Identification and fine mapping of a region showing a high frequency of allelic imbalance on chromosome 16q23.2 that corresponds to a prostate cancer susceptibility locus.

abstract：:E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell matrix adhesion receptors. We show here that inhibition of E-cadheri...

journal_title：Cancer research

authors： Sawada K,Mitra AK,Radjabi AR,Bhaskar V,Kistner EO,Tretiakova M,Jagadeeswaran S,Montag A,Becker A,Kenny HA,Peter ME,Ramakrishnan V,Yamada SD,Lengyel E

更新日期：2008-04-01 00:00:00

abstract：:Caveolin-1 is an integral protein of caveolae, known to play important roles in signal transduction and lipid transport. We demonstrate that caveolin-1 expression is significantly increased in primary and metastatic human prostate cancer after androgen ablation therapy. We also show that caveolin-1 is secreted by andr...

journal_title：Cancer research

authors： Tahir SA,Yang G,Ebara S,Timme TL,Satoh T,Li L,Goltsov A,Ittmann M,Morrisett JD,Thompson TC

更新日期：2001-05-15 00:00:00

abstract：:A quantitative assessment of rate-limiting steps in metastasis has always been challenging because of the difficulty of detecting small tumor cell populations. We have developed a highly sensitive assay for monitoring the metastatic dissemination of human tumor cells in the chick embryo and used this assay to investig...

journal_title：Cancer research

authors： Zijlstra A,Mellor R,Panzarella G,Aimes RT,Hooper JD,Marchenko ND,Quigley JP

更新日期：2002-12-01 00:00:00

abstract：:TER286 is a latent drug activated by human glutathione S-transferase (GST) isoforms P1-1 and A1-1 to produce a nitrogen mustard alkylating agent. M7609 human colon carcinoma, selected for resistance to doxorubicin, and MCF-7 human breast carcinoma, selected for resistance to cyclophosphamide, both showed increased sen...

journal_title：Cancer research

authors： Morgan AS,Sanderson PE,Borch RF,Tew KD,Niitsu Y,Takayama T,Von Hoff DD,Izbicka E,Mangold G,Paul C,Broberg U,Mannervik B,Henner WD,Kauvar LM

更新日期：1998-06-15 00:00:00

abstract：:The growth and survival of many types of cancer cells are known to be supported by specific growth factor/cytokine systems. Among these, the activation of c-kit receptor and its ligand steel factor participates in several types of human carcinogenesis. W mutations of laboratory mouse strains are loss of functional mut...

journal_title：Cancer research

authors： Li Q,Kondoh G,Inafuku S,Nishimune Y,Hakura A

更新日期：1996-10-01 00:00:00

abstract：:Chemokines play the key role in initiating immune responses by regulating the attraction and homing of immune cells to the lymphoid and nonlymphoid tissues. CXCL14 is a chemokine that in tumors may act as chemoattractant for monocytes and dendritic cells (DC), which may modulate antitumor immune responses in certain c...

journal_title：Cancer research

authors： Song EY,Shurin MR,Tourkova IL,Gutkin DW,Shurin GV

更新日期：2010-06-01 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00

abstract：:Human peripheral blood lymphocytes (PBL), obtained from patients with a variety of cancers, were incubated in vitro with phytohemagglutinin, concanavalin A, and crude or lectin-free T-cell growth factors. The lectin-activated PBL of nine patients were capable of lysing fresh autologous tumor during a 4-hr 51Cr release...

journal_title：Cancer research

authors： Mazumder A,Grimm EA,Zhang HZ,Rosenberg SA

更新日期：1982-03-01 00:00:00

abstract：:Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly understood. There is a significant clinical correlation between the expression of bone sialoprotein (BSP) and skeletal ...

journal_title：Cancer research

authors： Barnes GL,Javed A,Waller SM,Kamal MH,Hebert KE,Hassan MQ,Bellahcene A,Van Wijnen AJ,Young MF,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2003-05-15 00:00:00

abstract：:Intestinal radiation injury is dose limiting during abdominal and pelvic radiotherapy and critical for the outcome after accidental whole-body radiation exposure. The multifunctional cytokine, interleukin-11 (IL-11), ameliorates the intestinal radiation response, but its clinical use is hampered by severe toxicity aft...

journal_title：Cancer research

authors： Boerma M,Wang J,Burnett AF,Santin AD,Roman JJ,Hauer-Jensen M

更新日期：2007-10-01 00:00:00

abstract：:We used somatic cell hybridization to determine whether the regressor phenotype exhibited by UV-induced murine tumors was dominant or recessive and whether this technique could confer immunogenic properties on nonimmunogenic syngeneic tumors. We transfected a highly antigenic UV-induced C3H mouse tumor cell line (UV-2...

journal_title：Cancer research

authors： Chen PW,Kaba DS,Ananthaswamy HN

更新日期：1990-03-01 00:00:00

abstract：:CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint. Although increased CDC25A expression has been reported in various human cancer tissues, it remains u...

journal_title：Cancer research

authors： Ray D,Terao Y,Nimbalkar D,Hirai H,Osmundson EC,Zou X,Franks R,Christov K,Kiyokawa H

更新日期：2007-07-15 00:00:00

abstract：:The simultaneous distribution of monoclonal 131I-labeled anti-carcinoembryonic antigen (CEA) immunoglobulin (IgG) (NP-2) or 131I-labeled irrelevant myeloma IgG (Ag8) and [3H]thymidine was studied in hamsters bearing transplants of the GW-39 human colon carcinoma by qualitative double-tracer whole-body autoradiography....

journal_title：Cancer research

authors： Fand I,Sharkey RM,Primus FJ,Cohen SA,Goldenberg DM

更新日期：1987-04-15 00:00:00

abstract：:The current study is a continuation of our previous work showing that bone marrow activated in interleukin 2 has antitumor and antiviral activity in vitro. The antitumor efficacy of IL-2-activated bone marrow cells in vivo was assessed here. Our results indicated that bone marrow cells activated in IL-2 for 3 days (AB...

journal_title：Cancer research

authors： Agah R,Malloy B,Kerner M,Girgis E,Bean P,Twomey P,Mazumder A

更新日期：1989-11-01 00:00:00

abstract：:The invasive transformation of A-459 lung epithelial carcinoma cells has been linked to the autocrine regulation of malignant phenotypic changes by transforming growth factor beta (TGF-beta). Here we demonstrate, using stable 13C glucose isotopes, that the transformed phenotype is characterized by decreased CO2 produc...

journal_title：Cancer research

authors： Boros LG,Torday JS,Lim S,Bassilian S,Cascante M,Lee WN

更新日期：2000-03-01 00:00:00

abstract：:It has been suggested that P-glycoprotein (P-gp), an ATP-dependent transporter responsible for classical multidrug resistance, is also a volume-regulated chloride channel. We reexamined this hypothesis by use of whole-cell patch clamp recordings of three matched pairs of cell lines, which were either drug-sensitive or...

journal_title：Cancer research

authors： Dong Y,Chen KG,Durán GE,Kouyama K,Chao AC,Sikic BI,Gollapudi SV,Gupta S,Gardner P

更新日期：1994-10-01 00:00:00

abstract：:In order to study whether cell fusion would modify the DNA copy number of an amplified oncogene, somatic cell hybrids were made between the human neuroepithelioma cell line MCIXC and HeLaCOT human adenocarcinoma cells. MCIXC contains approximately 21 copies of the c-myc oncogene and HeLaCOT contains approximately 5 co...

journal_title：Cancer research

authors： Iman DS,Shay JW

更新日期：1989-08-15 00:00:00

abstract：:Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1) is a member of the CEA family of immunoglobulin-like adhesion molecules with two major splice variants, CEACAM1(a)-4L and CEACAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail. Both forms are down-regulated in prostate a...

journal_title：Cancer research

authors： Laurie NA,Comegys MM,Carreiro MP,Brown JF,Flanagan DL,Brilliant KE,Hixson DC

更新日期：2005-12-01 00:00:00

abstract：:DNA-dependent RNA polymerase A (or 1) was purified from murine myeloma MOPC 21 by diethylaminoethyl Sephadex chromatography. Further separation from DNA polymerases, protein kinase and DNA endonuclease was accomplished by polyriboadenylate-Sepharose affinity chromatography followed by gradient centrifugation. Yields f...

journal_title：Cancer research

authors： Hall SH,Smuckler EA

更新日期：1976-03-01 00:00:00

abstract：:A metastatic renal cell carcinoma (RCC) tumor model xenograft that expresses the targetable, membrane-bound tumor-associated antigen carbonic anhydrase type 9 (CA IX) is described. The xenograft, established from a high-grade type-2 chromophil RCC (cRCC), has been serially transplanted in immune compromised mice, in w...

journal_title：Cancer research

authors： Zisman A,Pantuck AJ,Bui MH,Said JW,Caliliw RR,Rao N,Shintaku P,Berger F,Gambhir SS,Belldegrun AS

更新日期：2003-08-15 00:00:00

abstract：:Studies of V79-171 cells were undertaken to determine what extracellular or intracellular derivative of the drug WR-2721 is associated with radioprotection. The effect of preincubation at 23 +/- 1 degree C with WR-2721, and with derivatives of WR-2721 produced in medium containing alkaline phosphatase, upon survival o...

journal_title：Cancer research

authors： Smoluk GD,Fahey RC,Calabro-Jones PM,Aguilera JA,Ward JF

更新日期：1988-07-01 00:00:00

abstract：:We have used photoaffinity labeling to investigate the distribution and function of daunomycin binding sites in Sarcoma 180 cells. When native daunomycin is irradiated at 366 or 488 nm in the presence of cells, the drug is irreversibly incorporated into cellular molecules. The cellular acceptor for the photoincorporat...

journal_title：Cancer research

authors： Yee G,Carey M,Tritton TR

更新日期：1984-05-01 00:00:00

abstract：:The peptide N-formyl-Met-Leu-Phe stimulates chemotaxis and metastasis in rat Walker carcinosarcoma cells by a receptor-mediated pathway. Since oxygen radical generation follows chemotactic stimulation in leukocytes, we looked for similar responses in the Walker tumor. Upon incubation with 10(-6) M N-formyl-Met-Leu-Phe...

journal_title：Cancer research

authors： Leroyer V,Werner L,Shaughnessy S,Goddard GJ,Orr FW

更新日期：1987-09-15 00:00:00

abstract：:Mutations in the human adenomatous polyposis coli (APC) gene are responsible for not only familial adenomatous polyposis but also many sporadic cancers of the digestive tract. Using homologous recombination in embryonic stem cells, we recently constructed Apc gene knockout mice that contained a truncation mutation at ...

journal_title：Cancer research

authors： Oshima H,Oshima M,Kobayashi M,Tsutsumi M,Taketo MM

更新日期：1997-05-01 00:00:00

abstract：:R24 is an IgG3 mouse monoclonal antibody which recognizes the ganglioside GD3. Two variants of R24, in which one (V2-R24) or both (V1-R24) light chains were substituted by MOPC-21 light chains, were isolated and characterized. R24 had a 40-fold higher avidity for GD3 than either variant, suggesting that high avidity b...

journal_title：Cancer research

authors： Chapman PB,Lonberg M,Houghton AN

更新日期：1990-03-01 00:00:00

abstract：:Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival, and differentiation. Aberrant Notch activation has been linked to a variety of human neoplasms. Here, we show that Notch1 signaling drives the vertical growth phase (VGP) of primary melanoma toward a more aggress...

journal_title：Cancer research

authors： Liu ZJ,Xiao M,Balint K,Smalley KS,Brafford P,Qiu R,Pinnix CC,Li X,Herlyn M

更新日期：2006-04-15 00:00:00

abstract：:Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk ...

journal_title：Cancer research

authors： Richman EL,Kenfield SA,Stampfer MJ,Paciorek A,Carroll PR,Chan JM

更新日期：2011-06-01 00:00:00

abstract：:DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer. In this study, we elucidated an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase in...

journal_title：Cancer research

authors： Fang F,Cardenas H,Huang H,Jiang G,Perkins SM,Zhang C,Keer HN,Liu Y,Nephew KP,Matei D

更新日期：2018-02-01 00:00:00

abstract：:The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R i...

journal_title：Cancer research

authors： Girnita A,Girnita L,del Prete F,Bartolazzi A,Larsson O,Axelson M

更新日期：2004-01-01 00:00:00

abstract：:Neuronal pentraxins (NPTX) and their corresponding receptors (NPTXR) have been studied as synapse-associated proteins in the nervous system, but their role in cancer is largely unknown. By applying a multidisciplinary, high-throughput proteomic approach, we have recently identified a peptide ligand motif for targeted ...

journal_title：Cancer research

authors： Bartolini A,Di Paolo D,Noghero A,Murgia D,Sementa AR,Cilli M,Pasqualini R,Arap W,Bussolino F,Ponzoni M,Pastorino F,Marchiò S

更新日期：2015-10-15 00:00:00