Interleukin 1 as an adjuvant for active specific immunotherapy in a murine tumor model.

abstract：:We describe a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted onto tumor deposits when most of the non-tumor-bound antibodies have already been cleared as avidin-bound complexes. The application of this principle to tumor detection by immunoscintigraphy was tested in 20 patients with histo...

journal_title：Cancer research

authors： Paganelli G,Magnani P,Zito F,Villa E,Sudati F,Lopalco L,Rossetti C,Malcovati M,Chiolerio F,Seccamani E

更新日期：1991-11-01 00:00:00

abstract：:Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expressi...

journal_title：Cancer research

authors： Beckmann PJ,Larson JD,Larsson AT,Ostergaard JP,Wagner S,Rahrmann EP,Shamsan GA,Otto GM,Williams RL,Wang J,Lee C,Tschida BR,Das P,Dubuc AM,Moriarity BS,Picard D,Wu X,Rodriguez FJ,Rosemarie Q,Krebs RD,Molan AM,Dem

更新日期：2019-03-01 00:00:00

abstract：:Little is known about the genetic changes underlying invasive tumor growth in bladder cancer. Because alterations that are linked to invasive tumor growth may be detectable in minimally invasive (stage pT1) but not in noninvasive (stage pTa) tumors, we searched for genetic differences between 28 pTa and 28 papillary p...

journal_title：Cancer research

authors： Richter J,Jiang F,Görög JP,Sartorius G,Egenter C,Gasser TC,Moch H,Mihatsch MJ,Sauter G

更新日期：1997-07-15 00:00:00

abstract：:CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis. In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammat...

journal_title：Cancer research

authors： Marelli G,Erreni M,Anselmo A,Taverniti V,Guglielmetti S,Mantovani A,Allavena P

更新日期：2017-08-15 00:00:00

abstract：:Chemotherapy, radiation, and growth inhibitory drugs preferentially eliminate actively growing cancer cells. Cancer recurrence is currently thought to be due to nondividing cancer stem/progenitor cells that are resistant to these therapies. Different therapeutic approaches need to be considered for the elimination of ...

journal_title：Cancer research

authors： Engelmann K,Shen H,Finn OJ

更新日期：2008-04-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a potent inhibitor of tumor growth and angiogenesis. The antiangiogenic activity of TSP-1 has been mapped to the procollagen homology region and the type 1 repeats (TSR) using synthetic peptides. To elucidate the molecular mechanisms that are involved in the inhibition of tumor growth by th...

journal_title：Cancer research

authors： Miao WM,Seng WL,Duquette M,Lawler P,Laus C,Lawler J

更新日期：2001-11-01 00:00:00

abstract：:Some, but not all, epidemiological studies have suggested that dichlorodiphenyltrichloroethane (DDT) may play a role in the development of breast cancer. These investigations have been conducted in countries where this substance has been banned for at least 20 years. We conducted a study in Mexico, a country in which ...

journal_title：Cancer research

authors： López-Carrillo L,Blair A,López-Cervantes M,Cebrián M,Rueda C,Reyes R,Mohar A,Bravo J

更新日期：1997-09-01 00:00:00

abstract：:Sixteen patients with previously treated acute nonlymphocytic leukemia or chronic myelogenous leukemia in blast crisis were given one to three courses of esorubicin by continuous infusion over 48 h. Dosage levels extended from 35 to 85 mg/m2. Four patients showed partial responses of short duration. Nonhematological t...

journal_title：Cancer research

authors： Kreis W,Rottach C,Budman DR,Chan K,Schulman P,Allen SL,Weiselberg L,Vinciguerra V

更新日期：1988-10-01 00:00:00

abstract：:Chronic exposure to UV radiation (UVR), especially in the UVA (315-400 nm) and UVB (280-315 nm) spectrum of sunlight, is the major risk factor for the development of nonmelanoma skin cancer. UVR is a complete carcinogen, which both initiates and promotes carcinogenesis. We found that protein kinase C epsilon (PKCepsil...

journal_title：Cancer research

authors： Wheeler DL,Martin KE,Ness KJ,Li Y,Dreckschmidt NE,Wartman M,Ananthaswamy HN,Mitchell DL,Verma AK

更新日期：2004-11-01 00:00:00

abstract：:The percentages of dark keratinocytes was quantitatively assessed in normal epidermis of Sencar mice before and after birth and in adult epidermis after topical application of several compounds of varying promoting efficiency. The percentage of dark keratinocytes reached a maximum at the 19th day of gestation (approxi...

journal_title：Cancer research

authors： Klein-Szanto AJ,Slaga TJ

更新日期：1981-11-01 00:00:00

abstract：:A rational monoclonal antibody (mAb)-based antitumor therapy approach has previously been shown to eradicate various established experimental and carcinogen-induced tumors in a majority of mice. This therapy comprised an agonistic mAb reactive with tumor necrosis factor-related apoptosis-inducing ligand receptor (DR5)...

journal_title：Cancer research

authors： Teng MW,Westwood JA,Darcy PK,Sharkey J,Tsuji M,Franck RW,Porcelli SA,Besra GS,Takeda K,Yagita H,Kershaw MH,Smyth MJ

更新日期：2007-08-01 00:00:00

abstract：:The inhibition of ribosomal RNA (rRNA) maturation by 5-fluorouridine (FUrd) in Novikoff hepatoma cells appears to depend upon the incorporation of the analog into the 45 S rRNA precursor. Precursor synthesized in the presence of FUrd is not processed into mature rRNA, but precursor synthesized in the absence of the an...

journal_title：Cancer research

authors： Wilkinson DS,Tlsty TD,Hanas RJ

更新日期：1975-11-01 00:00:00

abstract：:It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs). ...

journal_title：Cancer research

authors： Song P,Sekhon HS,Jia Y,Keller JA,Blusztajn JK,Mark GP,Spindel ER

更新日期：2003-01-01 00:00:00

abstract：:Retinoic acid (RA) is a master epigenetic regulator that plays a pivotal role in both breast morphogenesis and development. Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2...

journal_title：Cancer research

authors： Bistulfi G,Pozzi S,Ren M,Rossetti S,Sacchi N

更新日期：2006-11-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00

abstract：:To investigate the relationship between serum micronutrients and the subsequent risk of oral and pharyngeal cancer, a nested case-control study was conducted within a cohort of 25,802 adults in Washington County, MD, whose blood samples were collected in 1974 and stored at -70 degrees C for subsequent assays. The seru...

journal_title：Cancer research

authors： Zheng W,Blot WJ,Diamond EL,Norkus EP,Spate V,Morris JS,Comstock GW

更新日期：1993-02-15 00:00:00

abstract：:IgG polyclonal antiserum was generated in New Zealand White rabbits immunized with a 16-mer peptide consisting of a specific amino acid sequence at residues corresponding to the sixth to seventh predicted transmembrane domain of the human reduced folate carrier (RFC). Using Western immunoblotting to examine the cytoso...

journal_title：Cancer research

authors： Trippett TM,Garcia S,Manova K,Mody R,Cohen-Gould L,Flintoff W,Bertino JR

更新日期：2001-03-01 00:00:00

abstract：:Effective treatment of malignant carcinomas requires identification of proteins regulating epithelial cell proliferation. To this end, we compared gene expression profiles in murine colonocytes and their c-Myc-transformed counterparts, which possess enhanced proliferative potential. A surprisingly short list of deregu...

journal_title：Cancer research

authors： Thomas-Tikhonenko A,Viard-Leveugle I,Dews M,Wehrli P,Sevignani C,Yu D,Ricci S,el-Deiry W,Aronow B,Kaya G,Saurat JH,French LE

更新日期：2004-05-01 00:00:00

abstract：:Although many clinicians and researchers work to understand cancer, there has been limited success to effectively combine forces and collaborate over time, distance, data, and budget constraints. Here we present a workflow template for multidisciplinary cancer therapy that was developed during the 2nd Annual Workshop ...

journal_title：Cancer research

authors： McGuire MF,Enderling H,Wallace DI,Batra J,Jordan M,Kumar S,Panetta JC,Pasquier E

更新日期：2013-10-15 00:00:00

abstract：:Friend erythroleukemia cells can be induced to undergo erythroid differentiation by a variety of unrelated compounds. The fact that sodium butyrate causes reversible alterations in growth, morphology, and biochemistry in many cell systems prompted us to reexamine its pattern of induction of differentiation and to comp...

journal_title：Cancer research

authors： Friend C,Zajac-Kaye M,Holland JG,Pogo BG

更新日期：1987-01-15 00:00:00

abstract：:Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact o...

journal_title：Cancer research

authors： Mertens F,Strömberg U,Mandahl N,Dal Cin P,De Wever I,Fletcher CD,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van Den Berghe H,Vanni R,Willén H

更新日期：2002-07-15 00:00:00

abstract：:PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor hypoxia. Bioactivation occurs via one-electron reduction to DNA crosslinking metabolites in the absence of oxygen. However, certain tumor cell ...

journal_title：Cancer research

authors： Guise CP,Abbattista MR,Singleton RS,Holford SD,Connolly J,Dachs GU,Fox SB,Pollock R,Harvey J,Guilford P,Doñate F,Wilson WR,Patterson AV

更新日期：2010-02-15 00:00:00

abstract：:Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable exception to this is macrophage migration inhibitory factor (MIF). MIF,...

journal_title：Cancer research

authors： Winner M,Meier J,Zierow S,Rendon BE,Crichlow GV,Riggs R,Bucala R,Leng L,Smith N,Lolis E,Trent JO,Mitchell RA

更新日期：2008-09-15 00:00:00

abstract：:A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice ...

journal_title：Cancer research

authors： Alena F,Jimbow K,Ito S

更新日期：1990-06-15 00:00:00

abstract：:The laminin alpha5 chain is a component of laminin-10 (alpha5beta1gamma1) and -11 (alpha5beta2gamma1). In this study, we have screened 113 overlapping synthetic peptides from the laminin alpha5 globular domain (G-domain) for cell attachment activity with B16-F10 cells using peptide-coated dishes. Eleven attachment-act...

journal_title：Cancer research

authors： Hibino S,Shibuya M,Engbring JA,Mochizuki M,Nomizu M,Kleinman HK

更新日期：2004-07-15 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are especially refractory to treatment due to their negative hormone receptor and ErbB2/HER2 status. Therefore, the identification of cancer-associated deregulated signaling pathways is necessary to develop improved targeted therapies. Here, we show that expression of the ceramide...

journal_title：Cancer research

authors： Heering J,Weis N,Holeiter M,Neugart F,Staebler A,Fehm TN,Bischoff A,Schiller J,Duss S,Schmid S,Korte T,Herrmann A,Olayioye MA

更新日期：2012-06-01 00:00:00

abstract：:The photosensitization and survival recovery of cultured EJ human urinary bladder carcinoma cells containing nonexchangeable hematoporphyrin derivative (HPD) were studied. Cultures were incubated at 37 degrees C in growth medium supplemented with HPD (50 micrograms/ml) and 5% fetal bovine serum for 12 h followed by in...

journal_title：Cancer research

authors： Bellnier DA,Lin CW

更新日期：1985-06-01 00:00:00

abstract：:The antitumor effects of methotrexate with 5-fluorouracil against the Sarcoma 180 mouse tumor model were found to be schedule dependent. Pretreatment of tumor-bearing animals with methotrexate significantly enhanced the antitumor activity of the combination relative to simultaneous treatment or to those with methotrex...

journal_title：Cancer research

authors： Bertino JR,Sawicki WL,Lindquist CA,Gupta VS

更新日期：1977-01-01 00:00:00

abstract：:We previously reported that bone marrows of breast cancer patients contained tumor antigen-specific CD8(+) T cells with central or effector memory phenotype. Using a recently developed ret transgenic mouse melanoma model, we now show that bone marrows and tumors of transgenic mice contain high frequencies of CD8(+) T ...

journal_title：Cancer research

authors： Umansky V,Abschuetz O,Osen W,Ramacher M,Zhao F,Kato M,Schadendorf D

更新日期：2008-11-15 00:00:00

abstract：:The aldehyde reagent methoxyamine is able to interact with apurinic/apyrimidinic sites formed in vivo within cells and displays both an anti-cytotoxic and an antimutagenic activity on N-ethyl-N'-nitro-N-nitrosoguanidine-induced DNA damage in Chinese hamster ovary cells. To clarify the underlying mechanism we have exam...

journal_title：Cancer research

authors： Fortini P,Calcagnile A,Vrieling H,van Zeeland AA,Bignami M,Dogliotti E

更新日期：1993-03-01 00:00:00