,Bazarbachi T,Vignaud JM,Martinet Y

更新日期：2000-06-01 00:00:00

abstract：:The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantabl...

journal_title：Cancer research

authors： Resnicoff M,Abraham D,Yutanawiboonchai W,Rotman HL,Kajstura J,Rubin R,Zoltick P,Baserga R

更新日期：1995-06-01 00:00:00

abstract：:Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44(+) subpopulation of prostate cancer cells, with important implications for diagnosis and prognosis of this disease. miR-708 w...

journal_title：Cancer research

authors： Saini S,Majid S,Shahryari V,Arora S,Yamamura S,Chang I,Zaman MS,Deng G,Tanaka Y,Dahiya R

更新日期：2012-07-15 00:00:00

abstract：:Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Both p53-dependent an...

journal_title：Cancer research

authors： Choi BH,Kim CG,Bae YS,Lim Y,Lee YH,Shin SY

更新日期：2008-03-01 00:00:00

abstract：:Integrins interact with extracellular matrix (ECM) and deliver intracellular signaling for cell proliferation, survival, and motility. During tumor metastasis, integrin-mediated cell adhesion to and migration on the ECM proteins are required for cancer cell survival and adaptation to the new microenvironment. Using st...

journal_title：Cancer research

authors： Chen Y,Lu B,Yang Q,Fearns C,Yates JR 3rd,Lee JD

更新日期：2009-04-15 00:00:00

abstract：:The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited ...

journal_title：Cancer research

authors： Tantin D,Schild-Poulter C,Wang V,Haché RJ,Sharp PA

更新日期：2005-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis. Using breast cancer cell lines as a model system, we sought to discover gene expression signatures of EMT with clinical an...

journal_title：Cancer research

authors： Choi YL,Bocanegra M,Kwon MJ,Shin YK,Nam SJ,Yang JH,Kao J,Godwin AK,Pollack JR

更新日期：2010-03-15 00:00:00

abstract：:The influence of methotrexate (MTX), dibutyryl cyclic AMP, and actinomycin D on production of human chorionic gonadotropin (HCG) in normal first trimester human placental organ cultures was compared. Actinomycin D (10(-8) to 10(-6) M) elevated HCG production by as much as 3.5-fold in normal placenta, and a 2-fold incr...

journal_title：Cancer research

authors： Huot RI,Nardone RM,Stromberg K

更新日期：1987-01-15 00:00:00