Sequence-specific inhibition of DNA strand elongation by incorporation of 9-beta-D-arabinofuranosyladenine.

abstract：:DNA methylation was measured in human tumor cell lines and freshly explanted pediatric tumors by [3H]uridine labeling followed by DNA hydrolysis and high-performance liquid chromatography. The percentage of cytosine residues modified to 5-methylcytosine in 4 cell lines derived from pediatric tumors was increased or si...

journal_title：Cancer research

authors： Flatau E,Bogenmann E,Jones PA

更新日期：1983-10-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1alpha (HIF-1alpha) expression. We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signaling, on VEGF and HIF-1alpha expression and on angiogenesis, tu...

journal_title：Cancer research

authors： Pore N,Gupta AK,Cerniglia GJ,Jiang Z,Bernhard EJ,Evans SM,Koch CJ,Hahn SM,Maity A

更新日期：2006-09-15 00:00:00

abstract：:We studied the distribution of transcripts encoding the cytoplasmic domain of the membrane-anchored precursor epidermal growth factor (proEGFcyt) and a novel cytoplasmic proEGF splice isoform with a deleted exon 23 and an out-of-frame fusion of exon 24 (proEGFdel23) in human normal and neoplastic thyroid tissues. In p...

journal_title：Cancer research

authors： Pyka J,Glogowska A,Dralle H,Hoang-Vu C,Klonisch T

更新日期：2005-02-15 00:00:00

abstract：:Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44(+) subpopulation of prostate cancer cells, with important implications for diagnosis and prognosis of this disease. miR-708 w...

journal_title：Cancer research

authors： Saini S,Majid S,Shahryari V,Arora S,Yamamura S,Chang I,Zaman MS,Deng G,Tanaka Y,Dahiya R

更新日期：2012-07-15 00:00:00

abstract：:CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin ] is a prodrug that is converted to the active metabolite SN-38 by carboxylesterases. In its active form, the drug inhibits topoisomerase I, causes DNA damage, and induces apoptosis. Data in this study show metabolism of CPT-11 to SN-38 (7-ethyl...

journal_title：Cancer research

authors： Danks MK,Morton CL,Pawlik CA,Potter PM

更新日期：1998-01-01 00:00:00

abstract：:The anticancer effects of red wine have attracted considerable attention. Resveratrol (3,5,4'-trihydroxy-trans -stilbene) is a well-known polyphenolic compound of red wine with cancer chemopreventive activity. However, the basis for this activity is unclear. We studied leukotriene A(4) hydrolase (LTA(4)H) as a relevan...

journal_title：Cancer research

authors： Oi N,Jeong CH,Nadas J,Cho YY,Pugliese A,Bode AM,Dong Z

更新日期：2010-12-01 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasome, induces apoptosis in various tumor cells, but its mechanism of action is unclear. Treatment with PS-341 induces apoptosis in SUDHL6 (DHL6), but not SUDHL4 (DHL4), lymphoma cells. Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4...

journal_title：Cancer research

authors： Chauhan D,Li G,Shringarpure R,Podar K,Ohtake Y,Hideshima T,Anderson KC

更新日期：2003-10-01 00:00:00

abstract：:LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tissues inside tumor sites and recruits naïve T cells into the tumor. However, whether these infiltrating T cells are specific for tumor antigens is not known. We hypothesized that therapy with LIGHT can expand functional tumor-specific CD8(+...

journal_title：Cancer research

authors： Kanodia S,Da Silva DM,Karamanukyan T,Bogaert L,Fu YX,Kast WM

更新日期：2010-05-15 00:00:00

abstract：:Methotrexate (MTX) is one of the most commonly used agents in the treatment of solid malignancies; however, the toxicities of MTX to bone marrow and gastrointestinal tract complicate this therapy. We, therefore, propose a gene-dependent enzyme prodrug therapy to limit these toxicities by localizing the production of M...

journal_title：Cancer research

authors： Hamstra DA,Pagé M,Maybaum J,Rehemtulla A

更新日期：2000-02-01 00:00:00

abstract：:As recently characterized, following s.c. implantation into syngeneic C57BL/6 mice, E0771 tumor invades locally into dermal layers and peritoneum, metastasizes to the lung, and induces a nonspecific immunosuppression in the host. Using this breast medullar adenocarcinoma model, a therapy consisting of a single moderat...

journal_title：Cancer research

authors： Ewens A,Luo L,Berleth E,Alderfer J,Wollman R,Hafeez BB,Kanter P,Mihich E,Ehrke MJ

更新日期：2006-05-15 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a plausible mechanism linking diabetes and liver cancer prog...

journal_title：Cancer research

authors： Luo C,Liang J,Sharabi K,Hatting M,Perry EA,Tavares CDJ,Goyal L,Srivastava A,Bilodeau M,Zhu AX,Sicinski P,Puigserver P

更新日期：2020-08-15 00:00:00

abstract：:Despite descriptions of light-mediated therapy in ancient texts and the discovery of photodynamic therapy (PDT) in the early 1900s, the landmark article in 1978 in Cancer Research by Dougherty and his colleagues at the Roswell Park Cancer Institute remains rightly viewed as the starting point for clinical PDT in moder...

journal_title：Cancer research

authors： Cengel KA,Simone CB 2nd,Glatstein E

更新日期：2016-05-01 00:00:00

abstract：:In the chemotherapy of infectious diseases, selective toxicity has been achieved by designing curative regimens based on pharmacokinetic data. Selective toxicity of antitumor drugs has been demonstrated for rapidly growing large growth fraction tumors occurring in patients under age 30. In these tumors curative schedu...

journal_title：Cancer research

authors： Zubrod CG

更新日期：1978-12-01 00:00:00

abstract：:The phospholipids of both mitochondrial and microsomal membranes from normal liver, host liver, and Morris hepatoma 7777 were isolated, separated, and quantitated. The total as well as the individual fatty acid concentrations and compositions were determined. The total phosphlipids isolated from tumor mitochondria wer...

journal_title：Cancer research

authors： Reitz RC,Thompson JA,Morris HP

更新日期：1977-02-01 00:00:00

abstract：:The effect of sodium taurocholate on the biliary export of stable mutagenic phenolic glucuronide metabolites of benzo(a)pyrene from livers of corn oil- or 3-methylcholanthrene-treated rats was studied using a nonrecirculating perfusion system. Sterile bile samples were collected every 4 min and assayed for mutagens us...

journal_title：Cancer research

authors： Kari FW,Kauffman FC,Thurman RG

更新日期：1985-04-01 00:00:00

abstract：:Southern analysis has shown that DNA from 25% of primary estrogen receptor (ER) alpha-negative breast tumors displays aberrant methylation at one site within the ER gene CpG island. To examine more sites and increase sensitivity, we developed a methylation-specific PCR assay to map methylation of the entire ER CpG isl...

journal_title：Cancer research

authors： Lapidus RG,Nass SJ,Butash KA,Parl FF,Weitzman SA,Graff JG,Herman JG,Davidson NE

更新日期：1998-06-15 00:00:00

abstract：:The effect of pretreatment with L-asparaginase on the cytotoxicity of methotrexate (MTX) was studied in L5178Y murine leukemic cells and L-929 cells grown in vitro. The results were correlated with the effects of L-asparaginase on DNA synthesis. At low concentrations of the enzyme, pretreatment of cells enhanced the e...

journal_title：Cancer research

authors： Chlopkiewicz B,Koziorowska J

更新日期：1975-06-01 00:00:00

abstract：:Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not or...

journal_title：Cancer research

authors： Tse C,Shoemaker AR,Adickes J,Anderson MG,Chen J,Jin S,Johnson EF,Marsh KC,Mitten MJ,Nimmer P,Roberts L,Tahir SK,Xiao Y,Yang X,Zhang H,Fesik S,Rosenberg SH,Elmore SW

更新日期：2008-05-01 00:00:00

abstract：:Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly understood. There is a significant clinical correlation between the expression of bone sialoprotein (BSP) and skeletal ...

journal_title：Cancer research

authors： Barnes GL,Javed A,Waller SM,Kamal MH,Hebert KE,Hassan MQ,Bellahcene A,Van Wijnen AJ,Young MF,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2003-05-15 00:00:00

abstract：:Angiostatin, a proteolytic fragment of plasminogen, is a potent angiogenesis inhibitor able to suppress tumor growth and metastasis through inhibition of endothelial cell proliferation and migration. Previously, we showed that angiostatin binds and inhibits F(1)F(o) ATP synthase on the endothelial cell surface and tha...

journal_title：Cancer research

authors： Chi SL,Pizzo SV

更新日期：2006-01-15 00:00:00

abstract：:Neoplastic liver nodules and hepatocellular carcinomas (HCCs) were induced, by "resistant hepatocyte" model, 32 and 70 weeks after initiation with diethylnitrosamine, respectively, in F344 Brown Norway (BN), and (BNxF344)F1 rats. Nodule number/liver (N) did not significantly differ among rat strains, whereas nodule me...

journal_title：Cancer research

authors： De Miglio MR,Canzian F,Pascale RM,Simile MM,Muroni MR,Calvisi D,Romeo G,Feo F

更新日期：1999-09-15 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:The metabolites, transporters, and enzymes involved in choline metabolism are regarded as biomarkers for disease progression in a variety of cancers, but their in vivo detection is not ideal. Both magnetic resonance spectroscopy [MRS using chemical shift imaging (CSI) total choline (tCho)] and C-choline positron emiss...

journal_title：Cancer research

authors： Wehrl HF,Schwab J,Hasenbach K,Reischl G,Tabatabai G,Quintanilla-Martinez L,Jiru F,Chughtai K,Kiss A,Cay F,Bukala D,Heeren RM,Pichler BJ,Sauter AW

更新日期：2013-03-01 00:00:00

abstract：:The data of nine monolayer cultures, 48 multicellular spheroids, and 19 s.c. xenografts of LoVo cells were fitted, on an individual basis, by exponential and Gompertzian equations, respectively. The mean growth parameters alpha 0 (initial growth rate) and beta (retardation factor) of the three experimental systems pre...

journal_title：Cancer research

authors： Demicheli R,Foroni R,Ingrosso A,Pratesi G,Soranzo C,Tortoreto M

更新日期：1989-12-01 00:00:00

abstract：:One of the body's natural defense mechanisms against tumor cells is lysis of the invading cell by cytotoxic T-cells and natural killer (NK) cells. Five human hepatocellular carcinoma cell lines were found to have different sensitivities to killing by peripheral blood monocytes in a 51Cr release assay. This killing was...

journal_title：Cancer research

authors： Stevenson D,Binggeli R,Weinstein RC,Keck JG,Lai MC,Tong MJ

更新日期：1989-09-01 00:00:00

abstract：:Methylation associated inactivation of RASSF1, a putative tumor suppressor identified at 3p21.3, has been frequently observed in several human malignancies, including lung and breast cancers. To explore the penetrance of RASSF1 in gastric carcinogenesis, we performed expression and mutation analyses of 3 isotypes of R...

journal_title：Cancer research

authors： Byun DS,Lee MG,Chae KS,Ryu BG,Chi SG

更新日期：2001-10-01 00:00:00

abstract：:Cancer radiotherapy may be immunogenic, but it is unclear why its immunogenic effects are rarely sufficient to prevent tumor recurrence. Here, we report a novel Toll-like receptor 9 (TLR9)-dependent mechanism that initiates tumor regrowth after local radiotherapy. Systemic inhibition of TLR9, but not TLR4, delayed tum...

journal_title：Cancer research

authors： Gao C,Kozlowska A,Nechaev S,Li H,Zhang Q,Hossain DM,Kowolik CM,Chu P,Swiderski P,Diamond DJ,Pal SK,Raubitschek A,Kortylewski M

更新日期：2013-12-15 00:00:00

abstract：:A historical cohort of 68 female breast cancer patients from one institution who were enrolled in a multicenter randomized controlled trial between 1971 and 1973 were followed up to the beginning of 1986. Weight and height at the time of mastectomy were transformed into two indices of body size, namely the Quetelet In...

journal_title：Cancer research

authors： Suissa S,Pollak M,Spitzer WO,Margolese R

更新日期：1989-06-01 00:00:00

abstract：:TuAg.1 is a tumor-associated membrane glycoprotein first identified in rat hepatocellular carcinoma by monoclonal antibodies (mAbs) 324.5 and 324.9. This oncofetal antigen is also expressed by hepatocytes in cell culture but not normal adult hepatocytes in vivo. Affinity chromatography and preparative continuous eluti...

journal_title：Cancer research

authors： Lim YP,Fowler LC,Hixson DC,Wehbe T,Thompson NL

更新日期：1996-09-01 00:00:00