Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.

abstract：:To elucidate the role of tumor vascularization on the localization of adoptively transferred, interleukin 2-activated natural killer (A-NK) cells, pulmonary B16 melanoma metastases were analyzed with respect to location, morphological appearance, origin and density of microvessels, and infiltration by A-NK cells. The ...

journal_title：Cancer research

authors： Nannmark U,Johansson BR,Bryant JL,Unger ML,Hokland ME,Goldfarb RH,Basse PH

更新日期：1995-10-15 00:00:00

abstract：:Vaccination with antigens expressed by tumors is one strategy for stimulating enhanced T-cell responses against tumors. However, these peptide vaccines rarely result in efficient expansion of tumor-specific T cells or responses that protect against tumor growth. Mimotopes, or peptide mimics of tumor antigens, elicit i...

journal_title：Cancer research

authors： Buhrman JD,Jordan KR,U'ren L,Sprague J,Kemmler CB,Slansky JE

更新日期：2013-01-01 00:00:00

abstract：:Infection of tumor cells by herpes simplex virus 1 (HSV-1) results in cell destruction and production of progeny virion in a process referred to as viral oncolysis. In this study, an HSV-1 mutant (HSV1yCD) was engineered such that the viral ribonucleotide reductase gene is disrupted by sequences encoding yeast cytosin...

journal_title：Cancer research

authors： Nakamura H,Mullen JT,Chandrasekhar S,Pawlik TM,Yoon SS,Tanabe KK

更新日期：2001-07-15 00:00:00

abstract：:The objective of the present investigation was to evaluate the immunomodulating properties of tetramethylenebisacetamide (N,N' 1-diacetylputrescine, DAP), a known inducer of cellular differentiation. We examined the effect of DAP administration in vivo on splenic and nonadherent peritoneal natural killer (NK) cell act...

journal_title：Cancer research

authors： Bowlin TL,Rosenberger A,Stemerick D,Edwards ML

更新日期：1990-09-01 00:00:00

abstract：:To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA) coupled with representational difference analysis. Of 42 CpG islands identified by MCA/representational difference analysis, 7 CpG islands [methylated in carcinoma of the pancreas (MICP)] w...

journal_title：Cancer research

authors： Ueki T,Toyota M,Skinner H,Walter KM,Yeo CJ,Issa JP,Hruban RH,Goggins M

更新日期：2001-12-01 00:00:00

abstract：:The effect of retinoic acid (RA) on N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation of primary cultures of rat tracheal epithelial cells was investigated. RA inhibited transformation of rat tracheal epithelial cells by up to 95% at concentrations of 3.3 to 33 nM which did not substantially affect cell surv...

journal_title：Cancer research

authors： Mass MJ,Nettesheim P,Beeman DK,Barrett JC

更新日期：1984-12-01 00:00:00

abstract：:The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains poor despite decades of effort. The abundant extracellular matrix (ECM) in PDAC comprises a major fraction of the tumor mass and plays various roles in promoting resistance to therapies. However, nonselective depletion of ECM has led to poor patient out...

journal_title：Cancer research

authors： Tian C,Öhlund D,Rickelt S,Lidström T,Huang Y,Hao L,Zhao RT,Franklin O,Bhatia SN,Tuveson DA,Hynes RO

更新日期：2020-04-01 00:00:00

abstract：:The carcinogenicities for rats and mice of N-methyl-4-aminoazobenzene (MAB) and its hepatic microsomal metabolite N-hydroxy-N-methyl-4-aminoazobenzene (N-hydroxy-MAB) were compared under several conditions. N-Ethyl-4-aminoazobenzene, 4-aminoazobenzene, and their N-hydroxy derivatives were also included in some of the ...

journal_title：Cancer research

authors： Miller EC,Kadlubar FF,Miller JA,Pitot HC,Drinkwater NR

更新日期：1979-09-01 00:00:00

abstract：:FGF2 signaling in glioblastoma induces resistance to radiotherapy, so targeting FGF2/FGFR pathways might offer a rational strategy for tumor radiosensitization. To investigate this possibility, we evaluated a specific role for FGFR1 in glioblastoma radioresistance as modeled by U87 and LN18 glioblastomas in mouse xeno...

journal_title：Cancer research

authors： Gouazé-Andersson V,Delmas C,Taurand M,Martinez-Gala J,Evrard S,Mazoyer S,Toulas C,Cohen-Jonathan-Moyal E

更新日期：2016-05-15 00:00:00

abstract：:In a recent study, we showed that the plant alkaloid camptothecin (CPT) and its derivatives 9-nitro-CPT (9NC) and 9-amino-CPT (9AC) inhibit growth of both human melanocytes (MEL cells) and their malignant counterparts, malignant melanoma (BRO) cells in vitro. This growth inhibition was accompanied by an increase in th...

journal_title：Cancer research

authors： Pantazis P,Early JA,Mendoza JT,DeJesus AR,Giovanella BC

更新日期：1994-02-01 00:00:00

abstract：:A monoclonal antibody, 44-3A6, was raised against the human pulmonary adenocarcinoma cell line A549. This antibody recognizes a protein antigen at the cell surface, which is preserved after formalin fixation and paraffin embedding. Immunohistochemical staining of lung tissue with this antibody revealed diffuse immunor...

journal_title：Cancer research

authors： Lee I,Radosevich JA,Ma YX,Combs SG,Rosen ST,Gould VE

更新日期：1985-11-01 00:00:00

abstract：:The role of hereditary polymorphisms of the arylamine N-acetyltransferase 1 (NAT1) gene in the etiology of urinary bladder cancer is controversial. NAT1 is expressed in the urothelium and may O-acetylate hydroxyl amines, particularly in subjects with low NAT2 activity. Thus, NAT1 polymorphisms may affect the individua...

journal_title：Cancer research

authors： Cascorbi I,Roots I,Brockmöller J

更新日期：2001-07-01 00:00:00

abstract：:Neuroblastoma is a common solid tumor of childhood that is derived from the neural crest. Expression of epidermal growth factor (EGF) receptors (EGFRs) has been associated with enhanced cell growth and aggressive behavior in other tumors. Here, we examined the expression profile of EGFRs in neuroblastoma cell lines an...

journal_title：Cancer research

authors： Ho R,Minturn JE,Hishiki T,Zhao H,Wang Q,Cnaan A,Maris J,Evans AE,Brodeur GM

更新日期：2005-11-01 00:00:00

abstract：:Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majority of human colorectal cancers. Loss of functional APC protein activates the Wnt signal transduction pathway, allowing the nuclear accumulation of beta-catenin, which then binds to T-cell factor-4 (Tcf-4), causing increased transcripti...

journal_title：Cancer research

authors： Araki Y,Okamura S,Hussain SP,Nagashima M,He P,Shiseki M,Miura K,Harris CC

更新日期：2003-02-01 00:00:00

abstract：:Pristane (2,6,10,14-tetramethylpentadecane) is a C19-isoalkane that promotes the development of plasmacytomas in genetically susceptible BALB/c mice. Similarities between the effects of pristane and protein kinase C (PKC)-activating phorbol esters suggested that the tumor promoting activity of pristane might involve t...

journal_title：Cancer research

authors： Janz S,Gawrisch K,Lester DS

更新日期：1995-02-01 00:00:00

abstract：:In order to study whether cell fusion would modify the DNA copy number of an amplified oncogene, somatic cell hybrids were made between the human neuroepithelioma cell line MCIXC and HeLaCOT human adenocarcinoma cells. MCIXC contains approximately 21 copies of the c-myc oncogene and HeLaCOT contains approximately 5 co...

journal_title：Cancer research

authors： Iman DS,Shay JW

更新日期：1989-08-15 00:00:00

abstract：:Cancer radiotherapy may be immunogenic, but it is unclear why its immunogenic effects are rarely sufficient to prevent tumor recurrence. Here, we report a novel Toll-like receptor 9 (TLR9)-dependent mechanism that initiates tumor regrowth after local radiotherapy. Systemic inhibition of TLR9, but not TLR4, delayed tum...

journal_title：Cancer research

authors： Gao C,Kozlowska A,Nechaev S,Li H,Zhang Q,Hossain DM,Kowolik CM,Chu P,Swiderski P,Diamond DJ,Pal SK,Raubitschek A,Kortylewski M

更新日期：2013-12-15 00:00:00

abstract：:All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in cancer, and each isofor...

journal_title：Cancer research

authors： Prior IA,Lewis PD,Mattos C

更新日期：2012-05-15 00:00:00

abstract：:Intrahepatic cholangiocarcinoma is a treatment refractory malignancy with a high mortality and an increasing incidence worldwide. Recent studies have observed that activation of Notch and AKT signaling within mature hepatocytes is able to induce the formation of tumors displaying biliary lineage markers, thereby raisi...

journal_title：Cancer research

authors： Guest RV,Boulter L,Kendall TJ,Minnis-Lyons SE,Walker R,Wigmore SJ,Sansom OJ,Forbes SJ

更新日期：2014-02-15 00:00:00

abstract：:We have recently identified human epidermal growth factor-like immunoreactive factor synthesized and secreted by human breast cancer cells (MCF-7) as a secretory protein encoded by the pS2 gene, the transcription of which is directly induced by estrogen. We demonstrated in this paper that synthesis and secretion of pS...

journal_title：Cancer research

authors： Kida N,Yoshimura T,Mori K,Hayashi K

更新日期：1989-07-01 00:00:00

abstract：:Although obesity is one of the strongest risk factors for esophageal adenocarcinoma (EAC), the molecular mechanisms underlying this association remain unclear. We recently identified 4 EAC-specific master regulator transcription factors (MRTF) ELF3, KLF5, GATA6, and EHF. In the present study, Gene Set Enrichment Analy...

journal_title：Cancer research

authors： Ma S,Zhou B,Yang Q,Pan Y,Yang W,Freedland SJ,Ding LW,Freeman MR,Breunig JJ,Bhowmick NA,Pan J,Koeffler HP,Lin DC

更新日期：2021-01-05 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates angiogenesis by enhancing endothelial cell survival and migration. It is also known that Ang1 activates Tie2, an endothelial-specific tyrosine kinase receptor, but the molecular mechanism of this process is not clear. In this study, we investigated whether reactive oxygen species (ROS) p...

journal_title：Cancer research

authors： Kim YM,Kim KE,Koh GY,Ho YS,Lee KJ

更新日期：2006-06-15 00:00:00

abstract：:On the basis of reports of rat mammary- and pancreas-tumor models, we hypothesized that an increase in consumption of linoleic acid (LA) would also cause an enhancement in mouse skin-tumor promotion. SEN-CAR mice were placed on diets containing 0.8%, 2.2%, 3.5%, 4.5%, 5.6%, 7.0%, or 8.4% LA, 1 week after initiation wi...

journal_title：Cancer research

authors： Fischer SM,Leyton J,Lee ML,Locniskar M,Belury MA,Maldve RE,Slaga TJ,Bechtel DH

更新日期：1992-04-01 00:00:00

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:One of the body's natural defense mechanisms against tumor cells is lysis of the invading cell by cytotoxic T-cells and natural killer (NK) cells. Five human hepatocellular carcinoma cell lines were found to have different sensitivities to killing by peripheral blood monocytes in a 51Cr release assay. This killing was...

journal_title：Cancer research

authors： Stevenson D,Binggeli R,Weinstein RC,Keck JG,Lai MC,Tong MJ

更新日期：1989-09-01 00:00:00

abstract：:The alkylating agent temozolomide, commonly used in the treatment of malignant glioma, causes cellular cytotoxicity by forming O(6)-methylguanine adducts. In this report, we investigated whether temozolomide alters the activity of the transcription factor nuclear factor-kappaB (NF-kappaB). Temozolomide inhibits basal ...

journal_title：Cancer research

authors： Yamini B,Yu X,Dolan ME,Wu MH,Darga TE,Kufe DW,Weichselbaum RR

更新日期：2007-07-15 00:00:00

abstract：:Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified and highly expressed in lobular carcinomas of the breast. In this report, we evaluated the biological activity of FGFR1 in a wide range of in vitro assays. Conditional activation of FGFR1 in the nontransformed MCF10A human mammary cell line, MCF10A, r...

journal_title：Cancer research

authors： Xian W,Pappas L,Pandya D,Selfors LM,Derksen PW,de Bruin M,Gray NS,Jonkers J,Rosen JM,Brugge JS

更新日期：2009-03-15 00:00:00

abstract：:Malignant gliomas are the most common central nervous system tumors and the molecular mechanism driving their development and recurrence is still largely unknown, limiting the treatment of this disease. Here, we show that restoring the expression of miR-218, a microRNA commonly downregulated in glioma, dramatically re...

journal_title：Cancer research

authors： Tu Y,Gao X,Li G,Fu H,Cui D,Liu H,Jin W,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:Cell suspensions derived from 2 specimens of normal human urothelium and 13 human transitional cell carcinomas were studied by discontinuous density gradient centrifugation. The histochemical and proliferative properties of the fractions were evaluated. In normal urothelium, DNA synthesis was restricted to a subpopula...

journal_title：Cancer research

authors： Mackillop WJ,Bizarri JP,Ward GK

更新日期：1985-09-01 00:00:00

abstract：:Brain tumors such as medulloblastoma (MB) and glioblastoma multiforme (GBM) can derive from neural precursors. For instance, many MBs are thought to arise from the uncontrolled proliferation of cerebellar granule neuron precursors (GNP). GNPs normally proliferate in early postnatal stages in mice but then they become ...

journal_title：Cancer research

authors： Tatard VM,Xiang C,Biegel JA,Dahmane N

更新日期：2010-02-01 00:00:00