Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins.

abstract：:Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. To directly assess the function of the VHL gene product, we transfected the ...

journal_title：Cancer research

authors： Chen F,Kishida T,Duh FM,Renbaum P,Orcutt ML,Schmidt L,Zbar B

更新日期：1995-11-01 00:00:00

abstract：:Recent studies indicate that ovarian cancer may be highly responsive to antivascular therapeutics. We have developed an antivascular tumor therapeutic using the F3 peptide to target cisplatin-loaded nanoparticles (F3-Cis-Np) to tumor vessels. We show that although F3-Cis-Np bind with high specificity to both human ova...

journal_title：Cancer research

authors： Winer I,Wang S,Lee YE,Fan W,Gong Y,Burgos-Ojeda D,Spahlinger G,Kopelman R,Buckanovich RJ

更新日期：2010-11-01 00:00:00

abstract：:Defects in antitumor immune responses have been associated with increased release of prostaglandin E(2) (PGE(2)) as a result of overexpression of cyclooxygenase (COX)-2 by tumors. In this report, we examine the effects of PGE(2) on antitumor CD8(+) T-cell responses generated both by cross-presenting dendritic cells an...

journal_title：Cancer research

authors： Ahmadi M,Emery DC,Morgan DJ

更新日期：2008-09-15 00:00:00

abstract：:The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase...

journal_title：Cancer research

authors： Schümann M,Dobbelstein M

更新日期：2006-02-01 00:00:00

abstract：:MTW9, a transplantable mammary tumor in Wistar Furth rats, shows little growth unless host serum prolactin is increased. This study compares the response to ovariectomy of MTW9-MtT, a tumor developed in rats bearing the mammosomatotropic tumor MtTW10 (serum prolactin 500 to 7000 ng/ml) with MTW9-P developed in rats gi...

journal_title：Cancer research

authors： Diamond EJ,Koprak S,Shen SK,Hollander VP

更新日期：1976-01-01 00:00:00

abstract：:Studies of V79-171 cells were undertaken to determine what extracellular or intracellular derivative of the drug WR-2721 is associated with radioprotection. The effect of preincubation at 23 +/- 1 degree C with WR-2721, and with derivatives of WR-2721 produced in medium containing alkaline phosphatase, upon survival o...

journal_title：Cancer research

authors： Smoluk GD,Fahey RC,Calabro-Jones PM,Aguilera JA,Ward JF

更新日期：1988-07-01 00:00:00

abstract：:This work confirms the previous observation that a single application of N-hydroxy-2-fluorenylacetamide or N-hydroxy-3-fluorenylacetamide to the mammary gland of the rat induced a high incidence of tumors, whereas the corresponding arylamides, N-2-fluorenylacetamide (2-FAA) and N-3-fluorenylacetamide, were only weakly...

journal_title：Cancer research

authors： Malejka-Giganti D,Rydell RE,Gutmann HR

更新日期：1977-01-01 00:00:00

abstract：:Meningiomas are common tumors, representing 15% to 25% of all central nervous system tumors. NF2 gene inactivation on chromosome 22 has been shown as an early event in tumorigenesis; however, few factors underlying tumor growth and progression have been identified. The chromosomal abnormalities of 14q32 are often asso...

journal_title：Cancer research

authors： Zhang X,Gejman R,Mahta A,Zhong Y,Rice KA,Zhou Y,Cheunsuchon P,Louis DN,Klibanski A

更新日期：2010-03-15 00:00:00

abstract：:In the first Phase I clinical trials of endostatin as an antiangiogenic therapy for cancer, the protein was administered as an i.v. bolus for approximately 20-30 min each day. This protocol was based on experimental studies in which animals were treated by s.c. bolus once a day. However, it was not clear in the previo...

journal_title：Cancer research

authors： Kisker O,Becker CM,Prox D,Fannon M,D'Amato R,Flynn E,Fogler WE,Sim BK,Allred EN,Pirie-Shepherd SR,Folkman J

更新日期：2001-10-15 00:00:00

abstract：:Constitutively photomorphogenic 1 (COP1), a RING finger ubiquitin ligase with substrates including c-Jun and p53, was recently found to be overexpressed in a number of breast and ovarian tumor samples. In addition to its E3 activity, COP1 was also shown to be able to inhibit activator protein 1 (AP-1) transcription. T...

journal_title：Cancer research

authors： Yi C,Li S,Chen X,Wiemer EA,Wang J,Wei N,Deng XW

更新日期：2005-07-01 00:00:00

abstract：:The ability of polyribosomes, obtained from several bacterial species, to suppress the development of cutaneous SaD2 fibrosarcomas in DBA/2 mice were evaluated. Suppression of tumor appearance depended upon the tumor load at the time of treatment, dose of polyribosomes, and species source of polyribosomes, with Serrat...

journal_title：Cancer research

authors： Urban RW,Edwards BS,Segal W

更新日期：1980-05-01 00:00:00

abstract：:The MAGE-1 gene codes for a tumor-specific antigen, MZ2-E, that elicited a cytotoxic T-lymphocyte response in the melanoma patient from whom it was derived. We have developed a simplified method, using polymerase chain reaction amplification of exon 3 followed by restriction enzyme pattern analysis, to distinguish exp...

journal_title：Cancer research

authors： Zakut R,Topalian SL,Kawakami Y,Mancini M,Eliyahu S,Rosenberg SA

更新日期：1993-01-01 00:00:00

abstract：:Recombinant immunotoxins (RIT) have been highly successful in cancer therapy due, in part, to the high cancer-specific expression of cell surface antigens such as mesothelin, which is overexpressed in mesothelioma, ovarian, lung, breast, and pancreatic cancers, but is limited in normal cells. RG7787 is a clinically op...

journal_title：Cancer research

authors： Ali-Rahmani F,FitzGerald DJ,Martin S,Patel P,Prunotto M,Ormanoglu P,Thomas C,Pastan I

更新日期：2016-03-15 00:00:00

abstract：:The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes. The secreted lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX). Unexpectedly, the tumor suppressor activity map...

journal_title：Cancer research

authors： Min C,Yu Z,Kirsch KH,Zhao Y,Vora SR,Trackman PC,Spicer DB,Rosenberg L,Palmer JR,Sonenshein GE

更新日期：2009-08-15 00:00:00

abstract：:Metastatic prostate cancer continues to pose a difficult therapeutic challenge. Prostate cancer progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events is uncertain. Here we report spontaneous metastasis of human prostate cancer xenografts that...

journal_title：Cancer research

authors： Tsai CH,Tzeng SF,Chao TK,Tsai CY,Yang YC,Lee MT,Hwang JJ,Chou YC,Tsai MH,Cha TL,Hsiao PW

更新日期：2016-10-01 00:00:00

abstract：:The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new appro...

journal_title：Cancer research

authors： Gillet L,Dewals B,Farnir F,de Leval L,Vanderplasschen A

更新日期：2005-10-15 00:00:00

abstract：:Exposure of tumor cells to cytotoxic agents simultaneously activates a variety of intracellular signaling pathways. Some of these pathways involve enzymes from the protein kinase C (PKC) family of serine/threonine kinases. This family includes isoenzymes that negatively influence cell death, whereas other demonstrate ...

journal_title：Cancer research

authors： Filomenko R,Poirson-Bichat F,Billerey C,Belon JP,Garrido C,Solary E,Bettaieb A

更新日期：2002-03-15 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with immunoblastic B-cell lymphomas in immunosuppressed or human immunodeficiency virus-infected individuals and in SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors. The risk of tumors appearing in the hu-PBL-SCID...

journal_title：Cancer research

authors： Mosier DE,Picchio GR,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-10-01 00:00:00

abstract：:In vivo experiments performed with NIH (nu/nu, bg/bg, xid/xid) triple immunodeficient (TD) mice revealed the striking ability of i.v. injected B16-F1 and B16-F10 murine melanoma cells to colonize not only the lungs but also the liver of TD mice. Subsequently, B16 melanoma cell cultures, which express very low levels o...

journal_title：Cancer research

authors： Calorini L,Marozzi A,Byers HR,Waneck GL,Lee KW,Isselbacher KJ,Gattoni-Celli S

更新日期：1992-07-15 00:00:00

abstract：:The N-glucuronidation of three carcinogenic aromatic amines (4-aminobiphenyl, alpha-naphthylamine, and beta-naphthylamine) was investigated in hepatic microsomal preparations from two rat strains. In preparations from Wistar rats, individual variability was observed for the glucuronidation of the arylamines. This vari...

journal_title：Cancer research

authors： Green MD,Tephly TR

更新日期：1987-04-15 00:00:00

abstract：:One limitation of autologous bone marrow transplantation for patients with cancer has been the presence of tumor cells in the bone marrow. Methods to eliminate tumor cells while preserving hematopoietic stem cells have been sought. The present study was performed to analyze the in vitro effectiveness of light-activate...

journal_title：Cancer research

authors： Meagher RC,Rothman SA,Paul P,Koberna P,Willmer C,Baucco PA

更新日期：1989-07-01 00:00:00

abstract：:We have reported previously that the PTEN COOH-terminal 33 amino acids play a role in the maintenance of PTEN protein stability (Tolkacheva and Chan, Oncogene, 19: 680-689, 2000). By site-directed mutagenesis, we identified two threonine residues within this COOH-terminal region at codon 382 and 383 that may be target...

journal_title：Cancer research

authors： Tolkacheva T,Boddapati M,Sanfiz A,Tsuchida K,Kimmelman AC,Chan AM

更新日期：2001-07-01 00:00:00

abstract：:The p53 mutant 143Ala is a human temperature-sensitive mutant with two conformational states. To definitively determine whether the Fas signal transduction pathway and the function of the pathway are dependent on p53 status, we have established stable transfectants of p53 mutant 143Ala in two human cancer cell lines: ...

journal_title：Cancer research

authors： Li Y,Raffo AJ,Drew L,Mao Y,Tran A,Petrylak DP,Fine RL

更新日期：2003-04-01 00:00:00

abstract：:Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence dise...

journal_title：Cancer research

authors： Yu KD,Huang AJ,Fan L,Li WF,Shao ZM

更新日期：2012-01-15 00:00:00

abstract：:Peripheral lymphocytes from cancer patients receiving mitomycin C treatment were examined for cytogenetic effects. The treatment consisted of i.v. injections of mitomycin C at a dose of 4 mg given twice a week for 2 weeks. The lymphocytes were cultured in vitro for 72 hr with phytohemagglutinin and 5-bromodeoxyuridine...

journal_title：Cancer research

authors： Ohtsuru M,Ishii Y,Takai S,Higashi H,Kosaki G

更新日期：1980-02-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:Antivascular therapy directed against VEGF or its receptors (VEGFR) has been successful when administered at early stages of tumor vessel growth but is less effective when administered later. Tumor blood vessels are heterogeneous, so vessel subpopulations may differ in their requirements for tumor cell-secreted VEGF a...

journal_title：Cancer research

authors： Sitohy B,Nagy JA,Jaminet SC,Dvorak HF

更新日期：2011-11-15 00:00:00

abstract：:Potent luteinizing hormone-releasing hormone analogues are known to cause regression of hormone-dependent mammary tumors. We have observed that high and long-lasting serum levels of a potent luteinizing hormone-releasing hormone analogue [desglycyl10-(D-leucyl6) luteinizing hormone-releasing hormone ethylamide, leupro...

journal_title：Cancer research

authors： Okada H,Sakura Y,Kawaji H,Yashiki T,Mima H

更新日期：1983-04-01 00:00:00

abstract：:Patients receiving cytotoxic drugs are at an increased risk of bacterial infection. Drug-induced leukopenia may be responsible for depression of host defenses; however, there is little information concerning the qualitative effects, if any, of cytotoxic agents on granulocyte antibacterial activity. Since methotrexate ...

journal_title：Cancer research

authors： Hyams JS,Donaldson MH,Metcalf JA,Root RK

更新日期：1978-03-01 00:00:00

abstract：:Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer ...

journal_title：Cancer research

authors： Akagi I,Okayama H,Schetter AJ,Robles AI,Kohno T,Bowman ED,Kazandjian D,Welsh JA,Oue N,Saito M,Miyashita M,Uchida E,Takizawa T,Takenoshita S,Skaug V,Mollerup S,Haugen A,Yokota J,Harris CC

更新日期：2013-07-01 00:00:00