Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice.

Abstract:

:Spontaneous juvenile ovarian granulosa cell (GC) tumors that occur in young girls are similar to GC carcinomas that develop in SWR-derived inbred mice. We analyzed female offspring from a series of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility. Intercross F2 female mice were produced by reciprocal matings of (SWR x SJL)F1 and (SJL x SWR)F1 parents. Tumorigenesis in these F2 mice as well as in SWXJ recombinant inbred and congenic strains of mice derived from SWR and SJL showed significant (P < 0.001) association with Gct1, a dominant susceptibility locus on chromosome (CHR) 4 and with Gct2 on CHR 12. Suggestive (P < 0.01) association was found with Gct3 on CHR 15. A fourth susceptibility locus, Gct4 on CHR X, was demonstrated with a strong parent-of-origin effect associated with the paternal genotype. Imprinting and complex interactions among these four loci combine to establish the probability for GC tumorigenesis in this mouse model.

journal_name

Cancer Res

journal_title

Cancer research

authors

Beamer WG,Shultz KL,Tennent BJ,Nadeau JH,Churchill GA,Eicher EM

subject

Has Abstract

pub_date

1998-08-15 00:00:00

pages

3694-9

issue

16

eissn

0008-5472

issn

1538-7445

journal_volume

58

pub_type

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