MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis.

abstract：:In this study we describe the establishment of a leukemic cell line (BNML-CL/ara-C), originating from the 1-beta-D-arabinofuranosylcytosine (ara-C)-resistant brown Norway rat myelocytic leukemia model (BNML/ara-C), that retains the in vivo generated ara-C resistance. Its biological and biochemical characteristics have...

journal_title：Cancer research

authors： Richel DJ,Colly LP,Arkesteijn GJ,Arentsen-Honders MW,Kerster MG,ter Riet PM,Willemze R

更新日期：1990-10-15 00:00:00

abstract：:The influence of phorbol diesters on the in vitro hydrolysis of diacylglycerols was examined using enzymes from rat serum, porcine pancreas, and Rhizopus delemar. Two main phenomena were observed: 12-O-tetradecanoylphorbol-13-acetate (TPA), when added to the enzyme assay system, stimulated 2- to 3-fold the hydrolysis ...

journal_title：Cancer research

authors： Zhang ZC,Cabot MC

更新日期：1987-01-01 00:00:00

abstract：:Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates that activation of the Wnt/β-catenin pathway contributes to the devel...

journal_title：Cancer research

authors： Li L,Sheng Y,Li W,Hu C,Mittal N,Tohyama K,Seba A,Zhao YY,Ozer H,Zhu T,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:More than 70% of patients survive childhood cancer, but chemotherapy and radiation therapy may cause irreversible impairment of spermatogenesis. To treat infertility secondary to anticancer treatment for childhood cancer, we have developed a procedure to isolate germ cells from leukemic mice by fluorescence-activated ...

journal_title：Cancer research

authors： Fujita K,Tsujimura A,Miyagawa Y,Kiuchi H,Matsuoka Y,Takao T,Takada S,Nonomura N,Okuyama A

更新日期：2006-12-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP), also called ABCG2, confers resistance to anticancer agents such as 7-ethyl-10-hydroxycamptothecin (SN-38), mitoxantrone, and topotecan. We found previously that sulfated estrogens are physiologic substrates of BCRP. Flavonoids with weak estrogenic activities are called phytoest...

journal_title：Cancer research

authors： Imai Y,Tsukahara S,Asada S,Sugimoto Y

更新日期：2004-06-15 00:00:00

abstract：:Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R-CH2-R'), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human em...

journal_title：Cancer research

authors： Feldman MY,Balabanova H,Bachrach U,Pyshnov M

更新日期：1977-02-01 00:00:00

abstract：:B7 coregulatory ligands can be aberrantly expressed in human disease. In the context of cancer, these ligands may act as antigen-specific inhibitors of T-cell-mediated antitumoral immunity. We recently reported that B7-H1 expression by carcinomas of the kidney and bladder portends aggressive disease and diminished sur...

journal_title：Cancer research

authors： Roth TJ,Sheinin Y,Lohse CM,Kuntz SM,Frigola X,Inman BA,Krambeck AE,McKenney ME,Karnes RJ,Blute ML,Cheville JC,Sebo TJ,Kwon ED

更新日期：2007-08-15 00:00:00

abstract：:Specific progesterone binding by cultured human breast carcinoma T47D, MCF-7, and ZR75-1 cells was decreased 25-40% by epidermal growth factor (EGF), with a 50% effective dose of 0.1 nM EGF. Studies with the soluble and particulate fractions prepared after homogenization of T47D cells grown in glass roller bottles rev...

journal_title：Cancer research

authors： Sarup JC,Rao KV,Fox CF

更新日期：1988-09-15 00:00:00

abstract：:RS7, a murine IgG1 antibody raised against human lung carcinoma, possesses pancarcinoma reactivity. The antigen defined by this antibody is present in tumors of the lung, stomach, bladder, breast, ovary, uterus, and prostate. Efficient targeting and therapy by radiolabeled RS7 has been demonstrated previously in anima...

journal_title：Cancer research

authors： Shih LB,Xuan H,Aninipot R,Stein R,Goldenberg DM

更新日期：1995-12-01 00:00:00

abstract：:Bifunctional alkylating agents are known to produce cross-links between DNA and protein and between paired DNA strands. The possibility of discriminating these two classes of cross-links in L1210 cells treated with haloethylnitrosoureas or nitrogen mustard was explored with the alkaline elution technique. Two classes ...

journal_title：Cancer research

authors： Ewig RA,Kohn KW

更新日期：1978-10-01 00:00:00

abstract：:The major transmission route for Kaposi sarcoma-associated herpesvirus (KSHV) infection is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in HIV-positive individuals and is often the first presenting sign of AIDS. However, the oral target cells for KSHV infection and the cellu...

journal_title：Cancer research

authors： Li Y,Zhong C,Liu D,Yu W,Chen W,Wang Y,Shi S,Yuan Y

更新日期：2018-01-01 00:00:00

abstract：:Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and express...

journal_title：Cancer research

authors： Ono M,Handa K,Withers DA,Hakomori S

更新日期：1999-05-15 00:00:00

abstract：:Exposure of HeLa cells to 0.2 mM O6-methylguanine for 4 h or longer led to a 70-80% loss in the activity of the DNA-repair protein, O6-alkylguanine-DNA alkyltransferase. The decline in alkyltransferase activity brought about by O6-methylguanine was reversible on removing the base but at least 48 h were required for co...

journal_title：Cancer research

authors： Dolan ME,Morimoto K,Pegg AE

更新日期：1985-12-01 00:00:00

abstract：:Cell adhesion and spreading is a crucial step in the metastatic cascade of cancer cells, and interruption of this step is considered to be a logical strategy for prevention and treatment of tumor metastasis. Emodin is the major active component of the rhizome of Rheum palmatum L., with known anticancer activities. Her...

journal_title：Cancer research

authors： Huang Q,Shen HM,Shui G,Wenk MR,Ong CN

更新日期：2006-06-01 00:00:00

abstract：:A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to G...

journal_title：Cancer research

authors： Sweeney C,McClure GY,Fares MY,Stone A,Coles BF,Thompson PA,Korourian S,Hutchins LF,Kadlubar FF,Ambrosone CB

更新日期：2000-10-15 00:00:00

abstract：:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear c...

journal_title：Cancer research

authors： Ichinose Y,Yagawa K,Kaku M,Hara N,Ohta M

更新日期：1985-09-01 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:Defects in antitumor immune responses have been associated with increased release of prostaglandin E(2) (PGE(2)) as a result of overexpression of cyclooxygenase (COX)-2 by tumors. In this report, we examine the effects of PGE(2) on antitumor CD8(+) T-cell responses generated both by cross-presenting dendritic cells an...

journal_title：Cancer research

authors： Ahmadi M,Emery DC,Morgan DJ

更新日期：2008-09-15 00:00:00

abstract：:Sera from 91 adult acute nonlymphocytic leukemia patients were tested for circulating immune complexes by the C1q binding test. In 42 patients tested prior to the initiation of therapy, C1q binding activity was inversely correlated with leukemic infiltrate of the bone marrow (rs = -0.34, p less than 0.02), but it was ...

journal_title：Cancer research

authors： Crane MM,Rossen RD,McCredie KB,Trujillo JM

更新日期：1984-07-01 00:00:00

abstract：:Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a)...

journal_title：Cancer research

authors： Yasuda M,Takenoyama M,Obata Y,Sugaya M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2002-03-15 00:00:00

abstract：:The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced me...

journal_title：Cancer research

authors： Kodama M,Kodama T

更新日期：1975-04-01 00:00:00

abstract：:Cancer in a host induces responses that increase the ability of the microenvironment to sustain the growing mass, for example, angiogenesis, but cancer cells can have varying sensitivities to these sustainability signals. Here, we show that these sensitivities are significant determinants of ultimate tumor fate, espec...

journal_title：Cancer research

authors： Wilkie KP,Hahnfeldt P

更新日期：2013-06-15 00:00:00

abstract：:This report describes an early and direct action of oncogenic agents and its apparent consequences. Chemical carcinogen has been found to interact principally with a specific polypeptide in livers of normal rats. Short-term ingestion of carcinogen causes marked reductions in the concentrations of both the carcinogen:p...

journal_title：Cancer research

authors： Blackburn GR,Andrews JP,Rao KV,Sorof S

更新日期：1980-12-01 00:00:00

abstract：:Development of novel approaches for quantitative analysis of gene expression in intact tumor cells should provide new means for cancer detection and for studying the response of cancer cells to biological and therapeutic reagents. We developed procedures for detecting the levels of expression of multiple genes in fixe...

journal_title：Cancer research

authors： Peng XH,Cao ZH,Xia JT,Carlson GW,Lewis MM,Wood WC,Yang L

更新日期：2005-03-01 00:00:00

abstract：:The Notch ligand delta-like 4 (Dll4) has been identified as a promising target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers. In this study, we report the development of REGN421 (enoticumab), a fully human IgG1 monocl...

journal_title：Cancer research

authors： Kuhnert F,Chen G,Coetzee S,Thambi N,Hickey C,Shan J,Kovalenko P,Noguera-Troise I,Smith E,Fairhurst J,Andreev J,Kirshner JR,Papadopoulos N,Thurston G

更新日期：2015-10-01 00:00:00

abstract：:An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparentl...

journal_title：Cancer research

authors： Bast RC Jr,Okuda T,Plotkin E,Tarone R,Rapp HJ,Gelboin HV

更新日期：1976-06-01 00:00:00

abstract：:Nervous system tumors represent unique neoplasms that arise within the central and peripheral nervous system. Recent progress in generating genetically engineered mouse models of these tumors has advanced our understanding of the critical molecular and cellular events important for the development of these tumors. Rec...

journal_title：Cancer research

authors： Gutmann DH,Baker SJ,Giovannini M,Garbow J,Weiss W

更新日期：2003-06-01 00:00:00

abstract：:KAI1 (CD82) belongs to the transmembrane 4 superfamily in which members have inhibitory effects on tumor cell motility and metastasis. During reverse transcription-PCR analysis, we found a splice variant of KAI1 (spliced-KAI1) in which exon 7 was deleted. This exon encodes the 28 amino acids that span from the distal ...

journal_title：Cancer research

authors： Lee JH,Seo YW,Park SR,Kim YJ,Kim KK

更新日期：2003-11-01 00:00:00

abstract：:The cytotoxic activity against human tumor cells of toxic conjugates of Pseudomonas exotoxin with anti-transferrin receptor antibody or epidermal growth factor was potentiated up to 10 to 20-fold by the calcium antagonists verapamil, D-600, and diltiazem and by the lysosomotropic agent beta-glycylphenyl-naphthylamide....

journal_title：Cancer research

authors： Akiyama S,Seth P,Pirker R,FitzGerald D,Gottesman MM,Pastan I

更新日期：1985-03-01 00:00:00

abstract：:The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 +ve) and DU145 (CD44 -ve) and four breast cancer cell lines was confi...

journal_title：Cancer research

authors： Draffin JE,McFarlane S,Hill A,Johnston PG,Waugh DJ

更新日期：2004-08-15 00:00:00