Abstract：
:Metformin, a type 2 anti-diabetic drug and an activator of AMP-activated protein kinase (AMPK), has been shown to reduce infarct size and pathological changes affecting astroglia in animal models of ischemic stroke. In this study, we evaluated how metformin affects cell viability, apoptosis and determined the role of AMPK, as well as JNK p46/p54 and p38 kinases, in the observed phenomena in the culture of primary rat cortical astrocytes subjected to 12 h of oxygen and glucose deprivation (OGD). Metformin improved cell viability, reduced the fraction of apoptotic nuclei, and inhibited the activation of the executive caspase-3. Decreased activation of JNK p54 and p38 was associated with increased Bcl-XL expression and decreased mitochondrial leakage of cytochrome c. However, only cell viability and partially the fraction of apoptotic nuclei varied concomitantly with changes in AMPK activity, suggesting that AMPK is critical for metformin-mediated effects and regulates programmed cell death in a caspase-independent manner. Experiments with the inhibitors of JNK and p38 supports the role of these kinases in the drug-related inhibition of mitochondrial and extrinsic pathway of apoptosis.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Gabryel B,Liber Sdoi
10.5114/fn.2018.80866subject
Has Abstractpub_date
2018-01-01 00:00:00pages
328-336issue
4eissn
1641-4640issn
1509-572Xpii
34468journal_volume
56pub_type
杂志文章abstract：:Autopsy material of 18 patients, who died between 66-86 years of age and of 4 ones, who died between 20 and 38 years of age was investigated. The white matter of frontal lobe, corpus callosum and cerebellum was studied using histological and biochemical methods. According to the results of neuropathological studies, t...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Telepathology is the diagnostic work of a pathologist at a distance. It includes specific application fields which require specific system solutions. These comprise: a. frozen section service; b. expert consultations; c. remote control measurements, and d. education and training. Applications but, in addition, all asp...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Bovine spongiform encephalopathy (BSE) is a zoonosis being the origin of variant Creutzfeldt-Jakob disease and an important cattle disease in its own right. This association has driven both the research into the disease and extensive epidemiological investigations of practical value. Not only has the occurrence of BSE...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:Cerebral ischemia injury seriously endangers human health and its molecular mechanism is still not fully understood. microRNA-223 (miR-223) has been reported to be involved in many physiological functions but the specific role of miRNA-223 in ischemic neuronal injury is still unclear. An oxygen-glucose deprivation and...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2018.74659
更新日期：2018-01-01 00:00:00
abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Pathophysiologically, there seems to be multimerization of the extracellular domain of the protein with a possible gain of function on vascular smooth muscular cells. However,...
journal_title：Folia neuropathologica
pub_type： 信件
doi：10.5114/fn.2015.52414
更新日期：2015-01-01 00:00:00
abstract：:A contribution of B cells and autoantibodies has been demonstrated in MS leading to interest in the use of such autoantibodies as diagnostic or prognostic markers and as a basis for immunomodulatory therapy. ELISA and Western fail to detect reactivity against epitopes displayed by native antigens expressed on myelin s...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Glioblastoma, the most malignant astrocytic tumour, is associated with limited survival and thus rare metastases. We analysed a particularly interesting case - a 51-year-old male diagnosed within 2 years with primary and recurrent glioblastoma, isocitrate dehydrogenase (IDH)-wild type, as well as with numerous extra-c...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2019.83833
更新日期：2019-01-01 00:00:00
abstract：:The importance of chemokines seems to extend far beyond their well-known role as mediators of an inflammatory response. The most interesting hypothesis is that these molecules may influence the migration of progenitor cells during development. Primary sensory neurones have been shown to migrate towards RANTES in vitro...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2013.34199
更新日期：2013-01-01 00:00:00
abstract：:Prion-like transmission of protein aggregates or amyloid in several neurodegenerative diseases, such as Parkinson's disease, Huntington's disease and Alzheimer's disease, in addition to the transmissible spongiform encephalopathies (or prion diseases), has been proposed recently. This is a controversial idea and, in t...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Neuroacanthocytosis is a rare disease of nervous system with multisystem pathology. This review presents clinical syndromes and morphological changes of sporadic and familial forms of neuroacanthocytosis and is illustrated by the case of a 27-year-old man. Progressive extrapyramidal syndrome appeared at the age of 22....
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:The Warburg micro syndrome (WARBM) is a genetically heterogeneous syndrome linked to at least 4 loci. At the clinical level, WARBM is characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, corpus callosum hypoplasia, severe mental retardation, and hypogonadism. In some families additional cl...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2016.62537
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:Transsphenoidal surgery is the treatment of choice in Cushing's disease (CD), although even late recurrences occur in some patients. Low expression of O-6-methylguanine-DNA methyltransferase (MGMT) has been linked to a high risk of relapse in pituitary tumours, but the evidence for corticotroph adenomas is...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2020.102438
更新日期：2020-01-01 00:00:00
abstract：:PPAX6 is an important transcription factor which plays an essential role in brain morphogenesis and eye development. It is related to migration of neuroblasts to the cerebral cortex and deep telencephalic nuclei, and the specification of cellular and regional identity. Disturbances of brain development in two sib fetu...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The size frequency distributions of beta-amyloid (A beta) and prion protein (PrPsc) deposits were studied in Alzheimer's disease (AD) and the variant form of Creutzfeldt-Jakob disease (vCJD) respectively. All size distributions were unimodal and positively skewed. A beta deposits reached a greater maximum size and the...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Meningiomas are the most common primary extra-axial tumours of the central nervous system, however their metastatic spread beyond central nervous system is rare. Here we present the case of a 54-year-old male with anaplastic meningioma who, 1.5 years after initial diagnosis, developed a tumorous expansion in his left ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2019.91195
更新日期：2019-01-01 00:00:00
abstract：:Ganglioglioma is a tumor composed of neoplastic neurons and neoplastic glial cells mixed in different proportions. Astrocytes are the essential glial component. The tumor proliferates mostly in the temporal lobe cortex, scarcely in other areas of the brain. In ganglioglioma the population of ganglionic neurons is very...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The investigations were based on 3 cases with Leigh, 5 cases with Krabbe's, 4 cases of Alpers, 2 cases with Sandhoff, 1 case with Alexander's disease and 1 case with metachromatic leukodystrophy. In 1 case included into the study we have diagnosed nonketotic hyperglycinemia II. All the diseases under examination are r...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:The aim of our study was the estimation of the apoptosis process using in situ-end labelling of DNA breaks method on paraffin sections in 5 human cases of Alzheimer's disease (AD), 6 of Creutzfeldt-Jakob disease (CJD) and in 25 mice infected experimentally with the Fujisaki strain of CJD, killed sequentially at one-we...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare transmissible disease caused by accumulation of pathological prion protein in the CNS. sCJD typically affects patients in their sixties. The median disease duration in sCJD (6 months) is shorter than in variant Creutzfeldt-Jakob disease (vCJD) (14 months). The clinic...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:Chordoid glioma is a rare benign neoplasm of uncertain histogenesis occurring in the third ventricle/ /suprasellar region. Recently, data have emerged suggesting that chordoid glioma is a variant of ependymoma related to a specialised ependyma of the subcommisural organ or the lamina terminalis area. In this study, we...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Metallothioneins (MT) are common proteins in animal tissues. These proteins take part in the homeostasis of the ions of the metals which are necessary for the proper metabolism of the organism (zinc, copper), biosynthesis regulation and zincprotein activity (for example the activity of the zinc-dependant transcription...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary, progressive ischemic disease of small vessels of the brain characterized by migraine with aura (MA), recurrent subcortical ischemic episodes, cognitive decline and psychiatric disorders. CA...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2020.94009
更新日期：2020-01-01 00:00:00
abstract：:Neuronal and axonal degenerative changes in motor vagal neurons (DMNV) and sensory vagal neurons (nTS) in the medulla oblongata in newborns were studied. Material was taken from the autopsies of newborns, live and dead newborns, in different gestational weeks (aborted, immature, premature and mature). 46 cases were st...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Morphological alterations and the course of changes in motoneuron counts were studied by light microscopy (cresyl violet staining) in the L2/L3 region of the spinal cord of hemizygotic transgenic rats carrying the amyotrophic lateral sclerosis-associated mutant human gene for Cu,Zn superoxide dismutase (hSOD1G93A) and...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Tumours of astroglial origin, both malignant glioblastoma (GBM) and benign subependymal giant cell astrocytoma (SEGA), pose a serious medical problem. Casein kinase 2 (CK2), a member of the serine/threonine kinase family, has antiapoptotic properties and plays a vital role in glial tumour cell survival. It contributes...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2019.88452
更新日期：2019-01-01 00:00:00
abstract：:The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders....
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2017.70482
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS:Using Western blot we studied 1 ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2015.49969
更新日期：2015-01-01 00:00:00
abstract：:Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival a...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2020.96755
更新日期：2020-01-01 00:00:00
abstract：:Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. The role of calcification in the pathogenesis of pineal gland dysfunction remains unknown but the available data document that calcification is an organized, regul...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
