Abstract：
:Gene therapy strategies for cancer currently aim at targeting gene delivery to the malignant cell. In a mouse model of intracerebral Lewis lung carcinoma (3LL), adenoviral vectors transduce not only 3LL cells but also brain parenchymal cells including endothelial cells, neurons, microglia, and astrocytes in vivo. Furthermore, transgene expression persists longer in brain than in tumor. Transfer of IFN-gamma into brain parenchymal cells rather than tumor is both necessary and sufficient to generate antitumor therapeutic benefits. Therefore, parenchymal cells represent an effective and necessary target for delivery of genes that render the brain uninhabitable by the tumor.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Fathallah-Shaykh HM,Kafrouni AI,Zhao LJ,Smith GM,Forman Jsubject
Has Abstractpub_date
2000-04-01 00:00:00pages
1797-9issue
7eissn
0008-5472issn
1538-7445journal_volume
60pub_type
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