Abstract：
INTRODUCTION:Brain injury caused by ischaemic stroke is a major cause of disability and death throughout the world. The present study evaluates the neuroprotective effect of pseudopterosin A (PtA) against ischaemia-induced brain injury. MATERIAL AND METHODS:Ischaemia was induced by pMCAO model, and rats were separated in to three groups. A control group; an ischemic group receiving saline solution; and a PtA group receiving PtA (5 mg/kg, i.p.) for the period of three days, i.e. two days before surgery and after the surgery. Effect of PtA was assessed by estimating the infract volume and neurological deficits. Level of oxidative stress, inflammatory mediators, and markers of apoptosis were estimated in the brain tissues. Western blot assay and immunohistochemistry was done for the assessment of expressions of protein. RESULT:Data from the study suggest that treatment with PtA significantly decreases the infracted volume and neurological deficit score compared to the ischaemic group. Treatments with PtA attenuate the activity of antioxidant enzyme, and the level of inflammatory mediators and markers of apoptosis in the brain tissues of ischaemia-induced brain injury. Phosphorylation of FKHR, Bad, and Akt were significantly reduced in the PtA-treated group compared to the ischaemic group. CONCLUSIONS:The present study shows that pseudopterosin A attenuates neuronal injury in the pMCAO model by acting on the Akt signalling pathway.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Niu X,Yu C,Jiang G,Wu J,Tan X,Zhang W,Hou Ldoi
10.5114/fn.2018.76614subject
Has Abstractpub_date
2018-01-01 00:00:00pages
104-111issue
2eissn
1641-4640issn
1509-572Xpii
33123journal_volume
56pub_type
杂志文章abstract：:The importance of chemokines seems to extend far beyond their well-known role as mediators of an inflammatory response. The most interesting hypothesis is that these molecules may influence the migration of progenitor cells during development. Primary sensory neurones have been shown to migrate towards RANTES in vitro...
journal_title：Folia neuropathologica
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更新日期：2003-01-01 00:00:00
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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更新日期：2002-01-01 00:00:00
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journal_title：Folia neuropathologica
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journal_title：Folia neuropathologica
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doi：
更新日期：2004-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2004-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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doi：
更新日期：2010-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2009-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2005-01-01 00:00:00
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journal_title：Folia neuropathologica
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更新日期：1999-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：2009-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：1998-01-01 00:00:00
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journal_title：Folia neuropathologica
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doi：
更新日期：1998-01-01 00:00:00
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doi：
更新日期：2007-01-01 00:00:00
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