Abstract:
OBJECTIVES:Ischemic stroke remains one of the top ten causes of death in children. There is evidence for the role of pro-inflammatory cytokines, such as IL-6 and the -174G>C promoter polymorphism of the IL-6 gene, in the occurrence and outcome of stroke in adults. The aim of the present study was to determine a possible association between the -174G>C IL-6 polymorphism and occurrence of paediatric stroke, its symptoms and outcome. MATERIAL AND METHODS:The study group consisted of 340 individuals: 80 stroke children, 122 parents of patients and 138 controls. The -174G/C polymorphism was genotyped using the RFLP method. For the analysis of the relationship between genotypes and stroke we used two alternative methods: the case-control model and the transmission test for linkage disequilibrium using data from families. RESULTS:We observed no differences in the transmission of alleles from parents to children. We also did not find any statistical differences in distribution of genotypes and alleles between patients and controls. However, the analysis showed that post-stroke epilepsy was genotype-dependent. All children with epilepsy were G allele carriers and none of them was a CC homozygote whereas about 25% of children without epilepsy had the CC genotype. CONCLUSIONS:Our study did not show any associations between the IL-6 -174 G>C polymorphism and the occurrence of stroke but we observed a relation between post-stroke epilepsy and the G allele carrier-state.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Balcerzyk A,Nowak M,Kopyta I,Emich-Widera E,Pilarska E,Pienczk-Ręcławowicz K,Kaciński M,Wendorff J,Zak Isubject
Has Abstractpub_date
2012-01-01 00:00:00pages
147-51issue
2eissn
1641-4640issn
1509-572Xpii
18863journal_volume
50pub_type
杂志文章abstract::Intracranial lipomas are rare and usually benign in their course. We report a case of a giant intracranial lipoma presenting with raised intracranial pressure. Additionally, this patient was found to have a large lipoma of the anterior fontanelle. The clinical course and outcome of this patient is presented and releva...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in patients above 50 years of age. Its progressive course finally leads to immobilisation, and no effective therapy exists. Its pathogenesis includes both degenerative and inflammatory processes, however, its direct causes remain ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2015.56550
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2013.39722
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2014.43786
更新日期:2014-01-01 00:00:00
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2015.49969
更新日期:2015-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2018.80866
更新日期:2018-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Folia neuropathologica
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The aim of the study was to analyse in TEM the evolution of changes in structural elements of synaptic junctions of the cerebellar cortex in rats in valproate encephalopathy induced by chronic 12-month administration of sodium valproate - VPA (once daily intragastrically, in a dose of 200 mg/kg b.w.) and after withdra...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 信件
doi:10.5114/fn.2015.52414
更新日期:2015-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:10.5114/fn.2019.85929
更新日期:2019-01-01 00:00:00
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journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
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