B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy.

abstract：:Spheroids derived from the human bladder cancer cell line MGH-U1 were initiated in spinner culture and then transferred to multiwell plates which contained medium with varying concentrations of glucose and pyruvate. Growth of individual spheroids was monitored, and at different times after transfer spheroids were sect...

journal_title：Cancer research

authors： Tannock IF,Kopelyan I

更新日期：1986-06-01 00:00:00

abstract：:This study examined the association between 17p allelic loss and p53 gene mutation in a series of 16 esophageal adenocarcinomas arising on a background of Barrett's esophagus. Two highly polymorphic dinucleotide repeat polymorphisms mapping to 17p13 were analyzed to assess the frequency of 17p allelic loss in these tu...

journal_title：Cancer research

authors： Gleeson CM,Sloan JM,McGuigan JA,Ritchie AJ,Russell SE

更新日期：1995-08-01 00:00:00

abstract：:To investigate the mechanisms underlying contraction of the stomach wall in cases of gastric scirrhous carcinoma, we have developed an in vitro model for gastric cancer, in which both fibroblasts and gastric carcinoma cells are embedded within a collagen matrix. Gastric carcinoma cells of the scirrhous type (KATO-III)...

journal_title：Cancer research

authors： Ura H,Obara T,Yokota K,Shibata Y,Okamura K,Namiki M

更新日期：1991-07-01 00:00:00

abstract：:A cascade of events leading to hypertrophy has been proposed and implicated in growth regulation in a variety of normal and neoplastic cells and tissues. There is a tightly coupled temporal sequence: (a) cyclic adenosine 3':5'-monophosphate-dependent protein kinase (cAPK) activation; (b) ornithine decarboxylase (ODC) ...

journal_title：Cancer research

authors： Olson JW,Russell DH

更新日期：1980-12-01 00:00:00

abstract：:Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 l...

journal_title：Cancer research

authors： Bae E,Sato M,Kim RJ,Kwak MK,Naka K,Gim J,Kadota M,Tang B,Flanders KC,Kim TA,Leem SH,Park T,Liu F,Wakefield LM,Kim SJ,Ooshima A

更新日期：2014-11-01 00:00:00

abstract：:Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy number gain of TTPAL leads to gene overexpression in colorectal canc...

journal_title：Cancer research

authors： Gou H,Liang JQ,Zhang L,Chen H,Zhang Y,Li R,Wang X,Ji J,Tong JH,To KF,Sung JJY,Chan FKL,Fang JY,Yu J

更新日期：2019-07-01 00:00:00

abstract：:A method for the preparation of biologically active [3H]- and [13C]bleomycin A2 is described. Demethyl Cu(II):bleomycin A2, isolated after pyrolysis of Cu(II):bleomycin A2, was methylated with either [3H]-or [13C]methyl iodide, which resulted in Cu(II):bleomycin A2 labeled in the dimethylsulfonium moiety. Copper was r...

journal_title：Cancer research

authors： Roy SN,Orr GA,Brewer CF,Horwitz SB

更新日期：1981-11-01 00:00:00

abstract：:HL60 cells, human promyelocytic leukemia cells, can be induced to differentiate into more mature myeloid forms by dimethyl sulfoxide (DMSO) or retinoic acid (RA) and into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) or related compounds. Macrophage differentiation of HL60 cells by TPA treatment ...

journal_title：Cancer research

authors： Hirai H,Murakami T,Urabe A,Takaku F

更新日期：1985-06-01 00:00:00

abstract：:We evaluated the usefulness of L-dopa decarboxylase (DDC) as a tumor marker of neuroendocrine (NE) cell differentiation by measuring its expression in 432 human tumors of diverse types and origins. A subset of these tumors and cell lines derived from them also were studied for expression of two other general NE cell m...

journal_title：Cancer research

authors： Gazdar AF,Helman LJ,Israel MA,Russell EK,Linnoila RI,Mulshine JL,Schuller HM,Park JG

更新日期：1988-07-15 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:Glycosylation, a posttranslational modification, has a major role in recombinant anticancer therapeutic proteins, as most of the approved recombinant therapeutics are glycoproteins. The constant amino acid sequence of therapeutics determines the enzymatic activity, while the presence of glycans influences their pharma...

journal_title：Cancer research

authors： Nadeem T,Khan MA,Ijaz B,Ahmed N,Rahman ZU,Latif MS,Ali Q,Rana MA

更新日期：2018-06-01 00:00:00

abstract：:Colon carcinoma cells overexpress c-myc due to defective Wnt signaling, but only patients whose tumors have an amplified c-myc gene show improved disease-free and overall survival in response to 5-fluoruracil (5FU). Here we show that in two colon carcinoma cell lines that do not have an amplified c-myc gene but differ...

journal_title：Cancer research

authors： Arango D,Corner GA,Wadler S,Catalano PJ,Augenlicht LH

更新日期：2001-06-15 00:00:00

abstract：:Heregulin (HRG) is a member of the neuregulin family of ligands that have been shown to interact with and activate erbB receptors. A transgenic mouse model in which full-length HRG is overexpressed has proven that this protein can induce carcinomas in the murine mammary gland. These tumors display a high level of apop...

journal_title：Cancer research

authors： Weinstein EJ,Leder P

更新日期：2000-07-15 00:00:00

abstract：:Lipoblastomas are pediatric neoplasms resulting from transformation of adipocytes. These benign tumors are typically composed of adipose cells in different stages of maturation within a variably myxoid matrix, and they contain clonal rearrangements of chromosome band 8q12. Because lipoblastomas resemble embryonic adip...

journal_title：Cancer research

authors： Hibbard MK,Kozakewich HP,Dal Cin P,Sciot R,Tan X,Xiao S,Fletcher JA

更新日期：2000-09-01 00:00:00

abstract：:p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, an...

journal_title：Cancer research

authors： Jackson RJ,Engelman RW,Coppola D,Cantor AB,Wharton W,Pledger WJ

更新日期：2003-06-15 00:00:00

abstract：:Barrett's esophagus, a columnar metaplasia of the lower esophagus epithelium related to gastroesophageal reflux disease, is the strongest known risk factor for the development of esophageal adenocarcinoma (EAC). Understanding the signal transduction events involved in esophageal epithelium carcinogenesis may provide i...

journal_title：Cancer research

authors： Yen CJ,Izzo JG,Lee DF,Guha S,Wei Y,Wu TT,Chen CT,Kuo HP,Hsu JM,Sun HL,Chou CK,Buttar NS,Wang KK,Huang P,Ajani J,Hung MC

更新日期：2008-04-15 00:00:00

abstract：:Protein kinase C delta (PKCdelta), a Ca(2+)-independent, phospholipid-dependent serine/threonine kinase, is among the novel PKCs (delta, epsilon, and eta) expressed in mouse epidermis. We reported that FVB/N transgenic mice that overexpress ( approximately 8-fold) PKCdelta protein in basal epidermal cells and cells of...

journal_title：Cancer research

authors： Aziz MH,Wheeler DL,Bhamb B,Verma AK

更新日期：2006-01-15 00:00:00

abstract：:Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). To investigate the possible mechanisms of FLC tumor inhibition in the liver of interferon-treated mice, we developed an in vitro m...

journal_title：Cancer research

authors： Yasui H,Proietti E,Vignaux F,Eid P,Gresser I

更新日期：1990-06-15 00:00:00

abstract：:Cellular immune competence was found to be impaired in previous studies of patients with malignant brain tumors. In patients with nonneural tumors, we recently found that serum levels of acute-phase proteins were related to immune status as well as to tumor extent. To determine whether the serum proteins in patients w...

journal_title：Cancer research

authors： Weiss JF,Morantz RA,Bradley WP,Chretien PB

更新日期：1979-02-01 00:00:00

abstract：:Fibroblast growth factor (FGF) 8, also known as androgen-induced growth factor, was originally isolated from an androgen-dependent mouse mammary Shionogi carcinoma SC-3 cell line, in which it was shown to have androgen-regulated properties. We previously demonstrated that Fgf 8 transcripts were detected in several hum...

journal_title：Cancer research

authors： Tanaka A,Furuya A,Yamasaki M,Hanai N,Kuriki K,Kamiakito T,Kobayashi Y,Yoshida H,Koike M,Fukayama M

更新日期：1998-05-15 00:00:00

abstract：:Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with can...

journal_title：Cancer research

authors： Siolas D,Hannon GJ

更新日期：2013-09-01 00:00:00

abstract：:The peroxiredoxins (Prx) are conserved antioxidant proteins that use cysteine as the primary site of oxidation during the reduction of peroxides. Many organisms have more than one isoform of Prx. Deletion of TSA1, one of five Prxs in yeast Saccharomyces cerevisiae, results in accumulation of a broad spectrum of mutati...

journal_title：Cancer research

authors： Iraqui I,Faye G,Ragu S,Masurel-Heneman A,Kolodner RD,Huang ME

更新日期：2008-02-15 00:00:00

abstract：:We report that tumor necrosis factor (TNF) alpha induced a strong antitumor immune reaction when it was produced in arteries leading to tumors by gene transfer in vivo. We used a mouse model carrying a sarcoma-180 tumor in the right footpad and injected the fusogenic liposomes encapsulating the human TNF-alpha gene in...

journal_title：Cancer research

authors： Mizuguchi H,Nakagawa T,Toyosawa S,Nakanishi M,Imazu S,Nakanishi T,Tsutsumi Y,Nakagawa S,Hayakawa T,Ijuhin N,Mayumi T

更新日期：1998-12-15 00:00:00

abstract：:We generated DNA expression vectors encoding the full-length neu cDNA (designated pNeuN), the neu extracellular domain (pNeuE), or the neu extracellular and transmembrane domains (pNeuTM). The 293 cells transfected with pNeuN or pNeuTM expressed the neu extracellular domain on the surface membrane, whereas 293 cells t...

journal_title：Cancer research

authors： Chen Y,Hu D,Eling DJ,Robbins J,Kipps TJ

更新日期：1998-05-01 00:00:00

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:It is widely accepted that a major role of matrix metalloproteinases in the metastatic process is degradation of basement membrane during cancer cell invasion. We tested the hypothesis that the reduction in metastatic potential which has been demonstrated for B16F10 melanoma cells genetically engineered to overexpress...

journal_title：Cancer research

authors： Koop S,Khokha R,Schmidt EE,MacDonald IC,Morris VL,Chambers AF,Groom AC

更新日期：1994-09-01 00:00:00

abstract：:The major goal of epigenetic therapy is to reverse aberrant promoter hypermethylation and restore normal function of tumor suppressor genes by the use of chromatin-modifying drugs. Decitabine, or 5-aza-2'-deoxycytidine (5-aza-CdR), is a well-characterized drug that is now Food and Drug Administration approved for the ...

journal_title：Cancer research

authors： Yoo CB,Jeong S,Egger G,Liang G,Phiasivongsa P,Tang C,Redkar S,Jones PA

更新日期：2007-07-01 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00