Effects of the immunosuppressive drug niridazole in isogeneic and allogeneic mouse tumor systems in vivo.

abstract：:Estrogen receptor (ER) agonists and antagonists elicit distinct responses in non-small cell lung cancer (NSCLC) cells. To determine how such responses are generated, the expression of ERalpha, ERbeta, and ER coregulators in human lung fibroblasts and human NSCLC cell lines was evaluated by immunoblot. Ligand-dependent...

journal_title：Cancer research

authors： Hershberger PA,Vasquez AC,Kanterewicz B,Land S,Siegfried JM,Nichols M

更新日期：2005-02-15 00:00:00

abstract：:It has been proposed by MacMahon, on the basis of the variations among populations in the age distribution of fatal Hodgkin's disease, that there are two etiological factors, one important in young adults and the other important in middle-aged and elderly people. Correa has extended this by suggesting that those who d...

journal_title：Cancer research

authors： Szekely DR,Lee JA

更新日期：1977-12-01 00:00:00

abstract：:The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 ear...

journal_title：Cancer research

authors： Kondo S,Shinomura Y,Miyazaki Y,Kiyohara T,Tsutsui S,Kitamura S,Nagasawa Y,Nakahara M,Kanayama S,Matsuzawa Y

更新日期：2000-08-15 00:00:00

abstract：:Although African-American (AA) patients with prostate cancer tend to develop greater therapeutic resistance and faster prostate cancer recurrence compared with Caucasian-American (CA) men, the molecular mechanisms of this racial prostate cancer disparity remain undefined. In this study, we provide the first comprehens...

journal_title：Cancer research

authors： Kumar R,Bhat TA,Walsh EM,Chaudhary AK,O'Malley J,Rhim JS,Wang J,Morrison CD,Attwood K,Bshara W,Mohler JL,Yadav N,Chandra D

更新日期：2019-04-01 00:00:00

abstract：:Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and tumors induces high-output NO production that significantly enhances tumor radioresp...

journal_title：Cancer research

authors： Cook T,Wang Z,Alber S,Liu K,Watkins SC,Vodovotz Y,Billiar TR,Blumberg D

更新日期：2004-11-01 00:00:00

abstract：:Abnormal activation of DNA repair pathways by deregulated signaling of receptor tyrosine kinase systems is a compelling likelihood with significant implications in both cancer biology and treatment. Here, we show that due to a potential substrate switch, mutated variants of the receptor for hepatocyte growth factor Me...

journal_title：Cancer research

authors： Ganapathipillai SS,Medová M,Aebersold DM,Manley PW,Berthou S,Streit B,Blank-Liss W,Greiner RH,Rothen-Rutishauser B,Zimmer Y

更新日期：2008-07-15 00:00:00

abstract：:This set of experiments is the second of a series designed to explore alterations in cell dynamics and growth control of new populations of hepatocytes that appear to play a role in the carcinogenic process induced in the liver by chemical carcinogens. This is part of an ongoing study of the biochemical and molecular ...

journal_title：Cancer research

authors： Rotstein J,Sarma DS,Farber E

更新日期：1986-05-01 00:00:00

abstract：:To investigate the relationship between serum micronutrients and the subsequent risk of oral and pharyngeal cancer, a nested case-control study was conducted within a cohort of 25,802 adults in Washington County, MD, whose blood samples were collected in 1974 and stored at -70 degrees C for subsequent assays. The seru...

journal_title：Cancer research

authors： Zheng W,Blot WJ,Diamond EL,Norkus EP,Spate V,Morris JS,Comstock GW

更新日期：1993-02-15 00:00:00

abstract：:The effect of different preparative procedures for electron microscopy on the size and shape of murine oncornaviruses has been studied. With conventional negative staining procedures using neutral sodium phosphotungstate, both murine mammary tumor virus and murine leukemia virus appeared in head-and-tail forms, with a...

journal_title：Cancer research

authors： Sarkar NH,Manthey WJ,Sheffield JB

更新日期：1975-03-01 00:00:00

abstract：:We examined the therapeutic effect of lipopolysaccharide (LPS), a differentiation inducer, in combination with daunomycin, an antileukemia drug possessing differentiation-inducing potential, on a rat myelomonocytic leukemia (c-WRT-7). c-WRT-7 cells were found to differentiate into macrophage-like cells and to lose the...

journal_title：Cancer research

authors： Fujii Y,Yuki N,Takeichi N,Kobayashi H,Miyazaki T

更新日期：1987-03-15 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homologue (PTEN) is involved in cell proliferation, adhesion, and apoptosis. PTEN overexpression in mammary epithelium leads to reduced cell number and impaired differentiation and secretion. In contrast, overexpression of the proto-oncogene Wnt-1 in mammary epithelium leads...

journal_title：Cancer research

authors： Zhao H,Cui Y,Dupont J,Sun H,Hennighausen L,Yakar S

更新日期：2005-08-01 00:00:00

abstract：:MHC class I-restricted tumor antigen can be presented to CD8+ T cells by two distinct mechanisms. Direct presentation involves degradation of cytosolic proteins by the proteosome into peptides, transport of the peptides across the endoplasmic reticulum membrane, and expression of the MHC-peptide complex on the tumor c...

journal_title：Cancer research

authors： Guilloux Y,Bai XF,Liu X,Zheng P,Liu Y

更新日期：2001-02-01 00:00:00

abstract：:The role of the NKG2D immunoreceptor and its ligands in antitumor immune response is incompletely understood. Here, we report that effector immune cells infiltrating ovarian carcinoma are mostly CD8+ lymphocytes lacking CD28 but expressing the NKG2D costimulatory receptor. Human ovarian carcinoma expresses the novel N...

journal_title：Cancer research

authors： Conejo-Garcia JR,Benencia F,Courreges MC,Gimotty PA,Khang E,Buckanovich RJ,Frauwirth KA,Zhang L,Katsaros D,Thompson CB,Levine B,Coukos G

更新日期：2004-03-15 00:00:00

abstract：:A new form of therapy of experimental tumors, utilizing lymphokine-activated killer (LAK) cells and high doses of interleukin 2, has recently been applied in the treatment of human neoplasms. Severe side effects, suggestive of a diffuse vascular injury of unknown etiology, have prevented a more widespread application ...

journal_title：Cancer research

authors： Kotasek D,Vercellotti GM,Ochoa AC,Bach FH,White JG,Jacob HS

更新日期：1988-10-01 00:00:00

abstract：:p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, an...

journal_title：Cancer research

authors： Jackson RJ,Engelman RW,Coppola D,Cantor AB,Wharton W,Pledger WJ

更新日期：2003-06-15 00:00:00

abstract：:Genetic differences in metabolism of benzo(a)pyrene (BP) were investigated using cultured epidermal keratinocytes and dermal fibroblasts isolated from four inbred strains of mice: C3H/HeJms and C57BL/6J that are responsive; and DBA/2 and AKR/Jms that are nonresponsive in terms of inducibility of aryl hydrocarbon hydro...

journal_title：Cancer research

authors： Hosomi J,Nemoto N,Kuroki T

更新日期：1983-08-01 00:00:00

abstract：:Aluminum sulfonated phthalocyanine has potential as a suitable photosensitizer for use in the photodynamic therapy of cancer. In the present study, cellular uptake and retention of the individual mono-, di-, tri-, and tetrasulfonated derivatives (AlS1-4Pc) were examined in tissue culture and in normal and neoplastic t...

journal_title：Cancer research

authors： Chan WS,Marshall JF,Svensen R,Bedwell J,Hart IR

更新日期：1990-08-01 00:00:00

abstract：:Infection by human T-cell leukemia virus type (HTLV) I leads to adult T-cell leukemia and is also associated with the neurodegenerative disease HTLV-I-associated myelopathy/tropical spastic paraparesis. Leukocytes are attracted to sites of inflammation by chemokines. One such chemokine is monocyte chemoattractant prot...

journal_title：Cancer research

authors： Mori N,Ueda A,Ikeda S,Yamasaki Y,Yamada Y,Tomonaga M,Morikawa S,Geleziunas R,Yoshimura T,Yamamoto N

更新日期：2000-09-01 00:00:00

abstract：:It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

journal_title：Cancer research

authors： van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

更新日期：1989-06-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell-based therapies of tissue injury and degenerative diseases. However, extensive expansion ex vivo is a prerequisite to obtain the cell...

journal_title：Cancer research

authors： Røsland GV,Svendsen A,Torsvik A,Sobala E,McCormack E,Immervoll H,Mysliwietz J,Tonn JC,Goldbrunner R,Lønning PE,Bjerkvig R,Schichor C

更新日期：2009-07-01 00:00:00

abstract：:Melanoma incidence is increasing worldwide, and metastatic melanoma is almost completely resistant to every known therapy. New approaches to treating melanoma are urgently needed, and a greater understanding of the biology of melanoma invasion and metastasis will aid in their creation. A high proportion of invasive me...

journal_title：Cancer research

authors： Blackburn JS,Rhodes CH,Coon CI,Brinckerhoff CE

更新日期：2007-11-15 00:00:00

abstract：:A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's Developmental Therapeutics Program. An extensive analogue synthesis program was initiated; over 200 derivatives were synthesized and tested for antican...

journal_title：Cancer research

authors： Dexter DL,Hesson DP,Ardecky RJ,Rao GV,Tippett DL,Dusak BA,Paull KD,Plowman J,DeLarco BM,Narayanan VL

更新日期：1985-11-01 00:00:00

abstract：:Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Both p53-dependent an...

journal_title：Cancer research

authors： Choi BH,Kim CG,Bae YS,Lim Y,Lee YH,Shin SY

更新日期：2008-03-01 00:00:00

abstract：:The treatment of glioblastoma (GBM) remains challenging in part due to the presence of stem-like tumor-propagating cells that are resistant to standard therapies consisting of radiation and temozolomide. Among the novel and targeted agents under evaluation for the treatment of GBM are BRAF/MAPK inhibitors, but their e...

journal_title：Cancer research

authors： Lerner RG,Grossauer S,Kadkhodaei B,Meyers I,Sidorov M,Koeck K,Hashizume R,Ozawa T,Phillips JJ,Berger MS,Nicolaides T,James CD,Petritsch CK

更新日期：2015-12-15 00:00:00

abstract：:A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but did not potentiate drug toxicity in drug-sensitiv...

journal_title：Cancer research

authors： Coon JS,Knudson W,Clodfelter K,Lu B,Weinstein RS

更新日期：1991-02-01 00:00:00

abstract：:We have developed a model system which can be utilized for characterizing both the molecular basis of natural killer (NK):tumor interactions and the consequences of these interactions on tumor growth in vivo. This model system consists of several tumor lines which were derived from the murine lymphoma ASL1w under cond...

journal_title：Cancer research

authors： Smithson G,Wolcott RM,Chervenak R

更新日期：1992-08-01 00:00:00

abstract：:Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition...

journal_title：Cancer research

authors： Cohen SM,Ellwein LB,Okamura T,Masui T,Johansson SL,Smith RA,Wehner JM,Khachab M,Chappel CI,Schoenig GP

更新日期：1991-04-01 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:HeLa TCRC-1, is a monophenotypic cell line for the production of the carcinoplacental Regan isoenzyme of alkaline phosphatase. It has been previously reported that, when this cell line is grown in immunosuppressed rats, there is an alteration of phenotypic expression in that an isoenzyme that is referred to as oncoamn...

journal_title：Cancer research

authors： Singer RM

更新日期：1976-11-01 00:00:00

abstract：:The conditions for growing preneoplastic mammary epithelial cells in primary cell cultures with serum-free factor-defined medium were established in a series of experiments. The cells, grown in Dulbecco's modified Eagle's medium with 0.6 mM Ca2+, epidermal growth factor, transferrin, insulin, and Na2SeO3, were fibrobl...

journal_title：Cancer research

authors： Medina D,Oborn CJ

更新日期：1980-11-01 00:00:00