Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.

abstract：:SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, and lineage commitment in various tissues including the intestinal epithelium. Here, we present functional and cl...

journal_title：Cancer research

authors： Matheu A,Collado M,Wise C,Manterola L,Cekaite L,Tye AJ,Canamero M,Bujanda L,Schedl A,Cheah KS,Skotheim RI,Lothe RA,López de Munain A,Briscoe J,Serrano M,Lovell-Badge R

更新日期：2012-03-01 00:00:00

abstract：:There is still insufficient knowledge of the distribution of drinking habits in human populations, and more descriptive surveys are needed. Both prospective and retrospective epidemiological studies indicate that alcohol consumption is a cancer hazard. Prospective studies on excessive drinkers have shown an increased ...

journal_title：Cancer research

authors： Tuyns AJ

更新日期：1979-07-01 00:00:00

abstract：:Colorectal and lung cancers account for one-third of all cancer-related deaths worldwide. Previous studies suggested that Metadherin (MTDH) is involved in the development of colorectal and lung cancers. However, how MTDH regulates the pathogenesis of these cancers remains largely unknown. Using genetically modified mo...

journal_title：Cancer research

authors： Shen M,Xie S,Rowicki M,Michel S,Wei Y,Hang X,Wan L,Lu X,Yuan M,Jin JF,Jaschinski F,Zhou T,Klar R,Kang Y

更新日期：2020-11-25 00:00:00

abstract：:Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune response and improves ICB efficacy. Because ATM is an apical kinase in the radiation-induced DNA damage response, we investigated the effects of ATM inhibition...

journal_title：Cancer research

authors： Zhang Q,Green MD,Lang X,Lazarus J,Parsels JD,Wei S,Parsels LA,Shi J,Ramnath N,Wahl DR,Pasca di Magliano M,Frankel TL,Kryczek I,Lei YL,Lawrence TS,Zou W,Morgan MA

更新日期：2019-08-01 00:00:00

abstract：:Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that is a selective and potent inhibitor of the proteasome. We hypothesized that proteasome inhibition would lead to an accumulation of misfolded proteins in the cell resulting in endoplasmic reticulum (ER) stress. The ability of bor...

journal_title：Cancer research

authors： Nawrocki ST,Carew JS,Dunner K Jr,Boise LH,Chiao PJ,Huang P,Abbruzzese JL,McConkey DJ

更新日期：2005-12-15 00:00:00

abstract：:Ras associated with diabetes (Rad) is a Ras-related GTPase that promotes cell growth by accelerating cell cycle transitions. Rad knockdown induced cell cycle arrest and premature senescence without additional cellular stress in multiple cancer cell lines, indicating that Rad expression might be critical for the cell c...

journal_title：Cancer research

authors： Lee I,Yeom SY,Lee SJ,Kang WK,Park C

更新日期：2010-06-01 00:00:00

abstract：:Tumor-initiating properties of complete carcinogens such as 7,12-dimethylbenz(a)anthracene (DMBA) are well known but not the mechanism of DMBA-mediated tumor promotion. Our hypothesis is that interleukin (IL)-1alpha, an early proinflammatory cytokine that initiates a cascade of other cytokines and growth factors, is u...

journal_title：Cancer research

authors： Li X,Eckard J,Shah R,Malluck C,Frenkel K

更新日期：2002-01-15 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) inhibitors reduce angiogenic responses to a variety of stimuli, suggesting that products of COX-2 may mediate critical steps. Here, we show that thromboxane A2 (TXA2) is one of several eicosanoid products generated by activated human microvascular endothelial cells. Selective COX-2 antagonists...

journal_title：Cancer research

authors： Daniel TO,Liu H,Morrow JD,Crews BC,Marnett LJ

更新日期：1999-09-15 00:00:00

abstract：:SGN-40 is a humanized IgG1 antihuman CD40 that is currently in a phase I clinical trial for the treatment of multiple myeloma. As surface CD40 expression on B-lineage cells is maintained from pro-B cells to plasma cells, SGN-40 may be applicable to treatment of other B-cell neoplasias, including non-Hodgkin's lymphoma...

journal_title：Cancer research

authors： Law CL,Gordon KA,Collier J,Klussman K,McEarchern JA,Cerveny CG,Mixan BJ,Lee WP,Lin Z,Valdez P,Wahl AF,Grewal IS

更新日期：2005-09-15 00:00:00

abstract：:A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to G...

journal_title：Cancer research

authors： Sweeney C,McClure GY,Fares MY,Stone A,Coles BF,Thompson PA,Korourian S,Hutchins LF,Kadlubar FF,Ambrosone CB

更新日期：2000-10-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to treat. Despite the role it may play in tumor progression and response to therapy, microenvironmental (stromal) heterogeneity in TNBC has not been well characterized. To address this challenge, we investigated the transcript...

journal_title：Cancer research

authors： Saleh SMI,Bertos N,Gruosso T,Gigoux M,Souleimanova M,Zhao H,Omeroglu A,Hallett MT,Park M

更新日期：2017-09-01 00:00:00

abstract：:We studied loss of heterozygosity (LOH) on human chromosome 7q to determine the location of a putative tumor suppressor gene (TSG) in human primary prostate carcinomas. Samples were obtained from 16 primary prostate carcinomas surgically removed from patients at The University of Texas M. D. Anderson Cancer Center. Pa...

journal_title：Cancer research

authors： Zenklusen JC,Thompson JC,Troncoso P,Kagan J,Conti CJ

更新日期：1994-12-15 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:The purpose of the present study was to define the immunogenicity of two transplantable rat gliomas, designated F98 and D74, and to relate this to the phenotype and functional activity of tumor-infiltrating lymphocytes (TIL). Fischer rats, immunized with irradiated F98 tumor cells and challenged with intracerebral imp...

journal_title：Cancer research

authors： Tzeng JJ,Barth RF,Orosz CG,James SM

更新日期：1991-05-01 00:00:00

abstract：:Transcriptionally regulated growth-response genes play a pivotal role in the determination of the fate of a cell. p53 is known to transcriptionally regulate genes important in regulating cell growth potential. Using differential reverse transcription-PCR analysis of rat embryo fibroblast cells containing a temperature...

journal_title：Cancer research

authors： Madden SL,Galella EA,Riley D,Bertelsen AH,Beaudry GA

更新日期：1996-12-01 00:00:00

abstract：:Immunologic targeting of the oncoprotein HER2/neu with monoclonal antibodies is an important component of current therapeutic strategies for patients with locally and systemically advanced breast cancer. Engineered antibodies targeting HER2 may have agonist or antagonist effects on HER2, but little is known about whet...

journal_title：Cancer research

authors： Montgomery RB,Makary E,Schiffman K,Goodell V,Disis ML

更新日期：2005-01-15 00:00:00

abstract：:The relationship between natural cell-mediated cytotoxicity (NCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was examined in an Epstein-Barr virus-infected target cell system. The total ADCC reactivity to Epstein-Barr virus-infected target cells varied considerably with different effector cells, indicat...

journal_title：Cancer research

authors： Takasugi M,Mickey MR,Levine PH

更新日期：1982-04-01 00:00:00

abstract：:Vaccination with antigens expressed by tumors is one strategy for stimulating enhanced T-cell responses against tumors. However, these peptide vaccines rarely result in efficient expansion of tumor-specific T cells or responses that protect against tumor growth. Mimotopes, or peptide mimics of tumor antigens, elicit i...

journal_title：Cancer research

authors： Buhrman JD,Jordan KR,U'ren L,Sprague J,Kemmler CB,Slansky JE

更新日期：2013-01-01 00:00:00

abstract：:Because of its relatively indolent clinical course, chronic lymphocytic leukemia (CLL) offers a versatile model for testing novel therapeutic regimens and drug combinations. Nicotinamide is the main NAD(+) precursor and a direct inhibitor of four classes of enzymes, including the sirtuins. SIRT1, the main member of th...

journal_title：Cancer research

authors： Audrito V,Vaisitti T,Rossi D,Gottardi D,D'Arena G,Laurenti L,Gaidano G,Malavasi F,Deaglio S

更新日期：2011-07-01 00:00:00

abstract：:Oncogenic transformation of mouse 10T 1/2 fibroblasts induced upon exposure to X-ray or N-methyl-N'-nitro-N-nitrosoguanidine was suppressed if lipopolysaccharide (LPS) was present in the culture medium. The suppressive effect of LPS was exerted within 24 h after irradiation. Suppression was dependent on the concentrat...

journal_title：Cancer research

authors： Sakiyama H,Yasukawa M,Terasima T,Kanegasaki S

更新日期：1986-08-01 00:00:00

abstract：:There is widespread agreement that cancer gene discovery requires high-quality tumor samples. However, whether primary tumors or cultured samples are superior for cancer genomics has been a longstanding subject of debate. This debate has recently become more important because federally funded cancer genomics has been ...

journal_title：Cancer research

authors： Solomon DA,Kim JS,Ressom HW,Sibenaller Z,Ryken T,Jean W,Bigner D,Yan H,Waldman T

更新日期：2009-07-15 00:00:00

abstract：:Serum hypergastrinemia promotes the growth of colorectal adenocarcinoma. Some colorectal adenomas express cholecystokinin B/gastrin receptor mRNA, and thus hypergastrinemia may increase progression through the adenoma-carcinoma sequence. This was investigated in the multiple intestinal neoplasia APC(Min-/+) mouse. Ser...

journal_title：Cancer research

authors： Watson SA,Smith AM

更新日期：2001-01-15 00:00:00

abstract：:During the development of neoplasia, epithelial tissues undergo biochemical and structural changes that can manifest in tissue fluorescence. There have been several reports on different in vivo fluorescence characteristics between normal and precancerous (dysplastic) tissues. However, it has been difficult to identify...

journal_title：Cancer research

authors： Georgakoudi I,Jacobson BC,Müller MG,Sheets EE,Badizadegan K,Carr-Locke DL,Crum CP,Boone CW,Dasari RR,Van Dam J,Feld MS

更新日期：2002-02-01 00:00:00

abstract：:The expression of human leukocyte antigen (HLA) class I alleles was analyzed in 65 renal cell carcinomas using one-dimensional isoelectric focusing. Normal organ tissue and peripheral blood lymphocytes were used as controls. The patients were serologically typed using the standard microcytotoxicity test. Forty-two pat...

journal_title：Cancer research

authors： Luboldt HJ,Kubens BS,Rübben H,Grosse-Wilde H

更新日期：1996-02-15 00:00:00

abstract：:SR31747A is a sigma ligand with potent antiproliferative activity against tumor cells and for which three binding proteins have been identified to date: (a) SRBP-1 (also called sigma 1); (b) HIS; and (c) sigma 2. In this study, we characterized an additional SR31747A binding site, i.e., SRBP-2 (SR31747A-binding protei...

journal_title：Cancer research

authors： Vidal H,Mondesert G,Galiègue S,Carrière D,Dupuy PH,Carayon P,Combes T,Bribes E,Simony-Lafontaine J,Kramar A,Loison G,Casellas P

更新日期：2003-08-15 00:00:00

abstract：:Two populations of nuclear androgen receptors have been characterized in human prostatic tissue, and the levels and proportions of each were found to differ in normal prostates, benign hyperplastic prostates (BPH), and malignant prostates. A significant percentage (35 to 50%) of total nuclear androgen receptors was as...

journal_title：Cancer research

authors： Barrack ER,Bujnovszky P,Walsh PC

更新日期：1983-03-01 00:00:00

abstract：:Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To understand the pathogenesis and to develop new therapeutic strategies, it is essential to dissect the molecular mechanisms that regulate progr...

journal_title：Cancer research

authors： Yeh TS,Wu CW,Hsu KW,Liao WJ,Yang MC,Li AF,Wang AM,Kuo ML,Chi CW

更新日期：2009-06-15 00:00:00

abstract：:Lewis lung carcinoma cells (LLC) were isolated and cloned from metastatic lung nodules of C57BL/6 mice or from a cultured parental LLC line. Their dissemination abilities were defined in vivo by their capacities to disseminate to the lungs following s.c. or i.v. injection into mice and in an in vitro model for tumor d...

journal_title：Cancer research

authors： Young MR,Newby M,Meunier J

更新日期：1985-08-01 00:00:00

abstract：:Previous studies have documented the roles of transport via the reduced folate carrier, retention via polyglutamylation, and increased levels of the target enzyme, dihydrofolate reductase in sensitivity to methotrexate. Recent studies have shown that the mitochondrial enzymes in the cellular metabolism of serine, fola...

journal_title：Cancer research

authors： Vazquez A,Tedeschi PM,Bertino JR

更新日期：2013-01-15 00:00:00