Abstract：
:After many years of productive study on the signaling networks, posttranslational regulatory control of effector molecules remains an intensely investigated and continuously evolving field of research to connect signaling with phenotypic changes. In recent years, there have been intriguing results on the interaction of critical molecules to control the growth of cancer cells. This review article will focus on two critical convergence signaling nodules, Akt and p21-activated kinase, two integral components of phenotypic signaling during tumorigenesis. Here we will summarize the recent findings on how these master signaling nodules regulate their targets and alter the subcellular localization of their effectors to control their functionality. Based on the laboratory advances in the Akt and p21-activated kinase signaling pathways, it is conceivable to start defining novel avenues to develop targeted anticancer therapies.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kumar R,Hung MCdoi
10.1158/0008-5472.CAN-05-0189subject
Has Abstractpub_date
2005-04-01 00:00:00pages
2511-5issue
7eissn
0008-5472issn
1538-7445pii
65/7/2511journal_volume
65pub_type
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