abstract：:The Warburg micro syndrome (WARBM) is a genetically heterogeneous syndrome linked to at least 4 loci. At the clinical level, WARBM is characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, corpus callosum hypoplasia, severe mental retardation, and hypogonadism. In some families additional cl...

journal_title：Folia neuropathologica

authors： Kabzińska D,Mierzewska H,Senderek J,Kochański A

更新日期：2016-01-01 00:00:00

abstract：:Angiocentric glioma (AG) is a newly-classified, very rare, WHO grade I central nervous system (CNS) lesion, occurring usually in children and young adults. Only 52 patients with AG have been reported so far, making it one of the rarest neuropathological entities. Hereby we present two new cases of AG in young subjects...

journal_title：Folia neuropathologica

authors： Adamek D,Siwek GP,Chrobak AA,Herman-Sucharska I,Kwiatkowski S,Morga R,Radwańska E,Urbanowicz B

更新日期：2016-01-01 00:00:00

abstract：:Cerebellar cortical biopsies of the peritumoural region of seven patients with cerebellar haemangioma, mesencephalic meningioma, cerebellopontine astrocytoma, cerebellopontine meningioma, and medulloblastoma of cerebellar vermis were examined by means of conventional transmission electron microscopy. Granule cells sho...

journal_title：Folia neuropathologica

authors： Castejón OJ

更新日期：2016-01-01 00:00:00

abstract：:Unmethylated CpG DNA, as a stimulatory molecule, has potent pro-inflammatory effects in the central nervous system (CNS). Dexmedetomidine (DEX) has been confirmed to exert anti-inflammatory effects in CNS. Our study was aimed to explore the effects of DEX on tumor necrosis factor-α (TNF-α) expression in unmethylated C...

journal_title：Folia neuropathologica

authors： Chen C,Qian Y

更新日期：2016-01-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disorder associated with parkinsonism, ataxia, and autonomic dysfunction. Its pathology is primarily subcortical comprising vacuolation, neuronal loss, gliosis, and α-synucleinimmunoreactive glial cytoplasmic inclusions (GCI). To quantify cerebellar pathology i...

journal_title：Folia neuropathologica

authors： Armstrong RA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS:Using Western blot we studied 1 ...

journal_title：Folia neuropathologica

authors： Siedlecka M,Szlufik S,Grajkowska W,Roszkowski M,Jóźwiak J

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in patients above 50 years of age. Its progressive course finally leads to immobilisation, and no effective therapy exists. Its pathogenesis includes both degenerative and inflammatory processes, however, its direct causes remain ...

journal_title：Folia neuropathologica

authors： Kierdaszuk B,Berdynski M,Palczewski P,Golebiowski M,Zekanowski C,Kaminska AM

更新日期：2015-01-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Pathophysiologically, there seems to be multimerization of the extracellular domain of the protein with a possible gain of function on vascular smooth muscular cells. However,...

journal_title：Folia neuropathologica

authors： Erro R,Moccia M,Cervasio M,Penco S,De Caro Mdel B,Barone P

更新日期：2015-01-01 00:00:00

abstract：:We report the case of an 84-year-old male patient afflicted by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) showing minimal symptoms of disease. The patient was diagnosed on the basis of ultrastructural and genetic examinations. Ultrastructurally, a typical vascu...

journal_title：Folia neuropathologica

authors： Lewandowska E,Felczak P,Buczek J,Gramza K,Rafałowska J

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Activated microglia produce neurotoxic factors, including pro-inflammatory cytokines and nitric oxide (NO), in response to neuronal destruction. Therapeutic suppression of microglial release of these factors by various approaches including hypothermia is considered to be neuroprotective after severe brain ...

journal_title：Folia neuropathologica

authors： Matsui T,Kida H,Iha T,Obara T,Nomura S,Fujimiya T,Suzuki M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The efficacy of tempol and its acyl derivative tempol-C8 as retinoprotective agents was compared in a rat model of NMDA-induced retinal ganglion cell (RGC) damage. MATERIAL AND METHODS:Tempol or tempol-C8 in different doses was administered intraperitoneally to 6 weeks old (pre-adolescent) and 9-10 weeks ol...

journal_title：Folia neuropathologica

authors： Fiedorowicz M,Rejdak R,Schuettauf F,Wozniak M,Grieb P,Thaler S

更新日期：2014-01-01 00:00:00

abstract：:Genetic variants that confer susceptibility to Parkinson's disease (PD) show unbalanced distribution among different populations; genetic predisposition to either familial or sporadic forms of PD in Mexican-mestizo population has not been comprehensively studied. The aim of the present study was to analyze genetic var...

journal_title：Folia neuropathologica

authors： García S,López-Hernández LB,Suarez-Cuenca JA,Solano-Rojas M,Gallegos-Arreola MP,Gama-Moreno O,Valdez-Anguiano P,Canto P,Dávila-Maldonado L,Cuevas-García CF,Coral-Vázquez RM

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:During human myogenesis and synaptogenesis, the first contact between multiaxonal nerve terminals and the primary myotube occurs at an early stage of gestation, then monoaxonal nerve terminals form and postsynaptic clusters of acetylcholine-receptor are modified and redistributed to the site of muscle-nerv...

journal_title：Folia neuropathologica

authors： Fidziańska A,Jędrzejowska M,Madej-Pilarczyk A,Bojakowski J

更新日期：2013-01-01 00:00:00

abstract：:The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were ...

journal_title：Folia neuropathologica

authors： Ayrancı E,Altunkaynak BZ,Aktaş A,Rağbetli MÇ,Kaplan S

更新日期：2013-01-01 00:00:00

abstract：:Hyponatremia is a common disorder of water-electrolyte balance characterized by the decrease of plasma sodium ions concentration below 135 mM. Although water-electrolyte balance is regulated by a kidney, symptoms of hyponatremia are related to the disturbances of intracranial homeostasis and are attributed to brain sw...

journal_title：Folia neuropathologica

authors： Aleksandrowicz M,Koźniewska E

更新日期：2013-01-01 00:00:00

abstract：:The endothelial vacuolar and vesicular transports in traumatic human brain oedema have been reviewed and compared with experimental brain oedema in order to establish their role in both oedema formation and oedema resolution. Normal or "non-activated" and "activated" capillaries are found. The activated capillaries sh...

journal_title：Folia neuropathologica

authors： Castejón OJ

更新日期：2013-01-01 00:00:00

abstract：:Prion-like transmission of protein aggregates or amyloid in several neurodegenerative diseases, such as Parkinson's disease, Huntington's disease and Alzheimer's disease, in addition to the transmissible spongiform encephalopathies (or prion diseases), has been proposed recently. This is a controversial idea and, in t...

journal_title：Folia neuropathologica

authors： Hope J,Kirby L

更新日期：2012-01-01 00:00:00

abstract：:Globoid cell leukodystrophy (GLD, also known as Krabbe disease), whose pathophysiology is still not completely elucidated, is an inherited, metabolic, and neurodegenerative disease, caused by the deficiency of β-galactocerebrosidase (GALC) or in very rare cases by lack of active saposin A. We describe two patients, i...

journal_title：Folia neuropathologica

authors： Szymańska K,Ługowska A,Laure-Kamionowska M,Bekiesińska-Figatowska M,Gieruszczak-Białek D,Musielak M,Eichler S,Giese AK,Rolfs A

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Ischemic stroke remains one of the top ten causes of death in children. There is evidence for the role of pro-inflammatory cytokines, such as IL-6 and the -174G>C promoter polymorphism of the IL-6 gene, in the occurrence and outcome of stroke in adults. The aim of the present study was to determine a possibl...

journal_title：Folia neuropathologica

authors： Balcerzyk A,Nowak M,Kopyta I,Emich-Widera E,Pilarska E,Pienczk-Ręcławowicz K,Kaciński M,Wendorff J,Zak I

更新日期：2012-01-01 00:00:00

abstract：:The visual cortex undergoes age related changes that have been studied mainly in rats Maccaca Mulata, and human beings. Despite the fact that there is no extensive neuronal loss in aged brains, a lot of important pathological changes are found in the morphology of the neurons. The present study describes the morpholog...

journal_title：Folia neuropathologica

authors： Mavroudis I,Petrides F,Manani M,Theocharides C,Ciobica A,Padurariu M,Kiourexidou M,Njau S,Costa V,Baloyannis S

更新日期：2012-01-01 00:00:00

abstract：:The SMN (survival motor neuron) gene plays an important role in ontogenesis and its dysfunction leads to immatu-rity of skeletal muscles and motor neurons in the spinal cord. As a result of SMN mutations the affected cells die and clinical symptoms of spinal muscular atrophy (SMA) develop. Physiologically, SMN togethe...

journal_title：Folia neuropathologica

authors： Rafałowska J,Sulejczak D,Gadamski R,Dziewulska D

更新日期：2011-01-01 00:00:00

abstract：:Granular osmiophilic material (GOM) is a pathognomonic feature of CADASIL that may be a consequence of pathological processes triggered by Notch3 mutations. Since knowledge of the effects of CADASIL-associated GOM deposits is important to understand the molecular pathogenesis of this disorder, we performed a thorough ...

journal_title：Folia neuropathologica

authors： Lewandowska E,Dziewulska D,Parys M,Pasennik E

更新日期：2011-01-01 00:00:00

abstract：:Neuronal and axonal degenerative changes in motor vagal neurons (DMNV) and sensory vagal neurons (nTS) in the medulla oblongata in newborns were studied. Material was taken from the autopsies of newborns, live and dead newborns, in different gestational weeks (aborted, immature, premature and mature). 46 cases were st...

journal_title：Folia neuropathologica

authors： Islami H,Shabani R,Shabani D,Dacaj R,Manxhuka S,Azemi M,Krasniqi S,Kurtishi I

更新日期：2011-01-01 00:00:00

abstract：:In the present work, we investigated the effect of chronic haloperidol administration on the number of striatal neurons in guinea pigs. For this purpose, adult male guinea pigs were given daily injections of 1, 2 or 3 mg/kg of haloperidol for 6 weeks. After treatment, the animals were anesthetized via brief inhalation...

journal_title：Folia neuropathologica

authors： Altunkaynak BZ,Ozbek E,Aydin N,Aydin MD,Altunkaynak ME,Vuraler O,Unal B

更新日期：2011-01-01 00:00:00

abstract：:A contribution of B cells and autoantibodies has been demonstrated in MS leading to interest in the use of such autoantibodies as diagnostic or prognostic markers and as a basis for immunomodulatory therapy. ELISA and Western fail to detect reactivity against epitopes displayed by native antigens expressed on myelin s...

journal_title：Folia neuropathologica

authors： Jaśkiewicz E,Michałowska-Wender G,Pyszczek A,Wender M

更新日期：2010-01-01 00:00:00