Programmed cell death (apoptosis) in Alzheimer's disease and Creutzfeldt-Jakob disease.

Abstract:

:The aim of our study was the estimation of the apoptosis process using in situ-end labelling of DNA breaks method on paraffin sections in 5 human cases of Alzheimer's disease (AD), 6 of Creutzfeldt-Jakob disease (CJD) and in 25 mice infected experimentally with the Fujisaki strain of CJD, killed sequentially at one-week intervals. The numbers of apoptotic cells in CJD-infected mice in the later stages of the disease and in terminally ill mice were progressively higher that at the early stage of the disease. Further, we found a correlation between the intensity of apoptosis and major lesions hallmark of disease--the intensity of spongiform changes in the cerebral cortex but not in the accumulation of PrP in CJD infected mice. The number of A beta-amyloid plaques in AD was not related to apoptotic index. Our study showed that apoptosis is a very important event in these neurodegenerative diseases and may become a basic mechanism in loss of neurons.

journal_name

Folia Neuropathol

journal_title

Folia neuropathologica

authors

Jesionek-Kupnicka D,Buczyński J,Kordek R,Sobów T,Kłoszewska I,Papierz W,Liberski PP

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

233-5

issue

4

eissn

1641-4640

issn

1509-572X

journal_volume

35

pub_type

杂志文章
  • Pathophysiological basis of translational stroke research.

    abstract::The high incidence and the devastating consequences of stroke call for efficient therapies but despite extensive experimental evidence of neuroprotective improvements, most clinical treatments have failed. The poor translational success is attributed to the inappropriate selection of clinically irrelevant animal model...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Hossmann KA

    更新日期:2009-01-01 00:00:00

  • Erk activation as a possible mechanism of transformation of subependymal nodule into subependymal giant cell astrocytoma.

    abstract:INTRODUCTION:Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS:Using Western blot we studied 1 ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2015.49969

    authors: Siedlecka M,Szlufik S,Grajkowska W,Roszkowski M,Jóźwiak J

    更新日期:2015-01-01 00:00:00

  • Size frequency distributions of abnormal protein deposits in Alzheimer's disease and variant Creutzfeldt-Jakob disease.

    abstract::The size frequency distributions of beta-amyloid (A beta) and prion protein (PrPsc) deposits were studied in Alzheimer's disease (AD) and the variant form of Creutzfeldt-Jakob disease (vCJD) respectively. All size distributions were unimodal and positively skewed. A beta deposits reached a greater maximum size and the...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Armstrong RA

    更新日期:2007-01-01 00:00:00

  • Myositis specific antibodies: frequency in different populations.

    abstract::Myositis specific autoantibodies (MSA) are the most specific markers of idiopathic inflammatory myopathies (IIM). There is no evidence of presence MSA in patients with other neuromuscular or connective tissue diseases. We compared the frequency of MSA in two groups of IIM patients, one from Poland and one from North A...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Kowalska-Oledzka E,Stern LZ

    更新日期:2000-01-01 00:00:00

  • Rare C-6 vertebral involvement in a child with histiocytosis X: case report.

    abstract::The authors present a rare case of C-6 vertebral involvement in a 12-year-old boy with histiocytosis X. The patient presented with limitation in movements of neck and upper extremities. Computed tomography (CT) and magnetic resonance (MRI) imaging were used in the preoperative workup. Surgery was performed via an ante...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Salehpour F,Tubbs RS,Zarrintan S,Meshkini A,Hadidchi S,Pourfathi H,Azhough R,Fakhrjou A,Goodrich JT,Khaki AA

    更新日期:2007-01-01 00:00:00

  • Are granular osmiophilic material deposits an epiphenomenon in CADASIL?

    abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Pathophysiologically, there seems to be multimerization of the extracellular domain of the protein with a possible gain of function on vascular smooth muscular cells. However,...

    journal_title:Folia neuropathologica

    pub_type: 信件

    doi:10.5114/fn.2015.52414

    authors: Erro R,Moccia M,Cervasio M,Penco S,De Caro Mdel B,Barone P

    更新日期:2015-01-01 00:00:00

  • Reaction of microglial cells in human astrocytomas (preliminary report).

    abstract::Forty human primary brain tumors: twelve protoplasmic, six gemistocytic, four fibrillary and ten anaplastic astrocytomas, eight glioblastomas were submitted for immunohistochemical and histochemical characterization of microglia in tumor tissue and in its surroundings. The following antibodies were used: GFAP, ferriti...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Wierzba-Bobrowicz T,Kuchna I,Matyja E

    更新日期:1994-01-01 00:00:00

  • Some aspects of the inflammatory process.

    abstract::The inflammatory process is a nonspecific complex, stereotype, coordinated response of tissues to injury. This process involves vascular permeability, active migration of blood cells, and passage of plasma constituents into the injurious tissue. The molecules that mediate the initial events of inflammation are the adh...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Maślińska D,Gajewski M

    更新日期:1998-01-01 00:00:00

  • Association of mast cells with calcification in the human pineal gland.

    abstract::Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. The role of calcification in the pathogenesis of pineal gland dysfunction remains unknown but the available data document that calcification is an organized, regul...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Maślińska D,Laure-Kamionowska M,Deręgowski K,Maśliński S

    更新日期:2010-01-01 00:00:00

  • Influence of metallothioneins on zinc and copper distribution in brain tumours.

    abstract::Metallothioneins take part in the homeostasis of the ions of the metals which are necessary for the proper metabolism of the organism (zinc, copper), in biosynthesis regulation of the zinc-containing proteins and also in the detoxication of metals from the tissues. They also protect the tissue from the effects of free...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Floriańczyk B,Osuchowski J,Kaczmarczyk R,Trojanowski T,Stryjecka-Zimmer M

    更新日期:2003-01-01 00:00:00

  • Supratentorial astrocytoma associated with arteriovenous malformation. Case report.

    abstract::A case of the 18-year-old boy suffering from epilepsy since 8 years and suspected of microangioma is presented. The craniotomy revealed left parietal parasagittal superficially located neoplasm and arteriovenous malformation beneath. Unexpected fibrillary astrocytoma associated with vascular tumor was the diagnostic p...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Kroh H,Bidziński J,Majchrowski A

    更新日期:1994-01-01 00:00:00

  • Ultrastructural changes in neuronal and glial cells in subacute sclerosing panencephalitis: correlation with disease duration.

    abstract::This paper presents ultrastructural changes in neuronal and glial cells with special reference to intranuclear inclusion bodies in subacute sclerosing panencephalitis (SSPE) with different duration (from several weeks to seven years). Brain autopsy at ultrastructural level revealed the nucleocapsids of paramyxovirus i...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Lewandowska E,Szpak GM,Lechowicz W,Pasennik E,Sobczyk W

    更新日期:2001-01-01 00:00:00

  • Prenatal exposure of diclofenac sodium affects morphology but not axon number of the median nerve of rats.

    abstract::The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2013.34199

    authors: Ayrancı E,Altunkaynak BZ,Aktaş A,Rağbetli MÇ,Kaplan S

    更新日期:2013-01-01 00:00:00

  • The concentration of thyroid hormones and activities of iodothyronine deiodinases are altered in human brain gliomas.

    abstract::We have determined the cellular concentration of thyroxine (T4) and triiodothyronine (T3) and the activities of two brain iodothyronine deiodinases, type II (5'-D2) and type III (5-D3), in two types of tissues --tumour (26) and non-tumour (5), derived either from human gliomas with various histological malignancies or...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Nauman P,Bonicki W,Michalik R,Warzecha A,Czernicki Z

    更新日期:2004-01-01 00:00:00

  • Might prepatterned acetylcholine-receptor clusters on surface myotubes be a sign of neuromuscular-junction maturation failure?

    abstract:INTRODUCTION:During human myogenesis and synaptogenesis, the first contact between multiaxonal nerve terminals and the primary myotube occurs at an early stage of gestation, then monoaxonal nerve terminals form and postsynaptic clusters of acetylcholine-receptor are modified and redistributed to the site of muscle-nerv...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2013.39722

    authors: Fidziańska A,Jędrzejowska M,Madej-Pilarczyk A,Bojakowski J

    更新日期:2013-01-01 00:00:00

  • Distribution of metallothioneins in the brain neoplastic cells.

    abstract::Metallothioneins (MT) are common proteins in animal tissues. These proteins take part in the homeostasis of the ions of the metals which are necessary for the proper metabolism of the organism (zinc, copper), biosynthesis regulation and zincprotein activity (for example the activity of the zinc-dependant transcription...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Floriańczyk B,Osuchowski J,Kaczmarczyk R,Starosławska E,Trojanowski T

    更新日期:2005-01-01 00:00:00

  • Giant intracranial lipoma.

    abstract::Intracranial lipomas are rare and usually benign in their course. We report a case of a giant intracranial lipoma presenting with raised intracranial pressure. Additionally, this patient was found to have a large lipoma of the anterior fontanelle. The clinical course and outcome of this patient is presented and releva...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Tubbs RS,Louis RG Jr,Loukas M,Shoja MM,Blount JP

    更新日期:2007-01-01 00:00:00

  • MGMT expression in pituitary corticotroph adenomas and its relationship to clinical, pathological, and ultrastructural parameters in patients with Cushing's disease.

    abstract:INTRODUCTION:Transsphenoidal surgery is the treatment of choice in Cushing's disease (CD), although even late recurrences occur in some patients. Low expression of O-6-methylguanine-DNA methyltransferase (MGMT) has been linked to a high risk of relapse in pituitary tumours, but the evidence for corticotroph adenomas is...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2020.102438

    authors: Witek P,Maksymowicz M,Szamotulska K,Piaścik A,Wojciechowska-Luźniak A,Stasiewicz A,Witek J,Zieliński G

    更新日期:2020-01-01 00:00:00

  • Is the normal content of sulfhydryl groups attributable to sparing from dystrophic pathology in dystrophin-deficient muscles?

    abstract::Deficiency of dystrophin in skeletal muscles is supposed to be responsible for all the symptoms associated with Duchenne dystrophy (DMD) and Becker dystrophy (BMD). The dystrophin-deficient mdx mice, however, are clinically almost asymptomatic. Hence, other factor(s) might be responsible for the muscle pathology in DM...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Niebrój-Dobosz I,Fidziańska A,Glinka Z,Hausmanowa-Petrusewicz I

    更新日期:2002-01-01 00:00:00

  • Blood-brain barrier breakdown and cerebellar degeneration in the course of experimental neoplastic disease. Are circulating Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) and -2alpha(CINC-2alpha) the involved mediators?

    abstract::Cerebellar degeneration belongs to indirect effects of malignancy on the nervous system. Although the involvement of immune system is accepted as a hypothesis of its pathology, the clinical observations of ineffective immunomodulatory therapy suggest complex pathomechanisms, which await elucidation. The aim of this st...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Michalak S,Wender M,Michalowska-Wender G,Kozubski W

    更新日期:2010-01-01 00:00:00

  • Variability of localization and intensity of damage of the white matter of the brain and cerebellum in genetically conditioned diseases.

    abstract::The investigations were based on 3 cases with Leigh, 5 cases with Krabbe's, 4 cases of Alpers, 2 cases with Sandhoff, 1 case with Alexander's disease and 1 case with metachromatic leukodystrophy. In 1 case included into the study we have diagnosed nonketotic hyperglycinemia II. All the diseases under examination are r...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Kałuza J,Marszał E,Jamroz E,Pietruszewski J

    更新日期:1999-01-01 00:00:00

  • HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP): the role of HTLV-I-infected Th1 cells in the pathogenesis, and therapeutic strategy.

    abstract::Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy characterized by bilateral pyramidal tract involvement with sphincteric disturbances. The primary neuropathological feature of HAM/TSP is chronic myelitis characterized by perivas...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Nakamura T

    更新日期:2009-01-01 00:00:00

  • Neuronal cytoplasmic inclusions in tau, TDP-43, and FUS molecular subtypes of frontotemporal lobar degeneration share similar spatial patterns.

    abstract::The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders....

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2017.70482

    authors: A Armstrong R

    更新日期:2017-01-01 00:00:00

  • The interaction between lung cancer metastases to the brain and their surroundings.

    abstract:BACKGROUND AND STUDY PURPOSE:due to the fact that an interrelation between metastases of lung cancer to the brain and surroundings may influence the prognosis, we made attempts to answer the following questions: 1) how is the border between the tumour and its surroundings formed? 2) are there any differences in the gli...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Tabaka J,Nowacki P,Pankowski J

    更新日期:2006-01-01 00:00:00

  • Idiopathic hypertrophic pachymeningitis - case report and literature review.

    abstract::Idiopathic hypertrophic pachymeningitis (IHPM) is a rare pathological state, with still unclear aetiopathogenesis. We present a case of a 63-year-old woman with cranial variety of that disease. The manifestations of the disease included headaches, paresis of VI, IX, X nerves and cerebellar ataxia. The disease was diag...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Rudnik A,Larysz D,Gamrot J,Rudnik A,Skorupa A,Bierzyńska-Macyszyn G,Bazowski P

    更新日期:2007-01-01 00:00:00

  • Warburg micro syndrome type 1 associated with peripheral neuropathy and cardiomyopathy.

    abstract::The Warburg micro syndrome (WARBM) is a genetically heterogeneous syndrome linked to at least 4 loci. At the clinical level, WARBM is characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, corpus callosum hypoplasia, severe mental retardation, and hypogonadism. In some families additional cl...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2016.62537

    authors: Kabzińska D,Mierzewska H,Senderek J,Kochański A

    更新日期:2016-01-01 00:00:00

  • Neuroacanthocytosis. Review of literature and case report.

    abstract::Neuroacanthocytosis is a rare disease of nervous system with multisystem pathology. This review presents clinical syndromes and morphological changes of sporadic and familial forms of neuroacanthocytosis and is illustrated by the case of a 27-year-old man. Progressive extrapyramidal syndrome appeared at the age of 22....

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Rafałowska J,Drac H,Jamrozik Z

    更新日期:1996-01-01 00:00:00

  • The effect of short-term treatment with interferon beta 1a on acute experimental allergic encephalomyelitis.

    abstract::The clinical and histological picture and immunocytochemical expression of some cytokines on infiltrates in the central nervous system of Lewis rats were studied in adult rats in the course of short-term therapy of acute experimental allergic encephalomyelitis with interferon beta 1a (IFN beta 1a). There was establish...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Wender M,Michalak S,Wygladalska-Jernas H

    更新日期:2001-01-01 00:00:00

  • Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates.

    abstract::Introduction: Mixed dementia (MixD) refers to a combination of definite Alzheimer's disease (AD) and vascular encephalopathy. The existence of a "pure" type of vascular dementia (VaD) is controversial. There is a need to find magnetic resonance imaging (MRI) characteristics allowing the distinction between V...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2017.66711

    authors: De Reuck J,Auger F,Durieux N,Deramecourt V,Maurage CA,Cordonnier C,Pasquier F,Leys D,Bordet R

    更新日期:2017-01-01 00:00:00

  • Epithelioid schwannomas of the acoustic nerve.

    abstract::Epithelioid schwannomas occur predominantly in relation to peripheral nerves and are associated with histological and clinical malignancy. However, a variant of the epithelioid schwannoma involving cranial nerves is extremely rare. In this study we report three cases of epithelioid schwannomas originating from the aco...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Kroh H,Matyja E,Marchel A

    更新日期:2000-01-01 00:00:00