Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

abstract：:The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a significant feature of advanced stages of cancer. Moreover, we have fo...

journal_title：Cancer research

authors： Giurisato E,Lonardi S,Telfer B,Lussoso S,Risa-Ebrí B,Zhang J,Russo I,Wang J,Santucci A,Finegan KG,Gray NS,Vermi W,Tournier C

更新日期：2020-08-15 00:00:00

abstract：:The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. We examined the association between dietary cadmium expo...

journal_title：Cancer research

authors： Julin B,Wolk A,Bergkvist L,Bottai M,Akesson A

更新日期：2012-03-15 00:00:00

abstract：:Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression i...

journal_title：Cancer research

authors： Bartella V,Cascio S,Fiorio E,Auriemma A,Russo A,Surmacz E

更新日期：2008-06-15 00:00:00

abstract：:Libraries of compounds are increasingly becoming commercially available for the use of individual academic laboratories. A high-throughput system based on a stably integrated transcriptional reporter was used to screen a library of random compounds to identify agents that conferred robust augmentation of a signal tran...

journal_title：Cancer research

authors： Su GH,Sohn TA,Ryu B,Kern SE

更新日期：2000-06-15 00:00:00

abstract：:A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranea...

journal_title：Cancer research

authors： Zhang S,Phelan CM,Zhang P,Rousseau F,Ghadirian P,Robidoux A,Foulkes W,Hamel N,McCready D,Trudeau M,Lynch H,Horsman D,De Matsuda ML,Aziz Z,Gomes M,Costa MM,Liede A,Poll A,Sun P,Narod SA

更新日期：2008-04-01 00:00:00

abstract：:The transmembrane neural cell adhesion receptor L1 is a Wnt/β-catenin target gene expressed in many tumor types. In human colorectal cancer, L1 localizes preferentially to the invasive front of tumors and when overexpressed in colorectal cancer cells, it facilitates their metastasis to the liver. In this study, we inv...

journal_title：Cancer research

authors： Gavert N,Shvab A,Sheffer M,Ben-Shmuel A,Haase G,Bakos E,Domany E,Ben-Ze'ev A

更新日期：2013-09-15 00:00:00

abstract：:Molecular docking is a standard computational approach to predict binding modes of protein-ligand complexes by exploring alternative orientations and conformations of the ligand (i.e., by exploring ligand flexibility). Docking tools are largely used for virtual screening of small drug-like molecules, but their accurac...

journal_title：Cancer research

authors： Antunes DA,Moll M,Devaurs D,Jackson KR,Lizée G,Kavraki LE

更新日期：2017-11-01 00:00:00

abstract：:Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on...

journal_title：Cancer research

authors： Meier-Abt F,Bentires-Alj M,Rochlitz C

更新日期：2015-03-01 00:00:00

abstract：:Prostacyclin has been evaluated for its ability to inhibit tumor cell-induced platelet aggregation (TCIPA) induced by several rodent tumor lines: B16a (melanoma); 3LL (carcinoma); 15091A (adenocarcinoma); and W256 (carcinosarcoma). Aggregation of human platelets by all four lines was inhibited by prostaglandin I2 (PGI...

journal_title：Cancer research

authors： Menter DG,Onoda JM,Taylor JD,Honn KV

更新日期：1984-02-01 00:00:00

abstract：:Merbarone is a catalytic inhibitor of DNA topoisomerase (topo) II that does not stabilize DNA-topo II cleavable complexes. Although the cytotoxicity of and resistance to complex-stabilizing topo II inhibitors, such as etoposide, is thought to be mediated through stabilization of these complexes, the mechanisms of cyto...

journal_title：Cancer research

authors： Kusumoto H,Rodgers QE,Boege F,Raimondi SC,Beck WT

更新日期：1996-06-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-I has well-characterized mitogenic and antiapoptotic effects that are essential for maintenance of the normal prostate and may be important during regression of the normal prostate and/or prostate tumors induced by androgen-targeting therapies for prostate cancer. IGF-I activity is mod...

journal_title：Cancer research

authors： Nickerson T,Miyake H,Gleave ME,Pollak M

更新日期：1999-07-15 00:00:00

abstract：:Data on biodistribution and pharmacokinetics of Na2B12H11SH are few and lack in standardization. This study comprises a uniform series of 10 patients with glioblastoma administered Na2B12H11SH i.v. 24 h before surgery at a dose level used in earlier therapeutical trials (75 mg/kg body weight). Boron concentrations in ...

journal_title：Cancer research

authors： Haselsberger K,Radner H,Pendl G

更新日期：1994-12-15 00:00:00

abstract：:The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the antibody, however, lacked the ability to induce cell death. The antigen was purified, and characterized by co...

journal_title：Cancer research

authors： Zhong LT,Manzi A,Skowronski E,Notterpek L,Fluharty AL,Faull KF,Masada I,Rabizadeh S,Varsanyi-Nagy M,Ruan Y,Oh JD,Butcher LL,Bredesen DE

更新日期：2001-08-01 00:00:00

abstract：:To improve tumor:tissue ratios in immunoscintigraphy, a three-step targeting method has been developed. The reagents used were (a) a radioactive, low molecular weight chelate prepared from ionic gallium and a phenolic polyaminocarboxylic acid, which can be labeled either with the single-photon emitter 67Ga or with the...

journal_title：Cancer research

authors： Schuhmacher J,Klivényi G,Matys R,Stadler M,Regiert T,Hauser H,Doll J,Maier-Borst W,Zöller M

更新日期：1995-01-01 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:The androgen receptor (AR) regulates gene transcription by binding to androgen response elements in target gene promoters. The prostate-specific antigen (PSA) gene has a polymorphic androgen response element sequence with two alleles, A and G. We hypothesize that allelic differences in AR-driven PSA expression may inf...

journal_title：Cancer research

authors： Xue W,Irvine RA,Yu MC,Ross RK,Coetzee GA,Ingles SA

更新日期：2000-02-15 00:00:00

abstract：:Mechanism, in addition to protein kinase C activation may mediate 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated differentiation of leukemic cells. We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the pro...

journal_title：Cancer research

authors： Ways DK,Dodd RC,Earp HS

更新日期：1987-07-01 00:00:00

abstract：:Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibitors and to understa...

journal_title：Cancer research

authors： Mirzoeva OK,Das D,Heiser LM,Bhattacharya S,Siwak D,Gendelman R,Bayani N,Wang NJ,Neve RM,Guan Y,Hu Z,Knight Z,Feiler HS,Gascard P,Parvin B,Spellman PT,Shokat KM,Wyrobek AJ,Bissell MJ,McCormick F,Kuo WL,Mills GB,

更新日期：2009-01-15 00:00:00

abstract：:Despite the variety of approaches used, only a limited number of tumor-associated antigens have been described for each histological type of tumor. In this report, we present a new strategy involving molecular subtraction to identify novel melanoma-associated gene sequences. Toward this end, 156 complementary DNA clon...

journal_title：Cancer research

authors： Hutchins JT,Deans RJ,Mitchell MS,Uchiyama C,Kan-Mitchell J

更新日期：1991-03-01 00:00:00

abstract：:Calcium is universally required for cell growth and proliferation. Calmodulin is the main intracellular receptor for calcium. Although calcium and calmodulin are well known to be required for cell cycle regulation, the target pathways for their action remain poorly defined. Potential targets include the calcium/calmod...

journal_title：Cancer research

authors： Rodriguez-Mora OG,LaHair MM,McCubrey JA,Franklin RA

更新日期：2005-06-15 00:00:00

abstract：:Angiogenesis is a crucial step in tumor growth and progression. Its quantitation by microvessel counting is of prognostic value in several types of malignancies. Scarce data are available on angiogenesis in gastrointestinal tumors. We studied 36 adenomas and 178 large bowel carcinomas to evaluate the onset of angiogen...

journal_title：Cancer research

authors： Bossi P,Viale G,Lee AK,Alfano R,Coggi G,Bosari S

更新日期：1995-11-01 00:00:00

abstract：:HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen in 19%. There was a...

journal_title：Cancer research

authors： Borg A,Tandon AK,Sigurdsson H,Clark GM,Fernö M,Fuqua SA,Killander D,McGuire WL

更新日期：1990-07-15 00:00:00

abstract：:The effect of the adenosine diphosphoribosyltransferase inhibitors, the substituted benzamides, on the cytotoxicity of 6-thioguanine (6TG) was investigated. Nontoxic concentrations of benzamides potentiated the cytotoxicity of 6TG with a dose enhancement factor of 2, producing a 6-fold increase in cell killing at 10% ...

journal_title：Cancer research

authors： Moses K,Harris AL,Durkacz BW

更新日期：1988-10-15 00:00:00

abstract：:Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In...

journal_title：Cancer research

authors： Hakim F,Wang Y,Zhang SX,Zheng J,Yolcu ES,Carreras A,Khalyfa A,Shirwan H,Almendros I,Gozal D

更新日期：2014-03-01 00:00:00

abstract：:A series of arylalkyltriazenes has been investigated for its differential cytotoxicity towards the HT-29 (Mer+) and BE (Mer-) cell lines and for its ability to cause DNA strand breaks and cross-links. A monomethyltriazene (MMPT) and some hydroxymethyltriazene derivatives capable of generating the monomethyltriazene in...

journal_title：Cancer research

authors： Gibson NW,Hartley JA,LaFrance RJ,Vaughan K

更新日期：1986-10-01 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00

abstract：:Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular heterogeneity, it remains unclear whether CCIC within a tumor contain distinct subpopulations. Here, we describe the co-existence of ...

journal_title：Cancer research

authors： Srinivasan T,Walters J,Bu P,Than EB,Tung KL,Chen KY,Panarelli N,Milsom J,Augenlicht L,Lipkin SM,Shen X

更新日期：2016-06-01 00:00:00

abstract：:To assess the in vivo behavior of cytotoxic agents linked to antibodies, deferoxamine, known to form stable chelates with 67Ga, was conjugated with monoclonal antibodies using three different methods. One method used a homocoupling reagent, glutaraldehyde, whereas two other methods used heterocoupling reagents, N-succ...

journal_title：Cancer research

authors： Koizumi M,Endo K,Kunimatsu M,Sakahara H,Nakashima T,Kawamura Y,Watanabe Y,Saga T,Konishi J,Yamamuro T

更新日期：1988-03-01 00:00:00

abstract：:In contrast to methotrexate (MTX) and aminopterin (AMT), the 8-deaza analogues of these antifolates are not substrates for rabbit liver aldehyde oxidase. Since they are not converted to 7-hydroxy derivatives, they have been investigated with regard to their cytotoxicity for CCRF-CEM cells, transport into these cells, ...

journal_title：Cancer research

authors： Kuehl M,Brixner DI,Broom AD,Avery TL,Blakley RL

更新日期：1988-03-15 00:00:00

abstract：:We have used a transplantable experimental murine renal carcinoma (Renca) to evaluate the adjuvant immunotherapeutic potential of cytotoxic lymphocytes stimulated by in vitro incubation for 24 h with human recombinant interleukin 2 (rIL-2). The Renca tumor model is therapeutically challenging since, following intraren...

journal_title：Cancer research

authors： Salup RR,Wiltrout RH

更新日期：1986-07-01 00:00:00