Abstract:
:The discovery of Epstein-Barr virus (EBV) in 1964 gave birth to the field of viral oncology. Despite significant scientific and clinical developments in research on several other viruses discovered and linked to cancer risk much later, our understanding of EBV as a carcinogen and a possible target for therapeutic interventions remains limited. In this issue of Cancer Research, Chakravorty and colleagues present results of massive reanalysis of public RNA-sequencing data for 291 control and 1,051 tumor samples representing 15 cancer types. Their paired analysis of the viral and host transcriptome sheds light on mechanisms of EBV carcinogenicity and provides new leads for translational applications.See related article by Chakravorty et al., p. 6010.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Mbulaiteye SM,Prokunina-Olsson Ldoi
10.1158/0008-5472.CAN-19-2996subject
Has Abstractpub_date
2019-12-01 00:00:00pages
5917-5919issue
23eissn
0008-5472issn
1538-7445pii
79/23/5917journal_volume
79pub_type
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