Abstract：
:Cerebral ischemia injury seriously endangers human health and its molecular mechanism is still not fully understood. microRNA-223 (miR-223) has been reported to be involved in many physiological functions but the specific role of miRNA-223 in ischemic neuronal injury is still unclear. An oxygen-glucose deprivation and simulated reperfusion (OGD/R) model was constructed here to investigate the possible role miR-223 played in ischemic neuronal injury. The expression of miRNA-223 in the OGD/R model and its effect on cell proliferation were studied by qPCR and CCK8 assay. We observed that miR-223 was significantly over-expressed after OGD/R treatment and it suppressed significantly cortical neurons proliferation. To further study the mechanism involved, we predicted and examined the potential targets of miR-223 by targetscan, qPCR, western blot and luciferase reporter assay. We found that the expression level of type 1 insulin-like growth factor receptor (IGF1R) was negatively associated with the level of miR-223. Furthermore, the relative luciferase activity of pmirGLO-WT was inhibited obviously, while no significant change was observed in the pmirGLO-Mut group, indicating that miR-223 could bind to IGF1R. Similar cell proliferation suppression caused by miR-223 antagomir was observed when IGF1R was silenced. On the contrary, when cortical neurons were co-treated with miR-223 agomir and the cDNA of IGF1R which did not contain 3'- untranslated region, the inhibition caused by miR-223 disappeared. Our results suggested that miR-223 may suppress proliferation of cortical neurons that were treated with OGD/R via inhibiting IGF1R expression.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Feng SJ,Zhang XQ,Li JT,Dai XM,Zhao Fdoi
10.5114/fn.2018.74659subject
Has Abstractpub_date
2018-01-01 00:00:00pages
49-57issue
1eissn
1641-4640issn
1509-572Xpii
32361journal_volume
56pub_type
杂志文章abstract：:Morphometric analysis of the cerebellar cortex capillary cross-section area performed in experimental valproate encephalopathy using transmission electron microscopy showed that prolongation of VPA application resulted in more enhanced lumen narrowing manifested in gradual reduction in the mean value of the coefficien...
journal_title：Folia neuropathologica
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abstract：:Hyponatremia is a common disorder of water-electrolyte balance characterized by the decrease of plasma sodium ions concentration below 135 mM. Although water-electrolyte balance is regulated by a kidney, symptoms of hyponatremia are related to the disturbances of intracranial homeostasis and are attributed to brain sw...
journal_title：Folia neuropathologica
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doi：10.5114/fn.2018.78699
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journal_title：Folia neuropathologica
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abstract：:The aim of the study was to analyse in TEM the evolution of changes in structural elements of synaptic junctions of the cerebellar cortex in rats in valproate encephalopathy induced by chronic 12-month administration of sodium valproate - VPA (once daily intragastrically, in a dose of 200 mg/kg b.w.) and after withdra...
journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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更新日期：1994-01-01 00:00:00
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journal_title：Folia neuropathologica
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更新日期：2007-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2006-01-01 00:00:00
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2010-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：10.5114/fn.2017.68580
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journal_title：Folia neuropathologica
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doi：
更新日期：2010-01-01 00:00:00
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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doi：
更新日期：2011-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2006-01-01 00:00:00
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journal_title：Folia neuropathologica
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更新日期：2012-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
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