Abstract:
:Type beta transforming growth factor-growth inhibitor (TGF beta/GI) causes normal human prokeratinocytes to arrest growth predominantly in the G1 phase of the cell cycle within 48 h after log phase cultures are exposed to the factor in serum-free medium. The growth arrest induced by TGF beta/GI is reversible because the cells from treated cultures can be replated into fresh medium and grown into large colonies. Normal prokeratinocytes are demonstrated to secrete TGF beta/GI-like molecules into the culture medium and to have specific cell surface receptors for this molecule. In contrast, a human squamous cell carcinoma, SCC-25, does not arrest growth when exposed to TGF beta/GI. These cells, unlike the normal prokeratinocytes, do not exhibit detectable cell surface receptors for the factor.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Shipley GD,Pittelkow MR,Wille JJ Jr,Scott RE,Moses HLsubject
Has Abstractpub_date
1986-04-01 00:00:00pages
2068-71issue
4 Pt 2eissn
0008-5472issn
1538-7445journal_volume
46pub_type
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