Purging of small cell lung cancer cells from human bone marrow using ethiofos (WR-2721) and light-activated merocyanine 540 phototreatment.

abstract：:Mice transgenic for the human carcinoembryonic antigen (CEA) gene were prepared for use as a preclinical model for immunotherapy. A 32.6-kb fragment containing the complete human CEA gene and flanking sequences was isolated from a genomic cosmid clone and used to produce transgenic C57BL/6 mice. A homozygous line was ...

journal_title：Cancer research

authors： Clarke P,Mann J,Simpson JF,Rickard-Dickson K,Primus FJ

更新日期：1998-04-01 00:00:00

abstract：:Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The development of highl...

journal_title：Cancer research

authors： Morton JJ,Bird G,Refaeli Y,Jimeno A

更新日期：2016-11-01 00:00:00

abstract：:Laminin (LN)-5, a heterotrimer of alpha3, beta3, and gamma2 chains, has been suggested to be involved in tumor cell invasion. The present immunohistochemical study investigated the distribution of the LN gamma2 chain in 48 different human gastric adenocarcinomas. The immunohistochemical analysis showed two distinct pa...

journal_title：Cancer research

authors： Koshikawa N,Moriyama K,Takamura H,Mizushima H,Nagashima Y,Yanoma S,Miyazaki K

更新日期：1999-11-01 00:00:00

abstract：:Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differ...

journal_title：Cancer research

authors： Killian JK,Bilke S,Davis S,Walker RL,Killian MS,Jaeger EB,Chen Y,Hipp J,Pittaluga S,Raffeld M,Cornelison R,Smith WI Jr,Bibikova M,Fan JB,Emmert-Buck MR,Jaffe ES,Meltzer PS

更新日期：2009-02-01 00:00:00

abstract：:We evaluated the effects of local X-irradiation on microscopic or small macroscopic primary melanomas in the feet of C57BL/6 mice and the subsequent development of spontaneous femoral lymph node (LN) metastases. Doses of 30, 40, 55, 62.5, or 72.5 Gy often cured the foot tumor and metastases to regional femoral lymph n...

journal_title：Cancer research

authors： Nathanson SD,Westrick P,Anaya P,Hetzel FW,Jacobsen G

更新日期：1989-08-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:The aim of this study was to evaluate to what extent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 may explain the development of experimental cancer cachexia. For this purpose, C57BL/6J mice bearing a transplantable low differentiated rapidly growing tumor were passively immunized every other day with rab...

journal_title：Cancer research

authors： Gelin J,Moldawer LL,Lönnroth C,Sherry B,Chizzonite R,Lundholm K

更新日期：1991-01-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabilization, complete remissions are rare and a substantial proportion of...

journal_title：Cancer research

authors： Bauer S,Parry JA,Mühlenberg T,Brown MF,Seneviratne D,Chatterjee P,Chin A,Rubin BP,Kuan SF,Fletcher JA,Duensing S,Duensing A

更新日期：2010-01-01 00:00:00

abstract：:Most cancer cells utilize aerobic glycolysis, and activation of the phosphoinositide 3-kinase/Akt/mTOR pathway can promote this metabolic program to render cells glucose dependent. Although manipulation of glucose metabolism may provide a means to specifically eliminate cancer cells, mechanistic links between cell met...

journal_title：Cancer research

authors： Coloff JL,Macintyre AN,Nichols AG,Liu T,Gallo CA,Plas DR,Rathmell JC

更新日期：2011-08-01 00:00:00

abstract：:Neuroblastoma arises from the embryonal neural crest secondary to a block in differentiation. Long-term patient survival correlates inversely with the extent of differentiation, and treatment with retinoic acid or other prodifferentiation agents improves survival modestly. In this study, we show the histone chaperone ...

journal_title：Cancer research

authors： Barbieri E,De Preter K,Capasso M,Chen Z,Hsu DM,Tonini GP,Lefever S,Hicks J,Versteeg R,Pession A,Speleman F,Kim ES,Shohet JM

更新日期：2014-02-01 00:00:00

abstract：:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, an...

journal_title：Cancer research

authors： Long CW,Bruszewski JA,Christensen WL,Suk WA

更新日期：1979-08-01 00:00:00

abstract：:Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or par...

journal_title：Cancer research

authors： Nam HY,Han MW,Chang HW,Lee YS,Lee M,Lee HJ,Lee BW,Lee HJ,Lee KE,Jung MK,Jeon H,Choi SH,Park NH,Kim SY,Kim SW

更新日期：2013-07-15 00:00:00

abstract：:Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1 in several cancer types has recently accumulated, its role in melanoma tumor formation and ...

journal_title：Cancer research

authors： Trimmer C,Whitaker-Menezes D,Bonuccelli G,Milliman JN,Daumer KM,Aplin AE,Pestell RG,Sotgia F,Lisanti MP,Capozza F

更新日期：2010-10-01 00:00:00

abstract：:Quinocarmycin monicitrate (KW2152) and its analogue, DX-52-1, demonstrated specificity for melanomas in the National Cancer Institute in vitro human tumor cell line drug screen. In contrast to most cell lines, a 50% reduction in tumor cell burden (as measured protein) at the end of a 48-h drug incubation was produced ...

journal_title：Cancer research

authors： Plowman J,Dykes DJ,Narayanan VL,Abbott BJ,Saito H,Hirata T,Grever MR

更新日期：1995-02-15 00:00:00

abstract：:We evaluated whether antibody response correlates with tumor therapy by cytokine gene-modified tumor cell vaccines. To characterize the antibody (Ab) response against a known antigen, colon carcinoma C26 cells and C26 variants engineered to produce interleukin (IL) 12 or IL-4 were further transduced to express the hum...

journal_title：Cancer research

authors： Rodolfo M,Melani C,Zilocchi C,Cappetti B,Luison E,Arioli I,Parenza M,Canevari S,Colombo MP

更新日期：1998-12-15 00:00:00

abstract：:The ability of tumor cells to express elevated levels of proteinases capable of degrading tissue matrix and basement membrane components in vitro has been correlated to their invasive and metastatic potential. Many in vitro invasion assays have been performed either in the presence of serum or with tumor cells that ha...

journal_title：Cancer research

authors： Neri A,Bohoslawec O,Anderson TD,Tokes ZA

更新日期：1991-02-15 00:00:00

abstract：:It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in the etiology of pancreatic cancer, we have analyzed samples from patients with pancreatic cancer enrolled in the NFPTR for mutations...

journal_title：Cancer research

authors： Murphy KM,Brune KA,Griffin C,Sollenberger JE,Petersen GM,Bansal R,Hruban RH,Kern SE

更新日期：2002-07-01 00:00:00

abstract：:Aromatase is a key enzyme in intratumoral estrogen production required for the production of estrogens through the conversion of serum androgens in postmenopausal breast cancer patients. There have been, however, controversies regarding the intratumoral localization of aromatase in human breast carcinoma tissues. Ther...

journal_title：Cancer research

authors： Miki Y,Suzuki T,Tazawa C,Yamaguchi Y,Kitada K,Honma S,Moriya T,Hirakawa H,Evans DB,Hayashi S,Ohuchi N,Sasano H

更新日期：2007-04-15 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer deaths in the United States, with an overall 5-year survival rate of <5%. Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is highly resistant to conventional chemotherapies, underscoring the critical need for new molecular targ...

journal_title：Cancer research

authors： Scotti ML,Bamlet WR,Smyrk TC,Fields AP,Murray NR

更新日期：2010-03-01 00:00:00

abstract：:DNA methylation was measured in human tumor cell lines and freshly explanted pediatric tumors by [3H]uridine labeling followed by DNA hydrolysis and high-performance liquid chromatography. The percentage of cytosine residues modified to 5-methylcytosine in 4 cell lines derived from pediatric tumors was increased or si...

journal_title：Cancer research

authors： Flatau E,Bogenmann E,Jones PA

更新日期：1983-10-01 00:00:00

abstract：:Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for rapid membrane turnover. Nonetheless, we show here that, in mutant is...

journal_title：Cancer research

authors： Viswanath P,Radoul M,Izquierdo-Garcia JL,Ong WQ,Luchman HA,Cairncross JG,Huang B,Pieper RO,Phillips JJ,Ronen SM

更新日期：2018-05-01 00:00:00

abstract：:The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (CCR6) by multiple myeloma (MM) and microenvironment cells and their potential relationship with osteoclast (OC) formation and osteolytic bone lesions in MM patients was ...

journal_title：Cancer research

authors： Giuliani N,Lisignoli G,Colla S,Lazzaretti M,Storti P,Mancini C,Bonomini S,Manferdini C,Codeluppi K,Facchini A,Rizzoli V

更新日期：2008-08-15 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:Angiogenesis inhibitor TNP-470, 6-O-(N-chloroacetyl-carbamoyl)-fumagillol, semisynthetic analogue of fumagillin, has strong inhibitory activities against in vivo tumor growth and metastasis in a wide variety of tumors. However, it is still unknown whether this agent inhibits bone metastasis. We examined the effects of...

journal_title：Cancer research

authors： Sasaki A,Alcalde RE,Nishiyama A,Lim DD,Mese H,Akedo H,Matsumura T

更新日期：1998-02-01 00:00:00

abstract：:The effects of retinyl acetate and all-trans-retinoic acid on the growth rate, saturation density, and cytoplasmic underlapping of normal and carcinogen-initiated C3H/1OT1/2 cells were examined. Retinyl acetate (a) decreased the saturation density by as much as 45%, (b) had no effect on the growth rate, (c) reduced cy...

journal_title：Cancer research

authors： Mordan LJ,Bertram JS

更新日期：1983-02-01 00:00:00

abstract：:Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1,511 cases and 1,457 con...

journal_title：Cancer research

authors： Canova C,Hashibe M,Simonato L,Nelis M,Metspalu A,Lagiou P,Trichopoulos D,Ahrens W,Pigeot I,Merletti F,Richiardi L,Talamini R,Barzan L,Macfarlane GJ,Macfarlane TV,Holcátová I,Bencko V,Benhamou S,Bouchardy C,Kjaerheim

更新日期：2009-04-01 00:00:00

abstract：:Exposure of tumor cells to cytotoxic agents simultaneously activates a variety of intracellular signaling pathways. Some of these pathways involve enzymes from the protein kinase C (PKC) family of serine/threonine kinases. This family includes isoenzymes that negatively influence cell death, whereas other demonstrate ...

journal_title：Cancer research

authors： Filomenko R,Poirson-Bichat F,Billerey C,Belon JP,Garrido C,Solary E,Bettaieb A

更新日期：2002-03-15 00:00:00

abstract：:In cancer cachexia both cardiac and skeletal muscle suffer an important protein mobilization as a result of increased proteolysis. Administration of the beta2-agonist formoterol to both rats and mice bearing highly cachectic tumors resulted in an important reversal of the muscle-wasting process. The anti-wasting effec...

journal_title：Cancer research

authors： Busquets S,Figueras MT,Fuster G,Almendro V,Moore-Carrasco R,Ametller E,Argilés JM,López-Soriano FJ

更新日期：2004-09-15 00:00:00

abstract：:Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To understand the pathogenesis and to develop new therapeutic strategies, it is essential to dissect the molecular mechanisms that regulate progr...

journal_title：Cancer research

authors： Yeh TS,Wu CW,Hsu KW,Liao WJ,Yang MC,Li AF,Wang AM,Kuo ML,Chi CW

更新日期：2009-06-15 00:00:00

abstract：:A tetracosapeptide (peptide-24) corresponding to the amino-terminal sequence of the carcinoembryonic antigen (CEA) was synthesized and characterized. Antisera were produced to the peptide-24, and a radioimmunoassay was developed utilizing peptide-24 with a tyrosine residue on the amino-terminal end (Tyr-peptide-24). I...

journal_title：Cancer research

authors： Paul D,Flouret G,Tomita JT,Ranney K,Schenck J,Anderson B

更新日期：1981-06-01 00:00:00