Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes.

abstract：:We have examined a t(9;11)(p22;q23) chromosome translocation in an acute myeloid leukemia of an infant. The breakpoints on the two chromosomes occurred within introns of the involved genes: AF-9 on chromosome 9, and ALL-1 on chromosome 11. Sequence analysis identified heptamers flanking the breakpoints on both chromos...

journal_title：Cancer research

authors： Negrini M,Felix CA,Martin C,Lange BJ,Nakamura T,Canaani E,Croce CM

更新日期：1993-10-01 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:Activated beta-catenin regulates the transcription of oncogenic target genes and is critical for tumorigenesis. Because nuclear functions are frequently coupled, we investigated whether it also has a role in alternative splicing of oncogenic genes. We showed that stabilized beta-catenin caused alternative splicing of ...

journal_title：Cancer research

authors： Lee HK,Choi YS,Park YA,Jeong S

更新日期：2006-11-01 00:00:00

abstract：:Genetic alterations that occur in human breast cancers are believed to be of importance for initiation as well as progression of the disease. In order to find a genetic alteration that may be used as a prognostic marker, 82 familial breast carcinomas were analyzed for loss of constitutional heterozygosity at polymorph...

journal_title：Cancer research

authors： Lindblom A,Rotstein S,Skoog L,Nordenskjöld M,Larsson C

更新日期：1993-08-15 00:00:00

abstract：:Galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, contributes to the creation of an immunosuppressed microenvironment at sites of tumor growth. In spite of considerable progress in elucidating its role in tumor-immune escape, the mechanisms underlying the inhibitory functions of Gal1 remain obscur...

journal_title：Cancer research

authors： Dalotto-Moreno T,Croci DO,Cerliani JP,Martinez-Allo VC,Dergan-Dylon S,Méndez-Huergo SP,Stupirski JC,Mazal D,Osinaga E,Toscano MA,Sundblad V,Rabinovich GA,Salatino M

更新日期：2013-02-01 00:00:00

abstract：:Bile acids increase the proliferative activity of rat colonic epithelium. However, the mechanisms responsible are unknown. The present study examined the relationships between deoxycholate (DOC) induced surface cell sloughing, as measured by loss of DNA into the lumen and by light microscopy, and the subsequent increa...

journal_title：Cancer research

authors： Craven PA,Pfanstiel J,Saito R,DeRubertis FR

更新日期：1986-11-01 00:00:00

abstract：:Astrocytes, the most abundant type of glial cells in the brain, play critical roles in supporting neuronal development and brain function. Although astrocytes have been frequently detected in brain tumors, including medulloblastoma (MB), their functions in tumorigenesis are not clear. Here, we demonstrate that astrocy...

journal_title：Cancer research

authors： Liu Y,Yuelling LW,Wang Y,Du F,Gordon RE,O'Brien JA,Ng JMY,Robins S,Lee EH,Liu H,Curran T,Yang ZJ

更新日期：2017-12-01 00:00:00

abstract：:An established cloned human renal carcinoma line RC-1, which has been continuously maintained in culture for several years and which produces erythropoietin, was injected s.c. into BALB/c athymic mice and produced tumors. Tumorigenicity was directly correlated with the number of RC-1 cells inoculated. Tumor cell histo...

journal_title：Cancer research

authors： Shouval D,Anton M,Galun E,Sherwood JB

更新日期：1988-06-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer. AGR2 was induc...

journal_title：Cancer research

authors： Dumartin L,Whiteman HJ,Weeks ME,Hariharan D,Dmitrovic B,Iacobuzio-Donahue CA,Brentnall TA,Bronner MP,Feakins RM,Timms JF,Brennan C,Lemoine NR,Crnogorac-Jurcevic T

更新日期：2011-11-15 00:00:00

abstract：:To prevent their recognition as DNA breaks, the ends of linear chromosomes are organized into telomeres, which are made of proteins bound to telomere-specific, double-stranded repeats and to single-stranded DNA extensions, the G-tails. The mammalian heterogeneous nuclear ribonucleoparticule A1 and A2 proteins can bind...

journal_title：Cancer research

authors： Patry C,Bouchard L,Labrecque P,Gendron D,Lemieux B,Toutant J,Lapointe E,Wellinger R,Chabot B

更新日期：2003-11-15 00:00:00

abstract：:The clinical utility of cisplatin to treat human malignancies is often limited by the development of drug resistance. We have previously shown that cisplatin-resistant human KB adenocarcinoma cells that are cross-resistant to methotrexate and heavy metals have altered endocytic recycling. In this work, we tracked lipi...

journal_title：Cancer research

authors： Liang XJ,Mukherjee S,Shen DW,Maxfield FR,Gottesman MM

更新日期：2006-02-15 00:00:00

abstract：:Twenty-eight patients with metastatic malignant melanoma received anti-p97 murine monoclonal antibody (96.5) infused over 2 h at doses between 1 and 20 mg coupled to either 2.5 or 5.0 mCi of 111In by the bifunctional chelating agent diethyltriaminepentaacetic acid. Clearance of 111In from plasma closely fit an open, o...

journal_title：Cancer research

authors： Rosenblum MG,Murray JL,Haynie TP,Glenn HJ,Jahns MF,Benjamin RS,Frincke JM,Carlo DJ,Hersh EM

更新日期：1985-05-01 00:00:00

abstract：:The pharmacology of high-dose 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) has been studied by radiochemical and chromatographic techniques in eight patients. Plasma disappearance of FT was exponential, with a half-life of 8.8 hr. Plasma concentrations of 5-fluorouracil (FUra) were sustained at 12.8 nmol/ml (1.7 micro...

journal_title：Cancer research

authors： Benvenuto JA,Lu K,Hall SW,Benjamin RS,Loo TL

更新日期：1978-11-01 00:00:00

abstract：:The MRP (multidrug resistance protein) gene, a member of the ubiquitous superfamily of ATP-binding cassette transporters, is associated with the multidrug resistance of mammalian cells to natural product anticancer agents. We have previously shown that abrogation of MRP expression by gene targeting leads to hypersensi...

journal_title：Cancer research

authors： Rappa G,Lorico A,Flavell RA,Sartorelli AC

更新日期：1997-12-01 00:00:00

abstract：:The ability of the vitamin E (RRR-alpha-tocopherol) derivatives alpha-tocopheryl succinate (alpha-TOS) and alpha-tocopheryloxyacetic acid (alpha-TEA) to suppress tumor growth in preclinical animal models has recently led to increased interest in their potential use for treating human cancer. To make the use of these v...

journal_title：Cancer research

authors： Hahn T,Szabo L,Gold M,Ramanathapuram L,Hurley LH,Akporiaye ET

更新日期：2006-10-01 00:00:00

abstract：:The deregulated expression of cyclin E as measured by the overexpression of its low molecular weight (LMW) isoforms is a powerful predictor of poor outcome in patients with breast cancer. The mechanism by which these LMW forms give tumor cells a growth advantage is not known and is the subject of this article. In this...

journal_title：Cancer research

authors： Akli S,Zheng PJ,Multani AS,Wingate HF,Pathak S,Zhang N,Tucker SL,Chang S,Keyomarsi K

更新日期：2004-05-01 00:00:00

abstract：:The in vitro accuracy of DNA replication has been investigated through the measurement of the frequency with which noncomplementary nucleotides were incorporated during polynucleotide replication. The effect of beta-propiolactone treatment of deoxynucleotide templates, ribopolynucleotide templates, and the DNA polymer...

journal_title：Cancer research

authors： Sirover MA,Loeb LA

更新日期：1976-02-01 00:00:00

abstract：:This symposium was held in Trento, Italy, from June 27 to 29, 2006, and was co-chaired by Robert Weinberg and Enrico Mihich. The interactions between tumor cells and their microenvironment were discussed with particular emphasis on their molecular mechanisms. The roles of transforming growth factor beta signaling, uro...

journal_title：Cancer research

authors： Weinberg R,Mihich E

更新日期：2006-12-15 00:00:00

abstract：:Chronic inflammation has been hypothesized to be a risk factor for prostate cancer. The Toll-like receptor 4 (TLR4) presents the bacterial lipopolysaccharide (LPS), which interacts with ligand-binding protein and CD14 (LPS receptor) and activates expression of inflammatory genes through nuclear factor-kappaB and mitog...

journal_title：Cancer research

authors： Chen YC,Giovannucci E,Lazarus R,Kraft P,Ketkar S,Hunter DJ

更新日期：2005-12-15 00:00:00

abstract：:In this study of breast cancer specimens, the relationship between cytosolic estrogen (ER) and progesterone receptor (PR) content to the size of the respective growth fraction (GF) (expressed as percentage of proliferating tumor cells) was investigated. We applied the recently developed ligand-binding assay for extrac...

journal_title：Cancer research

authors： Vollmer G,Gerdes J,Knuppen R

更新日期：1989-07-15 00:00:00

abstract：:ALDH1(+)CD44(+) cells are putative tumor-initiating cells (TIC) in head and neck squamous cell carcinomas (HNC). miR-145 regulates tumorigenicity in various cancers but the breadth of its mechanistic contributions and potential therapeutic applications are not completely known. Here, we report that ALDH1(+)CD44(+)-HNC...

journal_title：Cancer research

authors： Yu CC,Tsai LL,Wang ML,Yu CH,Lo WL,Chang YC,Chiou GY,Chou MY,Chiou SH

更新日期：2013-06-01 00:00:00

abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

journal_title：Cancer research

authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

更新日期：1996-08-15 00:00:00

abstract：:Micropthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. The current study was undertaken to determine whether there is a relationship between Mitf expression and survival in patients with intermediate-thickness (1.0-4.0 mm) melanoma. Original paraffin blocks or slides of th...

journal_title：Cancer research

authors： Salti GI,Manougian T,Farolan M,Shilkaitis A,Majumdar D,Das Gupta TK

更新日期：2000-09-15 00:00:00

abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

journal_title：Cancer research

authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

更新日期：1980-10-01 00:00:00

abstract：:Mutations in the NH(2)-terminal regulatory domain of the beta-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic ...

journal_title：Cancer research

authors： Rios-Doria J,Kuefer R,Ethier SP,Day ML

更新日期：2004-10-15 00:00:00

abstract：:Patients with metastatic melanoma or multiple myeloma have a dismal prognosis because these aggressive malignancies resist conventional treatment. A promising new oncologic approach uses molecularly targeted therapeutics that overcomes apoptotic resistance and, at the same time, achieves tumor selectivity. The unexpec...

journal_title：Cancer research

authors： Qin JZ,Ziffra J,Stennett L,Bodner B,Bonish BK,Chaturvedi V,Bennett F,Pollock PM,Trent JM,Hendrix MJ,Rizzo P,Miele L,Nickoloff BJ

更新日期：2005-07-15 00:00:00

abstract：:Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

journal_title：Cancer research

authors： Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

更新日期：2002-08-15 00:00:00

abstract：:Cancer metastasis is a leading cause of cancer morbidity and mortality. More needs to be learned about mechanisms that control this process. In particular, the role of chemokine receptors in metastasis remains controversial. Here, using a highly metastatic breast cancer (4T1) model, we show that lung metastasis is a f...

journal_title：Cancer research

authors： Olkhanud PB,Baatar D,Bodogai M,Hakim F,Gress R,Anderson RL,Deng J,Xu M,Briest S,Biragyn A

更新日期：2009-07-15 00:00:00

abstract：:Impaired glucose metabolism and hyperinsulinemia have been hypothesized to increase breast cancer risk. However, findings from observational studies relating blood concentrations of hyperinsulinemia markers to breast cancer risk have been inconsistent. We prospectively evaluated whether hemoglobin A1c (HbA1c) concentr...

journal_title：Cancer research

authors： Lin J,Ridker PM,Rifai N,Lee IM,Manson JE,Buring JE,Zhang SM

更新日期：2006-03-01 00:00:00

abstract：:We and others have reported previously that adults with glioma are 1.5- to 4-fold less likely than controls to report a variety of allergic conditions. The consistent nature of this relationship calls for a biological explanation so that preventative or therapeutic modalities can be explored. We enrolled 403 newly dia...

journal_title：Cancer research

authors： Wiemels JL,Wiencke JK,Patoka J,Moghadassi M,Chew T,McMillan A,Miike R,Barger G,Wrensch M

更新日期：2004-11-15 00:00:00