Preclinical study of sequential tumor necrosis factor and interleukin 2 in the treatment of spontaneous canine neoplasms.

Abstract:

:Recombinant human tumor necrosis factor and recombinant human interleukin 2 were administered in a sequential schedule to 30 dogs with a variety of spontaneous neoplasms. Dose escalation of both drugs was performed, and a maximally tolerated dose of recombinant human tumor necrosis factor of 125 mg/m2 i.v. for 3 days, followed by 1.5 x 10(6) units/m2 of recombinant human interleukin 2 s.c. for 9 days, was derived. Dose-limiting toxicities were primarily gastrointestinal; however, weakness and malaise were seen during therapy at doses higher than the maximally tolerated dose. No clinically significant hematological toxicities were seen at any dose level. Objective tumor responses were seen in dogs with oral mucosal melanoma and cutaneous mastocytoma. Because of the histological, behavioral, and epidemiological similarities between human and canine tumor types, the canine cancer patient provides a unique model for the preclinical evaluation of recombinant cytokine therapy.

journal_name

Cancer Res

journal_title

Cancer research

authors

Moore AS,Theilen GH,Newell AD,Madewell BR,Rudolf AR

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

233-8

issue

1

eissn

0008-5472

issn

1538-7445

journal_volume

51

pub_type

杂志文章
  • Comparison of the structural and cytotoxic activity of novel 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone analogues.

    abstract::Eight analogues of 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone have been synthesized and tested for cytotoxicity against four different leukemic and lymphomic cell lines. For K562 and BSM cells, the toxicity could be correlated with the ease of reduction of the compounds as determined by the one-electr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Dzielendziak A,Butler J,Hoey BM,Lea JS,Ward TH

    更新日期:1990-04-01 00:00:00

  • Antitumor effects of a soluble insulin-like growth factor I receptor in human ovarian cancer cells: advantage of recombinant protein administration in vivo.

    abstract::Antitumor effects of a soluble form dominant negative of the type I insulin-like growth factor receptor (IGF-IR) designated as 486/STOP were evaluated in CaOV-3 human ovarian cancer cells by establishing stable transformants overexpressing 486/STOP and by administration of 486/STOP recombinant protein. Expression of 4...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hongo A,Kuramoto H,Nakamura Y,Hasegawa K,Nakamura K,Kodama J,Hiramatsu Y

    更新日期:2003-11-15 00:00:00

  • SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion.

    abstract::SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-5915

    authors: Wang H,Leav I,Ibaragi S,Wegner M,Hu GF,Lu ML,Balk SP,Yuan X

    更新日期:2008-03-15 00:00:00

  • The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.

    abstract::Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the possibly poor prognosis of the thin re...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Prehn RT

    更新日期:1996-03-01 00:00:00

  • Insulin-dependent leptin expression in breast cancer cells.

    abstract::Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-0642

    authors: Bartella V,Cascio S,Fiorio E,Auriemma A,Russo A,Surmacz E

    更新日期:2008-06-15 00:00:00

  • Physical activity after diagnosis and risk of prostate cancer progression: data from the cancer of the prostate strategic urologic research endeavor.

    abstract::Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-3932

    authors: Richman EL,Kenfield SA,Stampfer MJ,Paciorek A,Carroll PR,Chan JM

    更新日期:2011-06-01 00:00:00

  • Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration.

    abstract::Dendritic cells (DCs) are professional antigen-presenting cells, well equipped to initiate an immune response. Currently, tumor antigen-derived peptide loaded DCs are used in clinical vaccination in cancer patients. However, the optimal dose and route of administration of a DC vaccine still remain to be determined. Us...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Eggert AA,Schreurs MW,Boerman OC,Oyen WJ,de Boer AJ,Punt CJ,Figdor CG,Adema GJ

    更新日期:1999-07-15 00:00:00

  • Akt SUMOylation regulates cell proliferation and tumorigenesis.

    abstract::Proto-oncogene Akt plays essential roles in cell proliferation and tumorigenesis. Full activation of Akt is regulated by phosphorylation, ubiquitination, and acetylation. Here we report that SUMOylation of Akt is a novel mechanism for its activation. Systematically analyzing the role of lysine residues in Akt activati...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-0538

    authors: Li R,Wei J,Jiang C,Liu D,Deng L,Zhang K,Wang P

    更新日期:2013-09-15 00:00:00

  • Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth.

    abstract::Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-3455

    authors: Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

    更新日期:2015-01-01 00:00:00

  • Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.

    abstract::Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-17-1752

    authors: Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

    更新日期:2018-02-01 00:00:00

  • Semiautomated assessment of loss of heterozygosity and replication error in tumors.

    abstract::Loss of heterozygosity (LOH) and replication error (RER) are important phenomena in tumor development, with diagnostic and prognostic relevance. Therefore, screening for LOH and RER is a desirable first step in the molecular analysis of tumors. We used semiautomated procedures based on multicolor fluorescently labeled...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Canzian F,Salovaara R,Hemminki A,Kristo P,Chadwick RB,Aaltonen LA,de la Chapelle A

    更新日期:1996-07-15 00:00:00

  • Pharmacokinetic profile and metabolism of N-nitrosobutyl-(4-hydroxybutyl)amine in rats.

    abstract::N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

    更新日期:1988-07-01 00:00:00

  • Isolation of variant cells from SV-40 transformed human diploid fibroblasts.

    abstract::Variant cell lines that are sensitive to density-dependent inhibition of growth have been isolated from three of four SV40-transformed human fibroblast cell lines. Variants were isolated by plating the transformed cells at low density, by treating them with 5-fluorodeoxyuridine, or by growing them on glutaraldehyde-fi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rosenberg N,Schaeffer WI,Diamond L

    更新日期:1975-08-01 00:00:00

  • Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

    abstract::To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), in 22 inflammation-related genes, in a population-based case-control study conducted in Shanghai, China, where the incidence of biliary...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-0444

    authors: Hsing AW,Sakoda LC,Rashid A,Andreotti G,Chen J,Wang BS,Shen MC,Chen BE,Rosenberg PS,Zhang M,Niwa S,Chu L,Welch R,Yeager M,Fraumeni JF Jr,Gao YT,Chanock SJ

    更新日期:2008-08-01 00:00:00

  • Comparative dual label study of first and second generation antitumor-associated glycoprotein-72 monoclonal antibodies in colorectal cancer patients.

    abstract::Radiolabeled first-generation anti-tumor-associated glycoprotein-72 (TAG-72) monoclonal antibody (MAb), B72.3, has proven useful in detecting primary and secondary colorectal carcinoma. It has been anticipated that the development of second-generation, higher affinity, anti-TAG-72 MAbs, CC49 and CC83, would be of grea...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gallinger S,Reilly RM,Kirsh JC,Odze RD,Schmocker BJ,Hay K,Polihronis J,Damani MT,Shpitz B,Stern HS

    更新日期:1993-01-15 00:00:00

  • Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice.

    abstract::Mutations in the human adenomatous polyposis coli (APC) gene are responsible for not only familial adenomatous polyposis but also many sporadic cancers of the digestive tract. Using homologous recombination in embryonic stem cells, we recently constructed Apc gene knockout mice that contained a truncation mutation at ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Oshima H,Oshima M,Kobayashi M,Tsutsumi M,Taketo MM

    更新日期:1997-05-01 00:00:00

  • The Role of Cholesterol in Cancer.

    abstract::The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-15-2613

    authors: Kuzu OF,Noory MA,Robertson GP

    更新日期:2016-04-15 00:00:00

  • Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene.

    abstract::The modifying effect of four dose levels of butylated hydroxytoluene (BHT) on liver and bladder carcinogenesis by N-2-fluorenylacetamide (FAA) was studied in rats. FAA (200 ppm) was fed simultaneously with four levels of BHT (300, 1000, 3000, and 6000 ppm) to male F344 Fischer strain rats. Groups of animals were kille...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Maeura Y,Weisburger JH,Williams GM

    更新日期:1984-04-01 00:00:00

  • Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.

    abstract::Recently, we developed a nutritionally optimal medium for rapid clonal growth (greater than 1 population doubling/day) of normal human bronchial epithelial (NHBE) cells. Adding fetal bovine or adult human blood-derived serum to this medium depresses the clonal growth rate of NHBE cells in a dose-dependent fashion. In ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Lechner JF,McClendon IA,LaVeck MA,Shamsuddin AM,Harris CC

    更新日期:1983-12-01 00:00:00

  • Radioresistant cancer cells can be conditioned to enter senescence by mTOR inhibition.

    abstract::Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or par...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-3516

    authors: Nam HY,Han MW,Chang HW,Lee YS,Lee M,Lee HJ,Lee BW,Lee HJ,Lee KE,Jung MK,Jeon H,Choi SH,Park NH,Kim SY,Kim SW

    更新日期:2013-07-15 00:00:00

  • Suppression of natural killer and lymphocyte functions associated with carcinogen-induced premalignant hyperplastic nodules in rat liver.

    abstract::The effects of chemical carcinogenesis to produce premalignant hyperplastic nodules in rat liver on concomitant immune function were studied. Induction of hyperplastic nodules in Fischer rats was accomplished using a combined regimen of diethylnitrosamine, 2-acetylaminofluorene, and partial hepatectomy. Hyperplastic n...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Leu RW,Norton TR,Herriott MJ,Ringer DP,Kearns RJ

    更新日期:1985-07-01 00:00:00

  • The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell.

    abstract::The mechanism of action of the clinically used iron(III) chelator, desferrioxamine (DFO), on preventing iron (Fe) uptake from transferrin (Tf) has been investigated using the human melanoma cell line SK-MEL-28. This investigation was initiated due to the paucity of information on the mechanisms of action of DFO in neo...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Richardson D,Ponka P,Baker E

    更新日期:1994-02-01 00:00:00

  • Human ovarian carcinoma cells maintained on extracellular matrix versus plastic.

    abstract::The ability of culture dishes coated with an extracellular matrix (ECM) to act as a suitable substrate for human ovarian carcinoma cells in vitro has been examined. The plating efficiency on ECM was 30 to 80% (dispersed tumor cells from solid tumor tissue and effusions) with active proliferation of tumor cells being o...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Crickard K,Crickard U,Yoonessi M

    更新日期:1983-06-01 00:00:00

  • Mutagenesis and morphological transformation of mammalian cells by a non-bay-region polycyclic cyclopenta(cd)pyrene and its 3,4-oxide.

    abstract::Cyclopenta(cd)pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to be a direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide m...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gold A,Nesnow S,Moore M,Garland H,Curtis G,Howard B,Graham D,Eisenstadt E

    更新日期:1980-12-01 00:00:00

  • CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.

    abstract::Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to dete...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-15-3134

    authors: Feber A,Worth DC,Chakravarthy A,de Winter P,Shah K,Arya M,Saqib M,Nigam R,Malone PR,Tan WS,Rodney S,Freeman A,Jameson C,Wilson GA,Powles T,Beck S,Fenton T,Sharp TV,Muneer A,Kelly JD

    更新日期:2016-08-15 00:00:00

  • Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

    abstract::Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors from patients with hereditary nonpolyposis colon cancer and in a subset of patients with sporadic colorectal cancer (CRC). In sporadic CRC, three tumor phenotypes have been defined: microsatellite stable (MSS), low-frequency MS...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Cunningham JM,Christensen ER,Tester DJ,Kim CY,Roche PC,Burgart LJ,Thibodeau SN

    更新日期:1998-08-01 00:00:00

  • Immunocytochemical detection of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in rodent tissue sections.

    abstract::Calf thymus DNA was modified in vitro by cis-diamminedichloroplatinum(II) (cisDDP), complexed with methylated bovine serum albumin and used to immunize rabbits. The anti-cisDDP-DNA antiserum obtained was applied in a double peroxidase-antiperoxidase staining procedure to localize cisDDP-DNA and cis-diammine(1,1-cyclob...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Terheggen PM,Floot BG,Scherer E,Begg AC,Fichtinger-Schepman AM,den Engelse L

    更新日期:1987-12-15 00:00:00

  • Estramustine sensitizes human glioblastoma cells to irradiation.

    abstract::Estramustine is an estradiol-based antimicrotubule agent that accumulates in malignant glioma cells, resulting in a concentration-dependent inhibition of proliferation. This agent has been shown to synchronize human glioma cells at G2-M consistent with its known effects on the mitotic spindle and potentially could be ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yoshida D,Piepmeier J,Weinstein M

    更新日期:1994-03-15 00:00:00

  • CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice.

    abstract::The ubiquitin proteasome system is responsible for the proteolysis of important cell cycle and apoptosis-regulatory proteins. In this paper we report that the dipeptidyl proteasome inhibitor, phthalimide-(CH2)8CH-(cyclopentyl) CO-Arg(NO2)-Leu-H (CEP1612), induces apoptosis and inhibits tumor growth of the human lung c...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sun J,Nam S,Lee CS,Li B,Coppola D,Hamilton AD,Dou QP,Sebti SM

    更新日期:2001-02-15 00:00:00

  • Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-15-1796

    authors: Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

    更新日期:2016-06-01 00:00:00