Immunization against feline oncarnavirus disease using a killed tumor cell vaccine.

abstract：:Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. Here, we report that periostin, a highly expressed cell adhesion molec...

journal_title：Cancer research

authors： Michaylira CZ,Wong GS,Miller CG,Gutierrez CM,Nakagawa H,Hammond R,Klein-Szanto AJ,Lee JS,Kim SB,Herlyn M,Diehl JA,Gimotty P,Rustgi AK

更新日期：2010-07-01 00:00:00

abstract：:Monoclonal antibodies (mAb) are widely used in the treatment of non-Hodgkin's lymphoma and autoimmune diseases. Although the mechanism of action in vivo is not always known, the therapeutic activity of several approved mAbs depends on the binding of the Fcgamma regions to low-affinity Fcgamma receptors (FcgammaR) expr...

journal_title：Cancer research

authors： Stavenhagen JB,Gorlatov S,Tuaillon N,Rankin CT,Li H,Burke S,Huang L,Vijh S,Johnson S,Bonvini E,Koenig S

更新日期：2007-09-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with proven efficacy in multiple myeloma and non-Hodgkin's lymphoma. This study reports the effects of bortezomib in B-cell lymphoma cell lines with differing sensitivity to bortezomib to investigate factors that influence sensitivity. Bortezomib induced a time- and concentration-d...

journal_title：Cancer research

authors： Strauss SJ,Higginbottom K,Jüliger S,Maharaj L,Allen P,Schenkein D,Lister TA,Joel SP

更新日期：2007-03-15 00:00:00

abstract：:Because of their short range and high linear energy transfer, alpha-particles may be particularly effective in the treatment of neoplastic meningitis. Monoclonal antibody 81C6 was labeled with alpha-particle-emitting 211At using N-succinimidyl3-[211At]astatobenzoate, and the efficacy and toxicity of this immunoconjuga...

journal_title：Cancer research

authors： Zalutsky MR,McLendon RE,Garg PK,Archer GE,Schuster JM,Bigner DD

更新日期：1994-09-01 00:00:00

abstract：:SGN-40 is a humanized IgG1 antihuman CD40 that is currently in a phase I clinical trial for the treatment of multiple myeloma. As surface CD40 expression on B-lineage cells is maintained from pro-B cells to plasma cells, SGN-40 may be applicable to treatment of other B-cell neoplasias, including non-Hodgkin's lymphoma...

journal_title：Cancer research

authors： Law CL,Gordon KA,Collier J,Klussman K,McEarchern JA,Cerveny CG,Mixan BJ,Lee WP,Lin Z,Valdez P,Wahl AF,Grewal IS

更新日期：2005-09-15 00:00:00

abstract：:Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations to sporadic colorectal tumorigenesis is unclear. We therefore used P...

journal_title：Cancer research

authors： Samowitz WS,Powers MD,Spirio LN,Nollet F,van Roy F,Slattery ML

更新日期：1999-04-01 00:00:00

abstract：:Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt th...

journal_title：Cancer research

authors： Shiftan L,Israely T,Cohen M,Frydman V,Dafni H,Stern R,Neeman M

更新日期：2005-11-15 00:00:00

abstract：:A new double-label histochemical method is described which permits accurate quantitation of macrophage recruitment into neoplastic lesions in situ. Intratumoral macrophages are identified by their capacity to ingest colloidal iron particles from the interstitial fluid. Since colloidal iron is retained in a stable form...

journal_title：Cancer research

authors： Bugelski PJ,Kirsh RL,Poste G

更新日期：1983-11-01 00:00:00

abstract：:Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition...

journal_title：Cancer research

authors： Cohen SM,Ellwein LB,Okamura T,Masui T,Johansson SL,Smith RA,Wehner JM,Khachab M,Chappel CI,Schoenig GP

更新日期：1991-04-01 00:00:00

abstract：:SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, and lineage commitment in various tissues including the intestinal epithelium. Here, we present functional and cl...

journal_title：Cancer research

authors： Matheu A,Collado M,Wise C,Manterola L,Cekaite L,Tye AJ,Canamero M,Bujanda L,Schedl A,Cheah KS,Skotheim RI,Lothe RA,López de Munain A,Briscoe J,Serrano M,Lovell-Badge R

更新日期：2012-03-01 00:00:00

abstract：:It has been shown in previous studies that a variety of estrogen receptor (ER) beta mRNA transcripts are expressed in human breast cancer cell lines and tumors. To complement the RNA expression studies, we have developed ER-beta-specific antibodies to characterize ER-beta protein expression in breast cancer cell lines...

journal_title：Cancer research

authors： Fuqua SA,Schiff R,Parra I,Friedrichs WE,Su JL,McKee DD,Slentz-Kesler K,Moore LB,Willson TM,Moore JT

更新日期：1999-11-01 00:00:00

abstract：:TER286 is a latent drug activated by human glutathione S-transferase (GST) isoforms P1-1 and A1-1 to produce a nitrogen mustard alkylating agent. M7609 human colon carcinoma, selected for resistance to doxorubicin, and MCF-7 human breast carcinoma, selected for resistance to cyclophosphamide, both showed increased sen...

journal_title：Cancer research

authors： Morgan AS,Sanderson PE,Borch RF,Tew KD,Niitsu Y,Takayama T,Von Hoff DD,Izbicka E,Mangold G,Paul C,Broberg U,Mannervik B,Henner WD,Kauvar LM

更新日期：1998-06-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

journal_title：Cancer research

authors： Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

更新日期：2010-01-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:Tumor infiltration with effector CD8(+) T cells (T(eff)) predicts longer recurrence-free survival in many types of human cancer, illustrating the broad significance of T(eff) for effective immunosurveillance. Colorectal tumors with reduced accumulation of T(eff) express low levels of T(eff)-attracting chemokines such ...

journal_title：Cancer research

authors： Muthuswamy R,Berk E,Junecko BF,Zeh HJ,Zureikat AH,Normolle D,Luong TM,Reinhart TA,Bartlett DL,Kalinski P

更新日期：2012-08-01 00:00:00

abstract：:Therapeutic strategies targeting DNA repair pathway defects have been widely explored, but often only benefit small numbers of patients. Here we characterized potential predictive biomarkers for treatment with AsiDNA, a novel first-in-class DNA repair inhibitor. We evaluated genetic instability and DNA repair defects ...

journal_title：Cancer research

authors： Jdey W,Thierry S,Popova T,Stern MH,Dutreix M

更新日期：2017-08-15 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and inv...

journal_title：Cancer research

authors： Zhang J,Liang Q,Lei Y,Yao M,Li L,Gao X,Feng J,Zhang Y,Gao H,Liu DX,Lu J,Huang B

更新日期：2012-09-01 00:00:00

abstract：:Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are extremely rare in Asians, arguing against any of these being causative variants. This study sought to identify other varia...

journal_title：Cancer research

authors： Wu C,Hu Z,Yu D,Huang L,Jin G,Liang J,Guo H,Tan W,Zhang M,Qian J,Lu D,Wu T,Lin D,Shen H

更新日期：2009-06-15 00:00:00

abstract：:Glucocorticoids are widely used for the treatment of multiple myeloma. To investigate the direct actions of glucocorticoids on myeloma cells, we have used three cell lines of human multiple myeloma, OPM-1, OPM-2, and RPMI 8226. When growth curves of these cells were examined, OPM-1 cells were resistant, while OPM-2 we...

journal_title：Cancer research

authors： Gomi M,Moriwaki K,Katagiri S,Kurata Y,Thompson EB

更新日期：1990-03-15 00:00:00

abstract：:The effects of chemical carcinogenesis to produce premalignant hyperplastic nodules in rat liver on concomitant immune function were studied. Induction of hyperplastic nodules in Fischer rats was accomplished using a combined regimen of diethylnitrosamine, 2-acetylaminofluorene, and partial hepatectomy. Hyperplastic n...

journal_title：Cancer research

authors： Leu RW,Norton TR,Herriott MJ,Ringer DP,Kearns RJ

更新日期：1985-07-01 00:00:00

abstract：:Many tumors contain extensive regions of hypoxia. Because hypoxic cells are markedly more resistant to killing by radiation, repeated attempts have been made to improve the oxygenation of tumors to enhance radiotherapy. We have studied the oxygenation of tumor xenografts in nude mice after treatment with the farnesylt...

journal_title：Cancer research

authors： Cohen-Jonathan E,Evans SM,Koch CJ,Muschel RJ,McKenna WG,Wu J,Bernhard EJ

更新日期：2001-03-01 00:00:00

abstract：:The DNA of L1210 cells exposed to low concentrations of 1-(2-chloroethyl)=3-cyclohexyl-1-nitrosourea has been analyzed for the presence of single-strand breaks. DNA from 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea-treated cells both sediments more slowly than control DNA on alkaline sucrose gradients andshows a great...

journal_title：Cancer research

authors： Hilton J,Bowie DL,Gutin PH,Zito DM,Walker MD

更新日期：1977-07-01 00:00:00

abstract：:Phenotypic variability of the human neuroblastoma cell line SK-N-SH was studied with the use of three subclones that interconvert at a slower rate than the parent cell line, i.e., a neuroblast-type subclone (SH-SY5Y), a nonneuronal, strongly substrate adherent subclone (SH-EP), and an intermediate type subclone (SH-IN...

journal_title：Cancer research

authors： Sadée W,Yu VC,Richards ML,Preis PN,Schwab MR,Brodsky FM,Biedler JL

更新日期：1987-10-01 00:00:00

abstract：:The level of nonspecific lipid transfer protein in three Morris hepatomas of varying degrees of differentiation has been found to be less than 10% of the level in either host or control livers, whereas phosphatidylcholine transfer activity is slightly reduced for hepatomas compared to host livers (20 to 40%), though n...

journal_title：Cancer research

authors： Crain RC,Clark RW,Harvey BE

更新日期：1983-07-01 00:00:00

abstract：:Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. Early studies focused on the role ...

journal_title：Cancer research

authors： Samanta D,Semenza GL

更新日期：2016-11-15 00:00:00

abstract：:Although ethanol has generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in humans. Risks of oral, pharyngeal, laryngeal, esophageal, and liver cancer are elevated among drinkers, typically in proportion to the ...

journal_title：Cancer research

authors： Blot WJ

更新日期：1992-04-01 00:00:00

abstract：:Cdc37 is a co-chaperone protein that recruits several immature client kinases to Hsp90 for proper folding. Cdc37 up-regulation is a common early event in localized human prostate cancer. Although targeted overexpression in mice leads to prostate epithelial cell hyperplasia, the effect of Cdc37 dysregulation in human p...

journal_title：Cancer research

authors： Schwarze SR,Fu VX,Jarrard DF

更新日期：2003-08-01 00:00:00

abstract：:The induction of phase 2 detoxifying enzymes, such as UDP-glucuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione), provides an effective means of protection against a variety of carcinogens. Transcription fa...

journal_title：Cancer research

authors： Iida K,Itoh K,Kumagai Y,Oyasu R,Hattori K,Kawai K,Shimazui T,Akaza H,Yamamoto M

更新日期：2004-09-15 00:00:00

abstract：:More than 70% of patients survive childhood cancer, but chemotherapy and radiation therapy may cause irreversible impairment of spermatogenesis. To treat infertility secondary to anticancer treatment for childhood cancer, we have developed a procedure to isolate germ cells from leukemic mice by fluorescence-activated ...

journal_title：Cancer research

authors： Fujita K,Tsujimura A,Miyagawa Y,Kiuchi H,Matsuoka Y,Takao T,Takada S,Nonomura N,Okuyama A

更新日期：2006-12-01 00:00:00