Mapping of ER gene CpG island methylation-specific polymerase chain reaction.

abstract：:The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously reported that ROCK kinase expression increases with human and mouse pancrea...

journal_title：Cancer research

authors： Rath N,Munro J,Cutiongco MF,Jagiełło A,Gadegaard N,McGarry L,Unbekandt M,Michalopoulou E,Kamphorst JJ,Sumpton D,Mackay G,Vennin C,Pajic M,Timpson P,Olson MF

更新日期：2018-06-15 00:00:00

abstract：:Previous work showed that mice that had been thymectomized at 3 days of age tended, in later life, to develop a hyperplastic autoimmune gastritis and were also hypersusceptible to sarcogenesis by low dosages of 3-methylcholanthrene. In the present work, it was found that the hyperplastic autoimmune gastritis could be ...

journal_title：Cancer research

authors： Prehn LM

更新日期：1986-07-01 00:00:00

abstract：:Expression and function of the Fas apoptotic pathway was investigated in normal and malignant human breast epithelial cells. Nontransformed mammary epithelial cell lines all expressed high levels of Fas mRNA and protein, but only one of seven breast cancer cell lines (T47D) expressed high levels of Fas. Apoptosis was ...

journal_title：Cancer research

authors： Keane MM,Ettenberg SA,Lowrey GA,Russell EK,Lipkowitz S

更新日期：1996-10-15 00:00:00

abstract：:Estrogen independence and progression to a metastatic phenotype are hallmarks of therapeutic resistance and mortality in breast cancer patients. Metastasis has been associated with chemokine signaling through the SDF-1-CXCR4 axis. Thus, the development of estrogen independence and endocrine therapy resistance in breas...

journal_title：Cancer research

authors： Rhodes LV,Short SP,Neel NF,Salvo VA,Zhu Y,Elliott S,Wei Y,Yu D,Sun M,Muir SE,Fonseca JP,Bratton MR,Segar C,Tilghman SL,Sobolik-Delmaire T,Horton LW,Zaja-Milatovic S,Collins-Burow BM,Wadsworth S,Beckman BS,Wood CE

更新日期：2011-01-15 00:00:00

abstract：:c-abl, c-fos, c-Ha-ras, c-myc, and c-mos were expressed whereas c-sis, c-fms, c-rel, c-src, and c-myb expression was not detectable in C3H/10T1/2 Cl 8 (10T1/2) cells and in eight chemically and radiation-transformed 10T1/2 cell lines. The expression of c-abl, c-fos, c-Ha-ras, and c-myc was growth-related in nontransfo...

journal_title：Cancer research

authors： Shuin T,Billings PC,Lillehaug JR,Patierno SR,Roy-Burman P,Landolph JR

更新日期：1986-10-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. Anti-HPV16 E7 intracellular single-chain antibodies (scFvs) were constructed to down-regulate HPV16 E7 oncoprotein in HPV DNA-containing cell lines. In these studies, we transfected anti-E7 scFvs...

journal_title：Cancer research

authors： Wang-Johanning F,Gillespie GY,Grim J,Rancourt C,Alvarez RD,Siegal GP,Curiel DT

更新日期：1998-05-01 00:00:00

abstract：:Patients with lung cancer often present with metastatic disease and therefore have a very poor prognosis. The recent discovery of several novel ROS receptor tyrosine kinase molecular alterations in non-small cell lung cancer (NSCLC) presents a therapeutic opportunity for the development of new targeted treatment strat...

journal_title：Cancer research

authors： Jun HJ,Johnson H,Bronson RT,de Feraudy S,White F,Charest A

更新日期：2012-08-01 00:00:00

abstract：:Aberrant cholesterol metabolism is increasingly appreciated to be essential for prostate cancer initiation and progression. Transcript expression of the high-density lipoprotein-cholesterol receptor scavenger receptor B1 (SR-B1) is elevated in primary prostate cancer. Hypothesizing that SR-B1 expression may help facil...

journal_title：Cancer research

authors： Gordon JA,Noble JW,Midha A,Derakhshan F,Wang G,Adomat HH,Tomlinson Guns ES,Lin YY,Ren S,Collins CC,Nelson PS,Morrissey C,Wasan KM,Cox ME

更新日期：2019-07-01 00:00:00

abstract：:SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits sk...

journal_title：Cancer research

authors： Ming M,Han W,Zhao B,Sundaresan NR,Deng CX,Gupta MP,He YY

更新日期：2014-10-15 00:00:00

abstract：:Colorectal cancers from the mutator phenotype pathway display distinctive pathological features and confer a lesser aggressiveness than colorectal adenocarcinomas originated by the suppressor pathway. The goal of this work was to test whether tumors developed through the mutator pathway could show a decrease in matrix...

journal_title：Cancer research

authors： Morán A,Iniesta P,de Juan C,González-Quevedo R,Sánchez-Pernaute A,Díaz-Rubio E,Ramón y Cajal S,Torres A,Balibrea JL,Benito M

更新日期：2002-07-01 00:00:00

abstract：:Pyruvate kinase isozymes were studied in normal brain tissue (both fetal and adult) and in meningiomas and malignant gliomas. In fetal brain five different forms could be detected by electrophoresis (K4, K3M, K2M2, KM3, and M4). In adult brain the M4-type, K3M hybrid, and K4-type are present; the M isozyme is largely ...

journal_title：Cancer research

authors： van Veelen CW,Verbiest H,Vlug AM,Rijksen G,Staal GE

更新日期：1978-12-01 00:00:00

abstract：:The invasive transformation of A-459 lung epithelial carcinoma cells has been linked to the autocrine regulation of malignant phenotypic changes by transforming growth factor beta (TGF-beta). Here we demonstrate, using stable 13C glucose isotopes, that the transformed phenotype is characterized by decreased CO2 produc...

journal_title：Cancer research

authors： Boros LG,Torday JS,Lim S,Bassilian S,Cascante M,Lee WN

更新日期：2000-03-01 00:00:00

abstract：:B7-H3, a surface immunomodulatory glycoprotein, inhibits natural killer cells and T cells. The monoclonal antibody (mAb) 8H9 is specific for 4Ig-B7-H3, the long and principal form of B7-H3. Early results from radioimmunotherapy using 8H9 have shown promise in patients with metastatic solid tumors to the central nervou...

journal_title：Cancer research

authors： Xu H,Cheung IY,Guo HF,Cheung NK

更新日期：2009-08-01 00:00:00

abstract：:Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but the mechanisms by which it contributes to cancer development and patient outcome have yet to be fully elucidated. Here, we examined the effects of coculturing human-derived a...

journal_title：Cancer research

authors： Picon-Ruiz M,Pan C,Drews-Elger K,Jang K,Besser AH,Zhao D,Morata-Tarifa C,Kim M,Ince TA,Azzam DJ,Wander SA,Wang B,Ergonul B,Datar RH,Cote RJ,Howard GA,El-Ashry D,Torné-Poyatos P,Marchal JA,Slingerland JM

更新日期：2016-01-15 00:00:00

abstract：:Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a plausible mechanism linking diabetes and liver cancer prog...

journal_title：Cancer research

authors： Luo C,Liang J,Sharabi K,Hatting M,Perry EA,Tavares CDJ,Goyal L,Srivastava A,Bilodeau M,Zhu AX,Sicinski P,Puigserver P

更新日期：2020-08-15 00:00:00

abstract：:With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully predict the efficacy of these vaccines in humans. However, the only tumor models available to study vaccines against human papillomavirus (HPV) 16 have been developed in C57BL/6...

journal_title：Cancer research

authors： Eiben GL,Velders MP,Schreiber H,Cassetti MC,Pullen JK,Smith LR,Kast WM

更新日期：2002-10-15 00:00:00

abstract：:Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse the tumor phenotype. Here, we report the characterization of SB-590885, a novel triarylimidazole that selectively inhibits Raf kinases with more p...

journal_title：Cancer research

authors： King AJ,Patrick DR,Batorsky RS,Ho ML,Do HT,Zhang SY,Kumar R,Rusnak DW,Takle AK,Wilson DM,Hugger E,Wang L,Karreth F,Lougheed JC,Lee J,Chau D,Stout TJ,May EW,Rominger CM,Schaber MD,Luo L,Lakdawala AS,Adams JL,

更新日期：2006-12-01 00:00:00

abstract：:CUB domain-containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported previously that CDCP1 regulates anoikis resistance as well as cancer cell migration and invasion, although the underlying mechanisms have not been elucidated. In this study, we found that expres...

journal_title：Cancer research

authors： Miyazawa Y,Uekita T,Hiraoka N,Fujii S,Kosuge T,Kanai Y,Nojima Y,Sakai R

更新日期：2010-06-15 00:00:00

abstract：:The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismatches that occur at ...

journal_title：Cancer research

authors： Turner DP,Cortellino S,Schupp JE,Caretti E,Loh T,Kinsella TJ,Bellacosa A

更新日期：2006-08-01 00:00:00

abstract：:SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian,...

journal_title：Cancer research

authors： Orvis T,Hepperla A,Walter V,Song S,Simon J,Parker J,Wilkerson MD,Desai N,Major MB,Hayes DN,Davis IJ,Weissman B

更新日期：2014-11-15 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:Obesity enhances breast cancer risk in postmenopausal women and premenopausal women with genetic or familial risk factors. We have shown previously that within breast tissue, obesity increases macrophage-driven inflammation and promotes expansion of luminal epithelial cell populations that are hypothesized to be the c...

journal_title：Cancer research

authors： Chamberlin T,Clack M,Silvers C,Kuziel G,Thompson V,Johnson H,Arendt LM

更新日期：2020-10-15 00:00:00

abstract：:A unique electrophoretic form of lactate dehydrogenase (LDH-Z), formerly observed in a choriocarcinoma cell line (JEG-3) and first-trimester placenta, has been shown to be the same as that produced in hydatidiform mole and term placenta. We have also observed LDH-Z in second-trimester placenta, choriocarcinoma metasta...

journal_title：Cancer research

authors： Siciliano MJ,Bordelon-Riser ME,Freedman RS,Kohler PO

更新日期：1980-02-01 00:00:00

abstract：:Infection with Helicobacter pylori is a major cause of gastric cancer (GC). The association likely has been underestimated in the past due to disease-related clearance of the infection. On the other hand, only a minority of the infected individuals develop GC, and better risk stratification is therefore highly desirab...

journal_title：Cancer research

authors： Gao L,Michel A,Weck MN,Arndt V,Pawlita M,Brenner H

更新日期：2009-08-01 00:00:00

abstract：:Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with un...

journal_title：Cancer research

authors： Drummond DC,Noble CO,Guo Z,Hong K,Park JW,Kirpotin DB

更新日期：2006-03-15 00:00:00

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

journal_title：Cancer research

authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

更新日期：1980-10-01 00:00:00

abstract：:O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a critical role in protection from the carcinogenic effects of simple alkylating agents by repairing O(6)-alkylguanine adducts via a direct transfer reaction. Nitric oxide (NO) or species derived from it are known to be able to initiate neoplastic growth and cannot on...

journal_title：Cancer research

authors： Liu L,Xu-Welliver M,Kanugula S,Pegg AE

更新日期：2002-06-01 00:00:00

abstract：:Biochemical quantitation of estrogen receptors has been used to predict prognosis in breast cancer. Immunocytochemical analysis of estrogen receptors correlates with biochemical analysis but has very few follow-up studies in the literature to validate it as a prognostic indicator. 257 patients were followed for up to ...

journal_title：Cancer research

authors： Kinsel LB,Szabo E,Greene GL,Konrath J,Leight GS,McCarty KS Jr

更新日期：1989-02-15 00:00:00

abstract：:A direct ligand-banding radioassay for methotrexate (MTX) has been developed using dihydrofolate reductase, contained in the lysate of L1210 leukemia cells, as the binding determinant. The procedure is a two-phase reaction system where standard MTX concentrations or the sample being assayed in incubated with the reage...

journal_title：Cancer research

authors： Arons E,Rothenberg SP,Costa MD,Fischer C,Iqbal MP

更新日期：1975-08-01 00:00:00