Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition.

abstract：:The effect of different preparative procedures for electron microscopy on the size and shape of murine oncornaviruses has been studied. With conventional negative staining procedures using neutral sodium phosphotungstate, both murine mammary tumor virus and murine leukemia virus appeared in head-and-tail forms, with a...

journal_title：Cancer research

authors： Sarkar NH,Manthey WJ,Sheffield JB

更新日期：1975-03-01 00:00:00

abstract：:Increasing evidence points to an active stromal involvement in cancer initiation and progression. Cytokines derived from tumor cells are believed to modulate stromal cells to produce growth and angiogenic factors, which in turn provide the tumor with the necessary microenvironment for expansion and invasion. Transform...

journal_title：Cancer research

authors： Verona EV,Elkahloun AG,Yang J,Bandyopadhyay A,Yeh IT,Sun LZ

更新日期：2007-06-15 00:00:00

abstract：:DNA content and in situ sensitivity to denaturation were analyzed by flow cytometry of individual cell nuclei isolated from 40 breast carcinomas, nine fibroadenomas, and 14 samples of normal breast tissue. The extent of DNA denaturation induced by acid was expressed as alpha t, which represents the fraction of DNA sta...

journal_title：Cancer research

authors： Kunicka JE,Olszewski W,Rosen PP,Kimmel M,Melamed MR,Darzynkiewicz Z

更新日期：1989-11-15 00:00:00

abstract：:Cell differentiation within stem cell lineages can check proliferative potential, but nodal pathways that can limit tumor growth are obscure. Here, we report that lung cancer cell populations generate phenotypic and oncogenic plasticity via a switch between differentiation programs controlled by SOX2 and SOX9, thus al...

journal_title：Cancer research

authors： Lin SC,Chou YT,Jiang SS,Chang JL,Chung CH,Kao YR,Chang IS,Wu CW

更新日期：2016-12-01 00:00:00

abstract：:Recently the putative tumor suppressor gene p16INK4 was mapped to human chromosome 9p21, which is homologous to rat chromosome 5. Monosomy of rat chromosome 5 occurs with high frequency in rat kidney tumor-derived cell lines (ERC lines). Thus, we studied these lines in order to investigate the involvement of p15INK4B ...

journal_title：Cancer research

authors： Knapek DF,Serrano M,Beach D,Trono D,Walker CL

更新日期：1995-04-15 00:00:00

abstract：:The AP-2 transcription factors are required for normal growth and morphogenesis during mammalian development. Previous in vitro studies have also indicated that the AP-2 family of proteins may be involved in the etiology of human breast cancer. The AP-2 genes are expressed in many human breast cancer cell lines, and c...

journal_title：Cancer research

authors： Turner BC,Zhang J,Gumbs AA,Maher MG,Kaplan L,Carter D,Glazer PM,Hurst HC,Haffty BG,Williams T

更新日期：1998-12-01 00:00:00

abstract：:We have examined the effects of protein kinase C (PK-C) stimulation and cytosolic Ca2+ elevation on the in vitro induction of non-histocompatibility-restricted tumoricidal activity from human peripheral blood lymphocytes. The tumor cytolytic activity, as well as the number of cells recovered from interleukin 2 (IL-2)-...

journal_title：Cancer research

authors： McCrady CW,Li F,Grant AJ,Merchant RE,Carchman RA

更新日期：1988-02-01 00:00:00

abstract：:The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MC...

journal_title：Cancer research

authors： Benoit V,Chariot A,Delacroix L,Deregowski V,Jacobs N,Merville MP,Bours V

更新日期：2004-04-15 00:00:00

abstract：:The effects of the lipid-soluble dihydrofolate reductase inhibitor, trimetrexate, on the inhibition of thymidylate biosynthesis as a result of perturbation in cellular folate pools in H35 hepatoma cells in vitro has been investigated. Exposure of the cultures to increasing concentrations of trimetrexate between 2 and ...

journal_title：Cancer research

authors： Rhee MS,Balinska M,Bunni M,Priest DG,Maley GF,Maley F,Galivan J

更新日期：1990-07-01 00:00:00

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:Recent evidence from our laboratory and from others suggested that pretreatment with alpha-difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Many human tumor cells are resistant to chloroethylnitrosourea-induced DNA interstrand cross-linkin...

journal_title：Cancer research

authors： Seidenfeld J,Barnes D,Block AL,Erickson LC

更新日期：1987-09-01 00:00:00

abstract：:The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown to control constitutive Ca(2+) entry and cancer cell migration t...

journal_title：Cancer research

authors： Chantôme A,Potier-Cartereau M,Clarysse L,Fromont G,Marionneau-Lambot S,Guéguinou M,Pagès JC,Collin C,Oullier T,Girault A,Arbion F,Haelters JP,Jaffrès PA,Pinault M,Besson P,Joulin V,Bougnoux P,Vandier C

更新日期：2013-08-01 00:00:00

abstract：:Maspin, a serine protease inhibitor (serpin), can suppress tumor growth and metastasis in vivo and tumor cell motility and invasion in vitro. This may occur through maspin-mediated inhibition of pericellular proteolysis. In a recent report, we provided evidence that maspin may also suppress tumor progression by enhanc...

journal_title：Cancer research

authors： Liu J,Yin S,Reddy N,Spencer C,Sheng S

更新日期：2004-03-01 00:00:00

abstract：:Cancer is a leading cause of mortality throughout the world and new treatments are urgently needed. Recent studies suggest that bone marrow-derived mesenchymal stem cells (MSC) home to and incorporate within tumor tissue. We hypothesized that MSCs engineered to produce and deliver tumor necrosis factor-related apoptos...

journal_title：Cancer research

authors： Loebinger MR,Eddaoudi A,Davies D,Janes SM

更新日期：2009-05-15 00:00:00

abstract：:SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian,...

journal_title：Cancer research

authors： Orvis T,Hepperla A,Walter V,Song S,Simon J,Parker J,Wilkerson MD,Desai N,Major MB,Hayes DN,Davis IJ,Weissman B

更新日期：2014-11-15 00:00:00

abstract：:The sensitivity of mouse and human bone marrow hematopoietic precursor cells [colony-forming units committed to granulocyte-macrophage differentiatin (CFU-C)] was determined after in vitro incubation with chlorozotocin (2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose), or 1,3-bis(2-chloroethyl)-1-nitrosourea (BC...

journal_title：Cancer research

authors： Schein PS,Bull JM,Doukas D,Hoth D

更新日期：1978-02-01 00:00:00

abstract：:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear c...

journal_title：Cancer research

authors： Ichinose Y,Yagawa K,Kaku M,Hara N,Ohta M

更新日期：1985-09-01 00:00:00

abstract：:Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recru...

journal_title：Cancer research

authors： Barbero S,Mielgo A,Torres V,Teitz T,Shields DJ,Mikolon D,Bogyo M,Barilà D,Lahti JM,Schlaepfer D,Stupack DG

更新日期：2009-05-01 00:00:00

abstract：:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was elut...

journal_title：Cancer research

authors： Dowell BL,Segars JH,Metzgar RS

更新日期：1981-01-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effect...

journal_title：Cancer research

authors： Stemke-Hale K,Gonzalez-Angulo AM,Lluch A,Neve RM,Kuo WL,Davies M,Carey M,Hu Z,Guan Y,Sahin A,Symmans WF,Pusztai L,Nolden LK,Horlings H,Berns K,Hung MC,van de Vijver MJ,Valero V,Gray JW,Bernards R,Mills GB,Hennes

更新日期：2008-08-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:This report describes and presents some preliminary results from a prospective clinical investigation to determine the ablative effect of thiotepa (N,N',N''-triethylene phosphoramide) on superficial low-stage bladder cancer and the effectiveness of this agent in the prevention of recurrent or new tumors. In the small ...

journal_title：Cancer research

authors：

更新日期：1977-08-01 00:00:00

abstract：:Previous studies have documented the roles of transport via the reduced folate carrier, retention via polyglutamylation, and increased levels of the target enzyme, dihydrofolate reductase in sensitivity to methotrexate. Recent studies have shown that the mitochondrial enzymes in the cellular metabolism of serine, fola...

journal_title：Cancer research

authors： Vazquez A,Tedeschi PM,Bertino JR

更新日期：2013-01-15 00:00:00

abstract：:Twenty-one tumors from 18 patients (two independent tumors were obtained from each of three patients) with hepatocellular carcinomas were examined for loss of heterozygosity (LOH) at loci on chromosome 13q, using 15 polymorphic nucleotide sequences of microsatellites as genetic markers. The results revealed LOH in a c...

journal_title：Cancer research

authors： Zhang X,Xu HJ,Murakami Y,Sachse R,Yashima K,Hirohashi S,Hu SX,Benedict WF,Sekiya T

更新日期：1994-08-01 00:00:00

abstract：:Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majority of human colorectal cancers. Loss of functional APC protein activates the Wnt signal transduction pathway, allowing the nuclear accumulation of beta-catenin, which then binds to T-cell factor-4 (Tcf-4), causing increased transcripti...

journal_title：Cancer research

authors： Araki Y,Okamura S,Hussain SP,Nagashima M,He P,Shiseki M,Miura K,Harris CC

更新日期：2003-02-01 00:00:00

abstract：:RNA-DNA saturation hybridization experiments were used to estimate the extent of transcription of repetitive DNA sequences in polyoma-transformed and nontransformed mouse cells in culture. Measurements were made with RNA from nontransformed cells in both the subconfluent and confluent stages of growth, transformed cel...

journal_title：Cancer research

authors： Grady LJ,Campbell WP

更新日期：1975-06-01 00:00:00

abstract：:Oxidative stress exerted by superoxide-generating (redox-cycling) agents such as paraquat triggers the soxRS regulon of Escherichia coli. In this system, SoxR protein is the redox-sensitive activator of the soxS gene, the product of which then activates the approximately 10 promoters of this regulon. We found that 4-n...

journal_title：Cancer research

authors： Nunoshiba T,Demple B

更新日期：1993-07-15 00:00:00

abstract：:A large body of clinical, genetic, and biochemical evidence indicates that cyclooxygenase-2 (COX-2), a key enzyme for prostanoid biosynthesis, contributes to the promotion of colorectal cancer. COX-2-derived prostaglandin E2 (PGE2) is the most abundant prostaglandin found in several gastrointestinal malignancies. Alth...

journal_title：Cancer research

authors： Wang D,Buchanan FG,Wang H,Dey SK,DuBois RN

更新日期：2005-03-01 00:00:00

abstract：:Two subclones of L1210 murine leukemia (L1210-46.1 and L1210-56.3) were isolated in the absence of selective agents. Subclone 56.3 appeared to be more sensitive than was subclone 46.1 to treatment with dexamethasone, 1-beta-D-arabinofuranosyl cytosine, vincristine, and X-irradiation. No differences between the parent ...

journal_title：Cancer research

authors： Brouwer M,Smets LA,Jongsma AP

更新日期：1983-06-01 00:00:00

abstract：:The activity of gemcitabine (dFdC), an effective agent against solid tumors, depends on the incorporation of its triphosphate into DNA. In vitro investigations demonstrated that, depending on the sequence of template DNA, polymerases may pause after incorporation of gemcitabine nucleotide at either the 3'-terminal or ...

journal_title：Cancer research

authors： Gandhi V,Legha J,Chen F,Hertel LW,Plunkett W

更新日期：1996-10-01 00:00:00