Erk activation as a possible mechanism of transformation of subependymal nodule into subependymal giant cell astrocytoma.

Abstract:

INTRODUCTION:Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS:Using Western blot we studied 1 SEN and 3 SEGA samples; SEN and 1 SEGA came from the same TS patient. We evaluated e.g. the activation of the phosphorylated forms of proteins belonging to Akt, Erk and mTOR pathways. RESULTS:Differences in Erk pathway activation between SEN and SEGA were found. There was no upregulation of p-Erk, p-Mek or p-RSK1 in the SEN specimen, whilst we found these proteins to be significantly uptriggered in SEGA samples. Also, for the first time, we found p-Akt, p-GSK3 and p-PDK1 upregulated in both SEN and SEGA from the same TS patient. CONCLUSIONS:Our current study shows for the first time the possible mechanism of SEN/SEGA transformation, where Erk pathway hyperactivation seems to be significant. We hypothesize that SEN/SEGA transformation may depend on Erk potentiation.

journal_name

Folia Neuropathol

journal_title

Folia neuropathologica

authors

Siedlecka M,Szlufik S,Grajkowska W,Roszkowski M,Jóźwiak J

doi

10.5114/fn.2015.49969

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

8-14

issue

1

eissn

1641-4640

issn

1509-572X

pii

24860

journal_volume

53

pub_type

杂志文章
  • Evaluation of survival and maturation of cryopreserved dopaminergic fetal cells transplanted into rat striatum and an analysis of the host brain reaction to graft.

    abstract::A fetal, cryopreserved ventral mesencephalic rat tissue was transplanted into striatum of healthy adult rats. A stereotactic apparatus was used for transplantation of solid tissue blocks. The survival of transplanted dopaminergic cells in rat striatum was evaluated by means of histological and immunocytochemical metho...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Kosno-Kruszewska E,Wierzba-Bobrowicz T,Ilnicki K,Lechowicz W,Dymecki J

    更新日期:1996-01-01 00:00:00

  • Supratentorial astrocytoma associated with arteriovenous malformation. Case report.

    abstract::A case of the 18-year-old boy suffering from epilepsy since 8 years and suspected of microangioma is presented. The craniotomy revealed left parietal parasagittal superficially located neoplasm and arteriovenous malformation beneath. Unexpected fibrillary astrocytoma associated with vascular tumor was the diagnostic p...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Kroh H,Bidziński J,Majchrowski A

    更新日期:1994-01-01 00:00:00

  • Localization of endothelin in the blood-brain interphase in rat hippocampus after global cerebral ischemia.

    abstract::Electron microscopic immunocytochemical evaluation of localization and distribution of endothelins 1, 2 and 3 in the CA1 hippocampal sector in rats submitted to 10 min global cerebral ischemia was performed. The studies were done in different postischemic periods (10 min, 3, 6, 12 and 24 h) with postembedding immuno-g...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Gajkowska B,Mossakowski MJ

    更新日期:1995-01-01 00:00:00

  • Clinical findings and diagnostic tests in Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease.

    abstract::Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare transmissible disease caused by accumulation of pathological prion protein in the CNS. sCJD typically affects patients in their sixties. The median disease duration in sCJD (6 months) is shorter than in variant Creutzfeldt-Jakob disease (vCJD) (14 months). The clinic...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Krasnianski A,Meissner B,Heinemann U,Zerr I

    更新日期:2004-01-01 00:00:00

  • Increased vesicular and vacuolar transendothelial transport in traumatic human brain oedema. A review.

    abstract::The endothelial vacuolar and vesicular transports in traumatic human brain oedema have been reviewed and compared with experimental brain oedema in order to establish their role in both oedema formation and oedema resolution. Normal or "non-activated" and "activated" capillaries are found. The activated capillaries sh...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:10.5114/fn.2013.35951

    authors: Castejón OJ

    更新日期:2013-01-01 00:00:00

  • Are granular osmiophilic material deposits an epiphenomenon in CADASIL?

    abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Pathophysiologically, there seems to be multimerization of the extracellular domain of the protein with a possible gain of function on vascular smooth muscular cells. However,...

    journal_title:Folia neuropathologica

    pub_type: 信件

    doi:10.5114/fn.2015.52414

    authors: Erro R,Moccia M,Cervasio M,Penco S,De Caro Mdel B,Barone P

    更新日期:2015-01-01 00:00:00

  • Adrenal metastasis of anaplastic meningioma: report of a rare case.

    abstract::Meningiomas are the most common primary extra-axial tumours of the central nervous system, however their metastatic spread beyond central nervous system is rare. Here we present the case of a 54-year-old male with anaplastic meningioma who, 1.5 years after initial diagnosis, developed a tumorous expansion in his left ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2019.91195

    authors: Soukup J,Kasparova P,Vajda M,Ryska A

    更新日期:2019-01-01 00:00:00

  • Recurrent cerebral infarcts as the first manifestation of infection with the HIV virus.

    abstract::There is an increased risk of stroke in patients with HIV infection. One of the mechanisms is production of anticardiolipin (aCL) antibodies, induced by the virus. Many studies have documented a high incidence of aCL antibodies in patients with HIV infection and the increased risk of stroke, although there is no such ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Gorczyca I,Stanek M,Podlasin B,Furmanek M,Pniewski J

    更新日期:2005-01-01 00:00:00

  • Does lipopolysaccharide-based neuroinflammation induce microglia polarization?

    abstract::Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival a...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2020.96755

    authors: Hernandez Baltazar D,Nadella R,Barrientos Bonilla A,Flores Martínez Y,Olguín A,Heman Bozadas P,Rovirosa Hernández M,Cibrián Llanderal I

    更新日期:2020-01-01 00:00:00

  • Angiocentric glioma from a perspective of A-B-C classification of epilepsy associated tumors.

    abstract::Angiocentric glioma (AG) is a newly-classified, very rare, WHO grade I central nervous system (CNS) lesion, occurring usually in children and young adults. Only 52 patients with AG have been reported so far, making it one of the rarest neuropathological entities. Hereby we present two new cases of AG in young subjects...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2016.58914

    authors: Adamek D,Siwek GP,Chrobak AA,Herman-Sucharska I,Kwiatkowski S,Morga R,Radwańska E,Urbanowicz B

    更新日期:2016-01-01 00:00:00

  • Phenotypic diversity resulting from a point mutation.

    abstract::Paralytic tremor (pt), a hereditary neurological disorder of rabbits, is a recessive, X-linked point mutation in exon 2 of the plp gene, responsible for substitution of 38 His by Glu in the PLP molecule. Pt genotype is expressed in a range of phenotypes, distinguished by the severity of neurological symptoms. Variable...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Sypecka J,Domańska-Janik K

    更新日期:2006-01-01 00:00:00

  • The effect of short-term treatment with interferon beta 1a on acute experimental allergic encephalomyelitis.

    abstract::The clinical and histological picture and immunocytochemical expression of some cytokines on infiltrates in the central nervous system of Lewis rats were studied in adult rats in the course of short-term therapy of acute experimental allergic encephalomyelitis with interferon beta 1a (IFN beta 1a). There was establish...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Wender M,Michalak S,Wygladalska-Jernas H

    更新日期:2001-01-01 00:00:00

  • Might prepatterned acetylcholine-receptor clusters on surface myotubes be a sign of neuromuscular-junction maturation failure?

    abstract:INTRODUCTION:During human myogenesis and synaptogenesis, the first contact between multiaxonal nerve terminals and the primary myotube occurs at an early stage of gestation, then monoaxonal nerve terminals form and postsynaptic clusters of acetylcholine-receptor are modified and redistributed to the site of muscle-nerv...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2013.39722

    authors: Fidziańska A,Jędrzejowska M,Madej-Pilarczyk A,Bojakowski J

    更新日期:2013-01-01 00:00:00

  • Necrobiosis lipoidica and cutaneous anaesthesia: immunohistochemical study of neural fibres.

    abstract:BACKGROUND:Cutaneous anaesthesia in necrobiosis lipoidica (NL) has been attributed to the destruction of nerve fibres by the inflammatory process. In the 1980s, one study demonstrated a decrease in S100 positive neural fibres as proof of this. Thermalgic information is mainly dependent on small fibres, either myelinate...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Fernandez-Flores A

    更新日期:2008-01-01 00:00:00

  • Clinical, biochemical, neuropathological and molecular findings of the first Polish case of adenylosuccinase deficiency.

    abstract::Adenylosuccinase (ADSL) deficiency is an autosomal recessive disorder affecting mainly the nervous system. The disease causes psychomotor retardation, frequently with autistic features and epilepsy. ADSL deficiency may be diagnosed by detection of two abnormal metabolites in body fluids--succinyladenosine (S-Ado) and ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Mierzewska H,Schmidt-Sidor B,Lewandowska E,Grajkowska W,Kuśmierska K,Jurkiewicz E,Stepień T,Rafałowska J

    更新日期:2008-01-01 00:00:00

  • Morphological changes and selective loss of motoneurons in the lumbar part of the spinal cord in a rat model of familial amyotrophic lateral sclerosis (fALS).

    abstract::Morphological alterations and the course of changes in motoneuron counts were studied by light microscopy (cresyl violet staining) in the L2/L3 region of the spinal cord of hemizygotic transgenic rats carrying the amyotrophic lateral sclerosis-associated mutant human gene for Cu,Zn superoxide dismutase (hSOD1G93A) and...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Gadamski R,Chrapusta SJ,Wojda R,Grieb P

    更新日期:2006-01-01 00:00:00

  • Faulty position of cerebellar cortical neurons as a sequel of disturbed neuronal migration.

    abstract::The object of our report is the presentation of the morphological picture of cerebellar cortex malformation as a sequel of disturbed neuronal migration. In the disarranged tissue, cavities with a network of meningeal tissue and embedded pathological vessels were noted. The external granule cells did not form a proper ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Laure-Kamionowska M,Taraszewska A,Maślińska D,Raczkowska B

    更新日期:2006-01-01 00:00:00

  • Endothelin-like immunoreactivity in hippocampus following transient global cerebral ischemia. II. The blood-brain interphase.

    abstract::The effect of transient, global cerebral ischemia on the distribution of endothelin (ET) in blood-brain barrier (BBB) in CA1 area of hippocampus long-time after ischemia was estimated using post-embedding immunogold technique. ET-like immunoreactivity as a gold particles was localized in all compartments of the blood-...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Gajkowska B,Mossakowski MJ

    更新日期:1997-01-01 00:00:00

  • Idiopathic hypertrophic pachymeningitis - case report and literature review.

    abstract::Idiopathic hypertrophic pachymeningitis (IHPM) is a rare pathological state, with still unclear aetiopathogenesis. We present a case of a 63-year-old woman with cranial variety of that disease. The manifestations of the disease included headaches, paresis of VI, IX, X nerves and cerebellar ataxia. The disease was diag...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Rudnik A,Larysz D,Gamrot J,Rudnik A,Skorupa A,Bierzyńska-Macyszyn G,Bazowski P

    更新日期:2007-01-01 00:00:00

  • Blood-brain barrier breakdown and cerebellar degeneration in the course of experimental neoplastic disease. Are circulating Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) and -2alpha(CINC-2alpha) the involved mediators?

    abstract::Cerebellar degeneration belongs to indirect effects of malignancy on the nervous system. Although the involvement of immune system is accepted as a hypothesis of its pathology, the clinical observations of ineffective immunomodulatory therapy suggest complex pathomechanisms, which await elucidation. The aim of this st...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Michalak S,Wender M,Michalowska-Wender G,Kozubski W

    更新日期:2010-01-01 00:00:00

  • Immuno-electron microscopic demonstration of GABA and glutamate synapses in Mongolian gerbils hippocampus after ischemia.

    abstract::The subcellular distribution of glutamate and GABA in synapses of Mongolian gerbils hippocampus was examined using post-embedding immunogold staining method for electron microscopy. Immunolabelling was performed with 10 nm gold-antibody complexes for glutamate and GABA. The gold particle densities gave reliable inform...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Gajkowska B,Gadamski R,Mossakowski M

    更新日期:1995-01-01 00:00:00

  • Giant intracranial lipoma.

    abstract::Intracranial lipomas are rare and usually benign in their course. We report a case of a giant intracranial lipoma presenting with raised intracranial pressure. Additionally, this patient was found to have a large lipoma of the anterior fontanelle. The clinical course and outcome of this patient is presented and releva...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Tubbs RS,Louis RG Jr,Loukas M,Shoja MM,Blount JP

    更新日期:2007-01-01 00:00:00

  • Rare C-6 vertebral involvement in a child with histiocytosis X: case report.

    abstract::The authors present a rare case of C-6 vertebral involvement in a 12-year-old boy with histiocytosis X. The patient presented with limitation in movements of neck and upper extremities. Computed tomography (CT) and magnetic resonance (MRI) imaging were used in the preoperative workup. Surgery was performed via an ante...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Salehpour F,Tubbs RS,Zarrintan S,Meshkini A,Hadidchi S,Pourfathi H,Azhough R,Fakhrjou A,Goodrich JT,Khaki AA

    更新日期:2007-01-01 00:00:00

  • Crocin regulates the proliferation and migration of neural stem cells after cerebral ischemia by activating the Notch1 pathway.

    abstract:INTRODUCTION:To investigate the effects of crocin on proliferation and migration of endogenous neural stem cells and the Notch1 signalling pathway in rats after cerebral ischemia reperfusion. MATERIAL AND METHODS:SD rats were randomly divided into the sham operation group, model group and administration group (crocin)...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:10.5114/fn.2020.100063

    authors: An B,Ma Y,Xu Y,Liu X,Zhang X,Zhang J,Yang C

    更新日期:2020-01-01 00:00:00

  • Qualitative and quantitative analysis of locus coeruleus neurons in Parkinson's disease.

    abstract::The analysis of qualitative changes in the locus coeruleus (LC) was performed on brains from 21 cases of Parkinson's disease. Eleven cases were selected for quantitative analysis of the loss of LC noradrenergic pigmented neurons. The qualitative studies revealed uneven dissemination of the noradrenergic cells loss of ...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Bertrand E,Lechowicz W,Szpak GM,Dymecki J

    更新日期:1997-01-01 00:00:00

  • Morphometric analysis of the cerebellar cortex capillaries in the course of experimental valproate encephalopathy and after chronic exposure to sodium valproate using transmission electron microscopy.

    abstract::Morphometric analysis of the cerebellar cortex capillary cross-section area performed in experimental valproate encephalopathy using transmission electron microscopy showed that prolongation of VPA application resulted in more enhanced lumen narrowing manifested in gradual reduction in the mean value of the coefficien...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Sobaniec-Lotowska M,Sobaniec W,Augustynowicz A

    更新日期:2001-01-01 00:00:00

  • Research on alteration of neurons in vagal nuclei in medulla oblongata in newborns with respiratory distress.

    abstract::Neuronal and axonal degenerative changes in motor vagal neurons (DMNV) and sensory vagal neurons (nTS) in the medulla oblongata in newborns were studied. Material was taken from the autopsies of newborns, live and dead newborns, in different gestational weeks (aborted, immature, premature and mature). 46 cases were st...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Islami H,Shabani R,Shabani D,Dacaj R,Manxhuka S,Azemi M,Krasniqi S,Kurtishi I

    更新日期:2011-01-01 00:00:00

  • Neuroacanthocytosis. Review of literature and case report.

    abstract::Neuroacanthocytosis is a rare disease of nervous system with multisystem pathology. This review presents clinical syndromes and morphological changes of sporadic and familial forms of neuroacanthocytosis and is illustrated by the case of a 27-year-old man. Progressive extrapyramidal syndrome appeared at the age of 22....

    journal_title:Folia neuropathologica

    pub_type: 杂志文章,评审

    doi:

    authors: Rafałowska J,Drac H,Jamrozik Z

    更新日期:1996-01-01 00:00:00

  • Clinicopathological and ultrastructural study in two cases of chordoid glioma.

    abstract::Chordoid glioma is a rare benign neoplasm of uncertain histogenesis occurring in the third ventricle/ /suprasellar region. Recently, data have emerged suggesting that chordoid glioma is a variant of ependymoma related to a specialised ependyma of the subcommisural organ or the lamina terminalis area. In this study, we...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Taraszewska A,Bogucki J,Andrychowski J,Koszewski W,Czernicki Z

    更新日期:2003-01-01 00:00:00

  • Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease.

    abstract::We report here the first description of florid plaques--the hallmark of variant Creutzfeldt-Jakob disease (vCJD). These plaques are composed of broad bundles of amyloid, are highly neuritic and exhibited astrocytes and microglial cells. Collectively, they are more similar to neuritic plaques of Alzheimer's disease tha...

    journal_title:Folia neuropathologica

    pub_type: 杂志文章

    doi:

    authors: Liberski PP,Ironside J,McCardle L,Sherring A

    更新日期:2000-01-01 00:00:00