Abstract:
:Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. The role of calcification in the pathogenesis of pineal gland dysfunction remains unknown but the available data document that calcification is an organized, regulated process, rather than a passive aging phenomenon. The cellular biology and micro-environmental conditions required for calcification remain poorly understood but most studies have demonstrated evidence that mast cells are strongly implicated in this process. The aim of the present study was to examine the phenotype of mast cells associated with early stages and with the progressive development of calcification in the human pineal gland. The study was performed on pineal samples of 170 fetuses and children whose brains were autopsied and diagnosed during 1998-2002. The representative cerebral and pineal specimens were stained with haematoxylin and eosin or the von Kossa staining technique and for the distribution of mast cell tryptase, mast cell chymase, histamine H4 receptor and vascular network using biotinylated Ulex europaeus agglutinin. Tryptase mast cells were found in all stages of pineal gland development independently of the presence of local tissue lesions. All of them were always localized in the close vicinity of the blood vessels and expressed immunoreactivity to histamine H4 receptor antibody. Immunolocalization of mast cells by chymase antibody (and following dual immunostaining with both chymase and tryptase antibodies) demonstrated that these cells were few in number and were located in the subcapsular region of the gland. In our study, all functional mast cells that underwent activation and were co-localized with deposits of calcium did not contain chymase. All of them were stained with tryptase and represent the MC-T phenotype. Tryptase mast cells and extracellular tryptase were often associated with areas of early and more advanced stages of calcification. Our results lead to the conclusion that the tryptase mast cells play a major role in the pineal calcification process as sites where this process starts and as a source of production of numerous biologically active substances including tryptase that participate in calcification.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Maślińska D,Laure-Kamionowska M,Deręgowski K,Maśliński Ssubject
Has Abstractpub_date
2010-01-01 00:00:00pages
276-82issue
4eissn
1641-4640issn
1509-572Xpii
15813journal_volume
48pub_type
杂志文章abstract::Ganglioglioma is a tumor composed of neoplastic neurons and neoplastic glial cells mixed in different proportions. Astrocytes are the essential glial component. The tumor proliferates mostly in the temporal lobe cortex, scarcely in other areas of the brain. In ganglioglioma the population of ganglionic neurons is very...
journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
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abstract::A neuropathological analysis of 172 cases of AIDS in adults was carried out, to determine the occurrence and nature of the opportunistic infections of the central nervous system (CNS). The material comprised 155 cases of men, and 17 women. Mean age of patients was 38 years. Collection under study originated from the p...
journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
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更新日期:2004-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Folia neuropathologica
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更新日期:2006-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2014.45570
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2013.37707
更新日期:2013-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 信件
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journal_title:Folia neuropathologica
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doi:
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journal_title:Folia neuropathologica
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doi:
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journal_title:Folia neuropathologica
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doi:
更新日期:2008-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
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journal_title:Folia neuropathologica
pub_type: 杂志文章
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2013.34199
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journal_title:Folia neuropathologica
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doi:
更新日期:2007-01-01 00:00:00
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