Abstract:
:The aim of the study was to analyse in TEM the evolution of changes in structural elements of synaptic junctions of the cerebellar cortex in rats in valproate encephalopathy induced by chronic 12-month administration of sodium valproate - VPA (once daily intragastrically, in a dose of 200 mg/kg b.w.) and after withdrawal of this antiepileptic for 1 and 3 months. After 9 and 12 months of the experiment, synaptic endings of both the symmetrical and asymmetrical synapses in the neuropil of the cerebellar cortex, especially in the molecular layer, showed signs of severe damage (mainly swelling) and even disintegration. They were mostly observed in axodendritic endings and axospinal endings on the dendritic spines of Purkinje cells, being manifested in the presence of large vacuolar structures, electron lucent areas and swollen mitochondria within the cytoplasm. A reduced number of axonal synaptic vesicles (with more type F vesicles preserved) could be seen. One and 3 months after the end of chronic application of VPA, the synaptic junctions did not show morphological exponents of the repair processes. The alterations observed in the synapticjunctions of the cerebellar cortex may suggest disorders in neurotransmission processes, such as exhaustion and damage caused by ischaemia due to damage to the blood-brain barrier induced by VPA and/or its toxic metabolites.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Sobaniec-Lotowska MEsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
87-96issue
2eissn
1641-4640issn
1509-572Xjournal_volume
40pub_type
杂志文章abstract::Electron microscopic immunocytochemical evaluation of localization and distribution of endothelins 1, 2 and 3 in the CA1 hippocampal sector in rats submitted to 10 min global cerebral ischemia was performed. The studies were done in different postischemic periods (10 min, 3, 6, 12 and 24 h) with postembedding immuno-g...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Intracranial lipomas are rare and usually benign in their course. We report a case of a giant intracranial lipoma presenting with raised intracranial pressure. Additionally, this patient was found to have a large lipoma of the anterior fontanelle. The clinical course and outcome of this patient is presented and releva...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Ischemic stroke remains one of the top ten causes of death in children. There is evidence for the role of pro-inflammatory cytokines, such as IL-6 and the -174G>C promoter polymorphism of the IL-6 gene, in the occurrence and outcome of stroke in adults. The aim of the present study was to determine a possibl...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::The aim of our study was to present six cases with cystic changes within the white matter in infant brains and discuss the variants of this type of neuropathological lesions of the developing brain. Two of them exhibited the changes characteristic for cystic leucoencephalopathy. To the others with moderate involvement...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The post-mortem neuropathological investigations were carried out on 20 female New Zealand rabbits. Two main types of changes were found: inflammatory, including meningeal and perivascular infiltrates, and thrombotic within the nervous tissue. The findings revealed that active process within the CNS persists at least ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The authors present a rare case of C-6 vertebral involvement in a 12-year-old boy with histiocytosis X. The patient presented with limitation in movements of neck and upper extremities. Computed tomography (CT) and magnetic resonance (MRI) imaging were used in the preoperative workup. Surgery was performed via an ante...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS:Using Western blot we studied 1 ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2015.49969
更新日期:2015-01-01 00:00:00
abstract::Deficiency of dystrophin in skeletal muscles is supposed to be responsible for all the symptoms associated with Duchenne dystrophy (DMD) and Becker dystrophy (BMD). The dystrophin-deficient mdx mice, however, are clinically almost asymptomatic. Hence, other factor(s) might be responsible for the muscle pathology in DM...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and associated co-morbidities such as vascular disease and infection. In the light of recent evidence, this review reconsiders these risk fact...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:10.5114/fn.2019.85929
更新日期:2019-01-01 00:00:00
abstract::The effect of transient, global cerebral ischemia on the distribution of endothelin (ET) in blood-brain barrier (BBB) in CA1 area of hippocampus long-time after ischemia was estimated using post-embedding immunogold technique. ET-like immunoreactivity as a gold particles was localized in all compartments of the blood-...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Some data suggest that the central nervous system (CNS) is the main target of Staphylococcus alpha-toxin. Since this pathogen cannot penetrate the blood-brain barrier (BBB), the exact mechanism by which alpha-toxin affects the CNS remains unclear. Recent studies on the role of the innate immune system have shed light ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The endothelial vacuolar and vesicular transports in traumatic human brain oedema have been reviewed and compared with experimental brain oedema in order to establish their role in both oedema formation and oedema resolution. Normal or "non-activated" and "activated" capillaries are found. The activated capillaries sh...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:10.5114/fn.2013.35951
更新日期:2013-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2017.70482
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in patients above 50 years of age. Its progressive course finally leads to immobilisation, and no effective therapy exists. Its pathogenesis includes both degenerative and inflammatory processes, however, its direct causes remain ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2015.56550
更新日期:2015-01-01 00:00:00
abstract::The Warburg micro syndrome (WARBM) is a genetically heterogeneous syndrome linked to at least 4 loci. At the clinical level, WARBM is characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, corpus callosum hypoplasia, severe mental retardation, and hypogonadism. In some families additional cl...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2016.62537
更新日期:2016-01-01 00:00:00
abstract::Meningiomas are the most common primary extra-axial tumours of the central nervous system, however their metastatic spread beyond central nervous system is rare. Here we present the case of a 54-year-old male with anaplastic meningioma who, 1.5 years after initial diagnosis, developed a tumorous expansion in his left ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2019.91195
更新日期:2019-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2014.47846
更新日期:2014-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Granular osmiophilic material (GOM) is a pathognomonic feature of CADASIL that may be a consequence of pathological processes triggered by Notch3 mutations. Since knowledge of the effects of CADASIL-associated GOM deposits is important to understand the molecular pathogenesis of this disorder, we performed a thorough ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy characterized by bilateral pyramidal tract involvement with sphincteric disturbances. The primary neuropathological feature of HAM/TSP is chronic myelitis characterized by perivas...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract::The clinical and histological picture and immunocytochemical expression of some cytokines on infiltrates in the central nervous system of Lewis rats were studied in adult rats in the course of short-term therapy of acute experimental allergic encephalomyelitis with interferon beta 1a (IFN beta 1a). There was establish...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The subcellular distribution of glutamate and GABA in synapses of Mongolian gerbils hippocampus was examined using post-embedding immunogold staining method for electron microscopy. Immunolabelling was performed with 10 nm gold-antibody complexes for glutamate and GABA. The gold particle densities gave reliable inform...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The analysis of qualitative changes in the locus coeruleus (LC) was performed on brains from 21 cases of Parkinson's disease. Eleven cases were selected for quantitative analysis of the loss of LC noradrenergic pigmented neurons. The qualitative studies revealed uneven dissemination of the noradrenergic cells loss of ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Inherited neurodegenerative disorders are debilitating diseases that occur across different species, such as the domestic dog (Canis lupus familiaris), and many are caused by mutations in the same genes as corresponding human conditions. In the present study, we report an inherited neurodegenerative condition, term...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2017.68580
更新日期:2017-01-01 00:00:00
abstract::Globoid cell leukodystrophy (GLD, also known as Krabbe disease), whose pathophysiology is still not completely elucidated, is an inherited, metabolic, and neurodegenerative disease, caused by the deficiency of β-galactocerebrosidase (GALC) or in very rare cases by lack of active saposin A. We describe two patients, i...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:10.5114/fn.2012.32364
更新日期:2012-01-01 00:00:00
abstract::Cerebellar cortical biopsies of the peritumoural region of seven patients with cerebellar haemangioma, mesencephalic meningioma, cerebellopontine astrocytoma, cerebellopontine meningioma, and medulloblastoma of cerebellar vermis were examined by means of conventional transmission electron microscopy. Granule cells sho...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2016.60057
更新日期:2016-01-01 00:00:00
abstract::The gerbils brains after 3- and 4-minute-long ischemia caused by bilateral common carotid artery occlusion and 14 days survival were investigated using lectin techniques. Chosen lectins, represented by synthetic plant glycoproteids, which are specifically bound to particular sugar residues (receptors) located on the c...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Current basic research on tumorigenesis suggests that the accumulation of multiple genetic defects underlies the progression of initiated cells toward malignancy. Molecular abnormalities associated with primary brain tumors include a wide variety of changes in tumor-suppressor genes, proto-oncogenes and growth factors...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract::Prion-like transmission of protein aggregates or amyloid in several neurodegenerative diseases, such as Parkinson's disease, Huntington's disease and Alzheimer's disease, in addition to the transmissible spongiform encephalopathies (or prion diseases), has been proposed recently. This is a controversial idea and, in t...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00