Abstract：
:The early detection of prostate cancer is a life-saving event in patients harboring potentially aggressive disease. With the development of malignancy, there is a dramatic reduction in the zinc content of prostate tissue associated with the inability of cancer cells to accumulate the ion. In the current study, we used endogenous zinc as an imaging biomarker for prostate cancer detection and progression monitoring. We employed a novel fluorescent sensor for mobile zinc (ZPP1) to detect and monitor the development of prostate cancer in a transgenic mouse model of prostate adenocarcinoma, using in vivo optical imaging correlated with biological fluid-based methods. We showed that the progression of prostate cancer could be monitored in vivo judging by the decreasing zinc content in the prostates of tumor-bearing mice in an age-dependent manner. In a novel quantitative assay, we determined the concentration of mobile zinc in both prostate cell lysates and mouse prostate extracts through simple titration of the ZPP1 sensor. Our findings fulfill the promise of zinc-based prostate cancer diagnostics with the prospect for immediate clinical translation.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Ghosh SK,Kim P,Zhang XA,Yun SH,Moore A,Lippard SJ,Medarova Zdoi
10.1158/0008-5472.CAN-10-1008subject
Has Abstractpub_date
2010-08-01 00:00:00pages
6119-27issue
15eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-10-1008journal_volume
70pub_type
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