Paracrine stimulation of polarized secretion from monolayers of a neoplastic prostatic epithelial cell line by prostatic stromal cell proteins.

abstract：:Protein kinase Ciota (PKCiota) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer cells. However, the role of PKCiota in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12D) is activated by...

journal_title：Cancer research

authors： Regala RP,Davis RK,Kunz A,Khoor A,Leitges M,Fields AP

更新日期：2009-10-01 00:00:00

abstract：:The role of endogenous NO on cell survival was investigated in human melanoma cells and melanocytes. Inducible NO synthase (iNOS) was always expressed in a panel of melanoma cell lines from metastatic lesions and in normal adult melanocytes. iNOS was also detected by immunohistochemistry in melanoma cells from metasta...

journal_title：Cancer research

authors： Salvucci O,Carsana M,Bersani I,Tragni G,Anichini A

更新日期：2001-01-01 00:00:00

abstract：:Xeroderma pigmentosum (XP) is a sun-sensitive, cancer-prone genetic disorder characterized by a defect in nucleotide excision repair. The human nucleotide excision repair and transcription gene ERCC2 is able to restore survival to normal levels after exposure to UV light in XP complementation group D cells. No enhance...

journal_title：Cancer research

authors： Takayama K,Salazar EP,Lehmann A,Stefanini M,Thompson LH,Weber CA

更新日期：1995-12-01 00:00:00

abstract：:The detection of high-grade bladder tumors prior to invasion is crucial for a good prognosis. We recently found that the levels of hyaluronic acid (HA), a glycosaminoglycan, are elevated in the urine of bladder cancer patients, and small angiogenic HA fragments are present in the urine of high-grade bladder cancer pat...

journal_title：Cancer research

authors： Pham HT,Block NL,Lokeshwar VB

更新日期：1997-02-15 00:00:00

abstract：:In the multistep process of metastasis, "anchorage-independent growth," where cancer cells need to survive without cell-substratum interaction, is supposed to be important. In this study, we found that anchorage-independent growth analyzed using the soft agar colony formation assay correlated with hematogeneous intrah...

journal_title：Cancer research

authors： Nakanishi K,Sakamoto M,Yasuda J,Takamura M,Fujita N,Tsuruo T,Todo S,Hirohashi S

更新日期：2002-05-15 00:00:00

abstract：:Genetic abnormalities were assessed in 56 benign, low-, and high-grade ovarian tumors using comparative genomic hybridization (CGH) and analysis of loss of heterozygosity (LOH). In addition, 95 epithelial tumors were analyzed for microsatellite repeat instability. DNA sequence copy number abnormalities (CNAs) were not...

journal_title：Cancer research

authors： Iwabuchi H,Sakamoto M,Sakunaga H,Ma YY,Carcangiu ML,Pinkel D,Yang-Feng TL,Gray JW

更新日期：1995-12-15 00:00:00

abstract：:Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various v...

journal_title：Cancer research

authors： Pendurthi UR,Tran TT,Post M,Rao LV

更新日期：2005-11-01 00:00:00

abstract：:Partially purified preparations of mouse interferon, administered during the 2-day period following the administration of a toxic dose of 5-fluorouracil (FUra), yielded significant protection from mortality in BALB/c X DBA/2 F1 mice. Protection against FUra-induced toxicity was also observed when the interferon induce...

journal_title：Cancer research

authors： Stolfi RL,Martin DS,Sawyer RC,Spiegelman S

更新日期：1983-02-01 00:00:00

abstract：:Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This study shows for the ...

journal_title：Cancer research

authors： Rahrmann EP,Collier LS,Knutson TP,Doyal ME,Kuslak SL,Green LE,Malinowski RL,Roethe L,Akagi K,Waknitz M,Huang W,Largaespada DA,Marker PC

更新日期：2009-05-15 00:00:00

abstract：:Paclitaxel (Taxol) is a chemotherapeutic agent that prevents disassembly of microtubular polymers, causing a growth arrest in the G2-M phase of the cell cycle and leading to apoptotic death. Paclitaxel has remarkable efficacy against fast-growing tumors but possesses major drawbacks, such as poor solubility and lack o...

journal_title：Cancer research

authors： Guillemard V,Saragovi HU

更新日期：2001-01-15 00:00:00

abstract：:The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain we...

journal_title：Cancer research

authors： Lin EY,Pollard JW

更新日期：2007-06-01 00:00:00

abstract：:Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transform...

journal_title：Cancer research

authors： Chen Y,Li YH,Chen XP,Gong LM,Zhang SP,Chang ZJ,Zhang XF,Fu XY,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Leukemia following chemotherapy for breast cancer was studied among patients diagnosed during 1973-1985 within the population-based tumor registries in the Surveillance, Epidemiology, and End Results Program. Among 13,734 women given initial chemotherapy, 24 developed acute nonlymphocytic leukemia (ANLL) compared to 2...

journal_title：Cancer research

authors： Curtis RE,Boice JD Jr,Moloney WC,Ries LG,Flannery JT

更新日期：1990-05-01 00:00:00

abstract：:Early growth-response (EGR) genes are nuclear transcription factors that are implicated in regulating cell proliferation. Because these genes show divergent expression in various human tumors, we sought to determine their expression in nonmalignant and malignant prostate tissues. Total RNA extracted from prostate tiss...

journal_title：Cancer research

authors： Eid MA,Kumar MV,Iczkowski KA,Bostwick DG,Tindall DJ

更新日期：1998-06-01 00:00:00

abstract：:In the present study we have evaluated the prognostic significance of ploidy levels and proliferative activity in 279 cases of large bowel carcinomas which were included in a surgical prospective randomized trial. Ploidy levels and proliferative activity were determined on nuclei isolated from paraffin-embedded tissue...

journal_title：Cancer research

authors： Schutte B,Reynders MM,Wiggers T,Arends JW,Volovics L,Bosman FT,Blijham GH

更新日期：1987-10-15 00:00:00

abstract：:In meningeal carcinomatosis, retroviral vector-producer cells can be introduced into the thecal sac and circulate in the cerebrospinal fluid to reach malignant tumor cells in the leptomeninges, release vector particles, and selectively infect and transfer a gene of interest to these cells. Gene transfer experiments wi...

journal_title：Cancer research

authors： Ram Z,Walbridge S,Oshiro EM,Viola JJ,Chiang Y,Mueller SN,Blaese RM,Oldfield EH

更新日期：1994-04-15 00:00:00

abstract：:Biallelic somatic mutations of TCF1 coding for hepatocyte nuclear factor 1alpha (HNF1alpha) are found in 50% of the hepatocellular adenoma (HCA) cases usually associated with oral contraception. In rare cases, HNF1alpha germ line mutations could also predispose to familial adenomatosis. In order to identify new geneti...

journal_title：Cancer research

authors： Jeannot E,Poussin K,Chiche L,Bacq Y,Sturm N,Scoazec JY,Buffet C,Van Nhieu JT,Bellanné-Chantelot C,de Toma C,Laurent-Puig P,Bioulac-Sage P,Zucman-Rossi J

更新日期：2007-03-15 00:00:00

abstract：:Through a bladder cancer surveillance protocol, a sizable population of patients suitable for characterizing the dynamics and patterns of recurrent superficial transitional cell carcinoma has been identified. One hundred thirty-three patients have been followed after their first occurrence of transitional cell carcino...

journal_title：Cancer research

authors：

更新日期：1977-08-01 00:00:00

abstract：:Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important in regulating CSC properties and are considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated in ovarian CSC. High expression of miR-328 mainta...

journal_title：Cancer research

authors： Srivastava AK,Banerjee A,Cui T,Han C,Cai S,Liu L,Wu D,Cui R,Li Z,Zhang X,Xie G,Selvendiran K,Patnaik S,Karpf AR,Liu J,Cohn DE,Wang QE

更新日期：2019-05-01 00:00:00

abstract：:Prostate cancer develops through a stochastic mechanism whereby precancerous lesions on occasion progress to multifocal adenocarcinoma. Analysis of human benign and cancer prostate tissues revealed heterogeneous loss of TGF-β signaling in the cancer-associated stromal fibroblastic cell compartment. To test the hypothe...

journal_title：Cancer research

authors： Kiskowski MA,Jackson RS 2nd,Banerjee J,Li X,Kang M,Iturregui JM,Franco OE,Hayward SW,Bhowmick NA

更新日期：2011-05-15 00:00:00

abstract：:We examined the effect of human interferon (HuIFN) -alpha and -beta on the proliferation and differentiation induced by dimethyl sulfoxide (DMSO) of HL-60 human promyelocytic leukemia cells into mature granulocytes. Neither HuIFN-alpha nor -beta, alone, from 1 to 1000 IU/ml, nor the homologous mock HuIFN preparations ...

journal_title：Cancer research

authors： Hamburger AW,White CP,Siebenlist RE,Sedmak JJ,Grossberg SE

更新日期：1985-11-01 00:00:00

abstract：:Studies demonstrate that some colon cancers possess receptors for various gastrointestinal hormones or neurotransmitters, the occupation of which can affect growth. These results are limited because frequently only a small number of tumors are studied, only 1 or 2 receptors are sought, and the effect on cell function ...

journal_title：Cancer research

authors： Frucht H,Gazdar AF,Park JA,Oie H,Jensen RT

更新日期：1992-03-01 00:00:00

abstract：:The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions. Here, we describe for the first time the expression and function of Foxp3 in pancreatic ductal adenocarcinoma cells and tumors. Foxp3 e...

journal_title：Cancer research

authors： Hinz S,Pagerols-Raluy L,Oberg HH,Ammerpohl O,Grüssel S,Sipos B,Grützmann R,Pilarsky C,Ungefroren H,Saeger HD,Klöppel G,Kabelitz D,Kalthoff H

更新日期：2007-09-01 00:00:00

abstract：:Two newly synthesized nitrosoureido sugars have been evaluated for their antitumor activity and diabetogenic potential in a number of in vitro and in vivo preclinical tumor model systems. 2-Amino-2-deoxy-N'-methyl-N'-nitrosoureido-1,3,4,6-tetra-O-acetyl-alpha- D- mannopyranose (MAZ), a lipophilic mannosamine derivativ...

journal_title：Cancer research

authors： Bernacki RJ,Wilson GL,Mossman BT,Angelino N,Kanter PM,Korytnyk W

更新日期：1985-02-01 00:00:00

abstract：:Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the hypothesis that impeding the reuptake of bicarbonate produced extrace...

journal_title：Cancer research

authors： McIntyre A,Hulikova A,Ledaki I,Snell C,Singleton D,Steers G,Seden P,Jones D,Bridges E,Wigfield S,Li JL,Russell A,Swietach P,Harris AL

更新日期：2016-07-01 00:00:00

abstract：:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, ...

journal_title：Cancer research

authors： Tsukeda H,Mizuno S,Nitta K

更新日期：1978-08-01 00:00:00

abstract：:Recent studies have demonstrated that cytochrome c plays an important role in cell death. In the present study, we report that teniposide and various other chemotherapeutic agents induced a dose-dependent increase in the expression of the mitochondrial respiratory chain proteins cytochrome c, subunits I and IV of cyto...

journal_title：Cancer research

authors： Sánchez-Alcázar JA,Khodjakov A,Schneider E

更新日期：2001-02-01 00:00:00

abstract：:Cell division is essential for tumor development and progression. Methylation-mediated silencing caused by aberrant de novo methylation of CpG islands located in the promoter regions of growth regulatory genes occurs frequently in human cancers. We investigated the relationship between cell division and de novo methyl...

journal_title：Cancer research

authors： Velicescu M,Weisenberger DJ,Gonzales FA,Tsai YC,Nguyen CT,Jones PA

更新日期：2002-04-15 00:00:00

abstract：:Nuclear receptors are critical regulators of many physiological processes and have been shown to be involved in a variety of disease processes, including malignant neoplasms. Our laboratory is investigating the function of the retinoid-related orphan receptor gamma (RORgamma) and its possible role in disease. Studies ...

journal_title：Cancer research

authors： Ueda E,Kurebayashi S,Sakaue M,Backlund M,Koller B,Jetten AM

更新日期：2002-02-01 00:00:00

abstract：:We have previously shown that butyrate, a short-chain fatty acid fiber fermentation product, induces colonocyte apoptosis via a nonmitochondrial, Fas-mediated, extrinsic pathway. Interestingly, fermentable fiber when combined with fish oil containing docosahexaenoic acid (DHA, 22:6n-3) exhibits an enhanced ability to ...

journal_title：Cancer research

authors： Kolar SS,Barhoumi R,Lupton JR,Chapkin RS

更新日期：2007-06-01 00:00:00