Abstract：
:The influence of microtubule-associated proteins on the interaction of vincristine with microtubules and tubulin was examined. Microtubules containing associated proteins were prepared in vitro from tubulin preparations which contained the proteins or from pure 6S tubulin and isolated microtubule-associated proteins. The presence of the associated proteins caused microtubules to be converted to stable spiral structures upon reacting with vincristine. When the proteins were absent, spirals were not formed, and the microtubules were completely disassembled by vincristine. At 0 degrees, 6S tubulin was converted to amorphous aggregates by vincristine, whereas if the associated proteins were present spirals were formed.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Donoso JA,Haskins KM,Himes RHsubject
Has Abstractpub_date
1979-05-01 00:00:00pages
1604-10issue
5eissn
0008-5472issn
1538-7445journal_volume
39pub_type
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